Article
Oncology
Manuela Piazzi, Snezana Kojic, Cristina Capanni, Nemanja Stamenkovic, Alberto Bavelloni, Oriano Marin, Giovanna Lattanzi, William Blalock, Vittoria Cenni
Summary: Osteosarcoma is a rare malignancy primarily affecting children and young adults, and this study aimed to identify novel therapeutic targets for the disease. The protein Ankrd2, known for its role in muscle fibers, was found to play a role in osteosarcoma development, potentially acting as a double-faced cancer driver gene. Ankrd2 expression influenced cellular growth, migration, clonogenicity, and matrix metalloproteinase activity in various cell lines, presenting Ankrd2 as a novel player in osteosarcoma development.
Review
Oncology
Dandan Wang, Ruifeng Liu, Qiuning Zhang, Hongtao Luo, Junru Chen, Meng Dong, Yuhang Wang, Yuhong Ou, Zhiqiang Liu, Shilong Sun, Kehu Yang, Jinhui Tian, Zheng Li, Xiaohu Wang
Summary: This study investigated the radiobiological effects of charged particle irradiation on pancreatic cancer cell lines. The results showed that carbon ion irradiation had superior radiobiological effects compared to photon irradiation in the treatment of pancreatic cancer. Additionally, both carbon ion irradiation and proton irradiation had similar sensitization effects when combined with chemotherapy or targeted therapy.
FRONTIERS IN ONCOLOGY
(2022)
Article
Pathology
Xin Chen, Qian Lin Song, Jia Yu Wang, Rui Ji, Ze Hong Li, Ming Liang Cao, Xue Feng Mu, Duan Ying Guo, Yan Zhang, Jing Yang
Summary: PFN1 expression was decreased in the villous tissue of patients with URSA. Knockdown of PFN1 in trophoblastic cell lines significantly decreased migration, invasion ability, and cell viability, while increasing apoptosis. Overexpression of PFN1 had the opposite effects. PFN1 regulated trophoblast function through the PI3K/AKT signaling pathway, not the MAPK pathway. Knockdown of PFN1 in trophoblasts promoted tumor necrosis factor-α secretion to induce M1 polarization of macrophages via the NF-kB signaling pathway. These findings suggest that PFN1 has a broad therapeutic potential for patients with URSA.
AMERICAN JOURNAL OF PATHOLOGY
(2023)
Article
Cell Biology
Yiqing Cai, Liemei Lv, Tiange Lu, Mengfei Ding, Zhuoya Yu, Xiaomin Chen, Xiangxiang Zhou, Xin Wang
Summary: Metabolic reprogramming, specifically dysregulation of glutamine metabolism, plays a crucial role in tumorigenesis, microenvironment remodeling, and therapeutic resistance in DLBCL. High levels of glutamine are associated with poor clinical outcomes, while the derivative of glutamine, a-KG, is negatively correlated with invasiveness features. Treatment with DM-aKG significantly inhibits tumor growth by inducing apoptosis and non-apoptotic cell death. The study highlights the potential use of a-KG as a novel therapeutic strategy for DHL patients.
CELL DEATH DISCOVERY
(2023)
Article
Biochemistry & Molecular Biology
Alessio Parisi, Chris J. Beltran, Keith M. Furutani
Summary: This article presents the design and application of the Mayo Clinic Florida MKM (MCF MKM) and compares it with the local effect model (LEM). Through extensive benchmarking and predictions with in vitro data, it is found that the MCF MKM can be reliably used for RBE calculations.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Ye Feng, Ying Xu, Yongjian Gao, Yiying Chen, Xuefeng Wang, Zhi Chen
Summary: SOX2OT is an up-regulated oncogene in CRC, promoting cell proliferation, migration, and invasion. It acts as a competing endogenous RNA to upregulate SOX5 by sponging miR-194-5p, thus affecting tumorgenesis of CRC.
CELL DEATH & DISEASE
(2021)
Article
Biochemical Research Methods
Sven C. Voss, Nelson N. Orie, Wesal El-Saftawy, Stephanie Saghbazarian, Alanoud Al-Kaabi, Costas Georgakopoulos, Ioanna Athanasiadou, Vidya Mohamed-Ali, Mohammed Al-Maadheed
Summary: This study aimed to test the feasibility of using a directly HRP-conjugated anti-EPO primary antibody, which showed potential utility in reducing analysis time for purified samples with comparable specificity and sensitivity.
DRUG TESTING AND ANALYSIS
(2021)
Article
Biochemistry & Molecular Biology
Sascha Diehl, Guido Hildebrandt, Katrin Manda
Summary: This study examined the cytotoxic and radio-sensitizing effects of piperine, a major compound in black pepper, on two different human epithelial tumor cell lines. The results showed that piperine inhibited cell growth in a concentration- and time-dependent manner, and it also had an inhibitory effect on clonogenic survival after combined treatment with ionizing radiation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Medicinal
Beiwei Liang, Chunlai Li, Zhan Zhou, Yubo Xie
Summary: This study aimed to investigate the effect of hydromorphone on the growth of human gastric cancer cells. The results showed that within a certain concentration range, hydromorphone can suppress the growth of human gastric cancer cells, and the inhibitory effect is enhanced with longer incubation time and higher concentrations. Hydromorphone inhibits the growth of human gastric cancer cells through cell cycle arrest and induction of apoptosis.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2023)
Article
Multidisciplinary Sciences
Elena C. Sigmund, Lilian Baur, Philipp Schineis, Jorge Arasa, Victor Collado-Diaz, Martina Vranova, Rolf A. K. Stahl, Marcus Thelen, Cornelia Halin
Summary: ACKR3 is a scavenging receptor implicated in lymphatic development, with deficiency leading to lymphatic hyperplasia and cardiac defects in mice. However, in adult mice, LEC-expressed ACKR3 does not contribute to postnatal lymphangiogenesis or lymphatic function.
Article
Engineering, Biomedical
Alessio Parisi, Keith M. Furutani, Chris J. Beltran
Summary: This study systematically analyzed various biological weighting functions and microdosimetric models, revealing a common issue of overestimation of RBE values at high linear energy transfer. The importance of improving model accuracy was emphasized.
PHYSICS IN MEDICINE AND BIOLOGY
(2022)
Article
Immunology
Xiao-Mei Chen, Hui Li, Yu Wu, Lan-Lan Wang, Yang-Juan Bai, Yun-Ying Shi
Summary: Anti-EPO antibody-mediated pure red cell aplasia (PRCA) is a rare disease primarily seen in patients with chronic kidney disease receiving recombinant human erythropoietin (rHuEPO) treatment. Treatment options include discontinuation of rHuEPO, immunosuppressive agents, intravenous immunoglobulin, plasmapheresis, or kidney transplantation. We reported a successful case of a kidney transplant recipient with anti-EPO antibody-mediated PRCA, who achieved remission after consecutive plasmapheresis sessions and adjustment of immunosuppressive regimen.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medicine, Research & Experimental
Wenkun Fu, Wei Wang, Lunzhi Yuan, Yanzhen Lin, Xiumin Huang, Rirong Chen, Minping Cai, Che Liu, Liqiang Chen, Ming Zhou, Kun Wu, Huan Zhao, Dequan Pan, Jian Ma, Junping Hong, Bingke Zhai, Yali Zhang, Zhibo Kong, Yingbin Wang, Yixin Chen, Quan Yuan, Huachen Zhu, Tong Cheng, Yi Guan, Ningshao Xia
Summary: This study utilized a humanized mouse model with human lung xenografts to investigate SARS-CoV-2 infection. The results showed that the human lung xenografts closely resembled normal human lung structure, supported efficient replication and spread of SARS-CoV-2, caused severe lung damage, and induced a strong pro-inflammatory response. Treatment with IFN-alpha effectively inhibited viral replication in the lung xenografts. This model proves to be a valuable tool for studying SARS-CoV-2 lung infection pathogenesis and evaluating potential antiviral therapies.
Article
Biochemistry & Molecular Biology
Maria A. A. Surovtseva, Irina I. I. Kim, Natalia A. A. Bondarenko, Alexander P. P. Lykov, Kristina Yu. Krasner, Elena V. V. Chepeleva, Nataliya P. P. Bgatova, Alexander N. N. Trunov, Valery V. V. Chernykh, Olga V. V. Poveshchenko
Summary: In this study, corneal fibroblasts (CFs) with high proliferative potential were isolated and grown in a serum-free medium, and then reverted into keratocytes. These reverted cells maintained the morphology and functional properties of primary keratocytes, making them a potential source for tissue engineering and cell therapy of corneal pathologies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Yandong Huang, Qinyang Bai, Zhanlong Wang, Hongbo Yu, Yanru Li, Hao Lu, Huimin Kang, Xuewei Shi, Kai Feng
Summary: This study revealed that circ_0052184 promotes the occurrence and development of colorectal cancer by targeting the miR-604/HOXA9 axis, providing an explanation for the malignant progression of colorectal cancer at the molecular level.
ANALYTICAL CELLULAR PATHOLOGY
(2022)
Article
Biochemistry & Molecular Biology
H. Ehrenreich, M. Mitjans, S. Van der Auwera, T. P. Centeno, M. Begemann, H. J. Grabe, S. Bonn, K-A Nave
MOLECULAR PSYCHIATRY
(2018)
Article
Medicine, Research & Experimental
Hana Janova, Sahab Arinrad, Evan Balmuth, Marina Mitjans, Johannes Hertel, Mohamad Habes, Robert A. Bittner, Hong Pan, Sandra Goebbels, Martin Begemann, Ulrike C. Gerwig, Soenke Langner, Hauke B. Werner, Sarah Kittel-Schneider, Georg Homuth, Christos Davatzikos, Henry Voelzke, Brian L. West, Andreas Reif, Hans Joergen Grabe, Susann Boretius, Hannelore Ehrenreich, Klaus-Armin Nave
JOURNAL OF CLINICAL INVESTIGATION
(2018)
Letter
Clinical Neurology
Claudia Bartels, Hannelore Ehrenreich
MULTIPLE SCLEROSIS JOURNAL
(2018)
Letter
Clinical Neurology
Claudia Bartels, Hannelore Ehrenreich
MULTIPLE SCLEROSIS JOURNAL
(2018)
Article
Genetics & Heredity
Guiyan Ni, Gerhard Moser, Naomi R. Wray, S. Hong Lee
AMERICAN JOURNAL OF HUMAN GENETICS
(2018)
Article
Psychiatry
Claudia Bartels, Michael Wagner, Steffen Wolfsgruber, Hannelore Ehrenreich, Anja Schneider
AMERICAN JOURNAL OF PSYCHIATRY
(2018)
Article
Biochemistry & Molecular Biology
Hong Pan, Barbara Oliveira, Gesine Saher, Ekrem Dere, Daniel Tapken, Marina Mitjans, Jan Seidel, Janina Wesolowski, Debia Wakhloo, Christina Klein-Schmidt, Anja Ronnenberg, Kerstin Schwabe, Ralf Trippe, Kerstin Maetz-Rensing, Stefan Berghoff, Yazeed Al-Krinawe, Henrik Martens, Martin Begemann, Winfried Stoecker, Franz-Josef Kaup, Reinhard Mischke, Susann Boretius, Klaus-Armin Nave, Joachim K. Krauss, Michael Hollmann, Fred Luhder, Hannelore Ehrenreich
MOLECULAR PSYCHIATRY
(2019)
Article
Biochemistry & Molecular Biology
Marina Mitjans, Jan Seidel, Martin Begemann, Fabian Bockhop, Jorge Moya-Higueras, Vikas Bansal, Janina Wesolowski, Anna Seelbach, Manuel Ignacio Ibanez, Fatka Kovacevic, Oguzhan Duvar, Lourdes Fananas, Hannah-Ulrike Wolf, Generos Ortet, Peter Zwanzger, Verena Klein, Ina Lange, Andreas Taenzer, Manuela Dudeck, Lars Penke, Ludger Tebartz van Elst, Robert A. Bittner, Richard Schmidmeier, Roland Freese, Ruediger Mueller-Isberner, Jens Wiltfang, Thomas Bliesener, Stefan Bonn, Luise Poustka, Juergen L. Mueller, Barbara Arias, Hannelore Ehrenreich
MOLECULAR PSYCHIATRY
(2019)
Review
Biochemistry & Molecular Biology
Hannelore Ehrenreich, Karin Weissenborn, Martin Begemann, Markus Busch, Eduard Vieta, Kamilla W. Miskowiak
MOLECULAR MEDICINE
(2020)
Article
Biochemistry & Molecular Biology
Hannelore Ehrenreich, Justus Wilke, Agnes A. Steixner-Kumar
MOLECULAR PSYCHIATRY
(2021)
Article
Biochemistry & Molecular Biology
Agnes A. Steixner-Kumar, Vinicius Daguano Gastaldi, Jan Seidel, Albert Rosenberger, Martin Begemann, Hannelore Ehrenreich
Summary: Accumulation of early-life environmental risks, including cannabis and alcohol, strongly predicts the development of polytoxicomania, while genetic predisposition to this condition remains largely unexplored.
MOLECULAR PSYCHIATRY
(2021)
Review
Biochemistry & Molecular Biology
Martin Begemann, Oliver Gross, Dominik Wincewicz, Ruediger Hardeland, Vinicius Daguano Gastaldi, Eduard Vieta, Karin Weissenborn, Kamilla W. Miskowiak, Onnen Moerer, Hannelore Ehrenreich
Summary: The global spread of SARS-CoV-2 since fall 2019 has caused a major pandemic, with severe COVID-19 patients experiencing multiple organ failure and grave neuropsychiatric manifestations. The development of vaccines has shown promise, but few effective treatment options have emerged to modify the course and outcome of COVID-19. Substituting erythropoietin may help overcome the 'hypoxia paradox' and improve survival and functional status of patients with severe COVID-19.
MOLECULAR MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Hannelore Ehrenreich, Laura Fernandez Garcia-Agudo, Agnes A. Steixner-Kumar, Justus B. H. Wilke, Umer Javed Butt
Summary: Executive functions, learning, attention, and processing speed are important aspects of cognitive performance, which can be affected in neuropsychiatric disorders. Studies have shown that recombinant human erythropoietin (rhEPO) can improve cognitive abilities and reduce brain matter loss. The administration of rhEPO leads to an increase in pyramidal neurons and oligodendrocytes, while decreasing the number and activity of microglia. This process promotes neurogenesis and increases dendritic spine density, which may contribute to improved cognitive function.
MOLECULAR PSYCHIATRY
(2022)
Article
Biology
Sahab Arinrad, Constanze Depp, Sophie B. Siems, Andrew Octavian Sasmita, Maria A. Eichel, Anja Ronnenberg, Kurt Hammerschmidt, Katja A. Lueders, Hauke B. Werner, Hannelore Ehrenreich, Klaus-Armin Nave
Summary: The study shows that structural defects of intracortical myelin associated with neuroinflammation are key features of advanced brain aging. A mouse model with similar pathology exhibits behavioral abnormalities, but cognitive assessment is challenging due to motor-sensory functions. However, mice lacking Plp1 gene in ventricular zone stem cells exhibit subtle myelin defects only in certain brain regions and show no basic motor-sensory performance impairments. Interestingly, novel behavioral paradigms reveal catatonia-like symptoms and executive dysfunction.
Letter
Psychiatry
Barbara Oliveira, Hannelore Ehrenreich