Hypoxia-inducible factor 1–mediated characteristic features of cancer cells for tumor radioresistance

UCHL1 provides diagnostic and antimetastatic strategies due to its deubiquitinating effect on HIF-1α

(2015) Yoko Goto et al.   Nature Communications

Mitochondrial autophagy: Life and breath of the cell

(2014) Gregg L. Semenza   Autophagy

Aberrant IDH3α expression promotes malignant tumor growth by inducing HIF-1-mediated metabolic reprogramming and angiogenesis

(2014) L Zeng et al.   ONCOGENE

The hypoxic microenvironment upgrades stem-like properties of ovarian cancer cells

(2012) Dongming Liang et al.   BMC CANCER

Glucose-6-phosphate dehydrogenase, NADPH, and cell survival

(2012) Robert C. Stanton   IUBMB LIFE

Tp53-induced Glycolysis and Apoptosis Regulator (TIGAR) Protects Glioma Cells from Starvation-induced Cell Death by Up-regulating Respiration and Improving Cellular Redox Homeostasis

(2012) Christina Wanka et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mitochondrial localization of TIGAR under hypoxia stimulates HK2 and lowers ROS and cell death

(2012) E. C. Cheung et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular mechanisms mediating metastasis of hypoxic breast cancer cells

(2012) Gregg L. Semenza   TRENDS IN MOLECULAR MEDICINE

Hypoxia-inducible factors: mediators of cancer progression and targets for cancer therapy

(2012) Gregg L. Semenza   TRENDS IN PHARMACOLOGICAL SCIENCES

Cancer cells that survive radiation therapy acquire HIF-1 activity and translocate towards tumour blood vessels

(2012) Hiroshi Harada et al.   Nature Communications

HIF Induces Human Embryonic Stem Cell Markers in Cancer Cells

(2011) J. Mathieu et al.   CANCER RESEARCH

p53 regulates biosynthesis through direct inactivation of glucose-6-phosphate dehydrogenase

(2011) Peng Jiang et al.   NATURE CELL BIOLOGY

TP53 induced glycolysis and apoptosis regulator (TIGAR) knockdown results in radiosensitization of glioma cells

(2011) Miguel A. Peña-Rico et al.   RADIOTHERAPY AND ONCOLOGY

Hypoxia-Inducible Factor 1 in Tumor Radioresistance

(2010) Hiroshi Harada et al.   Current Signal Transduction Therapy

Mutational analysis of hypoxia-related genes HIF1α and CUL2 in common human cancers

(2009) SANG WOOK PARK et al.   APMIS

Treatment regimen determines whether an HIF-1 inhibitor enhances or inhibits the effect of radiation therapy

(2009) H Harada et al.   BRITISH JOURNAL OF CANCER

HIF-1 Inhibitors for Cancer Therapy: From Gene Expression to Drug Discovery

(2009) G. Semenza   CURRENT PHARMACEUTICAL DESIGN

Reactive Oxygen Species-generating Mitochondrial DNA Mutation Up-regulates Hypoxia-inducible Factor-1α Gene Transcription via Phosphatidylinositol 3-Kinase-Akt/Protein Kinase C/Histone Deacetylase Pathway

(2009) Nobuko Koshikawa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics

(2009) G L Semenza   ONCOGENE

TS-1 enhances the effect of radiotherapy by suppressing radiation-induced hypoxia-inducible factor-1 activation and inducing endothelial cell apoptosis

(2008) Lihua Zeng et al.   CANCER SCIENCE

The Akt/mTOR Pathway Assures the Synthesis of HIF-1α Protein in a Glucose- and Reoxygenation-dependent Manner in Irradiated Tumors

(2008) Hiroshi Harada et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mitochondrial Autophagy Is an HIF-1-dependent Adaptive Metabolic Response to Hypoxia

(2008) Huafeng Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of cancer cell metabolism by hypoxia-inducible factor 1

(2008) Gregg L. Semenza   SEMINARS IN CANCER BIOLOGY