Targeting tumor hypoxia and mitochondrial metabolism with anti-parasitic drugs to improve radiation response in high-grade gliomas
出版年份 2020 全文链接
标题
Targeting tumor hypoxia and mitochondrial metabolism with anti-parasitic drugs to improve radiation response in high-grade gliomas
作者
关键词
-
出版物
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
Volume 39, Issue 1, Pages -
出版商
Springer Science and Business Media LLC
发表日期
2020-10-07
DOI
10.1186/s13046-020-01724-6
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Ivermectin suppresses tumour growth and metastasis through degradation of PAK1 in oesophageal squamous cell carcinoma
- (2020) Liang Chen et al. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
- Disruption of Endolysosomal RAB5/7 Efficiently Eliminates Colorectal Cancer Stem Cells
- (2019) Mitsunobu Takeda et al. CANCER RESEARCH
- The kinase inhibitor SI113 induces autophagy and synergizes with quinacrine in hindering the growth of human glioblastoma multiforme cells
- (2019) Silvia Matteoni et al. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- Oxidative phosphorylation as a potential therapeutic target for cancer therapy
- (2019) Valentina Sica et al. INTERNATIONAL JOURNAL OF CANCER
- Repurposing quinacrine for treatment-refractory cancer
- (2019) Derek B. Oien et al. SEMINARS IN CANCER BIOLOGY
- The anti-malarial atovaquone selectively increases chemosensitivity in retinoblastoma via mitochondrial dysfunction-dependent oxidative damage and Akt/AMPK/mTOR inhibition
- (2018) Feng Ke et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Antibiotic ivermectin selectively induces apoptosis in chronic myeloid leukemia through inducing mitochondrial dysfunction and oxidative stress
- (2018) Jiaqiao Wang et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Targeting mitochondrial respiration as a therapeutic strategy for cervical cancer
- (2018) Shenglan Tian et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Lactic acid induces lactate transport and glycolysis/OXPHOS interconversion in glioblastoma
- (2018) Ke Duan et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Clinical trials targeting hypoxia
- (2018) Hannah Tharmalingham et al. BRITISH JOURNAL OF RADIOLOGY
- Antimalarial drug mefloquine inhibits nuclear factor kappa B signaling and induces apoptosis in colorectal cancer cells
- (2018) Xin Xu et al. CANCER SCIENCE
- Oxidative Phosphorylation as an Emerging Target in Cancer Therapy
- (2018) Thomas M. Ashton et al. CLINICAL CANCER RESEARCH
- Targeting mitochondria by anthelmintic drug atovaquone sensitizes renal cell carcinoma to chemotherapy and immunotherapy
- (2018) Dehong Chen et al. JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
- Atovaquone enhances doxorubicin’s efficacy via inhibiting mitochondrial respiration and STAT3 in aggressive thyroid cancer
- (2018) Zhuo Lv et al. JOURNAL OF BIOENERGETICS AND BIOMEMBRANES
- Notch1 signaling in melanoma cells promoted tumor-induced immunosuppression via upregulation of TGF-β1
- (2018) Zike Yang et al. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- Antimalarial drugs trigger lysosome-mediated cell death in chronic lymphocytic leukemia (CLL) cells
- (2018) Subhadip Das et al. LEUKEMIA RESEARCH
- Mefloquine targets β -catenin pathway and thus can play a role in the treatment of liver cancer
- (2018) Yu-Hui Li et al. MICROBIAL PATHOGENESIS
- A Repurposed Drug for Brain Cancer: Enhanced Atovaquone Amorphous Solid Dispersion by Combining a Spontaneously Emulsifying Component with a Polymer Carrier
- (2018) Hiroyuki Takabe et al. Pharmaceutics
- Effects of Biguanides on Growth and Glycolysis of Bladder and Colon Cancer Cells
- (2018) MICHAEL A. LEA et al. ANTICANCER RESEARCH
- Ivermectin inhibits the growth of glioma cells by inducing cell cycle arrest and apoptosis in vitro and in vivo
- (2018) Dandan Song et al. JOURNAL OF CELLULAR BIOCHEMISTRY
- Suppressing ROS-TFE3-dependent autophagy enhances ivermectin-induced apoptosis in human melanoma cells
- (2018) Faming Deng et al. JOURNAL OF CELLULAR BIOCHEMISTRY
- Papaverine and its derivatives radiosensitize solid tumors by inhibiting mitochondrial metabolism
- (2018) Martin Benej et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Ivermectin induces cell cycle arrest and apoptosis of HeLa cells via mitochondrial pathway
- (2018) Ping Zhang et al. CELL PROLIFERATION
- Quinacrine in endometrial cancer: Repurposing an old antimalarial drug
- (2017) Eleftheria Kalogera et al. GYNECOLOGIC ONCOLOGY
- The functional curcumin liposomes induce apoptosis in C6 glioblastoma cells and C6 glioblastoma stem cells in vitro and in animals
- (2017) Yahua Wang et al. International Journal of Nanomedicine
- Therapeutic strategies of drug repositioning targeting autophagy to induce cancer cell death: from pathophysiology to treatment
- (2017) Go J. Yoshida Journal of Hematology & Oncology
- HGG-12. HYPOXIA SEEMS TO BE FREQUENTLY UPREGULATED IN THE PEDIATRIC HIGH GRADE GLIOMA AND DIPG
- (2017) Anne-Florence Blandin et al. NEURO-ONCOLOGY
- Cancer acidity: An ultimate frontier of tumor immune escape and a novel target of immunomodulation
- (2017) Veronica Huber et al. SEMINARS IN CANCER BIOLOGY
- Coordinated regulation of growth, activity and transcription in natural populations of the unicellular nitrogen-fixing cyanobacterium Crocosphaera
- (2017) Samuel T. Wilson et al. Nature Microbiology
- Mefloquine effectively targets gastric cancer cells through phosphatase-dependent inhibition of PI3K/Akt/mTOR signaling pathway
- (2016) Yanwei Liu et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Anthelmintic drug ivermectin inhibits angiogenesis, growth and survival of glioblastoma through inducing mitochondrial dysfunction and oxidative stress
- (2016) Yingying Liu et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Gene expression-based discovery of atovaquone as a STAT3 inhibitor and anticancer agent
- (2016) M. Xiang et al. BLOOD
- Targeting the hypoxic fraction of tumours using hypoxia-activated prodrugs
- (2016) Roger M. Phillips CANCER CHEMOTHERAPY AND PHARMACOLOGY
- Ivermectin Induces Cytostatic Autophagy by Blocking the PAK1/Akt Axis in Breast Cancer
- (2016) Q. Dou et al. CANCER RESEARCH
- Eco-toxicological effects of the avermectin family with a focus on abamectin and ivermectin
- (2016) Shahla Hosseini Bai et al. CHEMOSPHERE
- Sorafenib and Quinacrine Target Anti-Apoptotic Protein MCL1: A Poor Prognostic Marker in Anaplastic Thyroid Cancer (ATC)
- (2016) J. Abdulghani et al. CLINICAL CANCER RESEARCH
- Targeting hypoxia to overcome radiation resistance in head & neck cancers: real challenge or clinical fairytale?
- (2016) René Baumann et al. Expert Review of Anticancer Therapy
- Therapeutic Strategy for Targeting Aggressive Malignant Gliomas by Disrupting Their Energy Balance
- (2016) Ahmed M. Hegazy et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Diffuse Intrinsic Pontine Glioma
- (2016) Tammy Hennika et al. JOURNAL OF CHILD NEUROLOGY
- The anti-malarial atovaquone increases radiosensitivity by alleviating tumour hypoxia
- (2016) Thomas M. Ashton et al. Nature Communications
- Repurposing atovaquone: Targeting mitochondrial complex III and OXPHOS to eradicate cancer stem cells
- (2016) Marco Fiorillo et al. Oncotarget
- Hypoxia and metabolic adaptation of cancer cells
- (2016) K L Eales et al. Oncogenesis
- Therapeutic strategies targeting cancer stem cells
- (2015) Go J. Yoshida et al. CANCER SCIENCE
- A Lactate-Induced Response to Hypoxia
- (2015) Dong Chul Lee et al. CELL
- A Novel Dual AMPK Activator/mTOR Inhibitor Inhibits Thyroid Cancer Cell Growth
- (2015) Robert L. Plews et al. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
- Metabolic reprogramming: the emerging concept and associated therapeutic strategies
- (2015) Go J. Yoshida JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- Hypoxia, cancer metabolism and the therapeutic benefit of targeting lactate/H+ symporters
- (2015) Ibtissam Marchiq et al. JOURNAL OF MOLECULAR MEDICINE-JMM
- Citrate concentrations increase with hypoperfusion in pediatric diffuse intrinsic pontine glioma
- (2015) Kristen W. Yeom et al. JOURNAL OF NEURO-ONCOLOGY
- Biomedical briefing
- (2015) NATURE MEDICINE
- Inhibition of Lactate Dehydrogenase to Treat Epilepsy
- (2015) Jong M. Rho NEW ENGLAND JOURNAL OF MEDICINE
- Quinacrine induces apoptosis in human leukemia K562 cells via p38 MAPK-elicited BCL2 down-regulation and suppression of ERK/c-Jun-mediated BCL2L1 expression
- (2015) Jung-Jung Changchien et al. TOXICOLOGY AND APPLIED PHARMACOLOGY
- Clinicopathology of diffuse intrinsic pontine glioma and its redefined genomic and epigenomic landscape
- (2015) Eshini Panditharatna et al. Cancer Genetics
- Mitochondrial biogenesis is required for the anchorage-independent survival and propagation of stem-like cancer cells
- (2015) Arianna De Luca et al. Oncotarget
- Quinacrine promotes autophagic cell death and chemosensitivity in ovarian cancer and attenuates tumor growth
- (2015) Ashwani Khurana et al. Oncotarget
- DIPG in Children – What Can We Learn from the Past?
- (2015) Magimairajan Issai Vanan et al. Frontiers in Oncology
- Effects of metformin and other biguanides on oxidative phosphorylation in mitochondria
- (2014) Hannah R. Bridges et al. BIOCHEMICAL JOURNAL
- Osteopontin-CD44 Signaling in the Glioma Perivascular Niche Enhances Cancer Stem Cell Phenotypes and Promotes Aggressive Tumor Growth
- (2014) Alexander Pietras et al. Cell Stem Cell
- The river blindness drug Ivermectin and related macrocyclic lactones inhibit WNT-TCF pathway responses in human cancer
- (2014) A. Melotti et al. EMBO Molecular Medicine
- Hypoxia sustains glioblastoma radioresistance through ERKs/DNA-PKcs/HIF-1α functional interplay
- (2014) FRANCESCO MARAMPON et al. INTERNATIONAL JOURNAL OF ONCOLOGY
- Diffuse intrinsic pontine glioma: a reassessment
- (2014) Nathan J. Robison et al. JOURNAL OF NEURO-ONCOLOGY
- Quinacrine Overcomes Resistance to Erlotinib by Inhibiting FACT, NF- B, and Cell-Cycle Progression in Non-Small Cell Lung Cancer
- (2014) J. K. T. Dermawan et al. MOLECULAR CANCER THERAPEUTICS
- Oncogene ablation-resistant pancreatic cancer cells depend on mitochondrial function
- (2014) Andrea Viale et al. NATURE
- Quinacrine for extremity melanoma in a mouse model of isolated limb perfusion (ILP)
- (2014) Minhyung Kim et al. SURGERY TODAY
- Chloroquine in Cancer Therapy: A Double-Edged Sword of Autophagy
- (2013) T. Kimura et al. CANCER RESEARCH
- Reprogramming Metabolism with Metformin Improves Tumor Oxygenation and Radiotherapy Response
- (2013) V. E. Zannella et al. CLINICAL CANCER RESEARCH
- In Vitro Drug Response and Efflux Transporters Associated with Drug Resistance in Pediatric High Grade Glioma and Diffuse Intrinsic Pontine Glioma
- (2013) Susanna J. E. Veringa et al. PLoS One
- Mefloquine exerts anticancer activity in prostate cancer cells via ROS-mediated modulation of Akt, ERK, JNK and AMPK signaling
- (2013) KUN-HUANG YAN et al. Oncology Letters
- Management of Diffuse Pontine Gliomas in Children: Recent Developments
- (2013) Rejin Kebudi et al. PEDIATRIC DRUGS
- Inhibition of autophagy and induction of breast cancer cell death by mefloquine, an antimalarial agent
- (2012) Natasha Sharma et al. CANCER LETTERS
- Quinacrine Inhibits Cell Growth and Induces Apoptosis in Human Gastric Cancer Cell Line SGC-7901
- (2012) Xiaoyang Wu et al. CURRENT THERAPEUTIC RESEARCH-CLINICAL AND EXPERIMENTAL
- Effects of hypoxia and HIFs on cancer metabolism
- (2012) Vera Mucaj et al. INTERNATIONAL JOURNAL OF HEMATOLOGY
- Lysosomal disruption preferentially targets acute myeloid leukemia cells and progenitors
- (2012) Mahadeo A. Sukhai et al. JOURNAL OF CLINICAL INVESTIGATION
- Metabolic symbiosis in cancer: Refocusing the Warburg lens
- (2012) Erica C. Nakajima et al. MOLECULAR CARCINOGENESIS
- Quinacrine-Mediated Autophagy and Apoptosis in Colon Cancer Cells Is Through a p53- and p21-Dependent Mechanism
- (2012) Purusottam Mohapatra et al. ONCOLOGY RESEARCH
- Targeting the Lactate Transporter MCT1 in Endothelial Cells Inhibits Lactate-Induced HIF-1 Activation and Tumor Angiogenesis
- (2012) Pierre Sonveaux et al. PLoS One
- Lactate Activates HIF-1 in Oxidative but Not in Warburg-Phenotype Human Tumor Cells
- (2012) Christophe J. De Saedeleer et al. PLoS One
- Energy metabolism of cancer: Glycolysis versus oxidative phosphorylation (Review)
- (2012) JIE ZHENG Oncology Letters
- Diffuse intrinsic pontine glioma: poised for progress
- (2012) Katherine E. Warren Frontiers in Oncology
- Quinacrine synergizes with 5-fluorouracil and other therapies in colorectal cancer
- (2011) Jean-Nicolas Gallant et al. CANCER BIOLOGY & THERAPY
- Lactate Influx through the Endothelial Cell Monocarboxylate Transporter MCT1 Supports an NF- B/IL-8 Pathway that Drives Tumor Angiogenesis
- (2011) F. Vegran et al. CANCER RESEARCH
- Beyond DNA binding - a review of the potential mechanisms mediating quinacrine's therapeutic activities in parasitic infections, inflammation, and cancers
- (2011) Reza Ehsanian et al. Cell Communication and Signaling
- Quinacrine has anticancer activity in breast cancer cells through inhibition of topoisomerase activity
- (2011) Ranjan Preet et al. INTERNATIONAL JOURNAL OF CANCER
- Metabolic Alterations in Highly Tumorigenic Glioblastoma Cells
- (2011) Yunfei Zhou et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Metabolic state of glioma stem cells and nontumorigenic cells
- (2011) E. Vlashi et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Aberrant Signaling Pathways in Glioma
- (2011) Mitsutoshi Nakada et al. Cancers
- The antiparasitic agent ivermectin induces chloride-dependent membrane hyperpolarization and cell death in leukemia cells
- (2010) S. Sharmeen et al. BLOOD
- HIF-1α inhibition by siRNA or chetomin in human malignant glioma cells: effects on hypoxic radioresistance and monitoring via CA9 expression
- (2010) Jacqueline Kessler et al. BMC CANCER
- The hypoxic microenvironment maintains glioblastoma stem cells and promotes reprogramming towards a cancer stem cell phenotype
- (2010) John M. Heddleston et al. CELL CYCLE
- Quinacrine Enhances Cisplatin-Induced Cytotoxicity in Four Cancer Cell Lines
- (2010) Yixiang Wang et al. CHEMOTHERAPY
- Inhibition of NF-κB Signaling by Quinacrine Is Cytotoxic to Human Colon Carcinoma Cell Lines and Is Synergistic in Combination with Tumor Necrosis Factor-related Apoptosis-inducing Ligand (TRAIL) or Oxaliplatin
- (2010) Tanvi S. Jani et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Reversal of P-glycoprotein-mediated multidrug resistancein vitroby doramectin and nemadectin
- (2010) Aili Gao et al. JOURNAL OF PHARMACY AND PHARMACOLOGY
- Bevacizumab in recurrent high-grade pediatric gliomas
- (2010) A. Narayana et al. NEURO-ONCOLOGY
- Cancer stem cells in glioblastoma—molecular signaling and therapeutic targeting
- (2010) Zhi Huang et al. Protein & Cell
- Hypoxia-Inducible Factors Regulate Tumorigenic Capacity of Glioma Stem Cells
- (2009) Zhizhong Li et al. CANCER CELL
- MYC-Induced Cancer Cell Energy Metabolism and Therapeutic Opportunities
- (2009) C. V. Dang et al. CLINICAL CANCER RESEARCH
- Direct control of mitochondrial function by mTOR
- (2009) Arvind Ramanathan et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Regional Hypoxia in Glioblastoma Multiforme Quantified with [18F]Fluoromisonidazole Positron Emission Tomography before Radiotherapy: Correlation with Time to Progression and Survival
- (2008) A. M. Spence et al. CLINICAL CANCER RESEARCH
- Malignant Gliomas in Adults
- (2008) Patrick Y. Wen et al. NEW ENGLAND JOURNAL OF MEDICINE
Become a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get StartedAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started