Article
Cell Biology
Gustavo J. C. Freitas, Ludmila Gouveia-Eufrasio, Eluzia C. P. Emidio, Hellem C. S. Carneiro, Ludmila de Matos Baltazar, Marliete C. Costa, Susana Frases, Glauber R. de Sousa Araujo, Tatiane A. Paixao, Brunno G. Sossai, Melissa Caza, James W. Kronstad, Nalu T. A. Peres, Daniel A. Santos
Summary: Cell size reduction is crucial for initial adaptation and tissue invasion during Cryptococcus neoformans pulmonary infection. The fungus develops mechanisms to resist the host's immune response and undergoes transcriptional changes that enhance virulence.
Article
Geriatrics & Gerontology
Ziad S. Mahmassani, Alec McKenzie, Jonathan J. Petrocelli, Naomi M. de Hart, Dennis K. Fix, Joshua J. Kelly, Lisa M. Baird, Michael T. Howard, Micah J. Drummond
Summary: Periods of inactivity in older adults lead to resistance to nutrient metabolism, causing abnormalities in skeletal muscle transcription and translation, which contributes to muscle dysfunction. Leucine can alter the translation of genes related to inactivity, as well as increase the translational efficiency of certain transcripts independent of mRNA abundance.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Julia S. P. Mawer, Jennifer Massen, Christina Reichert, Niklas Grabenhorst, Constantine Mylonas, Peter Tessarz
Summary: Ribosome biogenesis is a complex cellular process that involves integration of extracellular cues, such as metabolic state and intracellular signaling, transcriptional regulation, and chromatin accessibility at the ribosomal DNA. The recently identified histone modification, methylation of H2AQ105 (H2AQ105me), plays a key role in this process, dependent on the mTor signaling pathway and acetylation of histone H3. The ribonucleoprotein Nhp2 acts as an epigenetic reader of this modification, bridging rDNA chromatin with components of the small subunit processome to coordinate transcription of rRNA with its post-transcriptional processing.
Review
Cell Biology
Marianne Mercer, Seoyeon Jang, Chunyang Ni, Michael Buszczak
Summary: Regulation of mRNA translation is crucial for germ cell development and function across species, involving specific RNA binding proteins. These proteins are conserved and play similar roles in germ cells of various species, highlighting the importance of understanding the mechanisms controlling mRNA translation in germ cells.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Endocrinology & Metabolism
Mathilde Reyt, Michele Deantoni, Marion Baillet, Alexia Lesoinne, Sophie Laloux, Eric Lambot, Justine Demeuse, Chiara Calaprice, Caroline LeGoff, Fabienne Collette, Gilles Vandewalle, Pierre Maquet, Vincenzo Muto, Gregory Hammad, Christina Schmidt
Summary: This study found an association between daytime rest and 24-hour rest probability profiles, circadian timing, and neurobehavioral outcomes in healthy older adults. The results suggest that increasing daytime rest frequency is related to more fragmented nighttime rest and lower episodic memory performance.
JOURNAL OF PINEAL RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Pallavi Mohapatra, Sibasish Mohanty, Shamima Azma Ansari, Omprakash Shriwas, Arup Ghosh, Rachna Rath, Saroj Kumar Das Majumdar, Rajeeb K. Swain, Sunil K. Raghav, Rupesh Dash
Summary: CMTM6 is a major driver of cisplatin resistance in oral squamous cell carcinomas. The study explores the detailed mechanism of how CMTM6 rewires cisplatin resistance by regulating the ribosome biogenesis network.
Article
Cell Biology
Kezia Catharina Oxe, Dorthe Helena Larsen
Summary: Treacle/TCOF1 is an adaptor protein associated with nucleolar chromatin, playing important roles in promoting ribosome biogenesis and maintaining genome stability. Its involvement in cancer raises questions about its role in cancer development. On one hand, overexpression of Treacle may confer growth advantages to cancer cells, while on the other hand, its function as a gatekeeper in nucleolar DNA damage response may lead to mutations impairing its function.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Multidisciplinary Sciences
Pierre Sabatier, Christian M. Beusch, Amir A. Saei, Mike Aoun, Noah Moruzzi, Ana Coelho, Niels Leijten, Magnus Nordenskjold, Patrick Micke, Diana Maltseva, Alexander G. Tonevitsky, Vincent Millischer, J. Carlos Villaescusa, Sandeep Kadekar, Massimiliano Gaetani, Kamilya Altynbekova, Alexander Kel, Per-Olof Berggren, Oscar Simonson, Karl-Henrik Grinnemo, Rikard Holmdahl, Sergey Rodin, Roman A. Zubarev
Summary: The authors developed a method to simultaneously measure protein expression and thermal stability changes during cell type transitions, and applied this approach to study differences between human pluripotent stem cells and other cell types. They detected alterations of protein properties in numerous cellular pathways and components, proposing a method for maintaining pluripotency.
NATURE COMMUNICATIONS
(2021)
Article
Hematology
Jan-Erik Messling, Karl Agger, Kasper L. Andersen, Kristina Kromer, Hanna M. Kuepper, Anders H. Lund, Kristian Helin
Summary: Novel therapies are urgently needed for the treatment of acute myeloid leukemia (AML). A study identified RIOK2 as a potential target for AML treatment, as its loss leads to decreased protein synthesis and apoptosis in leukemic cells.
Review
Cell Biology
Kevin Tartour, Kiran Padmanabhan
Summary: Circadian rhythms synchronize organismal physiology and behavior with daily environmental changes. Disruption of rhythms is linked to various disorders, while the formation of circadian rhythms relies on multiple layers of complexity.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Environmental Sciences
Jiong Wu, Weiwei Zhang, Chenghua Li
Summary: As global warming progresses, heat and hypoxia have become important factors threatening marine organisms. Research on Apostichopus japonicus shows that the species can respond to heat, hypoxia, and heat-hypoxia stress by modulating the DNA methylation levels of circadian rhythm-related genes, ultimately increasing the activity of energy-related enzymes.
FRONTIERS IN MARINE SCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Emmanuel Giudice, Sylvie Georgeault, Regis Lavigne, Charles Pineau, Annie Trautwetter, Gwennola Ermel, Carlos Blanco, Reynald Gillet
Summary: Ribosome biogenesis is a complex process that relies on various assembly factors. We investigated this process by studying the impact of heat stress on the late stages of ribosome assembly, which led to the accumulation of 30S precursors. We used mass spectrometry-based proteomics and cryo-electron microscopy to determine the protein contents and structures of these precursors.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell & Tissue Engineering
Jiayi Chen, Guangqin Liu, Xinzheng Wang, Hao Hong, Tingting Li, Lin Li, Hongxiang Wang, Jiong Xie, Bohan Li, Ting Li, Dingyi Lu, Yakun Zhang, Haixin Zhao, Chengcheng Yao, Kaiqing Wen, Teng Li, Jing Chen, Shengming Wu, Kun He, Wei-Na Zhang, Jie Zhao, Na Wang, Qiuying Han, Qing Xia, Ji Qi, Juxiang Chen, Tao Zhou, Jianghong Man, Xue-Min Zhang, Ai-Ling Li, Xin Pan
Summary: This study explores the communication between glioblastoma stem cells (GSCs) and the microenvironment, revealing that GSCs secrete histamine to shape a pro-angiogenic tumor microenvironment. The secretion of histamine by GSCs is associated with the expression and modification of the HDC gene, and the histamine activates endothelial cells through the H1R-Ca2+-NF-kB axis, promoting angiogenesis and GBM progression. The findings suggest that targeting histamine could be a potential strategy for GBM therapy.
Article
Biochemistry & Molecular Biology
Oscar Horwath, Fabian Nordstrom, Ferdinand von Walden, William Apro, Marcus Moberg
Summary: Cumulative evidence supports the hypothesis that hypoxia acts as a regulator of muscle mass. This study examined the effect of hypoxia on signaling pathways and gene expression in human skeletal muscle after resistance exercise. The results showed that hypoxia attenuated ribosome signaling but did not affect satellite cell pool expansion and myogenic gene expression.
Article
Biochemistry & Molecular Biology
Itaru Samejima, Christos Spanos, Kumiko Samejima, Juri Rappsilber, Georg Kustatscher, William C. Earnshaw
Summary: We have used multiple techniques including chemical genetics, chromatin proteomics, and imaging to study the earliest chromatin transactions during cell entry into mitosis. Our findings reveal significant changes in the association of ribonucleoproteins with chromatin during the early stages of mitosis, as well as the loss of nuclear envelope barrier function and accumulation of cytoplasmic proteins on chromatin. These results provide valuable insights into the dynamics of chromatin during mitotic entry.
Article
Cell Biology
Bernadette Hotzi, Monika Kosztelnik, Balazs Hargitai, Krisztina Takacs-Vellai, Janos Barna, Kincso Borden, Andras Malnasi-Csizmadia, Monika Lippai, Csaba Ortutay, Caroline Bacquet, Angela Pasparaki, Tamas Aranyi, Nektarios Tavernarakis, Tibor Vellai
Review
Biochemistry & Molecular Biology
Janos Barna, Peter Csermely, Tibor Vellai
CELLULAR AND MOLECULAR LIFE SCIENCES
(2018)
Article
Multidisciplinary Sciences
Tibor Kovacs, Viktor Billes, Marcell Komlos, Bernadette Hotzi, Anna Manzeger, Anna Tarnoci, Diana Papp, Fanni Szikszai, Janka Szinyakovics, Akos Racz, Bela Noszal, Szilvia Veszelka, Fruzsina R. Walter, Maria A. Deli, Laszlo Hackler, Robert Alfoldi, Orsolya Huzian, Laszlo G. Puskas, Hanna Liliom, Krisztian Tarnok, Katalin Schlett, Adrienn Borsy, Ervin Welker, Attila L. Kovacs, Zsolt Padar, Attila Erdos, Adam Legradi, Annamaria Bjelik, Karoly Gulya, Balazs Gulyas, Tibor Vellai
SCIENTIFIC REPORTS
(2017)
Article
Biochemistry & Molecular Biology
Monika Kosztelnik, Anita Kurucz, Diana Papp, Emily Jones, Timea Sigmond, Janos Barna, Maria H. Traka, Tamas Lorincz, Andras Szarka, Gabor Banhegyi, Tibor Vellai, Tamas Korcsmaros, Orsolya Kapuy
Article
Biochemistry & Molecular Biology
Zsofia Rakvacs, Nora Kucsma, Melinda Gera, Barbara Igriczi, Katalin Kiss, Janos Barna, Daniel Kovacs, Tibor Vellai, Laszlo Bencs, Johannes M. Reisecker, Norbert Szoboszlai, Gergely Szakacs
CELLULAR AND MOLECULAR LIFE SCIENCES
(2019)
Article
Biochemistry & Molecular Biology
Vera Kutnyanszky, Balazs Hargitai, Bernadette Hotzi, Monika Kosztelnik, Csaba Ortutay, Tibor Kovacs, Eszter Gyory, Kincso Borden, Andrea Princz, Nektarios Tavernarakis, Tibor Vellai
MOLECULAR GENETICS AND GENOMICS
(2020)
Review
Biology
Daniel Kovacs, Marton Kovacs, Saqib Ahmed, Janos Barna
Summary: Heat shock transcription factors (HSFs) are crucial for protein homeostasis and are involved in various biological processes and diseases. The function of HSF family members is not fully understood, but important regulatory mechanisms have been identified.