Chloroquine combined with concurrent radiotherapy and temozolomide for newly diagnosed glioblastoma: a phase IB trial

A randomized, double-blind, window of opportunity trial evaluating the effects of chloroquine in breast cancer patients

(2019) Angel Arnaout et al.   BREAST CANCER RESEARCH AND TREATMENT

EGFRvIII expression triggers a metabolic dependency and therapeutic vulnerability sensitive to autophagy inhibition

(2018) Barry Jutten et al.   Autophagy

Re-purposing Chloroquine for Glioblastoma: Potential Merits and Confounding Variables

(2018) Patrick Weyerhäuser et al.   Frontiers in Oncology

European Association for Neuro-Oncology (EANO) guideline on the diagnosis and treatment of adult astrocytic and oligodendroglial gliomas

(2017) Michael Weller et al.   LANCET ONCOLOGY

Temozolomide induces autophagy in primary and established glioblastoma cells in an EGFR independent manner

(2017) Silvia Würstle et al.   Oncology Letters

The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary

(2016) David N. Louis et al.   ACTA NEUROPATHOLOGICA

Chloroquine, an autophagy inhibitor, potentiates the radiosensitivity of glioma initiating cells by inhibiting autophagy and activating apoptosis

(2016) Hongxing Ye et al.   BMC Neurology

Time to use a dose of Chloroquine as an adjuvant to anti-cancer chemotherapies

(2016) Steve Pascolo   EUROPEAN JOURNAL OF PHARMACOLOGY

The synergistic effect of combination temozolomide and chloroquine treatment is dependent on autophagy formation and p53 status in glioma cells

(2015) Seung Woo Lee et al.   CANCER LETTERS

Autophagy inhibition improves the efficacy of curcumin/temozolomide combination therapy in glioblastomas

(2015) Alfeu Zanotto-Filho et al.   CANCER LETTERS

A phase I/II trial of hydroxychloroquine in conjunction with radiation therapy and concurrent and adjuvant temozolomide in patients with newly diagnosed glioblastoma multiforme

(2014) Myrna R Rosenfeld et al.   Autophagy

Tumor Vessel Normalization by Chloroquine Independent of Autophagy

(2014) Hannelore Maes et al.   CANCER CELL

Chloroquine potentiates temozolomide cytotoxicity by inhibiting mitochondrial autophagy in glioma cells

(2014) Yusuke S. Hori et al.   JOURNAL OF NEURO-ONCOLOGY

Molecular pathologic diagnosis of epidermal growth factor receptor

(2014) C. L. Maire et al.   NEURO-ONCOLOGY

The worldwide incidence and prevalence of primary brain tumors: a systematic review and meta-analysis

(2014) Paula de Robles et al.   NEURO-ONCOLOGY

Chloroquine enhances temozolomide cytotoxicity in malignant gliomas by blocking autophagy

(2014) Encouse B. Golden et al.   Neurosurgical Focus

Single-cell RNA-seq highlights intratumoral heterogeneity in primary glioblastoma

(2014) A. P. Patel et al.   SCIENCE

FET-PET-based reirradiation and chloroquine in patients with recurrent glioblastoma

(2014) Angelika Bilger et al.   STRAHLENTHERAPIE UND ONKOLOGIE

An autophagy-dependent anticancer immune response determines the efficacy of melanoma chemotherapy

(2014) Mickaël Michaud et al.   OncoImmunology

The Somatic Genomic Landscape of Glioblastoma

(2013) Cameron W. Brennan et al.   CELL

Autophagy inhibition radiosensitizes in vitro, yet reduces radioresponses in vivo due to deficient immunogenic signalling

(2013) A Ko et al.   CELL DEATH AND DIFFERENTIATION

Autophagy and chemotherapy resistance: a promising therapeutic target for cancer treatment

(2013) X Sui et al.   Cell Death & Disease

Chloroquine overcomes resistance of lung carcinoma cells to the dual PI3K/mTOR inhibitor PI103 by lysosome-mediated apoptosis

(2012) Stefanie Enzenmüller et al.   ANTI-CANCER DRUGS

Chloroquine sensitizes breast cancer cells to chemotherapy independent of autophagy

(2012) Paola Maycotte et al.   Autophagy

Inhibition of Mitochondria- and Endoplasmic Reticulum Stress-Mediated Autophagy Augments Temozolomide-Induced Apoptosis in Glioma Cells

(2012) Chien-Ju Lin et al.   PLoS One

Chloroquine or Chloroquine-PI3K/Akt Pathway Inhibitor Combinations Strongly Promote γ-Irradiation-Induced Cell Death in Primary Stem-Like Glioma Cells

(2012) Elke Firat et al.   PLoS One

Revised Recommendations on Screening for Chloroquine and Hydroxychloroquine Retinopathy

(2011) Michael F. Marmor et al.   OPHTHALMOLOGY

Pro-survival AKT and ERK signaling from EGFR and mutant EGFRvIII enhances DNA double-strand break repair in human glioma cells

(2010) Sarah E. Golding et al.   CANCER BIOLOGY & THERAPY

The unfolded protein response protects human tumor cells during hypoxia through regulation of the autophagy genes MAP1LC3B and ATG5

(2009) Kasper M.A. Rouschop et al.   JOURNAL OF CLINICAL INVESTIGATION

Dose Escalation Methods in Phase I Cancer Clinical Trials

(2009) Christophe Le Tourneau et al.   JNCI-Journal of the National Cancer Institute

Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial

(2009) Roger Stupp et al.   LANCET ONCOLOGY

The deletion mutant EGFRvIII significantly contributes to stress resistance typical for the tumour microenvironment

(2009) Jan Theys et al.   RADIOTHERAPY AND ONCOLOGY

Autophagy is required during cycling hypoxia to lower production of reactive oxygen species

(2009) Kasper M.A. Rouschop et al.   RADIOTHERAPY AND ONCOLOGY