Review
Cell Biology
Morgane Lallier, Louise Marchandet, Brice Moukengue, Celine Charrier, Marc Baud'huin, Franck Verrecchia, Benjamin Ory, Francois Lamoureux
Summary: Osteosarcoma is the most common form of primary bone tumor affecting children and young adults, with a 5-year survival rate of 70%. Heat Shock Proteins play a significant role in cell proliferation, apoptosis inhibition, migration, and drug resistance in osteosarcoma. By studying HSP27, HSP60, HSP70, and HSP90, they can serve as potential clinical uses in osteosarcoma.
Article
Cell & Tissue Engineering
Ju-Fang Liu, Po-Chun Chen, Thai-Yen Ling, Chun-Han Hou
Summary: This study demonstrates that heat shock induces the expression of HSPs in hPDMCs through the activation of ROS, p38 MAPK, Akt signaling, and HSF1, which plays a protective role.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Multidisciplinary Sciences
Marie Pariollaud, Lara H. Ibrahim, Emanuel Irizarry, Rebecca M. Mello, Alanna B. Chan, Brian J. Altman, Reuben J. Shaw, Michael J. Bollong, R. Luke Wiseman, Katja A. Lamia
Summary: Chronic circadian disruption increases tumor burden in a mouse model of lung cancer through enhanced expression and nuclear accumulation of HSF1.
Review
Pharmacology & Pharmacy
Kha Wai Hon, Syafiq Asnawi Zainal Abidin, Iekhsan Othman, Rakesh Naidu
Summary: Colorectal cancer is characterized by metabolic reprogramming, which plays a crucial role in promoting tumor progression by modulating core metabolic pathways. Activation of oncogenes and loss of tumor suppressor genes regulate metabolic reprogramming, with protein kinases serving as integral components in facilitating interactions between signaling pathways and metabolic pathways in CRC.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Ukjin Lee, Eun-Young Cho, Eek-Hoon Jho
Summary: The Hippo signaling pathway plays a crucial role in maintaining the balance between cell proliferation and apoptosis, and its dysregulation is associated with tumor initiation, progression, and drug resistance.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Christopher Hubner, Hajo Haase
Summary: Zinc and ROS play roles in various physiological functions and are connected through their interaction with sulfur, forming a triad. Zinc can translate redox signals into zinc signals by binding to and releasing from thiols, affecting thiol oxidation and protein activity. The reciprocal interaction between zinc and redox-signaling involves shared molecular targets like active site cysteine thiols in PTP, showcasing their complex interplay on multiple levels.
Article
Oncology
Qi Shen, Rui Wang, Xinling Liu, Ping Song, Mingzhu Zheng, Xiaomin Ren, Jingang Ma, Zhong Lu, Jiaqiu Li
Summary: Based on recent research, this study explores the regulatory mechanism of glutamine metabolism in cancer cells, focusing on the activation of super-enhancers and their relationship to the transcription factor HSF1. The study identifies an HSF1-mediated super enhancer, lncRNA-LINC00857, which promotes the expression of SLC1A5/ASCT2 and facilitates glutamine transport. Targeting the HSF1/LINC00857/ANXA11 axis may provide a valuable therapeutic strategy against colorectal cancer.
Article
Biochemistry & Molecular Biology
Junmin Zhang, Xinming Li, Zhengjia Zhao, Wenqing Cai, Jianguo Fang
Summary: This article reviews the importance of thioredoxin (Trx) in regulating cancer-related signaling pathways and its potential therapeutic opportunities. Research has shown that Trx participates in multiple signaling pathways that influence cancer development and treatment by modulating the dynamic changes in protein structure and function. Future research directions include further exploring Trx-related signaling pathways and their upstream and downstream regulatory proteins, as well as developing novel anticancer drugs targeting the Trx signaling pathways.
ANTIOXIDANTS & REDOX SIGNALING
(2023)
Review
Oncology
Nasim Ebrahimi, Maral Afshinpour, Siavash Seifollahy Fakhr, Paniz Ghasempour Kalkhoran, Vida Shadman-Manesh, Samaneh Adelian, Sheida Beiranvand, Fatemeh Rezaei-Tazangi, Roya Khorram, Michael R. Hamblin, Amir Reza Aref
Summary: Colorectal cancer (CRC) is a major cause of cancer death worldwide. The presence of cancer stem cells (CSCs) contributes to therapy resistance and recurrence. This review examines the role of signaling pathways in colorectal CSCs and discusses potential drugs for treatment of resistant CRC.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2023)
Article
Plant Sciences
Jing Zhao, Xin-Chen Tian, Jia-Qi Zhang, Tan-Tan Li, Sen Qiao, Shu-Long Jiang
Summary: This study investigated the pharmacological effects and mechanisms of action of Tribulus terrestris extract on breast cancer using network pharmacology analysis and in vivo experiments. The results demonstrated that Tribulus terrestris extract had therapeutic effects on breast cancer and modulated the sphingolipid metabolism signaling pathways.
Review
Endocrinology & Metabolism
Sara Amjad, Sabah Nisar, Ajaz A. Bhat, Ab Rauf Shah, Michael P. Frenneaux, Khalid Fakhro, Mohammad Haris, Ravinder Reddy, Zoltan Patay, Joseph Baur, Puneet Bagga
Summary: NAD(+) plays a critical role in cellular bioenergetics and its depletion is associated with various diseases, making boosting NAD(+) levels a potential therapeutic strategy. However, the specific mechanisms of NAD(+) action require further investigation.
MOLECULAR METABOLISM
(2021)
Review
Biochemistry & Molecular Biology
Jiao Liu, Rui Kang, Daolin Tang
Summary: Ferroptosis is a type of lytic cell death caused by unrestricted lipid peroxidation and cell membrane damage, driven by complex signaling pathways and regulatory mechanisms. The main substrates of lipid peroxidation in ferroptosis are phospholipids rich in polyunsaturated fatty acids, positively regulated by various enzymes. Selective activation of autophagic degradation pathways promotes ferroptosis, while the system xc(-)-glutathione-GPX4 axis plays a limiting role.
Review
Biochemistry & Molecular Biology
Oleg Shuvalov, Yulia Kirdeeva, Alexandra Daks, Olga Fedorova, Sergey Parfenyev, Hans-Uwe Simon, Nickolai A. Barlev
Summary: This review focuses on a group of plant-derived natural compounds that target different pathways of cancer-associated metabolism simultaneously. These compounds show inhibitory activity against multiple metabolic pathways and important signaling pathways in cancer, making them promising for the improvement of antineoplastic therapy.
Article
Oncology
Karthik Balakrishnan, Kumaresan Ganesan
Summary: Metabolic dysregulation is an intrinsic hallmark of cancer cells, and investigating altered metabolic processes in the context of oncogenic signaling pathways can lead to the development of targeted cancer therapies. This study identified different oncogenic signaling pathways enriched in specific subtypes of gastric tumors, based on their metabolic rewiring. These pathways could serve as potential targets for selectively targeting different gastric cancer subtypes. The study also highlighted specific inhibitors that could be used to target gastric tumors with rewired glucose or fatty acid metabolism, paving the way for stratified and targeted gastric cancer therapeutics.
Review
Biochemistry & Molecular Biology
Yuanzhi Chen, Yingying He, Shubai Liu
Summary: Ovarian cancer is a leading cause of gynecological death worldwide, and RUNX1 plays an important role in its occurrence, development, and response to therapy. Decreased expression of RUNX1 improves chemotherapy sensitivity and provides support for diagnosis and treatment of ovarian cancer. However, the role of RUNX1 in ovarian cancer needs further investigation.
