Targeting microglial autophagic degradation in NLRP3 inflammasome-mediated neurodegenerative diseases
出版年份 2020 全文链接
标题
Targeting microglial autophagic degradation in NLRP3 inflammasome-mediated neurodegenerative diseases
作者
关键词
Microglial autophagy, Misfolded proteins, Neurodegenerative diseases, NLRP3 inflammasome, Neuroinflammation
出版物
AGEING RESEARCH REVIEWS
Volume 65, Issue -, Pages 101202
出版商
Elsevier BV
发表日期
2020-11-06
DOI
10.1016/j.arr.2020.101202
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Pioglitazone alleviates maternal sleep deprivation-induced cognitive deficits in male rat offspring by enhancing microglia-mediated neurogenesis
- (2020) Yue Han et al. BRAIN BEHAVIOR AND IMMUNITY
- Lipopolysaccharide induces neuroinflammation in microglia by activating the MTOR pathway and downregulating Vps34 to inhibit autophagosome formation
- (2020) Xiaoxia Ye et al. Journal of Neuroinflammation
- Glial cell diversity and methamphetamine-induced neuroinflammation in human cerebral organoids
- (2020) Jason Dang et al. MOLECULAR PSYCHIATRY
- Escins Isolated from Aesculus chinensis Bge. Promote the Autophagic Degradation of Mutant Huntingtin and Inhibit its Induced Apoptosis in HT22 cells
- (2020) Yueshan Sun et al. Frontiers in Pharmacology
- NLRP3 Inflammasome—A Key Player in Antiviral Responses
- (2020) Chunyuan Zhao et al. Frontiers in Immunology
- Polyphyllin VI Induces Caspase-1-Mediated Pyroptosis via the Induction of ROS/NF-κB/NLRP3/GSDMD Signal Axis in Non-Small Cell Lung Cancer
- (2020) Jin-Feng Teng et al. Cancers
- Microglial autophagy is impaired by prolonged exposure to β-amyloid peptides: evidence from experimental models and Alzheimer’s disease patients
- (2020) Carlos Pomilio et al. GeroScience
- NLRP3 inflammasome as prognostic factor and therapeutic target in primary progressive multiple sclerosis patients
- (2020) Sunny Malhotra et al. BRAIN
- Neuroimmune Connections in Aging and Neurodegenerative Diseases
- (2020) Hannah Scheiblich et al. TRENDS IN IMMUNOLOGY
- Microglia clear neuron-released α-synuclein via selective autophagy and prevent neurodegeneration
- (2020) Insup Choi et al. Nature Communications
- β-Amyloid Clustering around ASC Fibrils Boosts Its Toxicity in Microglia
- (2020) Lea L. Friker et al. Cell Reports
- Calcitriol Prevents Neuroinflammation and Reduces Blood-Brain Barrier Disruption and Local Macrophage/Microglia Activation
- (2020) Larissa Ragozo Cardoso de Oliveira et al. Frontiers in Pharmacology
- ATM loss disrupts the autophagy-lysosomal pathway
- (2020) Aifang Cheng et al. Autophagy
- 10-Hydroxydecanoic acid inhibits LPS-induced inflammation by targeting p53 in microglial cells
- (2020) Mengmeng You et al. INTERNATIONAL IMMUNOPHARMACOLOGY
- Lychee seed polyphenol inhibits Aβ-induced activation of NLRP3 inflammasome via the LRP1/AMPK mediated autophagy induction
- (2020) Wen-Qiao Qiu et al. BIOMEDICINE & PHARMACOTHERAPY
- Rosmarinic Acid Regulates Microglial M1/M2 Polarization via the PDPK1/Akt/HIF Pathway Under Conditions of Neuroinflammation
- (2020) Yicong Wei et al. INFLAMMATION
- Lychee seed polyphenol protects the blood–brain barrier through inhibiting Aβ(25–35)‐induced NLRP3 inflammasome activation via the AMPK / mTOR / ULK1‐mediated autophagy in bEnd .3 cells and APP / PS1 mice
- (2020) Rui Xiong et al. PHYTOTHERAPY RESEARCH
- Beclin1‐driven autophagy modulates the inflammatory response of microglia via NLRP3
- (2019) Judith Houtman et al. EMBO JOURNAL
- Maternal immune activation-induced PPARγ-dependent dysfunction of microglia associated with neurogenic impairment and aberrant postnatal behaviors in offspring
- (2019) Qiuying Zhao et al. NEUROBIOLOGY OF DISEASE
- NOD-like receptor protein 3 inflammasome drives postoperative mechanical pain in a sex-dependent manner
- (2019) Ashley M. Cowie et al. PAIN
- Honokiol-Mediated Mitophagy Ameliorates Postoperative Cognitive Impairment Induced by Surgery/Sevoflurane via Inhibiting the Activation of NLRP3 Inflammasome in the Hippocampus
- (2019) Ji-Shi Ye et al. Oxidative Medicine and Cellular Longevity
- Alborixin clears amyloid-β by inducing autophagy through PTEN-mediated inhibition of the AKT pathway
- (2019) Abubakar Wani et al. Autophagy
- Aggregated Tau activates NLRP3–ASC inflammasome exacerbating exogenously seeded and non-exogenously seeded Tau pathology in vivo
- (2019) Ilie-Cosmin Stancu et al. ACTA NEUROPATHOLOGICA
- Mitigation of cocaine-mediated mitochondrial damage, defective mitophagy and microglial activation by superoxide dismutase mimetics
- (2019) Annadurai Thangaraj et al. Autophagy
- Therapeutic potential of conditioned medium derived from oligodendrocytes cultured in a self-assembling peptide nanoscaffold in experimental autoimmune encephalomyelitis
- (2019) Ali Jahanbazi Jahan-Abad et al. BRAIN RESEARCH
- Rapamycin improves the neuroprotection effect of inhibition of NLRP3 inflammasome activation after TBI
- (2019) Yuhua Chen et al. BRAIN RESEARCH
- Inflammasomes in neuroinflammatory and neurodegenerative diseases
- (2019) Sofie Voet et al. EMBO Molecular Medicine
- Fyn kinase regulates misfolded α-synuclein uptake and NLRP3 inflammasome activation in microglia
- (2019) Nikhil Panicker et al. JOURNAL OF EXPERIMENTAL MEDICINE
- FTY720 Inhibits MPP+-Induced Microglial Activation by Affecting NLRP3 Inflammasome Activation
- (2019) Shu Yao et al. Journal of Neuroimmune Pharmacology
- A novel small molecular NLRP3 inflammasome inhibitor alleviates neuroinflammatory response following traumatic brain injury
- (2019) Ram Kuwar et al. Journal of Neuroinflammation
- Variants in NLRP3 and NLRC4 inflammasome associate with susceptibility and severity of multiple sclerosis
- (2019) Jaine LS Soares et al. Multiple Sclerosis and Related Disorders
- Kainic acid Induces production and aggregation of amyloid β-protein and memory deficits by activating inflammasomes in NLRP3- and NF-κB-stimulated pathways
- (2019) Yang Ruan et al. Aging-US
- Canonical and noncanonical inflammasomes in intestinal epithelial cells
- (2019) Nathaniel Winsor et al. CELLULAR MICROBIOLOGY
- Systemic inflammation impairs microglial Aβ clearance through NLRP 3 inflammasome
- (2019) Dario Tejera et al. EMBO JOURNAL
- Lipid and immune abnormalities causing age-dependent neurodegeneration and Parkinson’s disease
- (2019) Penelope J. Hallett et al. Journal of Neuroinflammation
- A Parkinson's disease gene, DJ-1, regulates anti-inflammatory roles of astrocytes through prostaglandin D2 synthase expression
- (2019) Dong-Joo Choi et al. NEUROBIOLOGY OF DISEASE
- Novel Insights Into the NLRP3 Inflammasome in Atherosclerosis
- (2019) Ying Jin et al. Journal of the American Heart Association
- Resveratrol Suppresses Aβ-Induced Microglial Activation Through the TXNIP/TRX/NLRP3 Signaling Pathway
- (2019) Lifang Feng et al. DNA AND CELL BIOLOGY
- Dioscin inhibits the growth of human osteosarcoma by inducing G2/M‐phase arrest, apoptosis, and GSDME‐dependent cell death in vitro and in vivo
- (2019) Qiuyue Ding et al. JOURNAL OF CELLULAR PHYSIOLOGY
- The Pyrin Inflammasome in Health and Disease
- (2019) Oskar Schnappauf et al. Frontiers in Immunology
- Update of inflammasome activation in microglia/macrophage in aging and aging‐related disease
- (2019) Meng‐yan Hu et al. CNS Neuroscience & Therapeutics
- The microglial NLRP3 inflammasome is activated by amyotrophic lateral sclerosis proteins
- (2019) Vandana Deora et al. GLIA
- Autophagy activation promotes clearance of α-synuclein inclusions in fibril-seeded human neural cells
- (2019) Jianqun Gao et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Serum Amyloid A-Mediated Inflammasome Activation of Microglial Cells in Cerebral Ischemia
- (2019) Jin Yu et al. JOURNAL OF NEUROSCIENCE
- NLRP3 inflammasome activation drives tau pathology
- (2019) Christina Ising et al. NATURE
- NLRP3 inflammasome in fibroblasts links tissue damage with inflammation in breast cancer progression and metastasis
- (2019) Nour Ershaid et al. Nature Communications
- Galectin-3 is required for the microglia-mediated brain inflammation in a model of Huntington’s disease
- (2019) Jian Jing Siew et al. Nature Communications
- In vivo characterization of functional states of cortical microglia during peripheral inflammation
- (2019) Karin Riester et al. BRAIN BEHAVIOR AND IMMUNITY
- URB597 protects against NLRP3 inflammasome activation by inhibiting autophagy dysfunction in a rat model of chronic cerebral hypoperfusion
- (2019) Shao-Hua Su et al. Journal of Neuroinflammation
- Spirostanol and sesquiterpenoid glycosides from the rhizomes of Trillium tschonoskii
- (2019) Dan Li et al. STEROIDS
- Prednisone alleviates demyelination through regulation of the NLRP3 inflammasome in a C57BL/6 mouse model of cuprizone-induced demyelination
- (2018) Hao Yu et al. BRAIN RESEARCH
- lincRNA-Cox2 regulates NLRP3 inflammasome and autophagy mediated neuroinflammation
- (2018) Zhenyi Xue et al. CELL DEATH AND DIFFERENTIATION
- MPTP-driven NLRP3 inflammasome activation in microglia plays a central role in dopaminergic neurodegeneration
- (2018) Eunju Lee et al. CELL DEATH AND DIFFERENTIATION
- Mitochonic acid 5 activates the MAPK–ERK–yap signaling pathways to protect mouse microglial BV-2 cells against TNFα-induced apoptosis via increased Bnip3-related mitophagy
- (2018) Qingyun Lei et al. CELLULAR & MOLECULAR BIOLOGY LETTERS
- Inflammation in CNS neurodegenerative diseases
- (2018) Jodie Stephenson et al. IMMUNOLOGY
- Targeting the NLRP3 Inflammasome-Related Pathways via Tianeptine Treatment-Suppressed Microglia Polarization to the M1 Phenotype in Lipopolysaccharide-Stimulated Cultures
- (2018) Joanna Ślusarczyk et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Inflammasome Activation by Methamphetamine Potentiates Lipopolysaccharide Stimulation of IL-1β Production in Microglia
- (2018) Enquan Xu et al. Journal of Neuroimmune Pharmacology
- MCC950, the Selective Inhibitor of Nucleotide Oligomerization Domain-Like Receptor Protein-3 Inflammasome, Protects Mice against Traumatic Brain Injury
- (2018) Saifudeen Ismael et al. JOURNAL OF NEUROTRAUMA
- Targeting the NLRP3 inflammasome in inflammatory diseases
- (2018) Matthew S. J. Mangan et al. NATURE REVIEWS DRUG DISCOVERY
- Neuronal Cell Death
- (2018) Michael Fricker et al. PHYSIOLOGICAL REVIEWS
- Loss of function of a rice TPR-domain RNA-binding protein confers broad-spectrum disease resistance
- (2018) Xiaogang Zhou et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Caspase-1 inhibition prevents glial inflammasome activation and pyroptosis in models of multiple sclerosis
- (2018) Brienne A. McKenzie et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The NLRP3-Caspase 1 Inflammasome Negatively Regulates Autophagy via TLR4-TRIF in Prion Peptide-Infected Microglia
- (2018) Mengyu Lai et al. Frontiers in Aging Neuroscience
- Systemic inhibition of the membrane attack complex impedes neuroinflammation in chronic relapsing experimental autoimmune encephalomyelitis
- (2018) Iliana Michailidou et al. Acta Neuropathologica Communications
- Inflammatory caspase-related pyroptosis: mechanism, regulation and therapeutic potential for inflammatory bowel disease
- (2018) Yuan-Yuan Yuan et al. Gastroenterology Report
- Protective Role of Autophagy in Nlrp3 Inflammasome Activation and Medial Thickening of Mouse Coronary Arteries
- (2018) Xinxu Yuan et al. AMERICAN JOURNAL OF PATHOLOGY
- Tetramethylpyrazine ameliorates experimental autoimmune encephalomyelitis by modulating the inflammatory response
- (2018) Xian-Yong Bai et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Inflammasome signalling in brain function and neurodegenerative disease
- (2018) Michael T. Heneka et al. NATURE REVIEWS NEUROSCIENCE
- Bidirectional Microglia–Neuron Communication in Health and Disease
- (2018) Zsuzsanna Szepesi et al. Frontiers in Cellular Neuroscience
- Caspase-1 inhibition alleviates cognitive impairment and neuropathology in an Alzheimer’s disease mouse model
- (2018) Joseph Flores et al. Nature Communications
- PBN11-8, a Cytotoxic Polypeptide Purified from Marine Bacillus, Suppresses Invasion and Migration of Human Hepatocellular Carcinoma Cells by Targeting Focal Adhesion Kinase Pathways
- (2018) Lanhong Zheng et al. Polymers
- Targeting NLRP3 Inflammasome in the Treatment of CNS Diseases
- (2018) Bo-Zong Shao et al. Frontiers in Molecular Neuroscience
- Microglial overexpression of fALS-linked mutant SOD1 induces SOD1 processing impairment, activation and neurotoxicity and is counteracted by the autophagy inducer trehalose
- (2018) Francesca Massenzio et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- Human immunodeficiency virus Type-1 single-stranded RNA activates the NLRP3 inflammasome and impairs autophagic clearance of damaged mitochondria in human microglia
- (2018) Pratima Rawat et al. GLIA
- Rapamycin combined with MCC950 to treat multiple sclerosis in experimental autoimmune encephalomyelitis
- (2018) Ling Xu et al. JOURNAL OF CELLULAR BIOCHEMISTRY
- Role of the NLRP3 inflammasome in cancer
- (2018) Maryam Moossavi et al. Molecular Cancer
- Inflammasome inhibition prevents α-synuclein pathology and dopaminergic neurodegeneration in mice
- (2018) Richard Gordon et al. Science Translational Medicine
- Microglia in Central Nervous System Inflammation and Multiple Sclerosis Pathology
- (2018) Sofie Voet et al. TRENDS IN MOLECULAR MEDICINE
- NLRP3 inflammasomes in macrophages drive colorectal cancer metastasis to the liver
- (2018) Qiaoting Deng et al. CANCER LETTERS
- Extracellular TDP-43 aggregates target MAPK/MAK/MRK overlapping kinase (MOK) and trigger caspase-3/IL-18 signaling in microglia
- (2017) María M. Leal-Lasarte et al. FASEB JOURNAL
- Progesterone therapy induces an M1 to M2 switch in microglia phenotype and suppresses NLRP3 inflammasome in a cuprizone-induced demyelination mouse model
- (2017) Roya Aryanpour et al. INTERNATIONAL IMMUNOPHARMACOLOGY
- Autophagy and Microglia: Novel Partners in Neurodegeneration and Aging
- (2017) Ainhoa Plaza-Zabala et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Amyloid-Beta and Phosphorylated Tau Accumulations Cause Abnormalities at Synapses of Alzheimer’s disease Neurons
- (2017) Ravi Rajmohan et al. JOURNAL OF ALZHEIMERS DISEASE
- NLR members NLRC4 and NLRP3 mediate sterile inflammasome activation in microglia and astrocytes
- (2017) Leslie Freeman et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Cutting Edge: TRAF6 Mediates TLR/IL-1R Signaling–Induced Nontranscriptional Priming of the NLRP3 Inflammasome
- (2017) Yue Xing et al. JOURNAL OF IMMUNOLOGY
- DJ-1 deficiency impairs autophagy and reduces alpha-synuclein phagocytosis by microglia
- (2017) Yuval Nash et al. JOURNAL OF NEUROCHEMISTRY
- The role of autophagy in pro-inflammatory responses of microglia activation via mitochondrial reactive oxygen species in vitro
- (2017) Junli Ye et al. JOURNAL OF NEUROCHEMISTRY
- The Ketone Body β-Hydroxybutyrate Does Not Inhibit Synuclein Mediated Inflammasome Activation in Microglia
- (2017) Vandana Deora et al. Journal of Neuroimmune Pharmacology
- Neuroinflammation contributes to autophagy flux blockage in the neurons of rostral ventrolateral medulla in stress-induced hypertension rats
- (2017) Dongshu Du et al. Journal of Neuroinflammation
- Protective and therapeutic role of 2-carba-cyclic phosphatidic acid in demyelinating disease
- (2017) Shinji Yamamoto et al. Journal of Neuroinflammation
- Peroxynitrite Activates the NLRP3 Inflammasome Cascade in SOD1(G93A) Mouse Model of Amyotrophic Lateral Sclerosis
- (2017) Ilaria Bellezza et al. MOLECULAR NEUROBIOLOGY
- Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin
- (2017) Yupeng Wang et al. NATURE
- Microglia-derived ASC specks cross-seed amyloid-β in Alzheimer’s disease
- (2017) Carmen Venegas et al. NATURE
- The critical role of Nramp1 in degrading α-synuclein oligomers in microglia under iron overload condition
- (2017) Kuo-Chen Wu et al. NEUROBIOLOGY OF DISEASE
- The NLRP3 Inflammasome is Involved in the Pathogenesis of Parkinson’s Disease in Rats
- (2017) Zhijuan Mao et al. NEUROCHEMICAL RESEARCH
- Cerebrospinal Fluid NLRP3 is Increased After Severe Traumatic Brain Injury in Infants and Children
- (2017) Jessica S. Wallisch et al. Neurocritical Care
- Hederagenin and α-hederin promote degradation of proteins in neurodegenerative diseases and improve motor deficits in MPTP-mice
- (2017) An-Guo Wu et al. PHARMACOLOGICAL RESEARCH
- NLRP3 Inflammasome in Neurological Diseases, from Functions to Therapies
- (2017) Limin Song et al. Frontiers in Cellular Neuroscience
- P2X7 Receptor Activation Modulates Autophagy in SOD1-G93A Mouse Microglia
- (2017) Paola Fabbrizio et al. Frontiers in Cellular Neuroscience
- Pathology of Neurodegenerative Diseases
- (2017) Brittany N. Dugger et al. Cold Spring Harbor Perspectives in Biology
- NLRP3-inflammasome inhibition prevents high fat and high sugar diets-induced heart damage through autophagy induction
- (2017) Luís E. Pavillard et al. Oncotarget
- Lack of the Nlrp3 Inflammasome Improves Mice Recovery Following Traumatic Brain Injury
- (2017) Natasha Irrera et al. Frontiers in Pharmacology
- Depot- and gender-specific expression of NLRP3 inflammasome and toll-like receptors in adipose tissue of cancer patients
- (2016) Michio Shimabukuro et al. BIOFACTORS
- Autophagy regulates MAVS signaling activation in a phosphorylation-dependent manner in microglia
- (2016) Jinbo Cheng et al. CELL DEATH AND DIFFERENTIATION
- The role of Resveratrol-induced mitophagy/autophagy in peritoneal mesothelial cells inflammatory injury via NLRP3 inflammasome activation triggered by mitochondrial ROS
- (2016) Jun Wu et al. EXPERIMENTAL CELL RESEARCH
- mTORC1 pathway disruption ameliorates brain inflammation following stroke via a shift in microglia phenotype from M1 type to M2 type
- (2016) Daojing Li et al. FASEB JOURNAL
- Green Tea Catechin Prevents Hypoxia/Reperfusion-Evoked Oxidative Stress-Regulated Autophagy-Activated Apoptosis and Cell Death in Microglial Cells
- (2016) Chang-Mu Chen et al. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
- Inflammasomes link vascular disease with neuroinflammation and brain disorders
- (2016) Nikolett Lénárt et al. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
- Hemin and Cobalt Protoporphyrin Inhibit NLRP3 Inflammasome Activation by Enhancing Autophagy: A Novel Mechanism of Inflammasome Regulation
- (2016) Katariina Nurmi et al. Journal of Innate Immunity
- HIV-1 Viral Protein R Activates NLRP3 Inflammasome in Microglia: implications for HIV-1 Associated Neuroinflammation
- (2016) Manmeet K. Mamik et al. Journal of Neuroimmune Pharmacology
- Class I PI3K inhibitor ZSTK474 mediates a shift in microglial/macrophage phenotype and inhibits inflammatory response in mice with cerebral ischemia/reperfusion injury
- (2016) Po Wang et al. Journal of Neuroinflammation
- Actions of the antihistaminergic clemastine on presymptomatic SOD1-G93A mice ameliorate ALS disease progression
- (2016) Savina Apolloni et al. Journal of Neuroinflammation
- Procyanidins alleviates morphine tolerance by inhibiting activation of NLRP3 inflammasome in microglia
- (2016) Yang Cai et al. Journal of Neuroinflammation
- Preparation and Antitumor Activity of CS5931, A Novel Polypeptide from Sea Squirt Ciona Savignyi
- (2016) Xiaoshuang Chen et al. Marine Drugs
- Trehalose rescues glial cell dysfunction in striatal cultures from HD R6/1 mice at early postnatal development
- (2016) Juan Perucho et al. MOLECULAR AND CELLULAR NEUROSCIENCE
- Sex- and Disease-Specific Inflammasome Signatures in Circulating Blood Leukocytes of Patients with Abdominal Aortic Aneurysm
- (2016) Xiaoyu Wu et al. MOLECULAR MEDICINE
- The NLRP3 and NLRP1 inflammasomes are activated in Alzheimer’s disease
- (2016) Marina Saresella et al. Molecular Neurodegeneration
- MicroRNA-7 targets Nod-like receptor protein 3 inflammasome to modulate neuroinflammation in the pathogenesis of Parkinson’s disease
- (2016) Yan Zhou et al. Molecular Neurodegeneration
- Interleukin 1α and the inflammatory process
- (2016) Nelson C Di Paolo et al. NATURE IMMUNOLOGY
- An interferon-β-resistant and NLRP3 inflammasome–independent subtype of EAE with neuronal damage
- (2016) Makoto Inoue et al. NATURE NEUROSCIENCE
- IL-33 ameliorates Alzheimer’s disease-like pathology and cognitive decline
- (2016) Amy K. Y. Fu et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Morphine paradoxically prolongs neuropathic pain in rats by amplifying spinal NLRP3 inflammasome activation
- (2016) Peter M. Grace et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Fenamate NSAIDs inhibit the NLRP3 inflammasome and protect against Alzheimer’s disease in rodent models
- (2016) Michael J. D. Daniels et al. Nature Communications
- Intraspinal bone-marrow cell therapy at pre- and symptomatic phases in a mouse model of amyotrophic lateral sclerosis
- (2016) Fernanda Gubert et al. Stem Cell Research & Therapy
- Modulation of inflammation by autophagy: Consequences for human disease
- (2015) Romana T. Netea-Maier et al. Autophagy
- Long-term treatment with Ginkgo biloba extract EGb 761 improves symptoms and pathology in a transgenic mouse model of Alzheimer’s disease
- (2015) Xu Liu et al. BRAIN BEHAVIOR AND IMMUNITY
- TDP-43 activates microglia through NF-κB and NLRP3 inflammasome
- (2015) Weihua Zhao et al. EXPERIMENTAL NEUROLOGY
- NLRP3 inflammasome is expressed by astrocytes in the SOD1 mouse model of ALS and in human sporadic ALS patients
- (2015) Sonja Johann et al. GLIA
- Rotenone-induced Impairment of Mitochondrial Electron Transport Chain Confers a Selective Priming Signal for NLRP3 Inflammasome Activation
- (2015) Ji-Hee Won et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The pathogenic role of the inflammasome in neurodegenerative diseases
- (2015) Leslie C. Freeman et al. JOURNAL OF NEUROCHEMISTRY
- HLA-DRα1-mMOG-35-55 treatment of experimental autoimmune encephalomyelitis reduces CNS inflammation, enhances M2 macrophage frequency, and promotes neuroprotection
- (2015) Gil Benedek et al. Journal of Neuroinflammation
- The ketone metabolite β-hydroxybutyrate blocks NLRP3 inflammasome–mediated inflammatory disease
- (2015) Yun-Hee Youm et al. NATURE MEDICINE
- A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases
- (2015) Rebecca C Coll et al. NATURE MEDICINE
- Inflammasomes: mechanism of action, role in disease and therapeutics
- (2015) Haitao Guo et al. NATURE MEDICINE
- AIM2 and NLRC4 inflammasomes contribute with ASC to acute brain injury independently of NLRP3
- (2015) Adam Denes et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Alternatively activated microglia and macrophages in the central nervous system
- (2015) Rafael Franco et al. PROGRESS IN NEUROBIOLOGY
- Mitochondria: diversity in the regulation of the NLRP3 inflammasome
- (2015) Prajwal Gurung et al. TRENDS IN MOLECULAR MEDICINE
- The role of TDP-43 in the pathogenesis of ALS and FTLD: Figure 1
- (2015) Marco Baralle et al. BIOCHEMICAL SOCIETY TRANSACTIONS
- NLRP3 Inflammasome Is Expressed and Functional in Mouse Brain Microglia but Not in Astrocytes
- (2015) Audrey Gustin et al. PLoS One
- Autophagy in microglia degrades extracellular β-amyloid fibrils and regulates the NLRP3 inflammasome
- (2014) Mi-Hyang Cho et al. Autophagy
- NLRP3, a Potential Therapeutic Target for Type 2 Diabetes?
- (2014) Shan-Shan Liu et al. CARDIOVASCULAR DRUGS AND THERAPY
- How the Innate Immune System Senses Trouble and Causes Trouble
- (2014) T. Hato et al. Clinical Journal of the American Society of Nephrology
- Activating Cannabinoid Receptor 2 Alleviates Pathogenesis of Experimental Autoimmune Encephalomyelitis Via Activation of Autophagy and Inhibiting NLRP3 Inflammasome
- (2014) Bo-Zong Shao et al. CNS Neuroscience & Therapeutics
- Brain Inflammation is a Common Feature of HIV-Infected Patients without HIV Encephalitis or Productive Brain Infection
- (2014) Eleonora Tavazzi et al. CURRENT HIV RESEARCH
- Microglia Activation Precedes the Anti-Opioid BDNF and NMDA Receptor Mechanisms Underlying Morphine Analgesic Tolerance
- (2014) Yosuke Matsushita et al. CURRENT PHARMACEUTICAL DESIGN
- Mitochondrial homeostasis: The interplay between mitophagy and mitochondrial biogenesis
- (2014) Konstantinos Palikaras et al. EXPERIMENTAL GERONTOLOGY
- NLRP3 Deficiency Ameliorates Neurovascular Damage in Experimental Ischemic Stroke
- (2014) Fan Yang et al. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
- Endothelial PINK1 Mediates the Protective Effects of NLRP3 Deficiency during Lethal Oxidant Injury
- (2014) Y. Zhang et al. JOURNAL OF IMMUNOLOGY
- Inhibiting ACAT1/SOAT1 in Microglia Stimulates Autophagy-Mediated Lysosomal Proteolysis and Increases A 1-42 Clearance
- (2014) Y. Shibuya et al. JOURNAL OF NEUROSCIENCE
- Phagocytosis of Microglia in the Central Nervous System Diseases
- (2014) Ruying Fu et al. MOLECULAR NEUROBIOLOGY
- Rapid inflammasome activation in microglia contributes to brain disease in HIV/AIDS
- (2014) John G Walsh et al. Retrovirology
- Sex-dependent differential activation of NLRP3 and AIM2 inflammasomes in SLE macrophages
- (2014) C.-A. Yang et al. RHEUMATOLOGY
- Role of mitochondria ROS generation in ethanol-induced NLRP3 inflammasome activation and cell death in astroglial cells
- (2014) Silvia Alfonso-Loeches et al. Frontiers in Cellular Neuroscience
- Alpha-synuclein biology in Lewy body diseases
- (2014) Woojin Scott Kim et al. Alzheimers Research & Therapy
- Fractalkine signaling and Tau hyper-phosphorylation are associated with autophagic alterations in lentiviral Tau and Aβ1-42 gene transfer models
- (2013) Michaeline L. Hebron et al. EXPERIMENTAL NEUROLOGY
- Human astrocytes express a novel NLRP2 inflammasome
- (2013) Julia Minkiewicz et al. GLIA
- Inflammation in neurodegenerative diseases - an update
- (2013) Sandra Amor et al. IMMUNOLOGY
- Onjisaponin B Derived from Radix Polygalae Enhances Autophagy and Accelerates the Degradation of Mutant α-Synuclein and Huntingtin in PC-12 Cells
- (2013) An-Guo Wu et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Microglia, neuroinflammation, and beta-amyloid protein in Alzheimer's disease
- (2013) Zhiyou Cai et al. INTERNATIONAL JOURNAL OF NEUROSCIENCE
- Mitochondrial Reactive Oxygen Species Induces NLRP3-Dependent Lysosomal Damage and Inflammasome Activation
- (2013) M. E. Heid et al. JOURNAL OF IMMUNOLOGY
- Cutting Edge: TLR Signaling Licenses IRAK1 for Rapid Activation of the NLRP3 Inflammasome
- (2013) T. Fernandes-Alnemri et al. JOURNAL OF IMMUNOLOGY
- Alcohol-induced IL-1β in the brain is mediated by NLRP3/ASC inflammasome activation that amplifies neuroinflammation
- (2013) Dora Lippai et al. JOURNAL OF LEUKOCYTE BIOLOGY
- Sustained Interleukin-1 Overexpression Exacerbates Tau Pathology Despite Reduced Amyloid Burden in an Alzheimer's Mouse Model
- (2013) S. Ghosh et al. JOURNAL OF NEUROSCIENCE
- Expression of the NLRP3 Inflammasome in Cerebral Cortex After Traumatic Brain Injury in a Rat Model
- (2013) Huan-Dong Liu et al. NEUROCHEMICAL RESEARCH
- Glial Uptake of Amyloid Beta Induces NLRP3 Inflammasome Formation via Cathepsin-Dependent Degradation of NLRP10
- (2013) Niamh Murphy et al. NEUROMOLECULAR MEDICINE
- Microglial Beclin 1 Regulates Retromer Trafficking and Phagocytosis and Is Impaired in Alzheimer’s Disease
- (2013) Kurt M. Lucin et al. NEURON
- Innate Immunity in the CNS: Redefining the Relationship between the CNS and Its Environment
- (2013) Antoine Lampron et al. NEURON
- Neuroprotective Function of DJ-1 in Parkinson’s Disease
- (2013) Hiroyoshi Ariga et al. Oxidative Medicine and Cellular Longevity
- Triggering of Inflammasome by Aggregated α–Synuclein, an Inflammatory Response in Synucleinopathies
- (2013) Gaia Codolo et al. PLoS One
- IRAK-1 bypasses priming and directly links TLRs to rapid NLRP3 inflammasome activation
- (2013) K.-M. Lin et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Oligomeric amyloid β induces IL-1β processing via production of ROS: implication in Alzheimer’s disease
- (2013) B Parajuli et al. Cell Death & Disease
- NLRP3 inflammasome activation in macrophage cell lines by prion protein fibrils as the source of IL-1β and neuronal toxicity
- (2012) Iva Hafner-Bratkovič et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- Regulation of microglia activation and deactivation by nuclear receptors
- (2012) Kaoru Saijo et al. GLIA
- Non-transcriptional Priming and Deubiquitination Regulate NLRP3 Inflammasome Activation
- (2012) Christine Juliana et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Greater cognitive deterioration in women than men with Alzheimer's disease: A meta analysis
- (2012) Karen Irvine et al. JOURNAL OF CLINICAL AND EXPERIMENTAL NEUROPSYCHOLOGY
- Blockade of adenosine A2A receptors prevents interleukin-1β-induced exacerbation of neuronal toxicity through a p38 mitogen-activated protein kinase pathway
- (2012) Ana Patrícia Simões et al. Journal of Neuroinflammation
- Deubiquitination of NLRP3 by BRCC3 Critically Regulates Inflammasome Activity
- (2012) Bénédicte F. Py et al. MOLECULAR CELL
- NLRP3 is activated in Alzheimer’s disease and contributes to pathology in APP/PS1 mice
- (2012) Michael T. Heneka et al. NATURE
- Activation of autophagy by inflammatory signals limits IL-1β production by targeting ubiquitinated inflammasomes for destruction
- (2012) Chong-Shan Shi et al. NATURE IMMUNOLOGY
- Sex-related factors in multiple sclerosis susceptibility and progression
- (2012) Rhonda R. Voskuhl et al. Nature Reviews Neurology
- Morphine activates neuroinflammation in a manner parallel to endotoxin
- (2012) X. Wang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Interferon- Therapy Against EAE Is Effective Only When Development of the Disease Depends on the NLRP3 Inflammasome
- (2012) M. Inoue et al. Science Signaling
- Microglial physiopathology: how to explain the dual role of microglia after acute neural disorders?
- (2012) Walace Gomes-Leal Brain and Behavior
- Attenuation of microglial and IL-1 signaling protects mice from acute alcohol-induced sedation and/or motor impairment
- (2011) Yue Wu et al. BRAIN BEHAVIOR AND IMMUNITY
- Autophagy: Renovation of Cells and Tissues
- (2011) Noboru Mizushima et al. CELL
- Role of microglia in CNS inflammation
- (2011) Manuel B. Graeber et al. FEBS LETTERS
- Autophagy Controls IL-1β Secretion by Targeting Pro-IL-1β for Degradation
- (2011) James Harris et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Caspase-1-Processed Cytokines IL-1 and IL-18 Promote IL-17 Production by and CD4 T Cells That Mediate Autoimmunity
- (2011) S. J. Lalor et al. JOURNAL OF IMMUNOLOGY
- Blocking IL-1 Signaling Rescues Cognition, Attenuates Tau Pathology, and Restores Neuronal -Catenin Pathway Function in an Alzheimer's Disease Model
- (2011) M. Kitazawa et al. JOURNAL OF IMMUNOLOGY
- Wild type and P301L mutant Tau promote neuro-inflammation and α-Synuclein accumulation in lentiviral gene delivery models
- (2011) Preeti J. Khandelwal et al. MOLECULAR AND CELLULAR NEUROSCIENCE
- Cognitive and Neuropsychiatric Profile of the Synucleinopathies
- (2010) Aimee W. Kao et al. ALZHEIMER DISEASE & ASSOCIATED DISORDERS
- Effects of gender in amyotrophic lateral sclerosis
- (2010) Pamela A. McCombe et al. Gender Medicine
- Inflammation in neurodegenerative diseases
- (2010) Sandra Amor et al. IMMUNOLOGY
- Autophagy: cellular and molecular mechanisms
- (2010) Danielle Glick et al. JOURNAL OF PATHOLOGY
- Role of microglia in neurotrauma
- (2010) David J. Loane et al. Neurotherapeutics
- Mutant superoxide dismutase 1-induced IL-1 accelerates ALS pathogenesis
- (2010) F. Meissner et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Development of Monocytes, Macrophages, and Dendritic Cells
- (2010) F. Geissmann et al. SCIENCE
- Altered mitochondria, energy metabolism, voltage-dependent anion channel, and lipid rafts converge to exhaust neurons in Alzheimer’s disease
- (2009) Isidre Ferrer JOURNAL OF BIOENERGETICS AND BIOMEMBRANES
- Cholesterol-dependent cytolysins induce rapid release of mature IL-1β from murine macrophages in a NLRP3 inflammasome and cathepsin B-dependent manner
- (2009) Jessica Chu et al. JOURNAL OF LEUKOCYTE BIOLOGY
- The inflammasome: a caspase-1-activation platform that regulates immune responses and disease pathogenesis
- (2009) Luigi Franchi et al. NATURE IMMUNOLOGY
- Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization
- (2008) Veit Hornung et al. NATURE IMMUNOLOGY
- The NALP3 inflammasome is involved in the innate immune response to amyloid-β
- (2008) Annett Halle et al. NATURE IMMUNOLOGY
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationCreate your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create Now