Review
Medicine, Research & Experimental
Xu Zheng, Dan Zhao, Ye Jin, Yang Liu, Da Liu
Summary: The NLRP3 inflammasome plays a crucial role in the innate immune system and is associated with the development of various gynecological diseases. Inhibitors of NLRP3 inflammasome have therapeutic potential in maintaining cellular and tissue health, but excessive use can lead to adverse effects.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Immunology
Wei Xiong, Xian-Fang Meng, Chun Zhang
Summary: Metabolic syndrome can lead to metabolic disorders and impair kidney structure and function, while persistent inflammation exacerbates renal damage. Inflammasomes are key in initiating inflammation, and understanding their role in kidney damage caused by metabolic disorders can provide new therapeutic perspectives for kidney diseases.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Xiaoyan Zhan, Qiang Li, Guang Xu, Xiaohe Xiao, Zhaofang Bai
Summary: NLRP3 is a cytosolic pattern recognition receptor that recognizes various molecular patterns associated with pathogens and damage. Its activation leads to the assembly of the inflammasome and cleavage of IL-1 beta and IL-18. Aberrant NLRP3 activation is linked with multiple inflammatory diseases, and efforts are being made to develop inhibitors. This review summarizes the latest advances in the mechanism of NLRP3 inflammasome activation and the development of pharmacological inhibitors.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Xiao-yan Wu, Jin-yan Lv, Shi-qing Zhang, Xin Yi, Zi-wei Xu, Yuan-xing Zhi, Bo-xin Zhao, Jian-xin Pang, Ken Kin Lam Yung, Shu-wen Liu, Ping-zheng Zhou
Summary: The study identified ML365 as a potent inhibitor targeting the TWIK2 channel, which effectively suppressed ATP-induced NLRP3 inflammasome activation without affecting other inflammasomes. Pharmacokinetic analysis revealed good oral bioavailability of ML365, highlighting its potential application in treating related inflammatory diseases.
ACTA PHARMACOLOGICA SINICA
(2022)
Review
Biochemistry & Molecular Biology
Tan Zhang, Shuzhe Ding, Ru Wang
Summary: NLRP3 is a crucial pattern recognition receptor in the innate immune system, with mitochondria playing a key role in inflammasome activation. Exercise is considered an important intervention to regulate immune responses, with different types of training impacting NLRP3 inflammasome activation differently.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Ma Su, Weiwei Wang, Feng Liu, Huanqiu Li
Summary: This review provides an overview of recent advances in the discovery of NLRP3 inflammasome inhibitors and their therapeutic potential. Various types of inhibitors, including the JC-series and BC-series, have been categorized, along with their origins, structures, bioactivity, and mechanisms of action. The importance of developing NLRP3 inflammasome inhibitors for treating various inflammatory diseases has been emphasized, with a focus on the need for more potent therapeutic strategies in the future.
CURRENT MEDICINAL CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Anukriti Mathur, Callum Kay, Yansong Xue, Abhimanu Pandey, Jiwon Lee, Weidong Jing, Daniel Enosi Tuipulotu, Jordan Lo Pilato, Shouya Feng, Chinh Ngo, Anyang Zhao, Cheng Shen, Melanie Rug, Lisa A. Miosge, Ines I. Atmosukarto, Jason D. Price, Sidra A. Ali, Elizabeth E. Gardiner, Avril A. B. Robertson, Milena M. Awad, Dena Lyras, Nadeem O. Kaakoush, Si Ming Man
Summary: Two virulence factors, lecithinase and perfringolysin O, from the human bacterial pathogen Clostridium perfringens, activate the NLRP3 inflammasome in mice and humans, inducing inflammation and cell death. Lecithinase enters vesicular structures and induces lysosomal membrane destabilization, leading to the release of inflammatory cytokines IL-1β and IL-18.
Review
Biochemistry & Molecular Biology
Ying Chen, Xingyan Ye, Germaine Escames, Wangrui Lei, Xin Zhang, Meng Li, Tong Jing, Yu Yao, Zhenye Qiu, Zheng Wang, Dario Acuna-Castroviejo, Yang Yang
Summary: The NOD-like receptor protein 3 (NLRP3) inflammasome is crucial in regulating innate immune responses and has been implicated in various inflammation-related diseases. This review discusses the activation and regulatory mechanism of the NLRP3 inflammasome, its role in different diseases, and potential therapeutic strategies targeting this complex.
CELLULAR & MOLECULAR BIOLOGY LETTERS
(2023)
Review
Oncology
Stavros P. Papadakos, Nikolaos Dedes, Elias Kouroumalis, Stamatios Theocharis
Summary: This article explores the impact of the NLRP3 inflammasome on hepatocellular carcinoma (HCC) and presents a hypothesis about its potential role. Hepatotropic viruses avoid the NLRP3 inflammasome to sustain chronic infection leading to cirrhosis, while the activation of NLRP3 promotes pro-tumorigenic effects in established tumors. Therefore, studying the role of the NLRP3 inflammasome in HCC is of great importance in identifying new therapeutic targets.
Article
Dentistry, Oral Surgery & Medicine
Y. Han, Y. Huang, P. Gao, Q. Yang, L. Jia, Y. Zheng, W. Li
Summary: Periodontitis is an oral chronic inflammatory disease characterized by periodontal pocket formation, loss of attachment, and alveolar bone resorption. Leptin plays a critical role in the pathogenesis of periodontitis by promoting proinflammatory M1 macrophage skewing. Targeting leptin/NLRP3 signaling may be a feasible approach for treating periodontitis.
JOURNAL OF DENTAL RESEARCH
(2022)
Review
Immunology
Zhilei Wang, Guang Xu, Zhiyong Li, Xiaohe Xiao, Jianyuan Tang, Zhaofang Bai
Summary: This article summarizes the role and mechanism of active ingredients such as licochalcone A, echinatin, isoliquiritigenin, and glycyrrhizin in Glycyrrhiza in targeting the NLRP3 inflammasome and treating related inflammatory diseases.
JOURNAL OF INFLAMMATION RESEARCH
(2022)
Article
Food Science & Technology
Li-Chun Ho, Ting-Yun Wu, Tsun-Mei Lin, Hung-Hsiang Liou, Shih-Yuan Hung
Summary: Despite high plasma levels of IL-1 beta in HD patients, caspase-1 and IL-1 beta in the PBMCs of HD patients were predominantly immature and not secreted in response to the canonical stimulus. Additionally, IS alone facilitated inflammasome-independent secretion of IL-1 beta from macrophages, but IS exposure before induction reduced the inducibility of the NLRP3 inflammasome, characterized by insufficient maturation of caspase-1.
Review
Chemistry, Medicinal
Carolina Pellegrini, Alma Martelli, Luca Antonioli, Matteo Fornai, Corrado Blandizzi, Vincenzo Calderone
Summary: The importance of NLRP3 inflammasome in the pathogenesis of cardiovascular diseases is being increasingly recognized, with potential therapeutic approaches including drug interventions. Research efforts are focused on understanding the role of NLRP3 inflammasome in CVD pathophysiology and exploring possible interventions.
MEDICINAL RESEARCH REVIEWS
(2021)
Article
Food Science & Technology
Po-Yen Lee, Ching-Chih Liu, Shu-Chi Wang, Kai-Yin Chen, Tzu-Chieh Lin, Po-Len Liu, Chien-Chih Chiu, I-Chen Chen, Yu-Hung Lai, Wei-Chung Cheng, Wei-Ju Chung, Hsin-Chih Yeh, Chi-Han Huang, Chia-Cheng Su, Shu-Pin Huang, Chia-Yang Li
Summary: ZEA suppresses macrophage-mediated innate immunity activated by LPS, attenuating the production of proinflammatory mediators and cytokines, inhibiting inflammatory signaling pathways, and repressing inflammasome activation. This suggests that ZEA-contaminated food intake may decrease innate immunity and increase adverse effects during infection.
Article
Dentistry, Oral Surgery & Medicine
S. Leng, W. Xu, L. Wu, L. Liu, J. Du, F. Yang, D. Huang, L. Zhang
Summary: Apical periodontitis is an inflammatory condition caused by immunological reaction to invading bacteria. NLRP3 plays a crucial role in the pathogenesis of this condition by disturbing the balance between Treg and Th17 cells. The dysregulation of NLRP3 exacerbates periapical inflammation and bone resorption.
JOURNAL OF DENTAL RESEARCH
(2023)
