Morphine paradoxically prolongs neuropathic pain in rats by amplifying spinal NLRP3 inflammasome activation

Hyperalgesia induced by low-dose opioid treatment before orthopaedic surgery

(2015) Nabil Hina et al.   EUROPEAN JOURNAL OF ANAESTHESIOLOGY

The P2X7 receptor directly interacts with the NLRP3 inflammasome scaffold protein

(2015) Alessia Franceschini et al.   FASEB JOURNAL

Opioid-Induced Central Immune Signaling: Implications for Opioid Analgesia

(2015) Peter M. Grace et al.   HEADACHE

MD-2 is required for disulfide HMGB1–dependent TLR4 signaling

(2015) Huan Yang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Effects of testosterone replacement in men with opioid-induced androgen deficiency

(2015) Shehzad Basaria et al.   PAIN

Interleukin-1 beta enhances endocytosis of glial glutamate transporters in the spinal dorsal horn through activating protein kinase C

(2014) Xisheng Yan et al.   GLIA

Astrocyte-neuron interaction in the substantia gelatinosa of the spinal cord dorsal horn via P2X7 receptor-mediated release of glutamate and reactive oxygen species

(2014) Christoph Ficker et al.   GLIA

Activation and Regulation of Cellular Inflammasomes: Gaps in Our Knowledge for Central Nervous System Injury

(2014) Juan Pablo de Rivero Vaccari et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Opioids for chronic noncancer pain: A position paper of the American Academy of Neurology

(2014) G. M. Franklin   NEUROLOGY

Activation of adult rat CNS endothelial cells by opioid-induced toll-like receptor 4 (TLR4) signaling induces proinflammatory, biochemical, morphological, and behavioral sequelae

(2014) P.M. Grace et al.   NEUROSCIENCE

Spinal HMGB1 induces TLR4-mediated long-lasting hypersensitivity and glial activation and regulates pain-like behavior in experimental arthritis

(2014) Nilesh M. Agalave et al.   PAIN

Toll-Like Receptor 4 Mutant and Null Mice Retain Morphine-Induced Tolerance, Hyperalgesia, and Physical Dependence

(2014) Theresa Alexandra Mattioli et al.   PLoS One

Disulfide-Containing High Mobility Group Box-1 Promotes N-Methyl-d-Aspartate Receptor Function and Excitotoxicity by Activating Toll-Like Receptor 4-Dependent Signaling in Hippocampal Neurons

(2013) Silvia Balosso et al.   ANTIOXIDANTS & REDOX SIGNALING

Immune Activation Promotes Depression 1 Month After Diffuse Brain Injury: A Role for Primed Microglia

(2013) Ashley M. Fenn et al.   BIOLOGICAL PSYCHIATRY

Predicting transition to chronic pain

(2013) A. Vania Apkarian et al.   CURRENT OPINION IN NEUROLOGY

Toll-like receptor signaling adapter proteins govern spread of neuropathic pain and recovery following nerve injury in male mice

(2013) Jennifer A Stokes et al.   Journal of Neuroinflammation

Ambulatory Diagnosis and Treatment of Nonmalignant Pain in the United States, 2000–2010

(2013) Matthew Daubresse et al.   MEDICAL CARE

Morphine hyperalgesia gated through microglia-mediated disruption of neuronal Cl− homeostasis

(2013) Francesco Ferrini et al.   NATURE NEUROSCIENCE

Origin and differentiation of microglia

(2013) Florent Ginhoux et al.   Frontiers in Cellular Neuroscience

Prior exposure to repeated morphine potentiates mechanical allodynia induced by peripheral inflammation and neuropathy

(2012) Lisa C. Loram et al.   BRAIN BEHAVIOR AND IMMUNITY

Remifentanil during cardiac surgery is associated with chronic thoracic pain 1 yr after sternotomy

(2012) L. van Gulik et al.   BRITISH JOURNAL OF ANAESTHESIA

NLRP3 Inflammasome Activity Is Negatively Controlled by miR-223

(2012) F. Bauernfeind et al.   JOURNAL OF IMMUNOLOGY

Genetically determined P2X7 receptor pore formation regulates variability in chronic pain sensitivity

(2012) Robert E Sorge et al.   NATURE MEDICINE

Analgesic tolerance without demonstrable opioid-induced hyperalgesia: A double-blinded, randomized, placebo-controlled trial of sustained-release morphine for treatment of chronic nonradicular low-back pain

(2012) Larry F. Chu et al.   PAIN

Chronic opioid use is associated with increased DNA methylation correlating with increased clinical pain

(2012) Alexandra Doehring et al.   PAIN

Morphine activates neuroinflammation in a manner parallel to endotoxin

(2012) X. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A clinical perspective of IL-1β as the gatekeeper of inflammation

(2011) Charles A. Dinarello   EUROPEAN JOURNAL OF IMMUNOLOGY

Toll-like receptors in chronic pain

(2011) Lauren Nicotra et al.   EXPERIMENTAL NEUROLOGY

Prior laparotomy or corticosterone potentiates lipopolysaccharide-induced fever and sickness behaviors

(2011) Leah E. Hains et al.   JOURNAL OF NEUROIMMUNOLOGY

Microglial Ca2+-Activated K+ Channels Are Possible Molecular Targets for the Analgesic Effects of S-Ketamine on Neuropathic Pain

(2011) Y. Hayashi et al.   JOURNAL OF NEUROSCIENCE

Exploring the Neuroimmunopharmacology of Opioids: An Integrative Review of Mechanisms of Central Immune Signaling and Their Implications for Opioid Analgesia

(2011) M. R. Hutchinson et al.   PHARMACOLOGICAL REVIEWS

Use of CNS medications and cognitive decline in the aged: a longitudinal population-based study

(2011) Juha Puustinen et al.   BMC Geriatrics

When does acute pain become chronic?

(2010) C Voscopoulos et al.   BRITISH JOURNAL OF ANAESTHESIA

A novel animal model of graded neuropathic pain: Utility to investigate mechanisms of population heterogeneity

(2010) Peter M. Grace et al.   JOURNAL OF NEUROSCIENCE METHODS

Pain Intensity and Duration Can Be Enhanced by Prior Challenge: Initial Evidence Suggestive of a Role of Microglial Priming

(2010) Leah E. Hains et al.   JOURNAL OF PAIN

Possible involvement of toll-like receptor 4/myeloid differentiation factor-2 activity of opioid inactive isomers causes spinal proinflammation and related behavioral consequences

(2010) M.R. Hutchinson et al.   NEUROSCIENCE

Different Anesthetic Techniques Associated with Different Incidences of Chronic Post-thoracotomy Pain: Low-Dose Remifentanil Plus Presurgical Epidural Analgesia is Preferable to High-Dose Remifentanil with Postsurgical Epidural Analgesia

(2009) Jean-Corentin Salengros et al.   JOURNAL OF CARDIOTHORACIC AND VASCULAR ANESTHESIA

Intrathecal Morphine Attenuates Recovery of Function after a Spinal Cord Injury

(2009) Michelle A. Hook et al.   JOURNAL OF NEUROTRAUMA

Altered quantitative sensory testing outcome in subjects with opioid therapy

(2009) Lucy Chen et al.   PAIN

Opioid-induced Hyperalgesia in Humans

(2008) Larry F. Chu et al.   CLINICAL JOURNAL OF PAIN

Non-stereoselective reversal of neuropathic pain by naloxone and naltrexone: involvement of toll-like receptor 4 (TLR4)

(2008) Mark R. Hutchinson et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Oral opioid use alters DNIC but not cold pain perception in patients with chronic pain – New perspective of opioid-induced hyperalgesia

(2008) Kerstin Carlin Ram et al.   PAIN

IL-1β signaling is required for mechanical allodynia induced by nerve injury and for the ensuing reduction in spinal cord neuronal GRK2

(2007) Wendy Kleibeuker et al.   BRAIN BEHAVIOR AND IMMUNITY

Dose translation from animal to human studies revisited

(2007) Shannon Reagan-Shaw et al.   FASEB JOURNAL

IL-1ra alleviates inflammatory hyperalgesia through preventing phosphorylation of NMDA receptor NR-1 subunit in rats

(2007) Rui-Xin Zhang et al.   PAIN