Triggering of Inflammasome by Aggregated α–Synuclein, an Inflammatory Response in Synucleinopathies

NLRP3 inflammasome activation in macrophage cell lines by prion protein fibrils as the source of IL-1β and neuronal toxicity

(2012) Iva Hafner-Bratkovič et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Inflammasomes in health and disease

(2012) Till Strowig et al.   NATURE

Immunology in clinic review series; focus on autoinflammatory diseases: inflammasomes: mechanisms of activation

(2011) A. K. Mankan et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Structured Regions of α-Synuclein Fibrils Include the Early-Onset Parkinson's Disease Mutation Sites

(2011) Gemma Comellas et al.   JOURNAL OF MOLECULAR BIOLOGY

Alpha-synuclein release by neurons activates the inflammatory response in a microglial cell line

(2011) Lydia Alvarez-Erviti et al.   NEUROSCIENCE RESEARCH

Misfolded α-synuclein and toll-like receptors: therapeutic targets for Parkinson's disease

(2011) Dawn Béraud et al.   PARKINSONISM & RELATED DISORDERS

The Inflammasomes

(2010) Kate Schroder et al.   CELL

IL-1: Discoveries, controversies and future directions

(2010) Charles A. Dinarello   EUROPEAN JOURNAL OF IMMUNOLOGY

Molecular Mechanism of NLRP3 Inflammasome Activation

(2010) Chengcheng Jin et al.   JOURNAL OF CLINICAL IMMUNOLOGY

 -Synuclein Activates Microglia by Inducing the Expressions of Matrix Metalloproteinases and the Subsequent Activation of Protease-Activated Receptor-1

(2010) E.-J. Lee et al.   JOURNAL OF IMMUNOLOGY

Endogenous ligands of TLR2 and TLR4: agonists or assistants?

(2010) Clett Erridge   JOURNAL OF LEUKOCYTE BIOLOGY

Future directions for immune modulation in neurodegenerative disorders: focus on Parkinson’s disease

(2010) Kathleen A. Maguire-Zeiss et al.   JOURNAL OF NEURAL TRANSMISSION

Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetes

(2010) Seth L Masters et al.   NATURE IMMUNOLOGY

Cholesterol Crystals Activate the NLRP3 Inflammasome in Human Macrophages: A Novel Link between Cholesterol Metabolism and Inflammation

(2010) Kristiina Rajamäki et al.   PLoS One

Altered redox state of monocytes from cryopyrin-associated periodic syndromes causes accelerated IL-1  secretion

(2010) S. Tassi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Thioredoxin-interacting protein links oxidative stress to inflammasome activation

(2009) Rongbin Zhou et al.   NATURE IMMUNOLOGY

Mutant α-Synuclein Overexpression Mediates Early Proinflammatory Activity

(2009) Xiaomin Su et al.   NEUROTOXICITY RESEARCH

Concentration Dependence of α-Synuclein Fibril Length Assessed by Quantitative Atomic Force Microscopy and Statistical-Mechanical Theory

(2008) Martijn E. van Raaij et al.   BIOPHYSICAL JOURNAL

Active Caspase-1 Is a Regulator of Unconventional Protein Secretion

(2008) Martin Keller et al.   CELL

Immunological features of α-synuclein in Parkinson's disease

(2008) Cintia Roodveldt et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Ly6c+“inflammatory monocytes” are microglial precursors recruited in a pathogenic manner in West Nile virus encephalitis

(2008) Daniel R. Getts et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Nitrated Alpha-Synuclein and Microglial Neuroregulatory Activities

(2008) Ashley D. Reynolds et al.   Journal of Neuroimmune Pharmacology

Targeted Overexpression of Human α-Synuclein Triggers Microglial Activation and an Adaptive Immune Response in a Mouse Model of Parkinson Disease

(2008) Shaji Theodore et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization

(2008) Veit Hornung et al.   NATURE IMMUNOLOGY

The NALP3 inflammasome is involved in the innate immune response to amyloid-β

(2008) Annett Halle et al.   NATURE IMMUNOLOGY

Lewy bodies in grafted neurons in subjects with Parkinson's disease suggest host-to-graft disease propagation

(2008) Jia-Yi Li et al.   NATURE MEDICINE

Innate Immune Activation Through Nalp3 Inflammasome Sensing of Asbestos and Silica

(2008) C. Dostert et al.   SCIENCE