Rapid inflammasome activation in microglia contributes to brain disease in HIV/AIDS

Signaling Mechanism of HIV-1 gp120 and Virion-Induced IL-1  Release in Primary Human Macrophages

(2014) R. Cheung et al.   JOURNAL OF IMMUNOLOGY

Differential type 1 interferon-regulated gene expression in the brain during AIDS: interactions with viral diversity and neurovirulence

(2013) Maria J. Polyak et al.   FASEB JOURNAL

Human astrocytes express a novel NLRP2 inflammasome

(2013) Julia Minkiewicz et al.   GLIA

K+ Efflux Is the Common Trigger of NLRP3 Inflammasome Activation by Bacterial Toxins and Particulate Matter

(2013) Raúl Muñoz-Planillo et al.   IMMUNITY

Monocyte/macrophages and their role in HIV neuropathogenesis

(2013) Tricia H. Burdo et al.   IMMUNOLOGICAL REVIEWS

HIV-1 Induces the First Signal to Activate the NLRP3 Inflammasome in Monocyte-Derived Macrophages

(2013) Juan C. Hernandez et al.   INTERVIROLOGY

MFGE8 inhibits inflammasome-induced IL-1β production and limits postischemic cerebral injury

(2013) Nicolas Deroide et al.   JOURNAL OF CLINICAL INVESTIGATION

IL-1β Production through the NLRP3 Inflammasome by Hepatic Macrophages Links Hepatitis C Virus Infection with Liver Inflammation and Disease

(2013) Amina A. Negash et al.   PLoS Pathogens

Targeting interleukin-1β in CAPS (cryopyrin-associated periodic) syndromes

(2012) Isabelle Koné-Paut et al.   AUTOIMMUNITY REVIEWS

Neurosteroid-mediated regulation of brain innate immunity in HIV/AIDS: DHEA-S suppresses neurovirulence

(2012) Ferdinand G. Maingat et al.   FASEB JOURNAL

Integrin α5β1 Activates the NLRP3 Inflammasome by Direct Interaction with a Bacterial Surface Protein

(2012) Hye-Kyoung Jun et al.   IMMUNITY

Polymorphisms in Inflammasomeʼ Genes and Susceptibility to HIV-1 Infection

(2012) Alessandra Pontillo et al.   JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

Innate immunity in the central nervous system

(2012) Richard M. Ransohoff et al.   JOURNAL OF CLINICAL INVESTIGATION

The NALP3 inflammasome is involved in neurotoxic prion peptide-induced microglial activation

(2012) Fushan Shi et al.   Journal of Neuroinflammation

LPS-induced release of IL-6 from glia modulates production of IL-1β in a JAK2-dependent manner

(2012) Aedín M Minogue et al.   Journal of Neuroinflammation

Regulation of inflammasome signaling

(2012) Vijay A K Rathinam et al.   NATURE IMMUNOLOGY

Toll-like receptor (TLR) and inflammasome actions in the central nervous system

(2012) Richa Hanamsagar et al.   TRENDS IN IMMUNOLOGY

IL-1β Signaling Promotes CNS-Intrinsic Immune Control of West Nile Virus Infection

(2012) Hilario J. Ramos et al.   PLoS Pathogens

Hiding in Plain Sight: How HIV Evades Innate Immune Responses

(2011) Nicolas Manel et al.   CELL

Neurocognitive dysfunction in the highly active antiretroviral therapy era

(2011) Nomvuyo Z. Mothobi et al.   CURRENT OPINION IN INFECTIOUS DISEASES

HIV-1 gp120 enhances outward potassium current via CXCR4 and cAMP-dependent protein kinase a signaling in cultured rat microglia

(2011) Changshui Xu et al.   GLIA

The NLRP3 Inflammasome Contributes to Brain Injury in Pneumococcal Meningitis and Is Activated through ATP-Dependent Lysosomal Cathepsin B Release

(2011) Tobias Hoegen et al.   JOURNAL OF IMMUNOLOGY

HIV-1 restriction factor SAMHD1 is a deoxynucleoside triphosphate triphosphohydrolase

(2011) David C. Goldstone et al.   NATURE

SAMHD1 is the dendritic- and myeloid-cell-specific HIV-1 restriction factor counteracted by Vpx

(2011) Nadine Laguette et al.   NATURE

The Cytokine Release Inhibitory Drug CRID3 Targets ASC Oligomerisation in the NLRP3 and AIM2 Inflammasomes

(2011) Rebecca C. Coll et al.   PLoS One

Interactions between human immunodeficiency virus (HIV)-1 Vpr expression and innate immunity influence neurovirulence

(2011) Hong Na et al.   Retrovirology

Innate Sensing of HIV-Infected Cells

(2011) Alice Lepelley et al.   PLoS Pathogens

Mechanisms Underlying Inflammation in Neurodegeneration

(2010) Christopher K. Glass et al.   CELL

A 3′UTR SNP in NLRP3 Gene is Associated With Susceptibility to HIV-1 Infection

(2010) Alessandra Pontillo et al.   JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

Plasmacytoid dendritic cells in HIV infection: striking a delicate balance

(2010) Patricia Fitzgerald-Bocarsly et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Interleukin 18 in the CNS

(2010) Silvia Alboni et al.   Journal of Neuroinflammation

The cytosolic exonuclease TREX1 inhibits the innate immune response to human immunodeficiency virus type 1

(2010) Nan Yan et al.   NATURE IMMUNOLOGY

Neurologic disease burden in treated HIV/AIDS predicts survival: A population-based study

(2010) P. Vivithanaporn et al.   NEUROLOGY

Hepatitis C Virus Core Protein Induces Neuroimmune Activation and Potentiates Human Immunodeficiency Virus-1 Neurotoxicity

(2010) Pornpun Vivithanaporn et al.   PLoS One

Mutant superoxide dismutase 1-induced IL-1  accelerates ALS pathogenesis

(2010) F. Meissner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Glyburide inhibits the Cryopyrin/Nalp3 inflammasome

(2009) Mohamed Lamkanfi et al.   JOURNAL OF CELL BIOLOGY

Neisseria gonorrhoeae Activates the Proteinase Cathepsin B to Mediate the Signaling Activities of the NLRP3 and ASC-Containing Inflammasome

(2009) Joseph A. Duncan et al.   JOURNAL OF IMMUNOLOGY

A Molecular Platform in Neurons Regulates Inflammation after Spinal Cord Injury

(2008) J. P. de Rivero Vaccari et al.   JOURNAL OF NEUROSCIENCE

Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization

(2008) Veit Hornung et al.   NATURE IMMUNOLOGY

The NALP3 inflammasome is involved in the innate immune response to amyloid-β

(2008) Annett Halle et al.   NATURE IMMUNOLOGY

Divergent TLR7 and TLR9 signaling and type I interferon production distinguish pathogenic and nonpathogenic AIDS virus infections

(2008) Judith N Mandl et al.   NATURE MEDICINE

HIV Infection of the Central Nervous System: Clinical Features and Neuropathogenesis

(2008) Lysa Boissé et al.   NEUROLOGIC CLINICS

Expression of proinflammatory cytokines and its relationship with virus infection in the brain of macaques inoculated with macrophage-tropic simian immunodeficiency virus

(2008) Hui Qin Xing et al.   NEUROPATHOLOGY