Amyloid-Beta and Phosphorylated Tau Accumulations Cause Abnormalities at Synapses of Alzheimer’s disease Neurons

Aβ-Dependent Inhibition of LTP in Different Intracortical Circuits of the Visual Cortex: The Role of RAGE

(2017) Nicola Origlia et al.   JOURNAL OF ALZHEIMERS DISEASE

Amyloid-β as a Modulator of Synaptic Plasticity

(2017) Mordhwaj S. Parihar et al.   JOURNAL OF ALZHEIMERS DISEASE

Amyloid-β Decreases Cell-Surface AMPA Receptors by Increasing Intracellular Calcium and Phosphorylation of GluR2

(2017) Shi-Jie Liu et al.   JOURNAL OF ALZHEIMERS DISEASE

Mitochondria-Targeted Antioxidants Protect Against Amyloid-β Toxicity in Alzheimer's Disease Neurons

(2017) Maria Manczak et al.   JOURNAL OF ALZHEIMERS DISEASE

Tau and Aβ imaging, CSF measures, and cognition in Alzheimer’s disease

(2016) Matthew R. Brier et al.   Science Translational Medicine

Reducing Ribosomal Protein S6 Kinase 1 Expression Improves Spatial Memory and Synaptic Plasticity in a Mouse Model of Alzheimer's Disease

(2015) A. Caccamo et al.   JOURNAL OF NEUROSCIENCE

Nitric Oxide Signaling Is Recruited As a Compensatory Mechanism for Sustaining Synaptic Plasticity in Alzheimer's Disease Mice

(2015) S. Chakroborty et al.   JOURNAL OF NEUROSCIENCE

Molecular imaging of neuropsychiatric symptoms in Alzheimer's and Parkinson's disease

(2015) Kentaro Hirao et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Absence of ALOX5 gene prevents stress-induced memory deficits, synaptic dysfunction and tauopathy in a mouse model of Alzheimer's disease

(2014) Y. B. Joshi et al.   HUMAN MOLECULAR GENETICS

Apolipoprotein E in Synaptic Plasticity and Alzheimer’s Disease: Potential Cellular and Molecular Mechanisms

(2014) Jaekwang Kim et al.   MOLECULES AND CELLS

Magnesium Protects Cognitive Functions and Synaptic Plasticity in Streptozotocin-Induced Sporadic Alzheimer’s Model

(2014) Zhi-Peng Xu et al.   PLoS One

Synaptic Aging is Associated with Mitochondrial Dysfunction, Reduced Antioxidant Contents and Increased Vulnerability to Amyloid-β Toxicity

(2013) Ricardo Quiroz-Baez et al.   Current Alzheimer Research

Deregulation of excitatory neurotransmission underlying synapse failure in Alzheimer's disease

(2013) Andrea C. Paula-Lima et al.   JOURNAL OF NEUROCHEMISTRY

Amyloid β precursor protein as a molecular target for amyloid β–induced neuronal degeneration in Alzheimer's disease

(2013) Elena Anahi Bignante et al.   NEUROBIOLOGY OF AGING

Deleterious effects of soluble amyloid-β oligomers on multiple steps of synaptic vesicle trafficking

(2013) Joohyun Park et al.   NEUROBIOLOGY OF DISEASE

Dysfunctional synapse in Alzheimer's disease – A focus on NMDA receptors

(2013) Sandra I. Mota et al.   NEUROPHARMACOLOGY

Therapeutics of Alzheimer's disease: Past, present and future

(2013) R. Anand et al.   NEUROPHARMACOLOGY

Ascending monoaminergic systems alterations in Alzheimer's disease. Translating basic science into clinical care

(2013) Ludwig Trillo et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Amyloid-β induced signaling by cellular prion protein and Fyn kinase in Alzheimer disease

(2013) Ji Won Um et al.   Prion

Targeting norepinephrine in mild cognitive impairment and Alzheimer's disease

(2013) Termpanit Chalermpalanupap et al.   Alzheimers Research & Therapy

VDAC structure, selectivity, and dynamics

(2012) Marco Colombini   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Abnormal interaction between the mitochondrial fission protein Drp1 and hyperphosphorylated tau in Alzheimer's disease neurons: implications for mitochondrial dysfunction and neuronal damage

(2012) M. Manczak et al.   HUMAN MOLECULAR GENETICS

Abnormal interaction of VDAC1 with amyloid beta and phosphorylated tau causes mitochondrial dysfunction in Alzheimer's disease

(2012) M. Manczak et al.   HUMAN MOLECULAR GENETICS

SRPK2 Phosphorylates Tau and Mediates the Cognitive Defects in Alzheimer's Disease

(2012) Y. Hong et al.   JOURNAL OF NEUROSCIENCE

Glutamate system, amyloid β peptides and tau protein: functional interrelationships and relevance to Alzheimer disease pathology

(2012) Timothy Revett et al.   JOURNAL OF PSYCHIATRY & NEUROSCIENCE

Alzheimer amyloid-β oligomer bound to postsynaptic prion protein activates Fyn to impair neurons

(2012) Ji Won Um et al.   NATURE NEUROSCIENCE

Dysregulation of Ca2+Homeostasis in Alzheimer’s Disease: Role in Acetylcholinesterase Production and AMPA Receptor Internalization

(2012) David H. Small   Neurodegenerative Diseases

Amyloid-β Acts as a Regulator of Neurotransmitter Release Disrupting the Interaction between Synaptophysin and VAMP2

(2012) Claire L. Russell et al.   PLoS One

Neurotransmitter receptors and cognitive dysfunction in Alzheimer's disease and Parkinson's disease

(2012) Yunqi Xu et al.   PROGRESS IN NEUROBIOLOGY

The serotonergic system in ageing and Alzheimer's disease

(2012) José Julio Rodríguez et al.   PROGRESS IN NEUROBIOLOGY

Brain excitability and connectivity of neuronal assemblies in Alzheimer's disease: From animal models to human findings

(2012) Marcello D’Amelio et al.   PROGRESS IN NEUROBIOLOGY

Alzheimer brain-derived tau oligomers propagate pathology from endogenous tau

(2012) Cristian A. Lasagna-Reeves et al.   Scientific Reports

Alzheimer’s disease Aβ assemblies mediating rapid disruption of synaptic plasticity and memory

(2012) Igor Klyubin et al.   Molecular Brain

Synapses and Dendritic Spines as Pathogenic Targets in Alzheimer’s Disease

(2012) Wendou Yu et al.   NEURAL PLASTICITY

Amyloid beta impairs mitochondrial anterograde transport and degenerates synapses in Alzheimer's disease neurons

(2011) Marcus J. Calkins et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Impaired mitochondrial dynamics and abnormal interaction of amyloid beta with mitochondrial protein Drp1 in neurons from patients with Alzheimer's disease: implications for neuronal damage

(2011) Maria Manczak et al.   HUMAN MOLECULAR GENETICS

Impaired mitochondrial biogenesis, defective axonal transport of mitochondria, abnormal mitochondrial dynamics and synaptic degeneration in a mouse model of Alzheimer's disease

(2011) M. J. Calkins et al.   HUMAN MOLECULAR GENETICS

Amyloid β: linking synaptic plasticity failure to memory disruption in Alzheimer’s disease

(2011) Tao Ma et al.   JOURNAL OF NEUROCHEMISTRY

Amyloid  -Induced Impairments in Hippocampal Synaptic Plasticity Are Rescued by Decreasing Mitochondrial Superoxide

(2011) T. Ma et al.   JOURNAL OF NEUROSCIENCE

Amyloid- /Fyn-Induced Synaptic, Network, and Cognitive Impairments Depend on Tau Levels in Multiple Mouse Models of Alzheimer's Disease

(2011) E. D. Roberson et al.   JOURNAL OF NEUROSCIENCE

Aβ1–42 inhibition of LTP is mediated by a signaling pathway involving caspase-3, Akt1 and GSK-3β

(2011) Jihoon Jo et al.   NATURE NEUROSCIENCE

The Aβ oligomer hypothesis for synapse failure and memory loss in Alzheimer’s disease

(2011) Sergio T. Ferreira et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Consolidation and reconsolidation of contextual fear memory requires mammalian target of rapamycin-dependent translation in the dorsal hippocampus

(2011) G.M. Gafford et al.   NEUROSCIENCE

Revisiting the cholinergic hypothesis in the development of Alzheimer's disease

(2011) Laura A. Craig et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Glutamate receptors in preclinical research on Alzheimer's disease: Update on recent advances

(2011) Neng-Wei Hu et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Inhibition of the interactions between eukaryotic initiation factors 4E and 4G impairs long-term associative memory consolidation but not reconsolidation

(2011) C. A. Hoeffer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Selective pharmacogenetic inhibition of mammalian target of Rapamycin complex I (mTORC1) blocks long-term synaptic plasticity and memory storage

(2011) Loredana Stoica et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Spines, Plasticity, and Cognition in Alzheimer's Model Mice

(2011) Tara Spires-Jones et al.   NEURAL PLASTICITY

The pathological process underlying Alzheimer’s disease in individuals under thirty

(2010) Heiko Braak et al.   ACTA NEUROPATHOLOGICA

The cholinergic system in aging and neuronal degeneration

(2010) Reinhard Schliebs et al.   BEHAVIOURAL BRAIN RESEARCH

Anti-PrPC monoclonal antibody infusion as a novel treatment for cognitive deficits in an alzheimer's disease model mouse

(2010) Erika Chung et al.   BMC NEUROSCIENCE

Dendritic Function of Tau Mediates Amyloid-β Toxicity in Alzheimer's Disease Mouse Models

(2010) Lars M. Ittner et al.   CELL

The Upside of APP at Synapses

(2010) Hyang-Sook Hoe et al.   CNS Neuroscience & Therapeutics

Molecular Interplay between Mammalian Target of Rapamycin (mTOR), Amyloid-β, and Tau

(2010) Antonella Caccamo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Memory Impairment in Transgenic Alzheimer Mice Requires Cellular Prion Protein

(2010) D. A. Gimbel et al.   JOURNAL OF NEUROSCIENCE

Convergence of Presenilin- and Tau-Mediated Pathways on Axonal Trafficking and Neuronal Function

(2010) E. Peethumnongsin et al.   JOURNAL OF NEUROSCIENCE

In the Adult Hippocampus, Chronic Nerve Growth Factor Deprivation Shifts GABAergic Signaling from the Hyperpolarizing to the Depolarizing Direction

(2010) L. Lagostena et al.   JOURNAL OF NEUROSCIENCE

Group II Metabotropic Glutamate Receptor Stimulation Triggers Production and Release of Alzheimer's Amyloid  42 from Isolated Intact Nerve Terminals

(2010) S. H. Kim et al.   JOURNAL OF NEUROSCIENCE

Microglial Receptor for Advanced Glycation End Product-Dependent Signal Pathway Drives  -Amyloid-Induced Synaptic Depression and Long-Term Depression Impairment in Entorhinal Cortex

(2010) N. Origlia et al.   JOURNAL OF NEUROSCIENCE

Caspase-3 triggers early synaptic dysfunction in a mouse model of Alzheimer's disease

(2010) Marcello D'Amelio et al.   NATURE NEUROSCIENCE

Amyloid-β and tau — a toxic pas de deux in Alzheimer's disease

(2010) Lars M. Ittner et al.   NATURE REVIEWS NEUROSCIENCE

Amyloid-β-Derived Diffusible Ligands Cause Impaired Axonal Transport of Mitochondria in Neurons

(2010) Xinglong Wang et al.   Neurodegenerative Diseases

Tau Mislocalization to Dendritic Spines Mediates Synaptic Dysfunction Independently of Neurodegeneration

(2010) Brian R. Hoover et al.   NEURON

The rise of a new GABA pharmacology

(2010) Hanns Möhler   NEUROPHARMACOLOGY

Alzheimer's Disease

(2010) Henry W. Querfurth et al.   NEW ENGLAND JOURNAL OF MEDICINE

Inhibition of mTOR by Rapamycin Abolishes Cognitive Deficits and Reduces Amyloid-β Levels in a Mouse Model of Alzheimer's Disease

(2010) Patricia Spilman et al.   PLoS One

Dysregulation of the mTOR Pathway Mediates Impairment of Synaptic Plasticity in a Mouse Model of Alzheimer's Disease

(2010) Tao Ma et al.   PLoS One

‘Too much good news’ – are Alzheimer mouse models trying to tell us how to prevent, not cure, Alzheimer's disease?

(2010) Kathleen R. Zahs et al.   TRENDS IN NEUROSCIENCES

Reduced IGF-1 Signaling Delays Age-Associated Proteotoxicity in Mice

(2009) Ehud Cohen et al.   CELL

Early Tau Pathology Involving the Septo-Hippocampal Pathway in a Tau Transgenic Model: Relevance to Alzheimers Disease

(2009) Karim Belarbi et al.   Current Alzheimer Research

Reduction of oxidative stress, amyloid deposition, and memory deficit by manganese superoxide dismutase overexpression in a transgenic mouse model of Alzheimer’s disease

(2009) Magali Dumont et al.   FASEB JOURNAL

RAGE-dependent signaling in microglia contributes to neuroinflammation, Aβ accumulation, and impaired learning/memory in a mouse model of Alzheimer’s disease

(2009) Fang Fang et al.   FASEB JOURNAL

Neuronal nicotinic acetylcholine receptor-cholesterol crosstalk in Alzheimer's disease

(2009) Francisco J. Barrantes et al.   FEBS LETTERS

Making synaptic plasticity and memory last: mechanisms of translational regulation

(2009) J. D. Richter et al.   GENES & DEVELOPMENT

Effects of lateral fluid percussion injury on cholinergic markers in the newborn piglet brain

(2009) Cornelius K. Donat et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE

Inhibition of Calcineurin-mediated Endocytosis and α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptors Prevents Amyloid β Oligomer-induced Synaptic Disruption

(2009) Wei-Qin Zhao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

β-Amyloid Impairs AMPA Receptor Trafficking and Function by Reducing Ca2+/Calmodulin-dependent Protein Kinase II Synaptic Distribution

(2009) Zhenglin Gu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Impaired Balance of Mitochondrial Fission and Fusion in Alzheimer's Disease

(2009) X. Wang et al.   JOURNAL OF NEUROSCIENCE

Amyloid beta mediates memory formation

(2009) A. Garcia-Osta et al.   LEARNING & MEMORY

Alpha7 neuronal nicotinic receptors: The missing link to understanding Alzheimer’s etiopathology?

(2009) Merouane Bencherif et al.   MEDICAL HYPOTHESES

The Insulin/Akt Signaling Pathway Is Targeted by Intracellular β-Amyloid

(2009) Han-Kyu Lee et al.   MOLECULAR BIOLOGY OF THE CELL

Cellular prion protein mediates impairment of synaptic plasticity by amyloid-β oligomers

(2009) Juha Laurén et al.   NATURE

Amyloid beta from axons and dendrites reduces local spine number and plasticity

(2009) Wei Wei et al.   NATURE NEUROSCIENCE

Amyloid-β as a positive endogenous regulator of release probability at hippocampal synapses

(2009) Efrat Abramov et al.   NATURE NEUROSCIENCE

Soluble Oligomers of Amyloid β Protein Facilitate Hippocampal Long-Term Depression by Disrupting Neuronal Glutamate Uptake

(2009) Shaomin Li et al.   NEURON

Does Alzheimer's disease begin in the brainstem?

(2009) G. Simic et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Nicotinic Acetylcholine Receptor Signalling: Roles in Alzheimer's Disease and Amyloid Neuroprotection

(2009) S. D. Buckingham et al.   PHARMACOLOGICAL REVIEWS

Synaptic transmission block by presynaptic injection of oligomeric amyloid beta

(2009) H. Moreno et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Oligomeric amyloid   associates with postsynaptic densities and correlates with excitatory synapse loss near senile plaques

(2009) R. M. Koffie et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Protection of synapses against Alzheimer's-linked toxins: Insulin signaling prevents the pathogenic binding of Aβ oligomers

(2009) Fernanda G. De Felice et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Overexpression of SOD-2 reduces hippocampal superoxide and prevents memory deficits in a mouse model of Alzheimer's disease

(2009) C. A. Massaad et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

mTOR signaling: At the crossroads of plasticity, memory and disease

(2009) Charles A. Hoeffer et al.   TRENDS IN NEUROSCIENCES

Amyloid Activates GSK-3β to Aggravate Neuronal Tauopathy in Bigenic Mice

(2008) Dick Terwel et al.   AMERICAN JOURNAL OF PATHOLOGY

The role of GSK-3 in synaptic plasticity

(2008) S Peineau et al.   BRITISH JOURNAL OF PHARMACOLOGY

Cholinergic Neuronal and Axonal Abnormalities Are Present Early in Aging and in Alzheimer Disease

(2008) Changiz Geula et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Blocking A 42 Accumulation Delays the Onset and Progression of Tau Pathology via the C Terminus of Heat Shock Protein70-Interacting Protein: A Mechanistic Link between A  and Tau Pathology

(2008) S. Oddo et al.   JOURNAL OF NEUROSCIENCE

Receptor for Advanced Glycation End Product-Dependent Activation of p38 Mitogen-Activated Protein Kinase Contributes to Amyloid- -Mediated Cortical Synaptic Dysfunction

(2008) N. Origlia et al.   JOURNAL OF NEUROSCIENCE

Removal of S6K1 and S6K2 leads to divergent alterations in learning, memory, and synaptic plasticity

(2008) M. D. Antion et al.   LEARNING & MEMORY

Rapid appearance and local toxicity of amyloid-β plaques in a mouse model of Alzheimer’s disease

(2008) Melanie Meyer-Luehmann et al.   NATURE

Amyloid-β protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory

(2008) Ganesh M Shankar et al.   NATURE MEDICINE

Presenilin-1 mutation impairs cholinergic modulation of synaptic plasticity and suppresses NMDA currents in hippocampus slices

(2008) Yue Wang et al.   NEUROBIOLOGY OF AGING

Systemic inhibition of mammalian target of rapamycin inhibits fear memory reconsolidation

(2008) Jacqueline Blundell et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Endocytosis Is Required for Synaptic Activity-Dependent Release of Amyloid-β In Vivo

(2008) John R. Cirrito et al.   NEURON

Amyloid-  overproduction causes abnormal mitochondrial dynamics via differential modulation of mitochondrial fission/fusion proteins

(2008) X. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Amyloid β-protein fragments 25-35 and 31-35 potentiate long-term depression in hippocampal CA1 region of rats in vivo

(2008) Li Cheng et al.   SYNAPSE

A role for the 5-HT1A, 5-HT4 and 5-HT6 receptors in learning and memory

(2008) M KING et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

5-HT7 receptors in the modulation of cognitive processes

(2007) Agata Cifariello et al.   BEHAVIOURAL BRAIN RESEARCH

Noradrenergic modulation of arousal

(2007) Craig W. Berridge   BRAIN RESEARCH REVIEWS

p38 Kinase Is Activated in the Alzheimer's Disease Brain

(2003) Kenneth Hensley et al.   JOURNAL OF NEUROCHEMISTRY

The neuronal MAP kinase cascade: a biochemical signal integration system subserving synaptic plasticity and memory

(2003) J. David Sweatt   JOURNAL OF NEUROCHEMISTRY