Wnt, Notch, and TGF-β Pathways Impinge on Hedgehog Signaling Complexity: An Open Window on Cancer

Notch3 Targeting: A Novel Weapon against Ovarian Cancer Stem Cells

(2019) Simona Ceccarelli et al.   Stem Cells International

Histone Modifications Drive Aberrant Notch3 Expression/Activity and Growth in T-ALL

(2019) Luca Tottone et al.   Frontiers in Oncology

A highlight on Sonic hedgehog pathway

(2018) Gabriela Basile Carballo et al.   Cell Communication and Signaling

Epigenetic regulation of the Hedgehog and Wnt pathways in cancer

(2018) Leon J Wils et al.   CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY

Notch signaling as a therapeutic target for acute lymphoblastic leukemia

(2018) Diana Bellavia et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Hedgehog pathway mutations drive oncogenic transformation in high-risk T-cell acute lymphoblastic leukemia

(2018) Melissa A. Burns et al.   LEUKEMIA

Itch/β-arrestin2-dependent non-proteolytic ubiquitylation of SuFu controls Hedgehog signalling and medulloblastoma tumorigenesis

(2018) Paola Infante et al.   Nature Communications

NOTCH3 inactivation increases triple negative breast cancer sensitivity to gefitinib by promoting EGFR tyrosine dephosphorylation and its intracellular arrest

(2018) Giulia Diluvio et al.   Oncogenesis

Intrathymic Notch3 and CXCR4 combinatorial interplay facilitates T-cell leukemia propagation

(2018) Francesca Ferrandino et al.   ONCOGENE

IL-4-dependent Jagged1 expression/processing is associated with survival of chronic lymphocytic leukemia cells but not with Notch activation

(2018) Filomena De Falco et al.   Cell Death & Disease

Notch and NF-κB: Coach and Players of Regulatory T-Cell Response in Cancer

(2018) Francesca Ferrandino et al.   Frontiers in Immunology

Congenital embryonal rhabdomyosarcoma caused by heterozygous concomitant PTCH1 and PTCH2 germline mutations

(2017) Julia Taeubner et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Loss of miR-107, miR-181c and miR-29a-3p Promote Activation of Notch2 Signaling in Pediatric High-Grade Gliomas (pHGGs)

(2017) Giuseppina Catanzaro et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Basal cell carcinoma pathogenesis and therapy involving hedgehog signaling and beyond

(2017) Anshika Bakshi et al.   MOLECULAR CARCINOGENESIS

Intratumoral Heterogeneity of Frameshift Mutations of GLI1 Encoding a Hedgehog Signaling Protein in Colorectal Cancers

(2017) Ju Hwa Lee et al.   PATHOLOGY & ONCOLOGY RESEARCH

Maml1 acts cooperatively with Gli proteins to regulate sonic hedgehog signaling pathway

(2017) Roberta Quaranta et al.   Cell Death & Disease

Hedgehog pathway activation in T-cell acute lymphoblastic leukemia predicts response to SMO and GLI1 inhibitors

(2016) A. Dagklis et al.   BLOOD

TGF-β Signaling in Cancer

(2016) Viqar Syed   JOURNAL OF CELLULAR BIOCHEMISTRY

Prolyl-isomerase Pin1 controls Notch3 protein expression and regulates T-ALL progression

(2016) G Franciosa et al.   ONCOGENE

Inhibition of Hedgehog-dependent tumors and cancer stem cells by a newly identified naturally occurring chemotype

(2016) Paola Infante et al.   Cell Death & Disease

Aberrant Wnt Signaling in Leukemia

(2016) Frank Staal et al.   Cancers

Targeting the Sonic Hedgehog Signaling Pathway: Review of Smoothened and GLI Inhibitors

(2016) Tadas Rimkus et al.   Cancers

A conserved role for Notch signaling in priming the cellular response to Shh through ciliary localisation of the key Shh transducer Smo

(2015) M. Stasiulewicz et al.   DEVELOPMENT

Notch Activity Modulates the Responsiveness of Neural Progenitors to Sonic Hedgehog Signaling

(2015) Jennifer H. Kong et al.   DEVELOPMENTAL CELL

The deregulated expression of miR-125b in acute myeloid leukemia is dependent on the transcription factor C/EBPα

(2015) P Vargas Romero et al.   LEUKEMIA

β-Catenin-Gli1 interaction regulates proliferation and tumor growth in medulloblastoma

(2015) Jenny Zinke et al.   Molecular Cancer

The Hedgehog Inhibitor Cyclopamine Reduces β-Catenin-Tcf Transcriptional Activity, Induces E-Cadherin Expression, and Reduces Invasion in Colorectal Cancer Cells

(2015) David Qualtrough et al.   Cancers

Wnt/β-catenin signaling inhibits the Shh pathway and impairs tumor growth in Shh-dependent medulloblastoma

(2014) Julia Pöschl et al.   ACTA NEUROPATHOLOGICA

Inhibition of hedgehog signaling by GANT58 induces apoptosis and shows synergistic antitumor activity with AKT inhibitor in acute T cell leukemia cells

(2014) Xiaoming Hou et al.   BIOCHIMIE

A Jagged Road to Lymphoma Aggressiveness

(2014) Vedran Radojcic et al.   CANCER CELL

Genome Sequencing of SHH Medulloblastoma Predicts Genotype-Related Response to Smoothened Inhibition

(2014) Marcel Kool et al.   CANCER CELL

Loss of Notch1-dependent p21Waf1/Cip1expression influences the Notch1 outcome in tumorigenesis

(2014) Samantha Cialfi et al.   CELL CYCLE

The Molecular Basis of Notch Signaling Regulation: A Complex Simplicity

(2014) R. Palermo et al.   CURRENT MOLECULAR MEDICINE

Roles for Hedgehog signaling in adult organ homeostasis and repair

(2014) R. Petrova et al.   DEVELOPMENT

Hedgehog pathway mutations in T-cell acute lymphoblastic leukemia

(2014) A. Dagklis et al.   HAEMATOLOGICA

Germline Mutations inSUFUCause Gorlin Syndrome–Associated Childhood Medulloblastoma and Redefine the Risk Associated WithPTCH1Mutations

(2014) Miriam J. Smith et al.   JOURNAL OF CLINICAL ONCOLOGY

Constitutive phosphorylation of the active Notch1 intracellular domain in chronic lymphocytic leukemia cells with NOTCH1 mutation

(2014) F De Falco et al.   LEUKEMIA

Notch and NF-kB signaling pathways regulate miR-223/FBXW7 axis in T-cell acute lymphoblastic leukemia

(2014) V Kumar et al.   LEUKEMIA

Identification of recurrent SMO and BRAF mutations in ameloblastomas

(2014) Robert T Sweeney et al.   NATURE GENETICS

Notch3/Jagged1 Circuitry Reinforces Notch Signaling and Sustains T-ALL

(2014) Maria Pelullo et al.   NEOPLASIA

Prolyl-isomerase Pin1 controls normal and cancer stem cells of the breast

(2013) Alessandra Rustighi et al.   EMBO Molecular Medicine

Frameshift mutation in the PTCH2 gene can cause nevoid basal cell carcinoma syndrome

(2013) Katsunori Fujii et al.   Familial Cancer

Cross-talk between Notch and Hedgehog regulates hepatic stellate cell fate in mice

(2013) Guanhua Xie et al.   HEPATOLOGY

Functional impact of NOTCH1 mutations in chronic lymphocytic leukemia

(2013) F Arruga et al.   LEUKEMIA

Mutations in the Hedgehog Pathway Genes SMO and PTCH1 in Human Gastric Tumors

(2013) Xi-De Wang et al.   PLoS One

Gli2 Acetylation at Lysine 757 Regulates Hedgehog-Dependent Transcriptional Output by Preventing Its Promoter Occupancy

(2013) Sonia Coni et al.   PLoS One

Epigenetic Inactivation of Notch-Hes Pathway in Human B-Cell Acute Lymphoblastic Leukemia

(2013) Shao-Qing Kuang et al.   PLoS One

Molecular subgroups of medulloblastoma: an international meta-analysis of transcriptome, genetic aberrations, and clinical data of WNT, SHH, Group 3, and Group 4 medulloblastomas

(2012) Marcel Kool et al.   ACTA NEUROPATHOLOGICA

Loss of SUFU Function in Familial Multiple Meningioma

(2012) Mervi Aavikko et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Pathways involved in Drosophila and human cancer development: the Notch, Hedgehog, Wingless, Runt, and Trithorax pathway

(2012) Klaus Geissler et al.   ANNALS OF HEMATOLOGY

Canonical and noncanonical Hedgehog pathway in the pathogenesis of multiple myeloma

(2012) S. Blotta et al.   BLOOD

Suppression of Acquired Docetaxel Resistance in Prostate Cancer through Depletion of Notch- and Hedgehog-Dependent Tumor-Initiating Cells

(2012) Josep Domingo-Domenech et al.   CANCER CELL

Targeting embryonic signaling pathways in cancer therapy

(2012) Pamela Jo Harris et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Dynamics of TGF-β/Smad signaling

(2012) Zhike Zi et al.   FEBS LETTERS

Somatic mutations in the notch, NF-KB, PIK3CA, and hedgehog pathways in human breast cancers

(2012) Xiang Jiao et al.   GENES CHROMOSOMES & CANCER

Overview of Primary Brain Tumors

(2012) Anita Huttner   HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA

Hedgehog Secretion and Signal Transduction in Vertebrates

(2012) Kaitlyn E. Ryan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Expression of Microphthalmia-associated Transcription Factor (MITF), Which Is Critical for Melanoma Progression, Is Inhibited by Both Transcription Factor GLI2 and Transforming Growth Factor-β

(2012) Marie-Jeanne Pierrat et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Glucocorticoid sensitivity of T-cell lymphoblastic leukemia/lymphoma is associated with glucocorticoid receptor-mediated inhibition of Notch1 expression

(2012) S Cialfi et al.   LEUKEMIA

Hedgehog Pathway Signaling Regulates Human Colon Carcinoma HT-29 Epithelial Cell Line Apoptosis and Cytokine Secretion

(2012) Agnes N. Yoshimoto et al.   PLoS One

Targeting Notch, a key pathway for ovarian cancer stem cells, sensitizes tumors to platinum therapy

(2012) S. M. McAuliffe et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genome-Wide Analysis of N1ICD/RBPJ Targets In Vivo Reveals Direct Transcriptional Regulation of Wnt, SHH, and Hippo Pathway Effectors by Notch1

(2012) Yaochen Li et al.   STEM CELLS

Attenuation of Notch and Hedgehog Signaling Is Required for Fate Specification in the Spinal Cord

(2012) Peng Huang et al.   PLoS Genetics

Trisomy 12 and elevated GLI1 and PTCH1 transcript levels are biomarkers for Hedgehog-inhibitor responsiveness in CLL

(2011) S. Decker et al.   BLOOD

A Role for the Primary Cilium in Notch Signaling and Epidermal Differentiation during Skin Development

(2011) Ellen J. Ezratty et al.   CELL

Targeting the Notch Ligand Jagged1 in Both Tumor Cells and Stroma in Ovarian Cancer

(2011) A. D. Steg et al.   CLINICAL CANCER RESEARCH

Endodermal Hedgehog signals modulate Notch pathway activity in the developing digestive tract mesenchyme

(2011) T.-H. Kim et al.   DEVELOPMENT

The controversial role of the Hedgehog pathway in normal and malignant hematopoiesis

(2011) B G Mar et al.   LEUKEMIA

Uncommitted precursor cells might contribute to increased incidence of embryonal rhabdomyosarcoma in heterozygous Patched1-mutant mice

(2011) F Nitzki et al.   ONCOGENE

Sonic Hedgehog Dependent Phosphorylation by CK1α and GRK2 Is Required for Ciliary Accumulation and Activation of Smoothened

(2011) Yongbin Chen et al.   PLOS BIOLOGY

Hedgehog beyond medulloblastoma and basal cell carcinoma

(2010) Stephan Teglund et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Role of Notch and its oncogenic signaling crosstalk in breast cancer

(2010) Shanchun Guo et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

NOTCH Signaling Is Required for Formation and Self-Renewal of Tumor-Initiating Cells and for Repression of Secretory Cell Differentiation in Colon Cancer

(2010) S. S. Sikandar et al.   CANCER RESEARCH

Non-redundant role for the transcription factor Gli1 at multiple stages of thymocyte development

(2010) Ekati Drakopoulou et al.   CELL CYCLE

Targeting Hedgehog -- a Cancer Stem Cell Pathway

(2010) A. A. Merchant et al.   CLINICAL CANCER RESEARCH

The Notch Target Hes1 Directly Modulates Gli1 Expression and Hedgehog Signaling: A Potential Mechanism of Therapeutic Resistance

(2010) K. C. Schreck et al.   CLINICAL CANCER RESEARCH

Notch signalling regulates left-right asymmetry through ciliary length control

(2010) S. S. Lopes et al.   DEVELOPMENT

Loss of WNT-TCF addiction and enhancement of HH-GLI1 signalling define the metastatic transition of human colon carcinomas

(2010) Frédéric Varnat et al.   EMBO Molecular Medicine

The output of Hedgehog signaling is controlled by the dynamic association between Suppressor of Fused and the Gli proteins

(2010) E. W. Humke et al.   GENES & DEVELOPMENT

Pleiotropic role for MYCN in medulloblastoma

(2010) F. J. Swartling et al.   GENES & DEVELOPMENT

Requirement of TGFβ Signaling for SMO-mediated Carcinogenesis

(2010) Qipeng Fan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Epidemiology and etiology of meningioma

(2010) Joseph Wiemels et al.   JOURNAL OF NEURO-ONCOLOGY

Hedgehog signaling pathway is activated in diffuse large B-cell lymphoma and contributes to tumor cell survival and proliferation

(2010) R R Singh et al.   LEUKEMIA

Histone deacetylase and Cullin3–RENKCTD11 ubiquitin ligase interplay regulates Hedgehog signalling through Gli acetylation

(2010) Gianluca Canettieri et al.   NATURE CELL BIOLOGY

Targeting cancer stem cells by inhibiting Wnt, Notch and Hedgehog pathways

(2010) Naoko Takebe et al.   Nature Reviews Clinical Oncology

The primary cilium: a signalling centre during vertebrate development

(2010) Sarah C. Goetz et al.   NATURE REVIEWS GENETICS

Numb activates the E3 ligase Itch to control Gli1 function through a novel degradation signal

(2010) L Di Marcotullio et al.   ONCOGENE

Cyclin D1 is a direct target of JAG1-mediated Notch signaling in breast cancer

(2009) Brenda Cohen et al.   BREAST CANCER RESEARCH AND TREATMENT

Wnt Signaling Stimulates Transcriptional Outcome of the Hedgehog Pathway by Stabilizing GLI1 mRNA

(2009) F. K. Noubissi et al.   CANCER RESEARCH

The Canonical Notch Signaling Pathway: Unfolding the Activation Mechanism

(2009) Raphael Kopan et al.   CELL

Hedgehog Signaling Is Dispensable for Adult Hematopoietic Stem Cell Function

(2009) Jie Gao et al.   Cell Stem Cell

Hedgehog Target Genes: Mechanisms of Carcinogenesis Induced by Aberrant Hedgehog Signaling Activation

(2009) Y. Katoh et al.   CURRENT MOLECULAR MEDICINE

Hedgehog-stimulated stem cells depend on non-canonical activity of the Notch co-activator Mastermind

(2009) C. Vied et al.   DEVELOPMENT

Notch Signaling: The Core Pathway and Its Posttranslational Regulation

(2009) Mark E. Fortini   DEVELOPMENTAL CELL

Wnt/β-Catenin Signaling: Components, Mechanisms, and Diseases

(2009) Bryan T. MacDonald et al.   DEVELOPMENTAL CELL

A GLI1-p53 inhibitory loop controls neural stem cell and tumour cell numbers

(2009) Barbara Stecca et al.   EMBO JOURNAL

Human colon cancer epithelial cells harbour active HEDGEHOG-GLI signalling that is essential for tumour growth, recurrence, metastasis and stem cell survival and expansion

(2009) Frédéric Varnat et al.   EMBO Molecular Medicine

Notch3 and pTα/pre-TCR sustain the in vivo function of naturally occurring regulatory T cells

(2009) Antonio F. Campese et al.   INTERNATIONAL IMMUNOLOGY

Progenitor cell proliferation in the retina is dependent on Notch-independent Sonic hedgehog/Hes1 activity

(2009) Dana S. Wall et al.   JOURNAL OF CELL BIOLOGY

Sonic hedgehog relates to colorectal carcinogenesis

(2009) Kozo Yoshikawa et al.   JOURNAL OF GASTROENTEROLOGY

Multiple recurrent genetic events converge on control of histone lysine methylation in medulloblastoma

(2009) Paul A Northcott et al.   NATURE GENETICS

Patched1 deletion increases N-Myc protein stability as a mechanism of medulloblastoma initiation and progression

(2009) W D Thomas et al.   ONCOGENE

Differential subcellular localization regulates c-Cbl E3 ligase activity upon Notch3 protein in T-cell leukemia

(2009) S Checquolo et al.   ONCOGENE

Jagged1 is the pathological link between Wnt and Notch pathways in colorectal cancer

(2009) V. Rodilla et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Notch signaling and diseases: An evolutionary journey from a simple beginning to complex outcomes

(2008) Claudio Talora et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Notch signaling mediates G1/S cell-cycle progression in T cells via cyclin D3 and its dependent kinases

(2008) I. Joshi et al.   BLOOD

Constitutively activated Notch signaling is involved in survival and apoptosis resistance of B-CLL cells

(2008) E. Rosati et al.   BLOOD

Stroma-Initiated Hedgehog Signaling Takes Center Stage in B-Cell Lymphoma

(2008) R. K. Lindemann   CANCER RESEARCH

Jagged-1 and Notch3 Juxtacrine Loop Regulates Ovarian Tumor Growth and Adhesion

(2008) J.-H. Choi et al.   CANCER RESEARCH

Frequent alterations ofhMLH1andRBSP3/HYA22at chromosomal 3p22.3 region in early and late-onset breast carcinoma: clinical and prognostic significance

(2008) Satyabrata Sinha et al.   CANCER SCIENCE

The Bone Morphogenetic Protein Pathway Is Inactivated in the Majority of Sporadic Colorectal Cancers

(2008) Liudmila L. Kodach et al.   GASTROENTEROLOGY

Hedgehog: functions and mechanisms

(2008) M. Varjosalo et al.   GENES & DEVELOPMENT

Medulloblastoma Stem Cells

(2008) Xing Fan et al.   JOURNAL OF CLINICAL ONCOLOGY

Integrated Genomics Identifies Five Medulloblastoma Subtypes with Distinct Genetic Profiles, Pathway Signatures and Clinicopathological Features

(2008) Marcel Kool et al.   PLoS One

Core Signaling Pathways in Human Pancreatic Cancers Revealed by Global Genomic Analyses

(2008) S. Jones et al.   SCIENCE

Notch signaling: Its role in epidermal homeostasis and in the pathogenesis of skin diseases

(2007) Ryuhei Okuyama et al.   JOURNAL OF DERMATOLOGICAL SCIENCE