Itch/β-arrestin2-dependent non-proteolytic ubiquitylation of SuFu controls Hedgehog signalling and medulloblastoma tumorigenesis
出版年份 2018 全文链接
标题
Itch/β-arrestin2-dependent non-proteolytic ubiquitylation of SuFu controls Hedgehog signalling and medulloblastoma tumorigenesis
作者
关键词
-
出版物
Nature Communications
Volume 9, Issue 1, Pages -
出版商
Springer Nature
发表日期
2018-03-01
DOI
10.1038/s41467-018-03339-0
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- PARP inhibitors enhance replication stress and cause mitotic catastrophe in MYCN-dependent neuroblastoma
- (2017) V Colicchia et al. ONCOGENE
- NanoLuc: A Small Luciferase Is Brightening Up the Field of Bioluminescence
- (2016) Christopher G. England et al. BIOCONJUGATE CHEMISTRY
- SCF (Fbxl17) ubiquitylation of Sufu regulates Hedgehog signaling and medulloblastoma development
- (2016) Madalina Raducu et al. EMBO JOURNAL
- In vitro models of medulloblastoma: Choosing the right tool for the job
- (2016) Delyan P. Ivanov et al. JOURNAL OF BIOTECHNOLOGY
- Inhibition of Hedgehog-dependent tumors and cancer stem cells by a newly identified naturally occurring chemotype
- (2016) Paola Infante et al. Cell Death & Disease
- The energy sensor AMPK regulates Hedgehog signaling in human cells through a unique Gli1 metabolic checkpoint
- (2016) Laura Di Magno et al. Oncotarget
- NanoLuc Complementation Reporter Optimized for Accurate Measurement of Protein Interactions in Cells
- (2015) Andrew S. Dixon et al. ACS Chemical Biology
- Genome Sequencing of SHH Medulloblastoma Predicts Genotype-Related Response to Smoothened Inhibition
- (2014) Marcel Kool et al. CANCER CELL
- Druggable glycolytic requirement for Hedgehog-dependent neuronal and medulloblastoma growth
- (2014) Laura Di Magno et al. CELL CYCLE
- Gli1/DNA interaction is a druggable target for Hedgehog-dependent tumors
- (2014) P. Infante et al. EMBO JOURNAL
- Germline Mutations inSUFUCause Gorlin Syndrome–Associated Childhood Medulloblastoma and Redefine the Risk Associated WithPTCH1Mutations
- (2014) Miriam J. Smith et al. JOURNAL OF CLINICAL ONCOLOGY
- Patched-1 Proapoptotic Activity Is Downregulated by Modification of K1413 by the E3 Ubiquitin-Protein Ligase Itchy Homolog
- (2014) X. L. Chen et al. MOLECULAR AND CELLULAR BIOLOGY
- Context-dependent signal integration by the GLI code: The oncogenic load, pathways, modifiers and implications for cancer therapy
- (2014) Fritz Aberger et al. SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
- Yin-Yang strands of PCAF/Hedgehog axis in cancer control
- (2014) Paola Infante et al. TRENDS IN MOLECULAR MEDICINE
- Structural basis of SUFU–GLI interaction in human Hedgehog signalling regulation
- (2013) Amy L. Cherry et al. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
- Personalizing the Treatment of Pediatric Medulloblastoma: Polo-like Kinase 1 as a Molecular Target in High-Risk Children
- (2013) J. Triscott et al. CANCER RESEARCH
- PCAF ubiquitin ligase activity inhibits Hedgehog/Gli1 signaling in p53-dependent response to genotoxic stress
- (2013) D Mazzà et al. CELL DEATH AND DIFFERENTIATION
- The mechanisms of Hedgehog signalling and its roles in development and disease
- (2013) James Briscoe et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Two cases of nevoid basal cell carcinoma syndrome associated with meningioma caused by a PTCH1 or SUFU germline mutation
- (2012) Chihiro Kijima et al. Familial Cancer
- MMPBSA.py: An Efficient Program for End-State Free Energy Calculations
- (2012) Bill R. Miller et al. Journal of Chemical Theory and Computation
- High Frequency of Germline SUFU Mutations in Children With Desmoplastic/Nodular Medulloblastoma Younger Than 3 Years of Age
- (2012) Laurence Brugières et al. JOURNAL OF CLINICAL ONCOLOGY
- Involvement of β-arrestins in cancer progression
- (2012) Shanshan Hu et al. MOLECULAR BIOLOGY REPORTS
- Rapid, reliable, and reproducible molecular sub-grouping of clinical medulloblastoma samples
- (2011) Paul A. Northcott et al. ACTA NEUROPATHOLOGICA
- Dual Phosphorylation of Suppressor of Fused (Sufu) by PKA and GSK3β Regulates Its Stability and Localization in the Primary Cilium
- (2011) Yan Chen et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Itraconazole Side Chain Analogues: Structure–Activity Relationship Studies for Inhibition of Endothelial Cell Proliferation, Vascular Endothelial Growth Factor Receptor 2 (VEGFR2) Glycosylation, and Hedgehog Signaling
- (2011) Wei Shi et al. JOURNAL OF MEDICINAL CHEMISTRY
- Systematic and Quantitative Assessment of the Ubiquitin-Modified Proteome
- (2011) Woong Kim et al. MOLECULAR CELL
- Spartin activates atrophin-1-interacting protein 4 (AIP4) E3 ubiquitin ligase and promotes ubiquitination of adipophilin on lipid droplets
- (2010) Christopher Hooper et al. BMC BIOLOGY
- Suppressor of fused and Spop regulate the stability, processing and function of Gli2 and Gli3 full-length activators but not their repressors
- (2010) C. Wang et al. DEVELOPMENT
- Heterogeneity of familial medulloblastoma and contribution of germline PTCH1 and SUFU mutations to sporadic medulloblastoma
- (2010) Ingrid Slade et al. Familial Cancer
- The output of Hedgehog signaling is controlled by the dynamic association between Suppressor of Fused and the Gli proteins
- (2010) E. W. Humke et al. GENES & DEVELOPMENT
- Arresting a Transient Receptor Potential (TRP) Channel
- (2010) Arun K. Shukla et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Numb activates the E3 ligase Itch to control Gli1 function through a novel degradation signal
- (2010) L Di Marcotullio et al. ONCOGENE
- Identification of aSUFUgermline mutation in a family with Gorlin syndrome
- (2009) L. Pastorino et al. AMERICAN JOURNAL OF MEDICAL GENETICS PART A
- Arrestin Development: Emerging Roles for β-arrestins in Developmental Signaling Pathways
- (2009) Jeffrey J. Kovacs et al. DEVELOPMENTAL CELL
- Control of the activity of WW-HECT domain E3 ubiquitin ligases by NDFIP proteins
- (2009) Thomas Mund et al. EMBO REPORTS
- Cilium-independent regulation of Gli protein function by Sufu in Hedgehog signaling is evolutionarily conserved
- (2009) M.-H. Chen et al. GENES & DEVELOPMENT
- Incomplete penetrance of the predisposition to medulloblastoma associated with germ-line SUFU mutations
- (2009) L. Brugieres et al. JOURNAL OF MEDICAL GENETICS
- The HECT-domain ubiquitin ligase Huwe1 controls neural differentiation and proliferation by destabilizing the N-Myc oncoprotein
- (2008) Xudong Zhao et al. NATURE CELL BIOLOGY
- Hedgehog signaling promotes the degradation of tumor suppressor Sufu through the ubiquitin–proteasome pathway
- (2008) S Yue et al. ONCOGENE
- -Arrestin-Mediated Localization of Smoothened to the Primary Cilium
- (2008) J. J. Kovacs et al. SCIENCE
Find the ideal target journal for your manuscript
Explore over 38,000 international journals covering a vast array of academic fields.
SearchAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started