Targeting embryonic signaling pathways in cancer therapy

Hedgehog signaling pathway as a therapeutic target in various types of cancer

(2011) Hideya Onishi et al.   CANCER SCIENCE

Targeting the Wnt/β-catenin signaling pathway in human cancers

(2011) Hisayuki Yao et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Embryonic signaling in melanoma: potential for diagnosis and therapy

(2011) Luigi Strizzi et al.   LABORATORY INVESTIGATION

Improved Survival with Vemurafenib in Melanoma with BRAF V600E Mutation

(2011) Paul B. Chapman et al.   NEW ENGLAND JOURNAL OF MEDICINE

Hedgehog signaling update

(2010) M. Michael Cohen Jr.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Down-regulation of Notch1 by gamma-secretase inhibition contributes to cell growth inhibition and apoptosis in ovarian cancer cells A2780

(2010) Mingyi Wang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Regulation of the Embryonic Morphogen Nodal by Notch4 Facilitates Manifestation of the Aggressive Melanoma Phenotype

(2010) K. M. Hardy et al.   CANCER RESEARCH

Primary Tumor Genotype Is an Important Determinant in Identification of Lung Cancer Propagating Cells

(2010) Stephen J. Curtis et al.   Cell Stem Cell

Targeting Wnt Signaling: Can We Safely Eradicate Cancer Stem Cells?

(2010) F. Takahashi-Yanaga et al.   CLINICAL CANCER RESEARCH

Controversies in Cancer Stem Cells: Targeting Embryonic Signaling Pathways

(2010) N. Takebe et al.   CLINICAL CANCER RESEARCH

Cancer Stem Cells and Self-renewal

(2010) C. A. O'Brien et al.   CLINICAL CANCER RESEARCH

Targeting Notch to Target Cancer Stem Cells

(2010) A. Pannuti et al.   CLINICAL CANCER RESEARCH

Epigenetic regulation of Wnt signaling pathway in urological cancer

(2010) Vera L. Costa et al.   Epigenetics

Regulatory Mechanism of Osteoclastogenesis by RANKL and Wnt Signals

(2010) Naoyuki Takahashi   Frontiers in Bioscience-Landmark

The therapeutic promise of the cancer stem cell concept

(2010) Natasha Y. Frank et al.   JOURNAL OF CLINICAL INVESTIGATION

Evaluation of Selective  -Secretase Inhibitor PF-03084014 for Its Antitumor Efficacy and Gastrointestinal Safety to Guide Optimal Clinical Trial Design

(2010) P. Wei et al.   MOLECULAR CANCER THERAPEUTICS

Chronic DLL4 blockade induces vascular neoplasms

(2010) Minhong Yan et al.   NATURE

Targeting cancer stem cells by inhibiting Wnt, Notch and Hedgehog pathways

(2010) Naoko Takebe et al.   Nature Reviews Clinical Oncology

Gefitinib or Chemotherapy for Non–Small-Cell Lung Cancer with Mutated EGFR

(2010) Makoto Maemondo et al.   NEW ENGLAND JOURNAL OF MEDICINE

Anaplastic Lymphoma Kinase Inhibition in Non–Small-Cell Lung Cancer

(2010) Eunice L. Kwak et al.   NEW ENGLAND JOURNAL OF MEDICINE

Improved Survival with Ipilimumab in Patients with Metastatic Melanoma

(2010) F. Stephen Hodi et al.   NEW ENGLAND JOURNAL OF MEDICINE

Hedgehog signaling: Endocrine gland development and function

(2009) M. Michael Cohen   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Nuclear factor kappaB-activated monocytes contribute to pancreatic cancer progression through the production of Shh

(2009) Akio Yamasaki et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

De novo Discovery of a  -Secretase Inhibitor Response Signature Using a Novel In vivo Breast Tumor Model

(2009) J. W. Watters et al.   CANCER RESEARCH

Preclinical Profile of a Potent  -Secretase Inhibitor Targeting Notch Signaling with In vivo Efficacy and Pharmacodynamic Properties

(2009) L. Luistro et al.   CANCER RESEARCH

The Canonical Notch Signaling Pathway: Unfolding the Activation Mechanism

(2009) Raphael Kopan et al.   CELL

DLL4 Blockade Inhibits Tumor Growth and Reduces Tumor-Initiating Cell Frequency

(2009) Timothy Hoey et al.   Cell Stem Cell

Protein Kinase CK2 in Health and Disease

(2009) I. Dominguez et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Notch Signaling: The Core Pathway and Its Posttranslational Regulation

(2009) Mark E. Fortini   DEVELOPMENTAL CELL

Discovery and Characterization of a Small Molecule Inhibitor of the PDZ Domain of Dishevelled

(2009) David Grandy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Discovery of a Potent and Orally Active Hedgehog Pathway Antagonist (IPI-926)

(2009) Martin R. Tremblay et al.   JOURNAL OF MEDICINAL CHEMISTRY

Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling

(2009) Shih-Min A. Huang et al.   NATURE

Direct inhibition of the NOTCH transcription factor complex

(2009) Raymond E. Moellering et al.   NATURE

Small molecule–mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer

(2009) Baozhi Chen et al.   Nature Chemical Biology

Treatment of Medulloblastoma with Hedgehog Pathway Inhibitor GDC-0449

(2009) Charles M. Rudin et al.   NEW ENGLAND JOURNAL OF MEDICINE

Inhibition of the Hedgehog Pathway in Advanced Basal-Cell Carcinoma

(2009) Daniel D. Von Hoff et al.   NEW ENGLAND JOURNAL OF MEDICINE

Hedgehog signaling is restricted to the stromal compartment during pancreatic carcinogenesis

(2009) H. Tian et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Epigenetically reprogramming metastatic tumor cells with an embryonic microenvironment

(2009) Fabricio F Costa et al.   Epigenomics

A Notch1 Ectodomain Construct Inhibits Endothelial Notch Signaling, Tumor Growth, and Angiogenesis

(2008) Y. Funahashi et al.   CANCER RESEARCH

Hedgehog Signaling in Development and Cancer

(2008) Jin Jiang et al.   DEVELOPMENTAL CELL

Concerted microRNA control of Hedgehog signalling in cerebellar neuronal progenitor and tumour cells

(2008) Elisabetta Ferretti et al.   EMBO JOURNAL

Deciphering the function of canonical Wnt signals in development and disease: conditional loss- and gain-of-function mutations of  -catenin in mice

(2008) T. Grigoryan et al.   GENES & DEVELOPMENT

Modulation of Notch Signaling by Antibodies Specific for the Extracellular Negative Regulatory Region of NOTCH3

(2008) Kang Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An Unbiased Evaluation of CK2 Inhibitors by Chemoproteomics

(2008) James S. Duncan et al.   MOLECULAR & CELLULAR PROTEOMICS

γ-secretase inhibitors reverse glucocorticoid resistance in T cell acute lymphoblastic leukemia

(2008) Pedro J Real et al.   NATURE MEDICINE

Notch signaling regulates tumor angiogenesis by diverse mechanisms

(2008) J Dufraine et al.   ONCOGENE