Sonic Hedgehog Dependent Phosphorylation by CK1α and GRK2 Is Required for Ciliary Accumulation and Activation of Smoothened

Genetic and biochemical definition of the Hedgehog receptor

(2010) X. Zheng et al.   GENES & DEVELOPMENT

G protein-coupled receptor kinase 2 promotes high-level Hedgehog signaling by regulating the active state of Smo through kinase-dependent and kinase-independent mechanisms in Drosophila

(2010) Y. Chen et al.   GENES & DEVELOPMENT

The primary cilium: a signalling centre during vertebrate development

(2010) Sarah C. Goetz et al.   NATURE REVIEWS GENETICS

Cilium-independent regulation of Gli protein function by Sufu in Hedgehog signaling is evolutionarily conserved

(2009) M.-H. Chen et al.   GENES & DEVELOPMENT

Converse Conformational Control of Smoothened Activity by Structurally Related Small Molecules

(2009) Hongbo Yang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Smoothened Adopts Multiple Active and Inactive Conformations Capable of Trafficking to the Primary Cilium

(2009) Christopher W. Wilson et al.   PLoS One

Small-molecule inhibitors reveal multiple strategies for Hedgehog pathway blockade

(2009) J. M. Hyman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Selective translocation of intracellular Smoothened to the primary cilium in response to Hedgehog pathway modulation

(2009) Yu Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hedgehog signal transduction by Smoothened: Pharmacologic evidence for a 2-step activation process

(2009) R. Rohatgi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pattern formation in the vertebrate neural tube: a sonic hedgehog morphogen-regulated transcriptional network

(2008) E. Dessaud et al.   DEVELOPMENT

Hedgehog Signaling in Development and Cancer

(2008) Jin Jiang et al.   DEVELOPMENTAL CELL

Hedgehog: functions and mechanisms

(2008) M. Varjosalo et al.   GENES & DEVELOPMENT

Smoothened Signaling in Vertebrates Is Facilitated by a G Protein-coupled Receptor Kinase

(2008) Melanie Philipp et al.   MOLECULAR BIOLOGY OF THE CELL

 -Arrestin-Mediated Localization of Smoothened to the Primary Cilium

(2008) J. J. Kovacs et al.   SCIENCE

Kinome siRNA Screen Identifies Regulators of Ciliogenesis and Hedgehog Signal Transduction

(2008) M. Evangelista et al.   Science Signaling