IL-4-dependent Jagged1 expression/processing is associated with survival of chronic lymphocytic leukemia cells but not with Notch activation

Common nonmutationalNOTCH1activation in chronic lymphocytic leukemia

(2017) Giulia Fabbri et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IL-4 rescues surface IgM expression in chronic lymphocytic leukemia

(2016) B. Guo et al.   BLOOD

IL-4 enhances expression and function of surface IgM in CLL cells

(2016) M. M. Aguilar-Hernandez et al.   BLOOD

The PI3K pathway: clinical inhibition in chronic lymphocytic leukemia

(2016) Jennifer R. Brown   SEMINARS IN ONCOLOGY

PI3K/AKT signaling inhibits NOTCH1 lysosome-mediated degradation

(2015) Natalia Platonova et al.   GENES CHROMOSOMES & CANCER

Ligand-Independent Mechanisms of Notch Activity

(2015) William Hunt Palmer et al.   TRENDS IN CELL BIOLOGY

Notch signaling sustains the expression of Mcl-1 and the activity of eIF4E to promote cell survival in CLL

(2015) Filomena De Falco et al.   Oncotarget

Chronic lymphocytic leukemia cells in lymph nodes show frequent NOTCH1 activation

(2015) A. Onaindia et al.   HAEMATOLOGICA

Idelalisib, an inhibitor of phosphatidylinositol 3-kinase p110 , for relapsed/refractory chronic lymphocytic leukemia

(2014) J. R. Brown et al.   BLOOD

Constitutive phosphorylation of the active Notch1 intracellular domain in chronic lymphocytic leukemia cells with NOTCH1 mutation

(2014) F De Falco et al.   LEUKEMIA

The Gene Expression Response of Chronic Lymphocytic Leukemia Cells to IL-4 Is Specific, Depends on ZAP-70 Status and Is Differentially Affected by an NFκB Inhibitor

(2014) Natalia Ruiz-Lafuente et al.   PLoS One

Notch3/Jagged1 Circuitry Reinforces Notch Signaling and Sustains T-ALL

(2014) Maria Pelullo et al.   NEOPLASIA

Jagged-1 juxtamembrane region: Biochemical characterization and cleavage by ADAM17 (TACE) catalytic domain

(2013) Maristella Coglievina et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Endothelial Cells Promote the Colorectal Cancer Stem Cell Phenotype through a Soluble Form of Jagged-1

(2013) Jia Lu et al.   CANCER CELL

Prolyl-isomerase Pin1 controls normal and cancer stem cells of the breast

(2013) Alessandra Rustighi et al.   EMBO Molecular Medicine

A revised NOTCH1 mutation frequency still impacts survival while the allele burden predicts early progression in chronic lymphocytic leukemia

(2013) P Sportoletti et al.   LEUKEMIA

Functional impact of NOTCH1 mutations in chronic lymphocytic leukemia

(2013) F Arruga et al.   LEUKEMIA

Gauging NOTCH1 Activation in Cancer Using Immunohistochemistry

(2013) Michael J. Kluk et al.   PLoS One

Emerging role of kinase-targeted strategies in chronic lymphocytic leukemia

(2012) A. Wiestner   BLOOD

γ-Secretase inhibitor I induces apoptosis in chronic lymphocytic leukemia cells by proteasome inhibition, endoplasmic reticulum stress increase and notch down-regulation

(2012) Emanuela Rosati et al.   INTERNATIONAL JOURNAL OF CANCER

Suppression of tongue squamous cell carcinoma growth by inhibition of Jagged1in vitroandin vivo

(2012) Tong-han Zhang et al.   JOURNAL OF ORAL PATHOLOGY & MEDICINE

Flow cytometric analysis of Notch1 and Jagged1 expression in normal blood cells and leukemia cells

(2012) ERIKO KANAMORI et al.   Experimental and Therapeutic Medicine

Role of stromal cell-mediated Notch signaling in CLL resistance to chemotherapy

(2012) A H Nwabo Kamdje et al.   Blood Cancer Journal

Mutations of NOTCH1 are an independent predictor of survival in chronic lymphocytic leukemia

(2011) D. Rossi et al.   BLOOD

Mechanism and Significance of cis-Inhibition in Notch Signalling

(2011) David del Álamo et al.   CURRENT BIOLOGY

Notch signaling: simplicity in design, versatility in function

(2011) E. R. Andersson et al.   DEVELOPMENT

The intracellular domain of Jagged-1 interacts with Notch1 intracellular domain and promotes its degradation through Fbw7 E3 ligase

(2011) Mi-Yeon Kim et al.   EXPERIMENTAL CELL RESEARCH

Whole-genome sequencing identifies recurrent mutations in chronic lymphocytic leukaemia

(2011) Xose S. Puente et al.   NATURE

Nurture versus Nature: The Microenvironment in Chronic Lymphocytic Leukemia

(2011) J. A. Burger   Hematology-American Society of Hematology Education Program

Ectodomain shedding of the Notch ligand Jagged1 is mediated by ADAM17, but is not a lipid-raft-associated event

(2010) Catherine A. Parr-Sturgess et al.   BIOCHEMICAL JOURNAL

The JAK3-selective inhibitor PF-956980 reverses the resistance to cytotoxic agents induced by interleukin-4 treatment of chronic lymphocytic leukemia cells: potential for reversal of cytoprotection by the microenvironment

(2010) A. J. Steele et al.   BLOOD

Phosphatidylinositol 3-kinase-  inhibitor CAL-101 shows promising preclinical activity in chronic lymphocytic leukemia by antagonizing intrinsic and extrinsic cellular survival signals

(2010) S. E. M. Herman et al.   BLOOD

NOTCH1 PEST domain mutation is an adverse prognostic factor in B-CLL

(2010) Paolo Sportoletti et al.   BRITISH JOURNAL OF HAEMATOLOGY

High Jagged1 Expression Predicts Poor Outcome in Clear Cell Renal Cell Carcinoma

(2010) Kerong Wu et al.   JAPANESE JOURNAL OF CLINICAL ONCOLOGY

The Multiple Facets of Ubiquitination in the Regulation of Notch Signaling Pathway

(2010) Stéphanie Le Bras et al.   TRAFFIC

Diverse marrow stromal cells protect CLL cells from spontaneous and drug-induced apoptosis: development of a reliable and reproducible system to assess stromal cell adhesion-mediated drug resistance

(2009) A. V. Kurtova et al.   BLOOD

A new genetic lesion in B-CLL: aNOTCH1PEST domain mutation

(2009) Mauro Di Ianni et al.   BRITISH JOURNAL OF HAEMATOLOGY

NOTCH2 links protein kinase C delta to the expression of CD23 in chronic lymphocytic leukaemia (CLL) cells

(2009) Rainer Hubmann et al.   BRITISH JOURNAL OF HAEMATOLOGY

The Canonical Notch Signaling Pathway: Unfolding the Activation Mechanism

(2009) Raphael Kopan et al.   CELL

Notch Signaling: The Core Pathway and Its Posttranslational Regulation

(2009) Mark E. Fortini   DEVELOPMENTAL CELL

Distinct Biological Roles for the Notch Ligands Jagged-1 and Jagged-2

(2009) Kuicheon Choi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Jagged1 is the pathological link between Wnt and Notch pathways in colorectal cancer

(2009) V. Rodilla et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Constitutively activated Notch signaling is involved in survival and apoptosis resistance of B-CLL cells

(2008) E. Rosati et al.   BLOOD

Guidelines for the diagnosis and treatment of chronic lymphocytic leukemia: a report from the International Workshop on Chronic Lymphocytic Leukemia updating the National Cancer Institute-Working Group 1996 guidelines

(2008) M. Hallek et al.   BLOOD

ADAM proteases: ligand processing and modulation of the Notch pathway

(2008) A. Zolkiewska   CELLULAR AND MOLECULAR LIFE SCIENCES

The many facets of Notch ligands

(2008) B D'Souza et al.   ONCOGENE