Article
Biochemistry & Molecular Biology
Antonio Tejera-Munoz, Laura Marquez-Exposito, Lucia Tejedor-Santamaria, Sandra Rayego-Mateos, Macarena Orejudo, Beatriz Suarez-Alvarez, Carlos Lopez-Larrea, Marta Ruiz-Ortega, Raul R. Rodrigues-Diez
Summary: CCN2 plays a role in both fibrotic responses and growth factor-induced oxidative and proinflammatory responses. Its coexistence with TGF-β is necessary for persistent fibrotic response, but the mechanisms involved are not fully understood. CCN2 increases T beta RII expression in VSMCs and maintains TGF-β pathway activation through an EGFR-SMAD dependent manner.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Developmental Biology
Sarah S. McCarthy, Michele Karolak, Leif Oxburgh
Summary: Expansion of interstitial cells in adult kidney is a hallmark of chronic disease, while their proliferation during fetal development is necessary for organ formation. Inactivation of TGF beta/Smad response in mouse interstitial cell lineage leads to overproliferation of interstitial cells regionally in the kidney medulla. Smad4 loss primarily reduces TGF beta signaling in the interstitium, while increasing Wnt/beta-catenin signaling.
Article
Cell Biology
Bruna Moretto Rodrigues, Lucas Solla Mathias, Igor de Carvalho Depra, Sarah Santiloni Cury, Miriane de Oliveira, Regiane Marques Castro Olimpio, Maria Teresa De Sibio, Bianca Mariani Goncalves, Celia Regina Nogueira
Summary: This study provides new directions for elucidating the mechanisms of T3 action on osteoblast metabolism, with potential future implications for the treatment of endocrine-related bone pathologies.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Oncology
Fan Feng, Zongqing Zhao, Xuechang Cai, Xueyuan Heng, Ximeng Ma
Summary: This study identifies CKS2 as a critical contributor to the development of gliomas, suggesting that it may serve as a novel therapeutic target for inhibiting the spread and infiltration of glioma.
Article
Medicine, Research & Experimental
Alex Boye
Summary: Early detection of cancer is crucial for cancer management and limited survival. Understanding cancer biology and key factors in cancer progression plays a significant role in cancer treatment.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Fisheries
Bang-ze Li, Chen-yang Lin, Wen-bin Xu, Yan-mei Zhang, Qing-jun Shao, Wei-ren Dong, Miao-an Shu
Summary: This study identified two Smads (Smad1 and Smad2/3) for the first time in the mud crab Scylla paramamosain. It was found that these Smads played a role in the innate immune response and bacterial clearance process.
FISH & SHELLFISH IMMUNOLOGY
(2023)
Article
Orthopedics
Nathalie G. M. Thielen, Arjan P. M. van Caam, Henk M. V. Beuningen, Elly L. Vitters, Martijn H. J. van den Bosch, Marije I. Koenders, Fons A. J. van de Loo, Esmeralda N. Blaney Davidson, Peter M. van der Kraan
Summary: The study aimed to block TGF-beta-induced SMAD1/5/9 signaling in primary human OA chondrocytes while maintaining functional SMAD2/3 signaling. The results demonstrated that using a low dose of SB-505124 inhibited SMAD1/5/9 phosphorylation and the expression of ID1 and ID3, while maintaining SMAD2/3 phosphorylation and the induction of JUNB and SERPINE1. In addition, TGF-beta regulated hypertrophic and dedifferentiation markers in OA chondrocytes, and blocking only the SMAD1/5/9 pathway showed stronger inhibition on TGF-beta-induced RUNX2 compared to blocking both SMAD pathways.
OSTEOARTHRITIS AND CARTILAGE
(2023)
Review
Cell Biology
Lih-Fhung Hiew, Chi-Him Poon, Heng-Ze You, Lee-Wei Lim
Summary: Research on TGF-beta/Smad signaling has shown its significance in neurogenesis and its potential impact on neuropsychiatric disorders. The relationship between TGF-beta/Smad signaling and neurogenesis in response to stressors suggests a role in stress response regulation and behavioral outcomes of mood disorders. Modifications to these signaling pathways have been found to have diverse effects on neurogenesis, highlighting the complexity of the interactions involved.
Article
Pharmacology & Pharmacy
Yuzhan Zhang, Ke Li, Yan Li, Weihao Zhao, Li Wang, Zhao Chen, Xiaotao Ma, Tian Yao, Jinhua Wang, Wei Dong, Xiancheng Li, Xuefei Tian, Rongguo Fu
Summary: This study found increased expression of DPP8 and DPP9 in renal proximal tubule epithelial cells of CKD patients, and using a DPP8/DPP9 inhibitor significantly attenuated tubulointerstitial injury and improved renal function.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Chen-Pang Hou, Ke-Hung Tsui, Syue-Ting Chen, Kang-Shuo Chang, Hsin-Ching Sung, Shu-Yuan Hsu, Yu-Hsiang Lin, Tsui-Hsia Feng, Horng-Heng Juang
Summary: GDF15 is a TGF beta-like cytokine that regulates target gene expression. TGF beta downregulates the expression of GDF15 through the activation of Smad signaling pathways. CAPE acts as an antagonist to block the effect of TGF beta on GDF15 expression.
Article
Oncology
Justin Joseph, Capucine R. Magaut, Simon Storevik, Luiz H. Geraldo, Thomas Mathivet, Md Abdul Latif, Justine Rudewicz, Joris Guyon, Matteo Gambaretti, Frida Haukas, Amalie Trones, Lars A. Romo Ystaas, Jubayer A. Hossain, Sandra Ninzima, Sylvain Cuvellier, Wenjing Zhou, Tushar Tomar, Barbara Klink, Lalit Rane, Bronwyn K. Irving, Joanne Marrison, Peter O'Toole, Heiko Wurdak, Jian Wang, Zhang Di, Even Birkeland, Frode S. Berven, Frank Winkler, Frank A. E. Kruyt, Andreas Bikfalvi, Rolf Bjerkvig, Thomas Daubon, Hrvoje Miletic
Summary: Analysis of TCGA data revealed a high activation of the TGF-beta pathway in GBMs compared to oligodendroglial tumors. Stimulation of GBM cell lines with TGF-beta 1 enhanced MT formation and communication via calcium signaling, while inhibition of the TGF-beta pathway significantly reduced MT formation and invasion. Downstream of TGF-beta, thrombospondin 1 (TSP1) was identified as a potential mediator of MT formation in GBM, which was upregulated upon TGF-beta stimulation and inhibited MT formation when knocked down in vitro and in vivo.
Review
Biochemistry & Molecular Biology
Li Wang, Hong-Lian Wang, Tong-Tong Liu, Hui-Yao Lan
Summary: This review discusses the diverse roles and signaling mechanisms of TGF-beta in diabetic nephropathy, focusing on latent versus active TGF-beta 1, TGF-beta receptors, and downstream Smad signaling molecules. The regulatory mechanisms of TGF-beta/Smad signaling in the development of DN, including Smad-dependent non-coding RNAs, are also dissected. Finally, potential therapeutic strategies for DN targeting TGF-beta signaling with various approaches are discussed.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Tianxiao Sun, Haihua Li, Yan Zhang, Guixin Xiong, Yuerun Liang, Fang Lu, Rong Zheng, Qi Zou, Jiejie Hao
Summary: In this study, it was found that DGM could inhibit TGF-beta 1-induced EMT in A549 cells and bleomycin-induced pulmonary fibrosis in rats. Furthermore, DGM treatment improved lung function, reduced lung inflammation and fibrosis, and decreased collagen deposition.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Senem Aykul, Jordan Maust, Vijayalakshmi Thamilselvan, Monique Floer, Erik Martinez-Hackert
Summary: The study revealed the significant regulatory role of TGF-beta family growth factors and inhibitors in adipocyte development, with SMAD1/5/8 signaling playing a crucial role in 3T3-L1 adipogenesis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Medicine, General & Internal
Piotr K. Zakrzewski
Summary: Endometrial cancer is a major gynecological cancer among women in their menopausal and postmenopausal age, and the canonical TGF beta pathway plays a crucial role in its development and progression. The TGF beta cascade can act as both a tumor suppressor and tumor promoter, with its effects on endometrial cancer cells depending on the cancer disease stage.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Cell Biology
Sarah E. McQuate, Alexandra M. Young, Eugenia Silva-Herzog, Eric Bunker, Mateo Hernandez, Fabrice de Chaumont, Xuedong Liu, Corrella S. Detweiler, Amy E. Palmer
CELLULAR MICROBIOLOGY
(2017)
Article
Biochemical Research Methods
Steven M. Hill, Laura M. Heiser, Thomas Cokelaer, Michael Unger, Nicole K. Nesser, Daniel E. Carlin, Yang Zhang, Artem Sokolov, Evan O. Paull, Chris K. Wong, Kiley Graim, Adrian Bivol, Haizhou Wang, Fan Zhu, Bahman Afsari, Ludmila V. Danilova, Alexander V. Favorov, Wai Shing Lee, Dane Taylor, Chenyue W. Hu, Byron L. Long, David P. Noren, Alexander J. Bisberg, Gordon B. Mills, Joe W. Gray, Michael Kellen, Thea Norman, Stephen Friend, Amina A. Qutub, Elana J. Fertig, Yuanfang Guan, Mingzhou Song, Joshua M. Stuart, Paul T. Spellman, Heinz Koeppl, Gustavo Stolovitzky, Julio Saez-Rodriguez, Sach Mukherjee
Article
Biochemistry & Molecular Biology
Conggang Zhang, Zeyu Liu, Eric Bunker, Adrian Ramirez, Schuyler Lee, Yinghua Peng, Aik-Choon Tan, S. Gail Eckhardt, Douglas A. Chapnick, Xuedong Liu
JOURNAL OF BIOLOGICAL CHEMISTRY
(2017)
Article
Biochemistry & Molecular Biology
Gilson J. Sanchez, Phillip A. Richmond, Eric N. Bunker, Samuel S. Karman, Joseph Azofeifa, Aaron T. Garnett, Quanbin Xu, Graycen E. Wheeler, Cathryn M. Toomey, Qinghong Zhang, Robin D. Dowell, Xuedong Liu
NUCLEIC ACIDS RESEARCH
(2018)
Article
Multidisciplinary Sciences
Yunfeng Li, Kai Jin, Eric Bunker, Xiaojuan Zhang, Xuemei Luo, Xuedong Liu, Bing Hao
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2018)
Article
Biochemical Research Methods
Yuchao Li, Mini Lee, Nury Kim, Guoyu Wu, Difan Deng, Jin Man Kim, Xuedong Liu, Won Do Heo, Zhike Zi
ACS SYNTHETIC BIOLOGY
(2018)
Article
Biochemistry & Molecular Biology
Conggang Zhang, Rongchun Wang, Zeyu Liu, Eric Bunker, Schuyler Lee, Michelle Giuntini, Douglas Chapnick, Xuedong Liu
JOURNAL OF BIOLOGICAL CHEMISTRY
(2019)
Review
Biochemistry & Molecular Biology
Zhike Zi
JOURNAL OF MOLECULAR BIOLOGY
(2019)
Article
Oncology
Marijn T. M. van Jaarsveld, Difan Deng, Diana Ordonez-Rueda, Malte Paulsen, Erik A. C. Wiemer, Zhike Zi
Article
Cell Biology
Xiaojuan Zhang, Quanbin Xu, Zhike Zi, Zeyu Liu, Chun Wan, Lauren Crisman, Jingshi Shen, Xuedong Liu
DEVELOPMENTAL CELL
(2020)
Article
Materials Science, Biomaterials
Yuchao Li, Heeyoung Lee, Won Do Heo, Zhike Zi
Summary: This study used mathematical modeling and synthetic biology approaches to show that plasma membrane-tethered TGF beta receptors can induce fast and sustained Smad2 activation upon light stimulations, suggesting that endocytosis is not required for TGF beta receptor internalization for Smad2 activation.
Article
Biotechnology & Applied Microbiology
Kun Wang, Liangzhen Hou, Xin Wang, Xiangwei Zhai, Zhaolian Lu, Zhike Zi, Weiwei Zhai, Xionglei He, Christina Curtis, Da Zhou, Zheng Hu
Summary: PhyloVelo is a computational framework that accurately estimates the velocity of transcriptomic dynamics by using monotonically expressed genes or genes with specific expression patterns. It integrates scRNA-seq data with lineage information to identify key genes and reconstruct the transcriptomic velocity field. PhyloVelo has been validated using simulated and real datasets, and has shown high accuracy and robustness in inferring complex lineage trajectories.
NATURE BIOTECHNOLOGY
(2023)
Article
Multidisciplinary Sciences
Hongqing Han, Guoyu Wu, Yuchao Li, Zhike Zi
Article
Multidisciplinary Sciences
Marijn T. M. van Jaarsveld, Difan Deng, Erik A. C. Wiemer, Zhike Zi
