Article
Multidisciplinary Sciences
Inas Elsayed, Robert Geraghty, Salwa O. Mekki, Ahmed A. Mohamedani, Susan Ahern, Omer E. H. Salim, Balgis B. M. Khalil, Sawsan Abdelrahim, Suliman H. Suliman, Moawia M. A. Elhassan, Salah O. Salah, Mohamed E. Salih, Abubakr H. Widatalla, Osman S. Abdelhamed, Xiaosheng Wang, Eanna J. Ryan, Des Winter, Salih Bakhiet, Kieran Sheahan
Summary: There is a significant clinical need for molecular pathology services for colorectal cancer in Sudan. In this study, researchers aimed to introduce a molecular genetic service for colorectal cancer in Sudan and explore the molecular features and their relationship to patient survival and clinicopathological characteristics. They found that a subtype of mismatch repair deficient colorectal cancer was present in 16% of cases, and a presumptive diagnosis of Lynch Syndrome was made in 14% of patients. The study also revealed a high mortality rate in Sudanese colorectal cancer patients, which was correlated with advanced disease stage and mismatch repair status.
SCIENTIFIC REPORTS
(2022)
Article
Chemistry, Multidisciplinary
Soon-Chan Kim, Ji Won Park, Ha-Young Seo, Minjung Kim, Jae-Hyeon Park, Ga-Hye Kim, Ja Oh Lee, Young-Kyoung Shin, Jeong Mo Bae, Bon-Kyoung Koo, Seung-Yong Jeong, Ja-Lok Ku
Summary: The study reveals the widespread subregional heterogeneity within single tumors, leading to varied drug responses, emphasizing the importance of understanding the molecular heterogeneity of each tumor and targeting common somatic driver mutations positioned in all tumor subregional clones.
Article
Oncology
Jing Zhang, Xin Zhang, Qian Wang, Yu-yin Xu, Qian-lan Yao, Dan Huang, Wei-qi Sheng, Xiao-li Zhu, Xiao-yan Zhou, Qian-ming Bai
Summary: The study aims to understand the clinicopathological characteristics and molecular alterations in different intratumoral components of colorectal cancer (CRC) with heterogeneity of mismatch repair (MMR) protein expression and microsatellite instability (MSI) status. Important clues for intratumoral heterogeneity of driver gene mutations in CRC were identified, emphasizing the importance of detecting MMR protein expression and other gene mutations in metastases before treatment.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Ahmed Malki, Rasha Abu ElRuz, Ishita Gupta, Asma Allouch, Semir Vranic, Ala-Eddin Al Moustafa
Summary: Colorectal cancer is the second leading cause of cancer-related mortality rates worldwide, with its prevalence still on the rise. Dysregulation of several cellular signaling pathways in CRC leads to malignant phenotypes. Studying signaling pathways helps elucidate the mechanisms of CRC progression and pharmacotherapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Satoshi Fujii, Daisuke Kotani, Masahiro Hattori, Masato Nishihara, Toshihide Shikanai, Junji Hashimoto, Yuki Hama, Takuya Nishino, Mizuto Suzuki, Ayatoshi Yoshidumi, Makoto Ueno, Yoshito Komatsu, Toshiki Masuishi, Hiroki Hara, Taito Esaki, Yoshiaki Nakamura, Hideaki Bando, Tomoyuki Yamada, Takayuki Yoshino
Summary: This study utilized deep learning techniques to extract pathomorphologic features from tissue section images, enabling the accurate prediction of genetic abnormalities in cancer. The results demonstrated high accuracy of this method and its potential for predicting genetic abnormalities without the need for gene tests.
CLINICAL CANCER RESEARCH
(2022)
Article
Oncology
Eun Kyoung Hong, Myriam Chalabi, Federica Landolfi, Francesca Castagnoli, Sae Jin Park, Karolina Sikorska, Arend Aalbers, Jose van den Berg, Monique van Leerdam, Jeong Min Lee, Regina Beets-Tan
Summary: This study assessed and compared the CT imaging features of colon cancer according to MMR status and found differences in tumor size and lymph node status between different MMR statuses. It suggests that considering MMR status in CT-based staging of colon cancer may help in selecting patients for neoadjuvant treatment.
EUROPEAN JOURNAL OF CANCER
(2022)
Review
Medicine, Research & Experimental
David Mas-Ponte, Marcel McCullough, Fran Supek
Summary: Genome sequencing is a powerful tool for detecting DNA repair failures in tumors and understanding their underlying mechanisms. Computational studies have revealed different mutation patterns resulting from failed DNA repair pathways, which can vary across different cancer types and genetic backgrounds. Deficiencies in DNA mismatch repair (MMR) can impact both cancer evolution and treatment outcomes.
Article
Pathology
Huu-Giao Nguyen, Oxana Lundstroem, Annika Blank, Heather Dawson, Alessandro Lugli, Maria Anisimova, Inti Zlobec
Summary: This study investigated the association between CMS classification and mucin-to-tumor area using a deep learning algorithm, and explored the expression of specific mucins in predicting CMS groups and clinical outcomes. The inter-observer agreement between pathologists' scores and the algorithm was excellent. The absence of mucin-expressing tumors in CMS2 provides an important phenotype-genotype correlation, and MUC5AC protein expression correlated with aggressive tumor features.
Article
Oncology
Jill C. Rubinstein, Ali Foroughi Pour, Jie Zhou, Todd B. Sheridan, Brian S. White, Jeffrey H. Chuang
Summary: This study utilizes deep learning to analyze tissue slides of colon cancer patients, aiming to identify and quantify tumor features and heterogeneity. The results show that MSI status can be predicted using H&E stained images with higher accuracy compared to traditional detection methods.
JOURNAL OF SURGICAL ONCOLOGY
(2023)
Article
Multidisciplinary Sciences
Graham S. Erwin, Gamze Gursoy, Rashid Al-Abri, Ashwini Suriyaprakash, Egor Dolzhenko, Kevin Zhu, Christian R. Hoerner, Shannon M. White, Lucia Ramirez, Ananya Vadlakonda, Alekhya Vadlakonda, Konor von Kraut, Julia Park, Charlotte M. Brannon, Daniel A. Sumano, Raushun A. Kirtikar, Alicia A. Erwin, Thomas J. Metzner, Ryan K. C. Yuen, Alice C. Fan, John T. Leppert, Michael A. Eberle, Mark Gerstein, Michael P. Snyder
Summary: In this study, repeat DNA sequence expansions were identified in 2,622 cancer genomes across 29 cancer types. Most of these expansions were specific to certain subtypes of cancer and were found to be distributed non-uniformly in the genome, showing enrichment near potential cis-regulatory elements. One specific expansion, a GAAA-repeat expansion, was detected in 34% of renal cell carcinoma samples and was shown to decrease cell proliferation in a dose-dependent manner when targeted with a GAAA-targeting molecule in preliminary experiments. Overall, this research suggests that repeat DNA sequence expansions may be an important and unexplored source of genetic variation in human cancer, providing a comprehensive catalogue for further study.
Review
Biochemistry & Molecular Biology
Ilio Vitale, Efrat Shema, Sherene Loi, Lorenzo Galluzzi
Summary: Tumors evolve under various pressures and exhibit considerable heterogeneity in genetic, phenotypic, and behavioral aspects. This intratumoral heterogeneity influences disease progression and treatment sensitivity, necessitating consideration of multiple levels of heterogeneity in future therapeutic approaches.
Article
Multidisciplinary Sciences
Xin Hu, Liuxing Wu, Yanxin Yao, Junfu Ma, Xiangchun Li, Hongru Shen, Luyang Liu, Hongji Dai, Wei Wang, Xinlei Chu, Chao Sheng, Meng Yang, Hong Zheng, Fengju Song, Kexin Chen, Ben Liu
Summary: This study comprehensively reveals the regulatory effect of eRNA on tumor immune cell infiltration and outcome in gastric cancer. It proposes eRNA as a potential prognostic index and biomarker in the response of immunotherapy. The different subtypes with distinct eRNA expression patterns show significant differences in survival rate, immune cell infiltration, and immunotherapy response.
Article
Oncology
Romain Cohen, Julien Taieb, Jack Fiskum, Greg Yothers, Richard Goldberg, Takayuki Yoshino, Steven Alberts, Carmen Allegra, Aimery de Gramont, Jean-Francois Seitz, Michael O'Connell, Daniel Haller, Norman Wolmark, Charles Erlichman, Alberto Zaniboni, Sara Lonardi, Rachel Kerr, Axel Grothey, Frank A. Sinicrope, Thierry Andre, Qian Shi
Summary: In patients with stage III colon cancer, the presence of microsatellite instability (MSI) in tumors may lead to improved overall survival and disease-free survival when oxaliplatin is added to fluoropyrimidine (FP) treatment.
JOURNAL OF CLINICAL ONCOLOGY
(2021)
Article
Biochemical Research Methods
Peng Zhang, Mingyue Liu, Ya Cui, Pan Zheng, Yang Liu
Summary: This study found that MSI-H and non-MSI-H samples exhibited clinical response and immune phenotypic differences in different cancer types. However, regardless of cancer types, the abundance of tumor-infiltrating immune cells was more strongly associated with clinical outcomes.
BRIEFINGS IN BIOINFORMATICS
(2021)
Review
Pharmacology & Pharmacy
Ruiqi Wang, Dan Cong, Yuansong Bai, Wenlong Zhang
Summary: Administration of fruquintinib after local radiotherapy demonstrated efficacy in a patient with metastatic colon cancer with high microsatellite instability and the KRAS exon 2 p. G12D mutation. Prior to fruquintinib, the patient received four cycles of pembrolizumab intravenous infusion with stable disease as the best outcome. Subsequent follow-up concurrent radiochemical therapy had little efficacy. However, fruquintinib led to sustained partial remission for 30 months in the patient. This highlights the potential of fruquintinib as a treatment option for specific populations with metastatic colorectal cancer.
FRONTIERS IN PHARMACOLOGY
(2023)