Fundamental Mechanisms of Regulated Cell Death and Implications for Heart Disease

Inflammation and NLRP3 Inflammasome Activation Initiated in Response to Pressure Overload by Ca 2+ /Calmodulin-Dependent Protein Kinase II δ Signaling in Cardiomyocytes Are Essential for Adverse Cardiac Remodeling

(2019) Takeshi Suetomi et al.   CIRCULATION

Midkine drives cardiac inflammation by promoting neutrophil trafficking and NETosis in myocarditis

(2019) Ludwig T. Weckbach et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Ferroptosis as a target for protection against cardiomyopathy

(2019) Xuexian Fang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Small-molecule allosteric inhibitors of BAX

(2019) Thomas P. Garner et al.   Nature Chemical Biology

Novel findings in neutrophil biology and their impact on cardiovascular disease

(2019) Aldo Bonaventura et al.   CARDIOVASCULAR RESEARCH

Cardiovascular toxicities associated with immune checkpoint inhibitors

(2019) Jiun-Ruey Hu et al.   CARDIOVASCULAR RESEARCH

T cell checkpoint regulators in the heart

(2019) Nir Grabie et al.   CARDIOVASCULAR RESEARCH

Ferroptotic cell death and TLR4/Trif signaling initiate neutrophil recruitment after heart transplantation

(2019) Wenjun Li et al.   JOURNAL OF CLINICAL INVESTIGATION

Protective effects of the mechanistic target of rapamycin against excess iron and ferroptosis in cardiomyocytes

(2018) Yuichi Baba et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Embryogenesis and Adult Life in the Absence of Intrinsic Apoptosis Effectors BAX, BAK, and BOK

(2018) Francine F.S. Ke et al.   CELL

The still uncertain identity of the channel-forming unit(s) of the mitochondrial permeability transition pore

(2018) Christopher P. Baines et al.   CELL CALCIUM

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018

(2018) Lorenzo Galluzzi et al.   CELL DEATH AND DIFFERENTIATION

Necroptosis in development and diseases

(2018) Bing Shan et al.   GENES & DEVELOPMENT

Myocarditis in Patients Treated With Immune Checkpoint Inhibitors

(2018) Syed S. Mahmood et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

PD-1 Modulates Radiation-Induced Cardiac Toxicity through Cytotoxic T Lymphocytes

(2018) Shisuo Du et al.   Journal of Thoracic Oncology

Increased reporting of fatal immune checkpoint inhibitor-associated myocarditis

(2018) Javid J Moslehi et al.   LANCET

MLKL Requires the Inositol Phosphate Code to Execute Necroptosis

(2018) Cole M. Dovey et al.   MOLECULAR CELL

Death-domain dimerization-mediated activation of RIPK1 controls necroptosis and RIPK1-dependent apoptosis

(2018) Huyan Meng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

BiallelicRIPK1mutations in humans cause severe immunodeficiency, arthritis, and intestinal inflammation

(2018) Delphine Cuchet-Lourenço et al.   SCIENCE

Cancer immunotherapy using checkpoint blockade

(2018) Antoni Ribas et al.   SCIENCE

A primer on caspase mechanisms

(2018) Monica L. Gonzalez Ramirez et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Apoptotic Caspases: Multiple or Mistaken Identities?

(2018) Kate McArthur et al.   TRENDS IN CELL BIOLOGY

Targeted Imaging for Cell Death in Cardiovascular Disorders

(2018) Aditya Shekhar et al.   JACC-Cardiovascular Imaging

The E3 ubiquitin ligase Pellino2 mediates priming of the NLRP3 inflammasome

(2018) Fiachra Humphries et al.   Nature Communications

Blocking CCL5-CXCL4 heteromerization preserves heart function after myocardial infarction by attenuating leukocyte recruitment and NETosis

(2018) Tanja Vajen et al.   Scientific Reports

Cooperative Domain Formation by Homologous Motifs in HOIL-1L and SHARPIN Plays A Crucial Role in LUBAC Stabilization

(2018) Hiroaki Fujita et al.   Cell Reports

Unsolved mysteries: How does lipid peroxidation cause ferroptosis?

(2018) Huizhong Feng et al.   PLOS BIOLOGY

TBK1 Suppresses RIPK1-Driven Apoptosis and Inflammation during Development and in Aging

(2018) Daichao Xu et al.   CELL

Prediction of acute myeloid leukaemia risk in healthy individuals

(2018) Sagi Abelson et al.   NATURE

New mitochondrial DNA synthesis enables NLRP3 inflammasome activation

(2018) Zhenyu Zhong et al.   NATURE

The hallmarks of successful anticancer immunotherapy

(2018) Lorenzo Galluzzi et al.   Science Translational Medicine

Fundamental Mechanisms of Immune Checkpoint Blockade Therapy

(2018) Spencer C. Wei et al.   Cancer Discovery

Immune Checkpoint Inhibitor Toxicity in 2018

(2018) Douglas B. Johnson et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Cardiovascular toxicities associated with immune checkpoint inhibitors: an observational, retrospective, pharmacovigilance study

(2018) Joe-Elie Salem et al.   LANCET ONCOLOGY

TBK1 and IKKε prevent TNF-induced cell death by RIPK1 phosphorylation

(2018) Elodie Lafont et al.   NATURE CELL BIOLOGY

Linking cellular stress responses to systemic homeostasis

(2018) Lorenzo Galluzzi et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Pathogen blockade of TAK1 triggers caspase-8–dependent cleavage of gasdermin D and cell death

(2018) Pontus Orning et al.   SCIENCE

Why F-ATP Synthase Remains a Strong Candidate as the Mitochondrial Permeability Transition Pore

(2018) Paolo Bernardi   Frontiers in Physiology

SPATA2 regulates the activation of RIPK1 by modulating linear ubiquitination

(2017) Ran Wei et al.   GENES & DEVELOPMENT

MLKL, the Protein that Mediates Necroptosis, Also Regulates Endosomal Trafficking and Extracellular Vesicle Generation

(2017) Seongmin Yoon et al.   IMMUNITY

Thioredoxin-1 actively maintains the pseudokinase MLKL in a reduced state to suppress disulfide bond-dependent MLKL polymer formation and necroptosis

(2017) Eduardo Reynoso et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Kinase-independent functions of RIPK1 regulate hepatocyte survival and liver carcinogenesis

(2017) Trieu-My Van et al.   JOURNAL OF CLINICAL INVESTIGATION

NLRP3 inflammasome assembly is regulated by phosphorylation of the pyrin domain

(2017) Andrea Stutz et al.   JOURNAL OF EXPERIMENTAL MEDICINE

NLRP3 Phosphorylation Is an Essential Priming Event for Inflammasome Activation

(2017) Nan Song et al.   MOLECULAR CELL

MK2 Phosphorylates RIPK1 to Prevent TNF-Induced Cell Death

(2017) Isabel Jaco et al.   MOLECULAR CELL

Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin

(2017) Yupeng Wang et al.   NATURE

p38MAPK/MK2-dependent phosphorylation controls cytotoxic RIPK1 signalling in inflammation and infection

(2017) Manoj B. Menon et al.   NATURE CELL BIOLOGY

MK2 phosphorylation of RIPK1 regulates TNF-mediated cell death

(2017) Yves Dondelinger et al.   NATURE CELL BIOLOGY

ABIN-1 regulates RIPK1 activation by linking Met1 ubiquitylation with Lys63 deubiquitylation in TNF-RSC

(2017) Slawomir A. Dziedzic et al.   NATURE CELL BIOLOGY

PELI1 functions as a dual modulator of necroptosis and apoptosis by regulating ubiquitination of RIPK1 and mRNA levels of c-FLIP

(2017) Huibing Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MLKL forms disulfide bond-dependent amyloid-like polymers to induce necroptosis

(2017) Shuzhen Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Persistence of the mitochondrial permeability transition in the absence of subunit c of human ATP synthase

(2017) Jiuya He et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Permeability transition in human mitochondria persists in the absence of peripheral stalk subunits of ATP synthase

(2017) Jiuya He et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

T cell costimulatory receptor CD28 is a primary target for PD-1–mediated inhibition

(2017) Enfu Hui et al.   SCIENCE

Pyroptosis: Gasdermin-Mediated Programmed Necrotic Cell Death

(2017) Jianjin Shi et al.   TRENDS IN BIOCHEMICAL SCIENCES

Regulation of RIPK1 activation by TAK1-mediated phosphorylation dictates apoptosis and necroptosis

(2017) Jiefei Geng et al.   Nature Communications

Cleavage of DFNA5 by caspase-3 during apoptosis mediates progression to secondary necrotic/pyroptotic cell death

(2017) Corey Rogers et al.   Nature Communications

Die later with ESCRT!

(2017) Wulf Tonnus et al.   Oncotarget

Interferon Receptor Signaling Pathways Regulating PD-L1 and PD-L2 Expression

(2017) Angel Garcia-Diaz et al.   Cell Reports

Phosphatidylserine externalization, “necroptotic bodies” release, and phagocytosis during necroptosis

(2017) Sefi Zargarian et al.   PLOS BIOLOGY

Atomistic simulations indicate the c-subunit ring of the F1Fo ATP synthase is not the mitochondrial permeability transition pore

(2017) Wenchang Zhou et al.   eLife

Autophagic cell death is dependent on lysosomal membrane permeability through Bax and Bak

(2017) Jason Karch et al.   eLife

The Mitochondrial Voltage-Dependent Anion Channel 1, Ca2+ Transport, Apoptosis, and Their Regulation

(2017) Varda Shoshan-Barmatz et al.   Frontiers in Oncology

Necroptosis and Inflammation

(2016) Kim Newton et al.   Annual Review of Biochemistry

Coinhibitory Pathways in Immunotherapy for Cancer

(2016) Susanne H. Baumeister et al.   Annual Review of Immunology

Studies on the role of apoptosis after transient myocardial ischemia: genetic deletion of the executioner caspases-3 and -7 does not limit infarct size and ventricular remodeling

(2016) Javier Inserte et al.   BASIC RESEARCH IN CARDIOLOGY

BOK Is a Non-canonical BCL-2 Family Effector of Apoptosis Regulated by ER-Associated Degradation

(2016) Fabien Llambi et al.   CELL

Inflammasome Complexes: Emerging Mechanisms and Effector Functions

(2016) Vijay A.K. Rathinam et al.   CELL

NF-κB Restricts Inflammasome Activation via Elimination of Damaged Mitochondria

(2016) Zhenyu Zhong et al.   CELL

K45A mutation of RIPK1 results in poor necroptosis and cytokine signaling in macrophages, which impacts inflammatory responses in vivo

(2016) B Shutinoski et al.   CELL DEATH AND DIFFERENTIATION

Exploiting death: apoptotic immunity in microbial pathogenesis

(2016) D S Ucker   CELL DEATH AND DIFFERENTIATION

The long noncoding RNA NRF regulates programmed necrosis and myocardial injury during ischemia and reperfusion by targeting miR-873

(2016) K Wang et al.   CELL DEATH AND DIFFERENTIATION

Mitochondria mediate cell membrane repair and contribute to Duchenne muscular dystrophy

(2016) Maria C Vila et al.   CELL DEATH AND DIFFERENTIATION

RIPK3 deficiency or catalytically inactive RIPK1 provides greater benefit than MLKL deficiency in mouse models of inflammation and tissue injury

(2016) K Newton et al.   CELL DEATH AND DIFFERENTIATION

Mechanisms and consequences of entosis

(2016) Shefali Krishna et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

NF2 Activates Hippo Signaling and Promotes Ischemia/Reperfusion Injury in the HeartNovelty and Significance

(2016) Takahisa Matsuda et al.   CIRCULATION RESEARCH

Residual Myocardial Iron Following Intramyocardial Hemorrhage During the Convalescent Phase of Reperfused ST-Segment–Elevation Myocardial Infarction and Adverse Left Ventricular RemodelingCLINICAL PERSPECTIVE

(2016) Heerajnarain Bulluck et al.   Circulation-Cardiovascular Imaging

SPATA2 promotes CYLD activity and regulates TNF‐induced NF‐κB signaling and cell death

(2016) Lisa Schlicher et al.   EMBO REPORTS

Role of cell death in the progression of heart failure

(2016) Gordon W. Moe et al.   HEART FAILURE REVIEWS

The Pseudokinase MLKL and the Kinase RIPK3 Have Distinct Roles in Autoimmune Disease Caused by Loss of Death-Receptor-Induced Apoptosis

(2016) Silvia Alvarez-Diaz et al.   IMMUNITY

MicroRNA-223-5p and -3p Cooperatively Suppress Necroptosis in Ischemic/Reperfused Hearts

(2016) Dongze Qin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

NLRP3 tyrosine phosphorylation is controlled by protein tyrosine phosphatase PTPN22

(2016) Marianne R. Spalinger et al.   JOURNAL OF CLINICAL INVESTIGATION

Co-operative and Hierarchical Binding of c-FLIP and Caspase-8: A Unified Model Defines How c-FLIP Isoforms Differentially Control Cell Fate

(2016) Michelle A. Hughes et al.   MOLECULAR CELL

Structural Basis and Functional Role of Intramembrane Trimerization of the Fas/CD95 Death Receptor

(2016) Qingshan Fu et al.   MOLECULAR CELL

SPATA2 Links CYLD to LUBAC, Activates CYLD, and Controls LUBAC Signaling

(2016) Paul R. Elliott et al.   MOLECULAR CELL

Pore-forming activity and structural autoinhibition of the gasdermin family

(2016) Jingjin Ding et al.   NATURE

Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores

(2016) Xing Liu et al.   NATURE

RIPK1 counteracts ZBP1-mediated necroptosis to inhibit inflammation

(2016) Juan Lin et al.   NATURE

CaMKII is a RIP3 substrate mediating ischemia- and oxidative stress–induced myocardial necroptosis

(2016) Ting Zhang et al.   NATURE MEDICINE

Necroptosis in development, inflammation and disease

(2016) Ricardo Weinlich et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Fulminant Myocarditis with Combination Immune Checkpoint Blockade

(2016) Douglas B. Johnson et al.   NEW ENGLAND JOURNAL OF MEDICINE

Cardiovascular Toxic Effects of Targeted Cancer Therapies

(2016) Javid J. Moslehi   NEW ENGLAND JOURNAL OF MEDICINE

Peroxidation of polyunsaturated fatty acids by lipoxygenases drives ferroptosis

(2016) Wan Seok Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Critical reappraisal confirms that Mitofusin 2 is an endoplasmic reticulum–mitochondria tether

(2016) Deborah Naon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A nuclease that mediates cell death induced by DNA damage and poly(ADP-ribose) polymerase-1

(2016) Y. Wang et al.   SCIENCE

Hearts deficient in both Mfn1 and Mfn2 are protected against acute myocardial infarction

(2016) A R Hall et al.   Cell Death & Disease

The E3 ubiquitin ligase TRIM31 attenuates NLRP3 inflammasome activation by promoting proteasomal degradation of NLRP3

(2016) Hui Song et al.   Nature Communications

SPATA2-Mediated Binding of CYLD to HOIP Enables CYLD Recruitment to Signaling Complexes

(2016) Sebastian Kupka et al.   Cell Reports

Lysosomal membrane permeabilization in cell death: new evidence and implications for health and disease

(2015) Ana Serrano-Puebla et al.   Annals of the New York Academy of Sciences

Dopamine Controls Systemic Inflammation through Inhibition of NLRP3 Inflammasome

(2015) Yiqing Yan et al.   CELL

Catch me if you can: targeting the mitochondrial permeability transition pore in myocardial infarction

(2015) A Linkermann et al.   CELL DEATH AND DIFFERENTIATION

Gasdermin D is an executor of pyroptosis and required for interleukin-1β secretion

(2015) Wan-ting He et al.   CELL RESEARCH

MicroRNA-103/107 Regulate Programmed Necrosis and Myocardial Ischemia/Reperfusion Injury Through Targeting FADDNovelty and Significance

(2015) Jian-Xun Wang et al.   CIRCULATION RESEARCH

How Do Cytotoxic Lymphocytes Kill Cancer Cells?

(2015) L. Martinez-Lostao et al.   CLINICAL CANCER RESEARCH

Necrostatin-1 alleviates reperfusion injury following acute myocardial infarction in pigs

(2015) Stefan Koudstaal et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

Lipopolysaccharide Primes the NALP3 Inflammasome by Inhibiting Its Ubiquitination and Degradation Mediated by the SCFFBXL2E3 Ligase

(2015) SeungHye Han et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The mitochondrial permeability transition pore and its role in myocardial ischemia reperfusion injury

(2015) Sang-Bing Ong et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

The mitochondrial permeability transition: A current perspective on its identity and role in ischaemia/reperfusion injury

(2015) Andrew P. Halestrap et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

NF-κB-Independent Role of IKKα/IKKβ in Preventing RIPK1 Kinase-Dependent Apoptotic and Necroptotic Cell Death during TNF Signaling

(2015) Yves Dondelinger et al.   MOLECULAR CELL

Glutaminolysis and Transferrin Regulate Ferroptosis

(2015) Minghui Gao et al.   MOLECULAR CELL

Phosphorylation and linear ubiquitin direct A20 inhibition of inflammation

(2015) Ingrid E. Wertz et al.   NATURE

Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling

(2015) Nobuhiko Kayagaki et al.   NATURE

Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death

(2015) Jianjin Shi et al.   NATURE

Anti–PD-1–Related Pneumonitis during Cancer Immunotherapy

(2015) Mizuki Nishino et al.   NEW ENGLAND JOURNAL OF MEDICINE

Cyclosporine before PCI in Patients with Acute Myocardial Infarction

(2015) Thien-Tri Cung et al.   NEW ENGLAND JOURNAL OF MEDICINE

Ferroptosis is Involved in Acetaminophen Induced Cell Death

(2015) Tamás Lőrincz et al.   PATHOLOGY & ONCOLOGY RESEARCH

The Mitochondrial Permeability Transition Pore: Channel Formation by F-ATP Synthase, Integration in Signal Transduction, and Role in Pathophysiology

(2015) Paolo Bernardi et al.   PHYSIOLOGICAL REVIEWS

Plasma Membrane Repair: A Central Process for Maintaining Cellular Homeostasis

(2015) Alisa D. Blazek et al.   PHYSIOLOGY

A cytosolic heat shock protein 90 and cochaperone CDC37 complex is required for RIP3 activation during necroptosis

(2015) Dianrong Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Adaptive Immune Resistance: How Cancer Protects from Immune Attack

(2015) A. Ribas   Cancer Discovery

LUBAC-Recruited CYLD and A20 Regulate Gene Activation and Cell Death by Exerting Opposing Effects on Linear Ubiquitin in Signaling Complexes

(2015) Peter Draber et al.   Cell Reports

RIP3, a kinase promoting necroptotic cell death, mediates adverse remodelling after myocardial infarction

(2014) Mark Luedde et al.   CARDIOVASCULAR RESEARCH

RIPK1 Regulates RIPK3-MLKL-Driven Systemic Inflammation and Emergency Hematopoiesis

(2014) James A. Rickard et al.   CELL

RIPK1 Blocks Early Postnatal Lethality Mediated by Caspase-8 and RIPK3

(2014) Christopher P. Dillon et al.   CELL

Regulation of Ferroptotic Cancer Cell Death by GPX4

(2014) Wan Seok Yang et al.   CELL

Unified Polymerization Mechanism for the Assembly of ASC-Dependent Inflammasomes

(2014) Alvin Lu et al.   CELL

Granzyme B-induced mitochondrial ROS are required for apoptosis

(2014) G Jacquemin et al.   CELL DEATH AND DIFFERENTIATION

Autosis and autophagic cell death: the dark side of autophagy

(2014) Y Liu et al.   CELL DEATH AND DIFFERENTIATION

Genetic deletion of the mitochondrial phosphate carrier desensitizes the mitochondrial permeability transition pore and causes cardiomyopathy

(2014) J Q Kwong et al.   CELL DEATH AND DIFFERENTIATION

Transforming Growth Factor β–Activated Kinase 1 Signaling Pathway Critically Regulates Myocardial Survival and Remodeling

(2014) Lei Li et al.   CIRCULATION

Autophagy as a pro-death pathway

(2014) Donna Denton et al.   IMMUNOLOGY AND CELL BIOLOGY

Cutting Edge: RIPK1 Kinase Inactive Mice Are Viable and Protected from TNF-Induced Necroptosis In Vivo

(2014) Apostolos Polykratis et al.   JOURNAL OF IMMUNOLOGY

FADD and Caspase-8 Mediate Priming and Activation of the Canonical and Noncanonical Nlrp3 Inflammasomes

(2014) P. Gurung et al.   JOURNAL OF IMMUNOLOGY

Genetic manipulation of the cardiac mitochondrial phosphate carrier does not affect permeability transition

(2014) Manuel Gutiérrez-Aguilar et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Ferrostatins Inhibit Oxidative Lipid Damage and Cell Death in Diverse Disease Models

(2014) Rachid Skouta et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

RIP3 Induces Apoptosis Independent of Pronecrotic Kinase Activity

(2014) Pratyusha Mandal et al.   MOLECULAR CELL

Mixed Lineage Kinase Domain-like Protein MLKL Causes Necrotic Membrane Disruption upon Phosphorylation by RIP3

(2014) Huayi Wang et al.   MOLECULAR CELL

Negative regulation of the NLRP3 inflammasome by A20 protects against arthritis

(2014) Lieselotte Vande Walle et al.   NATURE

Inflammatory caspases are innate immune receptors for intracellular LPS

(2014) Jianjin Shi et al.   NATURE

RIPK1 ensures intestinal homeostasis by protecting the epithelium against apoptosis

(2014) Nozomi Takahashi et al.   NATURE

RIPK1 maintains epithelial homeostasis by inhibiting apoptosis and necroptosis

(2014) Marius Dannappel et al.   NATURE

Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice

(2014) Jose Pedro Friedmann Angeli et al.   NATURE CELL BIOLOGY

Regulated necrosis: the expanding network of non-apoptotic cell death pathways

(2014) Tom Vanden Berghe et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Necroptosis

(2014) Andreas Linkermann et al.   NEW ENGLAND JOURNAL OF MEDICINE

Mammalian target of rapamycin coordinates iron metabolism with iron-sulfur cluster assembly enzyme and tristetraprolin

(2014) Peng Guan et al.   NUTRITION

Bnip3 mediates doxorubicin-induced cardiac myocyte necrosis and mortality through changes in mitochondrial signaling

(2014) Rimpy Dhingra et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Activation of the pseudokinase MLKL unleashes the four-helix bundle domain to induce membrane localization and necroptotic cell death

(2014) Joanne M. Hildebrand et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

RIP1 suppresses innate immune necrotic as well as apoptotic cell death during mammalian parturition

(2014) W. J. Kaiser et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hematopoietic RIPK1 deficiency results in bone marrow failure caused by apoptosis and RIPK3-mediated necroptosis

(2014) Justine E. Roderick et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Synchronized renal tubular cell death involves ferroptosis

(2014) Andreas Linkermann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identifying the components of the elusive mitochondrial permeability transition pore

(2014) J. Karch et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An uncoupling channel within the c-subunit ring of the F1FO ATP synthase is the mitochondrial permeability transition pore

(2014) K. N. Alavian et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Activity of Protein Kinase RIPK3 Determines Whether Cells Die by Necroptosis or Apoptosis

(2014) K. Newton et al.   SCIENCE

Caspase-mediated cleavage of phospholipid flippase for apoptotic phosphatidylserine exposure

(2014) K. Segawa et al.   SCIENCE

MLKL Compromises Plasma Membrane Integrity by Binding to Phosphatidylinositol Phosphates

(2014) Yves Dondelinger et al.   Cell Reports

Mitochondrial fatty acid oxidation alterations in heart failure, ischaemic heart disease and diabetic cardiomyopathy

(2013) N Fillmore et al.   BRITISH JOURNAL OF PHARMACOLOGY

Parthanatos: mitochondrial-linked mechanisms and therapeutic opportunities

(2013) Amos A Fatokun et al.   BRITISH JOURNAL OF PHARMACOLOGY

The NLRP3 inflammasome is up-regulated in cardiac fibroblasts and mediates myocardial ischaemia–reperfusion injury

(2013) Øystein Sandanger et al.   CARDIOVASCULAR RESEARCH

The Adaptor MAVS Promotes NLRP3 Mitochondrial Localization and Inflammasome Activation

(2013) Naeha Subramanian et al.   CELL

Mitochondrial Cristae Shape Determines Respiratory Chain Supercomplexes Assembly and Respiratory Efficiency

(2013) Sara Cogliati et al.   CELL

Role of the c subunit of the FOATP synthase in mitochondrial permeability transition

(2013) Massimo Bonora et al.   CELL CYCLE

Translocation of mixed lineage kinase domain-like protein to plasma membrane leads to necrotic cell death

(2013) Xin Chen et al.   CELL RESEARCH

Mlkl knockout mice demonstrate the indispensable role of Mlkl in necroptosis

(2013) Jianfeng Wu et al.   CELL RESEARCH

Activation of NADPH Oxidase 4 in the Endoplasmic Reticulum Promotes Cardiomyocyte Autophagy and Survival During Energy Stress Through the Protein Kinase RNA-Activated-Like Endoplasmic Reticulum Kinase/Eukaryotic Initiation Factor 2α/Activating Transcription Factor 4 Pathway

(2013) Sebastiano Sciarretta et al.   CIRCULATION RESEARCH

Mitochondrial Cardiolipin Is Required for Nlrp3 Inflammasome Activation

(2013) Shankar S. Iyer et al.   IMMUNITY

The Pseudokinase MLKL Mediates Necroptosis via a Molecular Switch Mechanism

(2013) James M. Murphy et al.   IMMUNITY

The Mitochondrial Calcium Uniporter (MCU): Molecular Identity and Physiological Roles

(2013) Maria Patron et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Toll-like Receptor 3-mediated Necrosis via TRIF, RIP3, and MLKL

(2013) William J. Kaiser et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Myocardial ischemia-reperfusion injury: a neglected therapeutic target

(2013) Derek J. Hausenloy et al.   JOURNAL OF CLINICAL INVESTIGATION

Cutting Edge: TLR Signaling Licenses IRAK1 for Rapid Activation of the NLRP3 Inflammasome

(2013) T. Fernandes-Alnemri et al.   JOURNAL OF IMMUNOLOGY

The Mitochondrial Antiviral Protein MAVS Associates with NLRP3 and Regulates Its Inflammasome Activity

(2013) S. Park et al.   JOURNAL OF IMMUNOLOGY

Therapeutic applications of PARP inhibitors: Anticancer therapy and beyond

(2013) Nicola J. Curtin et al.   MOLECULAR ASPECTS OF MEDICINE

Plasma membrane translocation of trimerized MLKL protein is required for TNF-induced necroptosis

(2013) Zhenyu Cai et al.   NATURE CELL BIOLOGY

Mst1 inhibits autophagy by promoting the interaction between Beclin1 and Bcl-2

(2013) Yasuhiro Maejima et al.   NATURE MEDICINE

ADP-ribosyl-acceptor hydrolase 3 regulates poly (ADP-ribose) degradation and cell death during oxidative stress

(2013) M. Mashimo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dimers of mitochondrial ATP synthase form the permeability transition pore

(2013) V. Giorgio et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IRAK-1 bypasses priming and directly links TLRs to rapid NLRP3 inflammasome activation

(2013) K.-M. Lin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Autosis is a Na+,K+-ATPase-regulated form of cell death triggered by autophagy-inducing peptides, starvation, and hypoxia-ischemia

(2013) Y. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PINK1-Phosphorylated Mitofusin 2 Is a Parkin Receptor for Culling Damaged Mitochondria

(2013) Y. Chen et al.   SCIENCE

Xk-Related Protein 8 and CED-8 Promote Phosphatidylserine Exposure in Apoptotic Cells

(2013) J. Suzuki et al.   SCIENCE

PLC , PKD1, and SSH1L Transduce RhoA Signaling to Protect Mitochondria from Oxidative Stress in the Heart

(2013) S. Y. Xiang et al.   Science Signaling

Widespread Mitochondrial Depletion via Mitophagy Does Not Compromise Necroptosis

(2013) Stephen W.G. Tait et al.   Cell Reports

Bax and Bak function as the outer membrane component of the mitochondrial permeability pore in regulating necrotic cell death in mice

(2013) Jason Karch et al.   eLife

Cardiac mTOR protects the heart against ischemia-reperfusion injury

(2012) Toshinori Aoyagi et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Mechanisms of Cell Death in Heart Disease

(2012) Klitos Konstantinidis et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

(2012) Scott J. Dixon et al.   CELL

Mixed Lineage Kinase Domain-like Protein Mediates Necrosis Signaling Downstream of RIP3 Kinase

(2012) Liming Sun et al.   CELL

TRIF Licenses Caspase-11-Dependent NLRP3 Inflammasome Activation by Gram-Negative Bacteria

(2012) Vijay A.K. Rathinam et al.   CELL

Sphingolipid Metabolism Cooperates with BAK and BAX to Promote the Mitochondrial Pathway of Apoptosis

(2012) Jerry E. Chipuk et al.   CELL

The RIP1/RIP3 Necrosome Forms a Functional Amyloid Signaling Complex Required for Programmed Necrosis

(2012) Jixi Li et al.   CELL

DAI/ZBP1/DLM-1 Complexes with RIP3 to Mediate Virus-Induced Programmed Necrosis that Is Targeted by Murine Cytomegalovirus vIRA

(2012) Jason W. Upton et al.   Cell Host & Microbe

Rheb is a Critical Regulator of Autophagy During Myocardial Ischemia

(2012) Sebastiano Sciarretta et al.   CIRCULATION

The Apoptosis Inhibitor ARC Alleviates the ER Stress Response to Promote β-Cell Survival

(2012) Wendy M. McKimpson et al.   DIABETES

The ‘complexities’ of life and death: Death receptor signalling platforms

(2012) Laura S. Dickens et al.   EXPERIMENTAL CELL RESEARCH

Oxidized Mitochondrial DNA Activates the NLRP3 Inflammasome during Apoptosis

(2012) Kenichi Shimada et al.   IMMUNITY

PAMPs and DAMPs: signal 0s that spur autophagy and immunity

(2012) Daolin Tang et al.   IMMUNOLOGICAL REVIEWS

Non-transcriptional Priming and Deubiquitination Regulate NLRP3 Inflammasome Activation

(2012) Christine Juliana et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Management of Immune-Related Adverse Events and Kinetics of Response With Ipilimumab

(2012) Jeffrey S. Weber et al.   JOURNAL OF CLINICAL ONCOLOGY

Programmed cell death 1 forms negative costimulatory microclusters that directly inhibit T cell receptor signaling by recruiting phosphatase SHP2

(2012) Tadashi Yokosuka et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cutting Edge: Nitric Oxide Inhibits the NLRP3 Inflammasome

(2012) E. Hernandez-Cuellar et al.   JOURNAL OF IMMUNOLOGY

PD-1 Protects against Inflammation and Myocyte Damage in T Cell-Mediated Myocarditis

(2012) M. L. Tarrio et al.   JOURNAL OF IMMUNOLOGY

Deubiquitination of NLRP3 by BRCC3 Critically Regulates Inflammasome Activity

(2012) Bénédicte F. Py et al.   MOLECULAR CELL

Cardiac angiogenic imbalance leads to peripartum cardiomyopathy

(2012) Ian S. Patten et al.   NATURE

CaMKII determines mitochondrial stress responses in heart

(2012) Mei-ling A. Joiner et al.   NATURE

Regulation of inflammasome signaling

(2012) Vijay A K Rathinam et al.   NATURE IMMUNOLOGY

Activation of autophagy by inflammatory signals limits IL-1β production by targeting ubiquitinated inflammasomes for destruction

(2012) Chong-Shan Shi et al.   NATURE IMMUNOLOGY

A Tale of Coronary Artery Disease and Myocardial Infarction

(2012) Elizabeth G. Nabel et al.   NEW ENGLAND JOURNAL OF MEDICINE

Bax regulates primary necrosis through mitochondrial dynamics

(2012) R. S. Whelan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mixed lineage kinase domain-like is a key receptor interacting protein 3 downstream component of TNF-induced necrosis

(2012) J. Zhao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Necrostatin-1 analogues: critical issues on the specificity, activity and in vivo use in experimental disease models

(2012) N Takahashi et al.   Cell Death & Disease

Survival Function of the FADD-CASPASE-8-cFLIPL Complex

(2012) Christopher P. Dillon et al.   Cell Reports

Cyclosporin variably and inconsistently reduces infarct size in experimental models of reperfused myocardial infarction: a systematic review and meta-analysis

(2011) WY Lim et al.   BRITISH JOURNAL OF PHARMACOLOGY

Bcl-xL Retrotranslocates Bax from the Mitochondria into the Cytosol

(2011) Frank Edlich et al.   CELL

NEMO and RIP1 Control Cell Fate in Response to Extensive DNA Damage via TNF-α Feedforward Signaling

(2011) Sharon Biton et al.   CELL

Autophagy: Renovation of Cells and Tissues

(2011) Noboru Mizushima et al.   CELL

Regulation of CD95/Fas signaling at the DISC

(2011) I N Lavrik et al.   CELL DEATH AND DIFFERENTIATION

BID regulates AIF-mediated caspase-independent necroptosis by promoting BAX activation

(2011) L Cabon et al.   CELL DEATH AND DIFFERENTIATION

Caspase-2: the orphan caspase

(2011) L Bouchier-Hayes et al.   CELL DEATH AND DIFFERENTIATION

Diastolic and Systolic Heart Failure Are Distinct Phenotypes Within the Heart Failure Spectrum

(2011) Barry A. Borlaug et al.   CIRCULATION

Inflammasome Activation of Cardiac Fibroblasts Is Essential for Myocardial Ischemia/Reperfusion Injury

(2011) Masanori Kawaguchi et al.   CIRCULATION

Programmed Necrosis, Not Apoptosis, in the Heart

(2011) Gloria Kung et al.   CIRCULATION RESEARCH

Mitochondria in Apoptosis: Bcl-2 Family Members and Mitochondrial Dynamics

(2011) Jean-Claude Martinou et al.   DEVELOPMENTAL CELL

Cofilin activation mediates Bax translocation to mitochondria during excitotoxic neuronal death

(2011) Inmaculada Posadas et al.   JOURNAL OF NEUROCHEMISTRY

cIAPs Block Ripoptosome Formation, a RIP1/Caspase-8 Containing Intracellular Cell Death Complex Differentially Regulated by cFLIP Isoforms

(2011) Maria Feoktistova et al.   MOLECULAR CELL

The Ripoptosome, a Signaling Platform that Assembles in Response to Genotoxic Stress and Loss of IAPs

(2011) Tencho Tenev et al.   MOLECULAR CELL

A Unified Model of Mammalian BCL-2 Protein Family Interactions at the Mitochondria

(2011) Fabien Llambi et al.   MOLECULAR CELL

The Soluble Form of Bax Regulates Mitochondrial Fusion via MFN2 Homotypic Complexes

(2011) Suzanne Hoppins et al.   MOLECULAR CELL

RIP3 mediates the embryonic lethality of caspase-8-deficient mice

(2011) William J. Kaiser et al.   NATURE

Catalytic activity of the caspase-8–FLIPL complex inhibits RIPK3-dependent necrosis

(2011) Andrew Oberst et al.   NATURE

Functional complementation between FADD and RIP1 in embryos and lymphocytes

(2011) Haibing Zhang et al.   NATURE

Non-canonical inflammasome activation targets caspase-11

(2011) Nobuhiko Kayagaki et al.   NATURE

Ubiquitylation in apoptosis: a post-translational modification at the edge of life and death

(2011) Domagoj Vucic et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

RIP1-Dependent and Independent Effects of Necrostatin-1 in Necrosis and T Cell Activation

(2011) YoungSik Cho et al.   PLoS One

The inflammasome promotes adverse cardiac remodeling following acute myocardial infarction in the mouse

(2011) E. Mezzaroma et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Autophagy-Dependent Anticancer Immune Responses Induced by Chemotherapeutic Agents in Mice

(2011) M. Michaud et al.   SCIENCE

Poly(ADP-Ribose) (PAR) Binding to Apoptosis-Inducing Factor Is Critical for PAR Polymerase-1-Dependent Cell Death (Parthanatos)

(2011) Y. Wang et al.   Science Signaling

The death-fold superfamily of homotypic interaction motifs

(2011) Kristof Kersse et al.   TRENDS IN BIOCHEMICAL SCIENCES

Endonuclease G does not play an obligatory role in poly(ADP-ribose) polymerase-dependent cell death after transient focal cerebral ischemia

(2010) Zhenfeng Xu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Cell Death in the Pathogenesis of Heart Disease: Mechanisms and Significance

(2010) Russell S. Whelan et al.   Annual Review of Physiology

Membrane Remodeling Induced by the Dynamin-Related Protein Drp1 Stimulates Bax Oligomerization

(2010) Sylvie Montessuit et al.   CELL

Virus Inhibition of RIP3-Dependent Necrosis

(2010) Jason W. Upton et al.   Cell Host & Microbe

Inhibiting Mitochondrial Fission Protects the Heart Against Ischemia/Reperfusion Injury

(2010) Sang-Bing Ong et al.   CIRCULATION

Inducible Dimerization and Inducible Cleavage Reveal a Requirement for Both Processes in Caspase-8 Activation

(2010) Andrew Oberst et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cyclophilin D controls mitochondrial pore–dependent Ca2+ exchange, metabolic flexibility, and propensity for heart failure in mice

(2010) John W. Elrod et al.   JOURNAL OF CLINICAL INVESTIGATION

The RING Domain of TRAF2 Plays an Essential Role in the Inhibition of TNFα-Induced Cell Death but Not in the Activation of NF-κB

(2010) Laiqun Zhang et al.   JOURNAL OF MOLECULAR BIOLOGY

The BCL-2 Family Reunion

(2010) Jerry E. Chipuk et al.   MOLECULAR CELL

BH3-Triggered Structural Reorganization Drives the Activation of Proapoptotic BAX

(2010) Evripidis Gavathiotis et al.   MOLECULAR CELL

Sphingosine-1-phosphate is a missing cofactor for the E3 ubiquitin ligase TRAF2

(2010) Sergio E. Alvarez et al.   NATURE

A role for mitochondria in NLRP3 inflammasome activation

(2010) Rongbin Zhou et al.   NATURE

Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome

(2010) Kiichi Nakahira et al.   NATURE IMMUNOLOGY

TNF receptor 2 pathway: drug target for autoimmune diseases

(2010) Denise Faustman et al.   NATURE REVIEWS DRUG DISCOVERY

The Fas–FADD death domain complex structure reveals the basis of DISC assembly and disease mutations

(2010) Liwei Wang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Population Trends in the Incidence and Outcomes of Acute Myocardial Infarction

(2010) Robert W. Yeh et al.   NEW ENGLAND JOURNAL OF MEDICINE

Dual autonomous mitochondrial cell death pathways are activated by Nix/BNip3L and induce cardiomyopathy

(2010) Y. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

BID, BIM, and PUMA Are Essential for Activation of the BAX- and BAK-Dependent Cell Death Program

(2010) D. Ren et al.   SCIENCE

Dependence Receptors: The Trophic Theory Revisited

(2010) P. Mehlen   Science Signaling

Phosphorylation-Driven Assembly of the RIP1-RIP3 Complex Regulates Programmed Necrosis and Virus-Induced Inflammation

(2009) YoungSik Cho et al.   CELL

Receptor Interacting Protein Kinase-3 Determines Cellular Necrotic Response to TNF-α

(2009) Sudan He et al.   CELL

Role of BNIP3 and NIX in cell death, autophagy and mitophagy

(2009) J Zhang et al.   CELL DEATH AND DIFFERENTIATION

The Cytoprotective Effects of Tumor Necrosis Factor Are Conveyed Through Tumor Necrosis Factor Receptor–Associated Factor 2 in the Heart

(2009) Jana S. Burchfield et al.   Circulation-Heart Failure

DAI/ZBP1 recruits RIP1 and RIP3 through RIP homotypic interaction motifs to activate NF-κB

(2009) Manuele Rebsamen et al.   EMBO REPORTS

Parthanatos, a messenger of death

(2009) Karen Kate David   Frontiers in Bioscience-Landmark

Lysine 63-linked Polyubiquitination of TAK1 at Lysine 158 Is Required for Tumor Necrosis Factor α- and Interleukin-1β-induced IKK/NF-κB and JNK/AP-1 Activation

(2009) Yihui Fan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cardiac macrophage migration inhibitory factor inhibits JNK pathway activation and injury during ischemia/reperfusion

(2009) Dake Qi et al.   JOURNAL OF CLINICAL INVESTIGATION

Cutting Edge: NF- B Activating Pattern Recognition and Cytokine Receptors License NLRP3 Inflammasome Activation by Regulating NLRP3 Expression

(2009) F. G. Bauernfeind et al.   JOURNAL OF IMMUNOLOGY

Stepwise Activation of BAX and BAK by tBID, BIM, and PUMA Initiates Mitochondrial Apoptosis

(2009) Hyungjin Kim et al.   MOLECULAR CELL

The Fas–FADD death domain complex structure unravels signalling by receptor clustering

(2009) Fiona L. Scott et al.   NATURE

Nicotinic Acid, Nicotinamide, and Nicotinamide Riboside: A Molecular Evaluation of NAD+ Precursor Vitamins in Human Nutrition

(2008) Katrina L Bogan et al.   Annual Review of Nutrition

Identification of a Molecular Signaling Network that Regulates a Cellular Necrotic Cell Death Pathway

(2008) Junichi Hitomi et al.   CELL

Innate apoptotic immunity: the calming touch of death

(2008) R B Birge et al.   CELL DEATH AND DIFFERENTIATION

Transcriptional control by PARP-1: chromatin modulation, enhancer-binding, coregulation, and insulation

(2008) W Lee Kraus   CURRENT OPINION IN CELL BIOLOGY

Chemical Inhibition of the Mitochondrial Division Dynamin Reveals Its Role in Bax/Bak-Dependent Mitochondrial Outer Membrane Permeabilization

(2008) Ann Cassidy-Stone et al.   DEVELOPMENTAL CELL

Mitochondria-specific transgenic overexpression of phospholipid hydroperoxide glutathione peroxidase (GPx4) attenuates ischemia/reperfusion-associated cardiac dysfunction

(2008) Erinne R. Dabkowski et al.   FREE RADICAL BIOLOGY AND MEDICINE

Regulation of apoptosis by XIAP ubiquitin-ligase activity

(2008) A. J. Schile et al.   GENES & DEVELOPMENT

c-IAP1 and c-IAP2 Are Critical Mediators of Tumor Necrosis Factor α (TNFα)-induced NF-κB Activation

(2008) Eugene Varfolomeev et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Protection of Cardiomyocytes from Ischemic/Hypoxic Cell Death via Drbp1 and pMe2GlyDH in Cardio-specificARCTransgenic Mice

(2008) Jong-Ok Pyo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Caspase-14 reveals its secrets

(2008) Geertrui Denecker et al.   JOURNAL OF CELL BIOLOGY

A randomized, placebo-controlled trial to evaluate the tolerability, safety, pharmacokinetics, and pharmacodynamics of a potent inhibitor of poly(ADP-ribose) polymerase (INO-1001) in patients with ST-elevation myocardial infarction undergoing primary percutaneous coronary intervention: results of the TIMI 37 trial

(2008) David A. Morrow et al.   JOURNAL OF THROMBOSIS AND THROMBOLYSIS

cIAP1 and cIAP2 Facilitate Cancer Cell Survival by Functioning as E3 Ligases that Promote RIP1 Ubiquitination

(2008) Mathieu J.M. Bertrand et al.   MOLECULAR CELL

Bax- or Bak-Induced Mitochondrial Fission Can Be Uncoupled from Cytochrome c Release

(2008) Clare Sheridan et al.   MOLECULAR CELL

Macrophage migration inhibitory factor stimulates AMP-activated protein kinase in the ischaemic heart

(2008) Edward J. Miller et al.   NATURE

BAX activation is initiated at a novel interaction site

(2008) Evripidis Gavathiotis et al.   NATURE

Mitofusin 2 tethers endoplasmic reticulum to mitochondria

(2008) Olga Martins de Brito et al.   NATURE

Identification of RIP1 kinase as a specific cellular target of necrostatins

(2008) Alexei Degterev et al.   Nature Chemical Biology

Effect of Cyclosporine on Reperfusion Injury in Acute Myocardial Infarction

(2008) Christophe Piot et al.   NEW ENGLAND JOURNAL OF MEDICINE

Mechanisms Underlying Acute Protection From Cardiac Ischemia-Reperfusion Injury

(2008) Elizabeth Murphy et al.   PHYSIOLOGICAL REVIEWS

Autophagy is an adaptive response in desmin-related cardiomyopathy

(2008) P. Tannous et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Osmotic Stress and Viscous Retardation of the Na,K-ATPase Ion Pump

(2007) Mikael Esmann et al.   BIOPHYSICAL JOURNAL