Protective effects of the mechanistic target of rapamycin against excess iron and ferroptosis in cardiomyocytes

Characterization of ferroptosis in murine models of hemochromatosis

(2017) Hao Wang et al.   HEPATOLOGY

Ferroptosis: bug or feature?

(2017) Scott J. Dixon   IMMUNOLOGICAL REVIEWS

Emerging roles for lipids in non-apoptotic cell death

(2016) L Magtanong et al.   CELL DEATH AND DIFFERENTIATION

Ferroptosis is an autophagic cell death process

(2016) Minghui Gao et al.   CELL RESEARCH

Mechanisms of ferroptosis

(2016) Jennifer Yinuo Cao et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Residual Myocardial Iron Following Intramyocardial Hemorrhage During the Convalescent Phase of Reperfused ST-Segment–Elevation Myocardial Infarction and Adverse Left Ventricular RemodelingCLINICAL PERSPECTIVE

(2016) Heerajnarain Bulluck et al.   Circulation-Cardiovascular Imaging

Reduction in mitochondrial iron alleviates cardiac damage during injury

(2016) H.-C. Chang et al.   EMBO Molecular Medicine

Ferroptosis: Death by Lipid Peroxidation

(2016) Wan Seok Yang et al.   TRENDS IN CELL BIOLOGY

Crosstalk between cystine and glutathione is critical for the regulation of amino acid signaling pathways and ferroptosis

(2016) Xinlei Yu et al.   Scientific Reports

Cardiac mTOR rescues the detrimental effects of diet-induced obesity in the heart after ischemia-reperfusion

(2015) Toshinori Aoyagi et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Redox- and non-redox-metal-induced formation of free radicals and their role in human disease

(2015) Marian Valko et al.   ARCHIVES OF TOXICOLOGY

Regulated Necrotic Cell Death: The Passive Aggressive Side of Bax and Bak

(2015) J. Karch et al.   CIRCULATION RESEARCH

Glutaminolysis and Transferrin Regulate Ferroptosis

(2015) Minghui Gao et al.   MOLECULAR CELL

Ferroptosis as a p53-mediated activity during tumour suppression

(2015) Le Jiang et al.   NATURE

Cardiac ferroportin regulates cellular iron homeostasis and is important for cardiac function

(2015) Samira Lakhal-Littleton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of Ferroptotic Cancer Cell Death by GPX4

(2014) Wan Seok Yang et al.   CELL

Ferrostatins Inhibit Oxidative Lipid Damage and Cell Death in Diverse Disease Models

(2014) Rachid Skouta et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Mammalian target of rapamycin coordinates iron metabolism with iron-sulfur cluster assembly enzyme and tristetraprolin

(2014) Peng Guan et al.   NUTRITION

Pharmacological inhibition of cystine–glutamate exchange induces endoplasmic reticulum stress and ferroptosis

(2014) Scott J Dixon et al.   eLife

mTOR complex 2-Akt signaling at mitochondria-associated endoplasmic reticulum membranes (MAM) regulates mitochondrial physiology

(2013) C. Betz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Iron Metabolism, Hepcidin, and Anemia in Orthotopic Heart Transplantation Recipients Treated with Mammalian Target of Rapamycin

(2013) P. Przybylowski et al.   TRANSPLANTATION PROCEEDINGS

ROS‐Mediated PARP Activity Undermines Mitochondrial Function After Permeability Transition Pore Opening During Myocardial Ischemia–Reperfusion

(2013) Jacqueline M. Schriewer et al.   Journal of the American Heart Association

Cardiac mTOR protects the heart against ischemia-reperfusion injury

(2012) Toshinori Aoyagi et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

(2012) Scott J. Dixon et al.   CELL

mTOR Regulates Cellular Iron Homeostasis through Tristetraprolin

(2012) Marina Bayeva et al.   Cell Metabolism

Physiological Roles of the Permeability Transition Pore

(2012) Catherine Brenner et al.   CIRCULATION RESEARCH

Effect of Iron Chelation on Myocardial Infarct Size and Oxidative Stress in ST-Elevation–Myocardial Infarction

(2012) William Chan et al.   Circulation-Cardiovascular Interventions

Iron Overload in Human Disease

(2012) Robert E. Fleming et al.   NEW ENGLAND JOURNAL OF MEDICINE

Non-transferrin bound iron: A key role in iron overload and iron toxicity

(2011) Pierre Brissot et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Phosphoinositide-3 Kinase Signaling in Cardiac Hypertrophy and Heart Failure

(2011) Toshinori Aoyagi et al.   CURRENT PHARMACEUTICAL DESIGN

Cardiac iron and cardiac disease in males and females with transfusion-dependent thalassemia major: a T2* magnetic resonance imaging study

(2011) M. Marsella et al.   HAEMATOLOGICA

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

(2011) Joungmok Kim et al.   NATURE CELL BIOLOGY

Advances in metal-induced oxidative stress and human disease

(2011) Klaudia Jomova et al.   TOXICOLOGY

mTOR attenuates the inflammatory response in cardiomyocytes and prevents cardiac dysfunction in pathological hypertrophy

(2010) Xiaoxiao Song et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Autophagy: assays and artifacts

(2010) Sandra Barth et al.   JOURNAL OF PATHOLOGY

Direct control of mitochondrial function by mTOR

(2009) Arvind Ramanathan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Myocyte injury along myofibers in left ventricular remodeling after myocardial infarction

(2009) Y. Kusakari et al.   Interactive Cardiovascular and Thoracic Surgery

Downregulation of ferritin heavy chain increases labile iron pool, oxidative stress and cell death in cardiomyocytes

(2008) Shigemiki Omiya et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY