Blocking CCL5-CXCL4 heteromerization preserves heart function after myocardial infarction by attenuating leukocyte recruitment and NETosis

Leukocyte diversity in resolving and nonresolving mechanisms of cardiac remodeling

(2017) Bochra Tourki et al.   FASEB JOURNAL

Chemokine interactome mapping enables tailored intervention in acute and chronic inflammation

(2017) Philipp von Hundelshausen et al.   Science Translational Medicine

Cardiac Fibroblast Activation Post-Myocardial Infarction: Current Knowledge Gaps

(2017) Yonggang Ma et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Neutrophils orchestrate post-myocardial infarction healing by polarizing macrophages towards a reparative phenotype

(2016) Michael Horckmans et al.   EUROPEAN HEART JOURNAL

MKEY, a Peptide Inhibitor of CXCL4‐CCL5 Heterodimer Formation, Protects Against Stroke in Mice

(2016) Yifang Fan et al.   Journal of the American Heart Association

Recruitment of classical monocytes can be inhibited by disturbing heteromers of neutrophil HNP1 and platelet CCL5

(2015) Jean-Eric Alard et al.   Science Translational Medicine

Minimal Invasive Surgical Procedure of Inducing Myocardial Infarction in Mice

(2015) Adelina Curaj et al.   Jove-Journal of Visualized Experiments

ESC Working Group Cellular Biology of the Heart: Position Paper: improving the preclinical assessment of novel cardioprotective therapies

(2014) S. Lecour et al.   CARDIOVASCULAR RESEARCH

Embryonic and Adult-Derived Resident Cardiac Macrophages Are Maintained through Distinct Mechanisms at Steady State and during Inflammation

(2014) Slava Epelman et al.   IMMUNITY

Controlled intramyocardial release of engineered chemokines by biodegradable hydrogels as a treatment approach of myocardial infarction

(2014) Delia Projahn et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Inflammatory role and prognostic value of platelet chemokines in acute coronary syndrome

(2014) Johanna Brandt et al.   THROMBOSIS AND HAEMOSTASIS

CCR5 Inhibition Prevents Cardiac Dysfunction in the SIV/Macaque Model of HIV

(2014) Kathleen M. Kelly et al.   Journal of the American Heart Association

Peptide Inhibitor of CXCL4–CCL5 Heterodimer Formation, MKEY, Inhibits Experimental Aortic Aneurysm Initiation and Progression

(2013) Yasunori Iida et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

VWF-mediated leukocyte recruitment with chromatin decondensation by PAD4 increases myocardial ischemia/reperfusion injury in mice

(2013) A. S. Savchenko et al.   BLOOD

Synchronized integrin engagement and chemokine activation is crucial in neutrophil extracellular trap-mediated sterile inflammation

(2013) J. Rossaint et al.   BLOOD

Platelet factor 4 mediates vascular smooth muscle cell injury responses

(2013) G. Shi et al.   BLOOD

Distinct functions of chemokine receptor axes in the atherogenic mobilization and recruitment of classical monocytes

(2013) Oliver Soehnlein et al.   EMBO Molecular Medicine

Leukocyte Behavior in Atherosclerosis, Myocardial Infarction, and Heart Failure

(2013) F. K. Swirski et al.   SCIENCE

Platelet chemokines in health and disease

(2013) Ela Karshovska et al.   THROMBOSIS AND HAEMOSTASIS

Exchange of extracellular domains of CCR1 and CCR5 reveals confined functions in CCL5-mediated cell recruitment

(2013) Birgit K. Kramp et al.   THROMBOSIS AND HAEMOSTASIS

Disruption of Platelet-derived Chemokine Heteromers Prevents Neutrophil Extravasation in Acute Lung Injury

(2012) Jochen Grommes et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Differential roles of angiogenic chemokines in endothelial progenitor cell-induced angiogenesis

(2012) Isabella Kanzler et al.   BASIC RESEARCH IN CARDIOLOGY

Anti-Inflammatory Therapeutic Approaches to Reduce Acute Atherosclerotic Complications

(2011) Isabella Kanzler et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Chemokines: established and novel targets in atherosclerosis

(2011) Rory R. Koenen et al.   EMBO Molecular Medicine

CC chemokine CCL5 plays a central role impacting infarct size and post-infarction heart failure in mice

(2011) Fabrizio Montecucco et al.   EUROPEAN HEART JOURNAL

Repair After Myocardial Infarction, Between Fantasy and Reality

(2011) Elisa A. Liehn et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

CCR5 Signaling Suppresses Inflammation and Reduces Adverse Remodeling of the Infarcted Heart, Mediating Recruitment of Regulatory T Cells

(2010) Marcin Dobaczewski et al.   AMERICAN JOURNAL OF PATHOLOGY

A New Monocyte Chemotactic Protein-1/Chemokine CC Motif Ligand-2 Competitor Limiting Neointima Formation and Myocardial Ischemia/Reperfusion Injury in Mice

(2010) Elisa A. Liehn et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Therapeutic targeting of chemokine interactions in atherosclerosis

(2010) Rory R. Koenen et al.   NATURE REVIEWS DRUG DISCOVERY

Neutrophil Extracellular Traps: How to Generate and Visualize Them

(2010) Volker Brinkmann et al.   Jove-Journal of Visualized Experiments

Core2 1-6-N-Glucosaminyltransferase-I Deficiency Protects Injured Arteries From Neointima Formation in ApoE-Deficient Mice

(2009) Huan Wang et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Chemokine CCL5/RANTES inhibition reduces myocardial reperfusion injury in atherosclerotic mice

(2009) Vincent Braunersreuther et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Disrupting functional interactions between platelet chemokines inhibits atherosclerosis in hyperlipidemic mice

(2009) Rory R Koenen et al.   NATURE MEDICINE

A Novel RANTES Antagonist Prevents Progression of Established Atherosclerotic Lesions in Mice

(2008) Vincent Braunersreuther et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Ccr1 deficiency reduces inflammatory remodelling and preserves left ventricular function after myocardial infarction

(2008) E. A. Liehn et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Chemokine receptor antagonists: overcoming developmental hurdles

(2008) Richard Horuk   NATURE REVIEWS DRUG DISCOVERY

RANTES is required for ischaemia-induced angiogenesis, which may hamper RANTES-targeted anti-atherosclerotic therapy

(2008) Peter Westerweel et al.   THROMBOSIS AND HAEMOSTASIS