Ubiquitylation in apoptosis: a post-translational modification at the edge of life and death

Deletion of cIAP1 and cIAP2 in murine B lymphocytes constitutively activates cell survival pathways and inactivates the germinal center response

(2011) S. Gardam et al.   BLOOD

The Mechanism of Linkage-Specific Ubiquitin Chain Elongation by a Single-Subunit E2

(2011) Katherine E. Wickliffe et al.   CELL

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

(Un)expected roles of c-IAPs in apoptotic and NFκB signaling pathways

(2011) Eugene Varfolomeev et al.   CELL CYCLE

Antiapoptotic Drugs: A Therapautic Strategy for the Prevention of Neurodegenerative Diseases

(2011) Francesc X. Sureda et al.   CURRENT PHARMACEUTICAL DESIGN

SHARPIN is a component of the NF-κB-activating linear ubiquitin chain assembly complex

(2011) Fuminori Tokunaga et al.   NATURE

SHARPIN forms a linear ubiquitin ligase complex regulating NF-κB activity and apoptosis

(2011) Fumiyo Ikeda et al.   NATURE

Linear ubiquitination prevents inflammation and regulates immune signalling

(2011) Björn Gerlach et al.   NATURE

SCFFBW7 regulates cellular apoptosis by targeting MCL1 for ubiquitylation and destruction

(2011) Hiroyuki Inuzuka et al.   NATURE

Sensitivity to antitubulin chemotherapeutics is regulated by MCL1 and FBW7

(2011) Ingrid E. Wertz et al.   NATURE

The p53 Pathway as a Target in Cancer Therapeutics: Obstacles and Promise

(2011) A. Mandinova et al.   Science Translational Medicine

Expression, biological activities and mechanisms of action of A20 (TNFAIP3)

(2010) Lynn Verstrepen et al.   BIOCHEMICAL PHARMACOLOGY

Making sense of ubiquitin ligases that regulate p53

(2010) Abhinav K. Jain et al.   CANCER BIOLOGY & THERAPY

Ubiquitin becomes ubiquitous in cancer

(2010) Dingding Shi et al.   CANCER BIOLOGY & THERAPY

Phosphorylation by Casein Kinase I Promotes the Turnover of the Mdm2 Oncoprotein via the SCFβ-TRCP Ubiquitin Ligase

(2010) Hiroyuki Inuzuka et al.   CANCER CELL

What Determines the Specificity and Outcomes of Ubiquitin Signaling?

(2010) Fumiyo Ikeda et al.   CELL

cIAP1 and TAK1 protect cells from TNF-induced necrosis by preventing RIP1/RIP3-dependent reactive oxygen species production

(2010) N Vanlangenakker et al.   CELL DEATH AND DIFFERENTIATION

A novel F-box protein is required for caspase activation during cellular remodeling in Drosophila

(2010) M. Bader et al.   DEVELOPMENT

c-IAP1 and UbcH5 promote K11-linked polyubiquitination of RIP1 in TNF signalling

(2010) Jasmin N Dynek et al.   EMBO JOURNAL

Phosphorylation of Mcl-1 by CDK1–cyclin B1 initiates its Cdc20-dependent destruction during mitotic arrest

(2010) Margaret E Harley et al.   EMBO JOURNAL

The Notch signaling pathway: Molecular basis of cell context dependency

(2010) Ralf Schwanbeck et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Ubiquitin Makes Its Mark on Immune Regulation

(2010) Barbara A. Malynn et al.   IMMUNITY

DrosophilaIAP antagonists form multimeric complexes to promote cell death

(2010) Cristinel Sandu et al.   JOURNAL OF CELL BIOLOGY

p53 at a glance

(2010) C. A. Brady et al.   JOURNAL OF CELL SCIENCE

Enterocyte-specific A20 deficiency sensitizes to tumor necrosis factor–induced toxicity and experimental colitis

(2010) Lars Vereecke et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Ubiquitin Binding to A20 ZnF4 Is Required for Modulation of NF-κB Signaling

(2010) Ivan Bosanac et al.   MOLECULAR CELL

Systematic In Vivo RNAi Analysis Identifies IAPs as NEDD8-E3 Ligases

(2010) Meike Broemer et al.   MOLECULAR CELL

Catalysis of Lysine 48-Specific Ubiquitin Chain Assembly by Residues in E2 and Ubiquitin

(2010) Monica C. Rodrigo-Brenni et al.   MOLECULAR CELL

ARTS and Siah Collaborate in a Pathway for XIAP Degradation

(2010) Jason B. Garrison et al.   MOLECULAR CELL

Enhancement of proteasome activity by a small-molecule inhibitor of USP14

(2010) Byung-Hoon Lee et al.   NATURE

Fbw7 controls neural stem cell differentiation and progenitor apoptosis via Notch and c-Jun

(2010) Joerg D Hoeck et al.   NATURE NEUROSCIENCE

Translating p53 into the clinic

(2010) Chit Fang Cheok et al.   Nature Reviews Clinical Oncology

Molecular mechanisms of necroptosis: an ordered cellular explosion

(2010) Peter Vandenabeele et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The ubiquitous nature of cancer: the role of the SCFFbw7 complex in development and transformation

(2010) K M Crusio et al.   ONCOGENE

The p53 orchestra: Mdm2 and Mdmx set the tone

(2010) Mark Wade et al.   TRENDS IN CELL BIOLOGY

Reactivation of p53: from peptides to small molecules

(2010) Christopher J. Brown et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Non-Canonical NF-κB Activation and Abnormal B Cell Accumulation in Mice Expressing Ubiquitin Protein Ligase-Inactive c-IAP2

(2010) Dietrich B. Conze et al.   PLOS BIOLOGY

RING Domain E3 Ubiquitin Ligases

(2009) Raymond J. Deshaies et al.   Annual Review of Biochemistry

Can’t live without them, can live with them: roles of caspases during vital cellular processes

(2009) Yael Feinstein-Rotkopf et al.   APOPTOSIS

SnapShot: F Box Proteins II

(2009) Jeffrey R. Skaar et al.   CELL

RIP Kinases at the Crossroads of Cell Death and Survival

(2009) Wim Declercq et al.   CELL

The Secret Life of Smad4

(2009) Jeffrey L. Wrana   CELL

Cullin3-Based Polyubiquitination and p62-Dependent Aggregation of Caspase-8 Mediate Extrinsic Apoptosis Signaling

(2009) Zhaoyu Jin et al.   CELL

Blinded by the Light: The Growing Complexity of p53

(2009) Karen H. Vousden et al.   CELL

Regulation of death receptor signaling by the ubiquitin system

(2009) I E Wertz et al.   CELL DEATH AND DIFFERENTIATION

Mdm2-mediated ubiquitylation: p53 and beyond

(2009) J-C Marine et al.   CELL DEATH AND DIFFERENTIATION

Therapeutic strategies within the ubiquitin proteasome system

(2009) A G Eldridge et al.   CELL DEATH AND DIFFERENTIATION

CYLD: a tumor suppressor deubiquitinase regulating NF-κB activation and diverse biological processes

(2009) S-C Sun   CELL DEATH AND DIFFERENTIATION

The multiple levels of regulation by p53 ubiquitination

(2009) J T Lee et al.   CELL DEATH AND DIFFERENTIATION

Life and death by death receptors

(2009) Maria Eugenia Guicciardi et al.   FASEB JOURNAL

Targeting inhibitor of apoptosis proteins for therapeutic intervention

(2009) Chudi Ndubaku et al.   Future Medicinal Chemistry

The Many Roles of FAS Receptor Signaling in the Immune System

(2009) Andreas Strasser et al.   IMMUNITY

The E3 Ubiquitin Ligase cIAP1 Binds and Ubiquitinates Caspase-3 and -7 via Unique Mechanisms at Distinct Steps in Their Processing

(2009) Young Eun Choi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Temporal regulation ofDrosophilaIAP1 determines caspase functions in sensory organ development

(2009) Akiko Koto et al.   JOURNAL OF CELL BIOLOGY

USP7 counteracts SCFβTrCP- but not APCCdh1-mediated proteolysis of Claspin

(2009) Helene Faustrup et al.   JOURNAL OF CELL BIOLOGY

A20 takes on tumors: tumor suppression by an ubiquitin-editing enzyme

(2009) Barbara A. Malynn et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A20 Negatively Regulates T Cell Receptor Signaling to NF- B by Cleaving Malt1 Ubiquitin Chains

(2009) M. Duwel et al.   JOURNAL OF IMMUNOLOGY

USP9X Enhances the Polarity and Self-Renewal of Embryonic Stem Cell-derived Neural Progenitors

(2009) Lachlan A. Jolly et al.   MOLECULAR BIOLOGY OF THE CELL

Small-molecule inhibitor of USP7/HAUSP ubiquitin protease stabilizes and activates p53 in cells

(2009) F. Colland et al.   MOLECULAR CANCER THERAPEUTICS

A Ubiquitin Replacement Strategy in Human Cells Reveals Distinct Mechanisms of IKK Activation by TNFα and IL-1β

(2009) Ming Xu et al.   MOLECULAR CELL

βTrCP- and Rsk1/2-Mediated Degradation of BimEL Inhibits Apoptosis

(2009) Elinor Dehan et al.   MOLECULAR CELL

Ubiquitin-like Sequence in ASK1 Plays Critical Roles in the Recognition and Stabilization by USP9X and Oxidative Stress-Induced Cell Death

(2009) Hiroaki Nagai et al.   MOLECULAR CELL

Recruitment of the Linear Ubiquitin Chain Assembly Complex Stabilizes the TNF-R1 Signaling Complex and Is Required for TNF-Mediated Gene Induction

(2009) Tobias L. Haas et al.   MOLECULAR CELL

Ribosomal Protein S7 Is Both a Regulator and a Substrate of MDM2

(2009) Yan Zhu et al.   MOLECULAR CELL

Deubiquitinase USP9X stabilizes MCL1 and promotes tumour cell survival

(2009) Martin Schwickart et al.   NATURE

Involvement of linear polyubiquitylation of NEMO in NF-κB activation

(2009) Fuminori Tokunaga et al.   NATURE CELL BIOLOGY

Denosumab for Prevention of Fractures in Postmenopausal Women with Osteoporosis

(2009) Steven R. Cummings et al.   NEW ENGLAND JOURNAL OF MEDICINE

Inactivation of HAUSP in vivo modulates p53 function

(2009) N Kon et al.   ONCOGENE

Phosphorylation of p53 by IκB kinase 2 promotes its degradation by β-TrCP

(2009) Yifeng Xia et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Restoring p53 Function in Cancer: Novel Therapeutic Approaches for Applying the Brakes to Tumorigenesis

(2009) Alessandra Cintio et al.   Recent Patents on Anti-Cancer Drug Discovery

The ubiquitin-editing enzyme A20 (TNFAIP3) is a central regulator of immunopathology

(2009) Lars Vereecke et al.   TRENDS IN IMMUNOLOGY

Signaling to NF- B: Regulation by Ubiquitination

(2009) I. E. Wertz et al.   Cold Spring Harbor Perspectives in Biology

Tumor Suppressive Functions of p53

(2009) J. T. Zilfou et al.   Cold Spring Harbor Perspectives in Biology

The ubiquitin system, disease, and drug discovery

(2008) Matthew D Petroski   BMC BIOCHEMISTRY

The role of NF-κB in lymphoid malignancies

(2008) Graham Packham   BRITISH JOURNAL OF HAEMATOLOGY

Microphthalmia-Associated Transcription Factor Is a Critical Transcriptional Regulator of Melanoma Inhibitor of Apoptosis in Melanomas

(2008) J. N. Dynek et al.   CANCER RESEARCH

ABT-263: A Potent and Orally Bioavailable Bcl-2 Family Inhibitor

(2008) C. Tse et al.   CANCER RESEARCH

MDM2 Regulates Dihydrofolate Reductase Activity through Monoubiquitination

(2008) M. Maguire et al.   CANCER RESEARCH

TNF-α Induces Two Distinct Caspase-8 Activation Pathways

(2008) Lai Wang et al.   CELL

Regulation of apoptosis in Drosophila

(2008) H Steller   CELL DEATH AND DIFFERENTIATION

The IκB kinase – a bridge between inflammation and cancer

(2008) Michael Karin   CELL RESEARCH

Transgenic rescue of ataxia mice reveals a male-specific sterility defect

(2008) Stephen Crimmins et al.   DEVELOPMENTAL BIOLOGY

Mechanisms of proteasome inhibitor action and resistance in cancer

(2008) David J. McConkey et al.   DRUG RESISTANCE UPDATES

Atypical ubiquitin chains: new molecular signals. ‘Protein Modifications: Beyond the Usual Suspects’ Review Series

(2008) Fumiyo Ikeda et al.   EMBO REPORTS

Regulation of apoptosis by XIAP ubiquitin-ligase activity

(2008) A. J. Schile et al.   GENES & DEVELOPMENT

c-IAP1 and c-IAP2 Are Critical Mediators of Tumor Necrosis Factor α (TNFα)-induced NF-κB Activation

(2008) Eugene Varfolomeev et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ERK and the F-box Protein βTRCP Target STAT1 for Degradation

(2008) Surinder M. Soond et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TWEAK-FN14 signaling induces lysosomal degradation of a cIAP1–TRAF2 complex to sensitize tumor cells to TNFα

(2008) James E. Vince et al.   JOURNAL OF CELL BIOLOGY

cIAP1 and cIAP2 Facilitate Cancer Cell Survival by Functioning as E3 Ligases that Promote RIP1 Ubiquitination

(2008) Mathieu J.M. Bertrand et al.   MOLECULAR CELL

Inactivation of Effector Caspases through Nondegradative Polyubiquitylation

(2008) Mark Ditzel et al.   MOLECULAR CELL

X-linked and cellular IAPs modulate the stability of C-RAF kinase and cell motility

(2008) Taner Dogan et al.   NATURE CELL BIOLOGY

Control of HIPK2 stability by ubiquitin ligase Siah-1 and checkpoint kinases ATM and ATR

(2008) Melanie Winter et al.   NATURE CELL BIOLOGY

Nonredundant and complementary functions of TRAF2 and TRAF3 in a ubiquitination cascade that activates NIK-dependent alternative NF-κB signaling

(2008) Sivakumar Vallabhapurapu et al.   NATURE IMMUNOLOGY

Noncanonical NF-κB activation requires coordinated assembly of a regulatory complex of the adaptors cIAP1, cIAP2, TRAF2 and TRAF3 and the kinase NIK

(2008) Brian J Zarnegar et al.   NATURE IMMUNOLOGY

T cell antigen receptor stimulation induces MALT1 paracaspase–mediated cleavage of the NF-κB inhibitor A20

(2008) Beatrice Coornaert et al.   NATURE IMMUNOLOGY

Is NF-κB a good target for cancer therapy? Hopes and pitfalls

(2008) Véronique Baud et al.   NATURE REVIEWS DRUG DISCOVERY

Targeting steroid hormone receptors for ubiquitination and degradation in breast and prostate cancer

(2008) A Rodriguez-Gonzalez et al.   ONCOGENE

Both cIAP1 and cIAP2 regulate TNF -mediated NF- B activation

(2008) D. J. Mahoney et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Essential Cytoplasmic Translocation of a Cytokine Receptor-Assembled Signaling Complex

(2008) A. Matsuzawa et al.   SCIENCE

The BCL-2 protein family: opposing activities that mediate cell death

(2007) Richard J. Youle et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY