MicroRNA-223-5p and -3p Cooperatively Suppress Necroptosis in Ischemic/Reperfused Hearts

Overexpression of miR-223 Tips the Balance of Pro- and Anti-hypertrophic Signaling Cascades toward Physiologic Cardiac Hypertrophy

(2016) Liwang Yang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CaMKII is a RIP3 substrate mediating ischemia- and oxidative stress–induced myocardial necroptosis

(2016) Ting Zhang et al.   NATURE MEDICINE

Regulated necrosis: disease relevance and therapeutic opportunities

(2016) Marcus Conrad et al.   NATURE REVIEWS DRUG DISCOVERY

MiRNA-Mediated Macrophage Polarization and its Potential Role in the Regulation of Inflammatory Response

(2016) Kobina Essandoh et al.   SHOCK

MicroRNA-103/107 Regulate Programmed Necrosis and Myocardial Ischemia/Reperfusion Injury Through Targeting FADDNovelty and Significance

(2015) Jian-Xun Wang et al.   CIRCULATION RESEARCH

Necrostatin-1 alleviates reperfusion injury following acute myocardial infarction in pigs

(2015) Stefan Koudstaal et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

Pharmacologic Inhibition of the NLRP3 Inflammasome Preserves Cardiac Function After Ischemic and Nonischemic Injury in the Mouse

(2015) Carlo Marchetti et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Necroptosis and its role in inflammation

(2015) Manolis Pasparakis et al.   NATURE

The diverse role of RIP kinases in necroptosis and inflammation

(2015) John Silke et al.   NATURE IMMUNOLOGY

Diverse Activators of the NLRP3 Inflammasome Promote IL-1β Secretion by Triggering Necrosis

(2015) Sean P. Cullen et al.   Cell Reports

miR-223: An inflammatory oncomiR enters the cardiovascular field

(2014) Fatiha Taïbi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Loss of duplexmiR-223 (5p and 3p) aggravates myocardial depression and mortality in polymicrobial sepsis

(2014) Xiaohong Wang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

RIPK1 Regulates RIPK3-MLKL-Driven Systemic Inflammation and Emergency Hematopoiesis

(2014) James A. Rickard et al.   CELL

E2F1-regulated miR-30b suppresses Cyclophilin D and protects heart from ischemia/reperfusion injury and necrotic cell death

(2014) K Wang et al.   CELL DEATH AND DIFFERENTIATION

Mixed Lineage Kinase Domain-like Protein MLKL Causes Necrotic Membrane Disruption upon Phosphorylation by RIP3

(2014) Huayi Wang et al.   MOLECULAR CELL

Necrostatin-1 inhibits Hmgb1-IL-23/IL-17 pathway and attenuates cardiac ischemia reperfusion injury

(2014) Anbin Zhang et al.   TRANSPLANT INTERNATIONAL

Ischemia/reperfusion activates myocardial innate immune response: the key role of the toll-like receptor

(2014) Gemma Vilahur et al.   Frontiers in Physiology

Study of Cardioprotective Effects of Necroptosis Inhibitors on Isolated Rat Heart Subjected to Global Ischemia–Reperfusion

(2013) Yu. V. Dmitriev et al.   BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE

Inhibition of MicroRNA-92a Protects Against Ischemia/Reperfusion Injury in a Large-Animal Model

(2013) Rabea Hinkel et al.   CIRCULATION

Myocardial reperfusion injury: looking beyond primary PCI

(2013) Georg M. Fröhlich et al.   EUROPEAN HEART JOURNAL

Agonist antibody activates death receptor 6 downstream signaling involving TRADD recruitment

(2013) Rui Hu et al.   FEBS LETTERS

Combination of necroptosis and apoptosis inhibition enhances cardioprotection against myocardial ischemia–reperfusion injury

(2013) Shizuka Koshinuma et al.   Journal of Anesthesia

Reperfusion therapy for STEMI: is there still a role for thrombolysis in the era of primary percutaneous coronary intervention?

(2013) Anthony H Gershlick et al.   LANCET

Two independent pathways of regulated necrosis mediate ischemia-reperfusion injury

(2013) A. Linkermann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanisms of Cell Death in Heart Disease

(2012) Klitos Konstantinidis et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Inhibition of RIP1-dependent necrosis prevents adverse cardiac remodeling after myocardial ischemia–reperfusion in vivo

(2012) Martinus I. F. J. Oerlemans et al.   BASIC RESEARCH IN CARDIOLOGY

Targeting cell death in the reperfused heart: Pharmacological approaches for cardioprotection

(2012) Martinus I.F.J. Oerlemans et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

NLRP3 Inflammasome Activity Is Negatively Controlled by miR-223

(2012) F. Bauernfeind et al.   JOURNAL OF IMMUNOLOGY

Necrostatin-1 analogues: critical issues on the specificity, activity and in vivo use in experimental disease models

(2012) N Takahashi et al.   Cell Death & Disease

Role of microRNAs in the reperfused myocardium towards post-infarct remodelling

(2011) H. Zhu et al.   CARDIOVASCULAR RESEARCH

In Vivo Cardioprotection by Pitavastatin From Ischemic-reperfusion Injury Through Suppression of IKK/NF-κB and Upregulation of pAkt–e-NOS

(2011) Salma Malik et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Downregulation of microRNA-29 by antisense inhibitors and a PPAR-γ agonist protects against myocardial ischaemia–reperfusion injury

(2010) Yumei Ye et al.   CARDIOVASCULAR RESEARCH

MicroRNA-494 Targeting Both Proapoptotic and Antiapoptotic Proteins Protects Against Ischemia/Reperfusion-Induced Cardiac Injury

(2010) Xiaohong Wang et al.   CIRCULATION

MicroRNAs modulate the noncanonical transcription factor NF-κB pathway by regulating expression of the kinase IKKα during macrophage differentiation

(2010) Tao Li et al.   NATURE IMMUNOLOGY

Divergent Tumor Necrosis Factor Receptor–Related Remodeling Responses in Heart Failure

(2009) Tariq Hamid et al.   CIRCULATION

MicroRNA-320 Is Involved in the Regulation of Cardiac Ischemia/Reperfusion Injury by Targeting Heat-Shock Protein 20

(2009) Xiao-Ping Ren et al.   CIRCULATION

The role of TNF-α receptors p55 and p75 in acute myocardial ischemia/reperfusion injury and late preconditioning

(2008) Michael P. Flaherty et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY