Unsolved mysteries: How does lipid peroxidation cause ferroptosis?

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018

(2018) Lorenzo Galluzzi et al.   CELL DEATH AND DIFFERENTIATION

Quantitative Profiling of Protein Carbonylations in Ferroptosis by an Aniline-Derived Probe

(2018) Ying Chen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

FINO2 initiates ferroptosis through GPX4 inactivation and iron oxidation

(2018) Michael M. Gaschler et al.   Nature Chemical Biology

Ferroptosis is newly characterized form of neuronal cell death in response to arsenite exposure

(2018) Qianghu Tang et al.   NEUROTOXICOLOGY

Modeling the effects of lipid peroxidation during ferroptosis on membrane properties

(2018) Eran Agmon et al.   Scientific Reports

The p53 Tumor Suppressor in the Control of Metabolism and Ferroptosis

(2018) Keerthana Gnanapradeepan et al.   Frontiers in Endocrinology

Dependency of a therapy-resistant state of cancer cells on a lipid peroxidase pathway

(2017) Vasanthi S. Viswanathan et al.   NATURE

Salinomycin kills cancer stem cells by sequestering iron in lysosomes

(2017) Trang Thi Mai et al.   Nature Chemistry

Full length RTN3 regulates turnover of tubular endoplasmic reticulum via selective autophagy

(2017) Paolo Grumati et al.   eLife

On the Mechanism of Cytoprotection by Ferrostatin-1 and Liproxstatin-1 and the Role of Lipid Peroxidation in Ferroptotic Cell Death

(2017) Omkar Zilka et al.   ACS Central Science

Five-Membered Ring Peroxide Selectively Initiates Ferroptosis in Cancer Cells

(2016) Rachel P. Abrams et al.   ACS Chemical Biology

Identification of baicalein as a ferroptosis inhibitor by natural product library screening

(2016) Yangchun Xie et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

An essential role for functional lysosomes in ferroptosis of cancer cells

(2016) S. Torii et al.   BIOCHEMICAL JOURNAL

Emerging roles for lipids in non-apoptotic cell death

(2016) L Magtanong et al.   CELL DEATH AND DIFFERENTIATION

Endoplasmic Reticulum Stress and Associated ROS

(2016) Hafiz Zeeshan et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Translocon component Sec62 acts in endoplasmic reticulum turnover during stress recovery

(2016) Fiorenza Fumagalli et al.   NATURE CELL BIOLOGY

Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis

(2016) Valerian E Kagan et al.   Nature Chemical Biology

ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition

(2016) Sebastian Doll et al.   Nature Chemical Biology

Global survey of cell death mechanisms reveals metabolic regulation of ferroptosis

(2016) Kenichi Shimada et al.   Nature Chemical Biology

Peroxidation of polyunsaturated fatty acids by lipoxygenases drives ferroptosis

(2016) Wan Seok Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Editorial: Impact of Lipid Peroxidation on the Physiology and Pathophysiology of Cell Membranes

(2016) Angel Catalá et al.   Frontiers in Physiology

A Mitochondrial-Targeted Nitroxide Is a Potent Inhibitor of Ferroptosis

(2016) Tanja Krainz et al.   ACS Central Science

Human Haploid Cell Genetics Reveals Roles for Lipid Metabolism Genes in Nonapoptotic Cell Death

(2015) Scott J. Dixon et al.   ACS Chemical Biology

Regulation of endoplasmic reticulum turnover by selective autophagy

(2015) Aliaksandr Khaminets et al.   NATURE

Ferroptosis as a p53-mediated activity during tumour suppression

(2015) Le Jiang et al.   NATURE

Regulation of Ferroptotic Cancer Cell Death by GPX4

(2014) Wan Seok Yang et al.   CELL

Ferrostatins Inhibit Oxidative Lipid Damage and Cell Death in Diverse Disease Models

(2014) Rachid Skouta et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice

(2014) Jose Pedro Friedmann Angeli et al.   NATURE CELL BIOLOGY

Lipid Peroxidation: Production, Metabolism, and Signaling Mechanisms of Malondialdehyde and 4-Hydroxy-2-Nonenal

(2014) Antonio Ayala et al.   Oxidative Medicine and Cellular Longevity

Pharmacological inhibition of cystine–glutamate exchange induces endoplasmic reticulum stress and ferroptosis

(2014) Scott J Dixon et al.   eLife

Cell death and diseases related to oxidative stress:4-hydroxynonenal (HNE) in the balance

(2013) S Dalleau et al.   CELL DEATH AND DIFFERENTIATION

Thermodynamic and kinetic investigations of the release of oxidized phospholipids from lipid membranes and its effect on vascular integrity

(2013) Charles T.R. Heffern et al.   CHEMISTRY AND PHYSICS OF LIPIDS

Pathophysiological relevance of aldehydic protein modifications

(2013) Neven Zarkovic et al.   Journal of Proteomics

Widespread Mitochondrial Depletion via Mitophagy Does Not Compromise Necroptosis

(2013) Stephen W.G. Tait et al.   Cell Reports

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

(2012) Scott J. Dixon et al.   CELL

Evaluation of lipid damage related to pathological and physiological conditions

(2012) Solange Cristina Garcia et al.   DRUG AND CHEMICAL TOXICOLOGY

Lipoxygenase and Leukotriene Pathways: Biochemistry, Biology, and Roles in Disease

(2011) Jesper Z. Haeggström et al.   CHEMICAL REVIEWS

Free Radical Lipid Peroxidation: Mechanisms and Analysis

(2011) Huiyong Yin et al.   CHEMICAL REVIEWS

Defining human ERAD networks through an integrative mapping strategy

(2011) John C. Christianson et al.   NATURE CELL BIOLOGY

Mechanisms of 4-Hydroxy-2-nonenal Induced Pro- and Anti-Apoptotic Signaling

(2010) Pankaj Chaudhary et al.   BIOCHEMISTRY

Glutathione Peroxidase 4 Senses and Translates Oxidative Stress into 12/15-Lipoxygenase Dependent- and AIF-Mediated Cell Death

(2008) Alexander Seiler et al.   Cell Metabolism

Antioxidants reduce endoplasmic reticulum stress and improve protein secretion

(2008) J. D. Malhotra et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA