Ferroptosis is Involved in Acetaminophen Induced Cell Death

Regulation of Ferroptotic Cancer Cell Death by GPX4

(2014) Wan Seok Yang et al.   CELL

Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice

(2014) Jose Pedro Friedmann Angeli et al.   NATURE CELL BIOLOGY

Role of receptor interacting protein (RIP)1 on apoptosis-inducing factor-mediated necroptosis during acetaminophen-evoked acute liver failure in mice

(2014) Ye-Fa Zhang et al.   TOXICOLOGY LETTERS

Necrostatin-1 protects against reactive oxygen species (ROS)-induced hepatotoxicity in acetaminophen-induced acute liver failure

(2014) Kenji Takemoto et al.   FEBS Open Bio

Plasma and liver acetaminophen-protein adduct levels in mice after acetaminophen treatment: Dose–response, mechanisms, and clinical implications

(2013) Mitchell R. McGill et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

(2012) Scott J. Dixon et al.   CELL

Oxidant stress, mitochondria, and cell death mechanisms in drug-induced liver injury: Lessons learned from acetaminophen hepatotoxicity

(2012) Hartmut Jaeschke et al.   DRUG METABOLISM REVIEWS

Acetaminophen-induced liver injury in rats and mice: Comparison of protein adducts, mitochondrial dysfunction, and oxidative stress in the mechanism of toxicity

(2012) Mitchell R. McGill et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Current issues with acetaminophen hepatotoxicity—A clinically relevant model to test the efficacy of natural products

(2011) Hartmut Jaeschke et al.   LIFE SCIENCES

HepaRG cells: A human model to study mechanisms of acetaminophen hepatotoxicity

(2010) Mitchell R. McGill et al.   HEPATOLOGY

Molecular mechanisms of necroptosis: an ordered cellular explosion

(2010) Peter Vandenabeele et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Role of caspase-1 and interleukin-1β in acetaminophen-induced hepatic inflammation and liver injury

(2010) C. David Williams et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

BGP-15 inhibits caspase-independent programmed cell death in acetaminophen-induced liver injury

(2009) Gábor Nagy et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Identification of RIP1 kinase as a specific cellular target of necrostatins

(2008) Alexei Degterev et al.   Nature Chemical Biology

Interspecies differences in acetaminophen sensitivity of human, rat, and mouse primary hepatocytes

(2008) Katalin Jemnitz et al.   TOXICOLOGY IN VITRO