Impaired neurodevelopmental pathways in autism spectrum disorder: a review of signaling mechanisms and crosstalk

Disrupted circuits in mouse models of autism spectrum disorder and intellectual disability

(2018) Carla EM Golden et al.   CURRENT OPINION IN NEUROBIOLOGY

Vitamin A Deficiency Induces Autistic-Like Behaviors in Rats by Regulating the RARβ-CD38-Oxytocin Axis in the Hypothalamus

(2018) Xi Lai et al.   MOLECULAR NUTRITION & FOOD RESEARCH

An analytical framework for whole-genome sequence association studies and its implications for autism spectrum disorder

(2018) Donna M. Werling et al.   NATURE GENETICS

Mechanisms of Wnt signaling and control

(2018) Stephanie Grainger et al.   Wiley Interdisciplinary Reviews-Systems Biology and Medicine

Wnt/β-catenin signaling stimulates the expression and synaptic clustering of the autism-associated Neuroligin 3 gene

(2018) Matías A. Medina et al.   Translational Psychiatry

The Wnt Signaling Pathway and Related Therapeutic Drugs in Autism Spectrum Disorder

(2018) Seung Min Bae et al.   Clinical Psychopharmacology and Neuroscience

Neonatal Tbr1 Dosage Controls Cortical Layer 6 Connectivity

(2018) Siavash Fazel Darbandi et al.   NEURON

A Probiotic Mixture Regulates T Cell Balance and Reduces Atopic Dermatitis Symptoms in Mice

(2018) Han Wool Kim et al.   Frontiers in Microbiology

Delineating the Common Biological Pathways Perturbed by ASD’s Genetic Etiology: Lessons from Network-Based Studies

(2017) Oded Oron et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The autism-linked UBE3A T485A mutant E3 ubiquitin ligase activates the Wnt/β-catenin pathway by inhibiting the proteasome

(2017) Jason J. Yi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Neuroligin 4 regulates synaptic growth via the bone morphogenetic protein (BMP) signaling pathway at theDrosophilaneuromuscular junction

(2017) Xinwang Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cellular Functions of the Autism Risk Factor PTCHD1 in Mice

(2017) David Tora et al.   JOURNAL OF NEUROSCIENCE

Retinoic acid-related orphan receptor alpha (RORA) variants are associated with autism spectrum disorder

(2017) Arezou Sayad et al.   METABOLIC BRAIN DISEASE

Activation of adenosine A2A receptor signaling regulates the expression of cytokines associated with immunologic dysfunction in BTBR T + Itpr3 tf /J mice

(2017) Mushtaq A. Ansari et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Ptchd1 deficiency induces excitatory synaptic and cognitive dysfunctions in mouse

(2017) D C Ung et al.   MOLECULAR PSYCHIATRY

Refining the role of de novo protein-truncating variants in neurodevelopmental disorders by using population reference samples

(2017) Jack A Kosmicki et al.   NATURE GENETICS

Primary cilia as a novel horizon between neuron and environment

(2017) Qiaojie Xiong et al.   Neural Regeneration Research

Targeting sonic hedgehog signaling in neurological disorders

(2017) Sita Sharan Patel et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Bone Morphogenetic Protein–Based Therapeutic Approaches

(2017) Jonathan W. Lowery et al.   Cold Spring Harbor Perspectives in Biology

Chd8 Mutation Leads to Autistic-like Behaviors and Impaired Striatal Circuits

(2017) Randall J. Platt et al.   Cell Reports

Leveraging blood serotonin as an endophenotype to identify de novo and rare variants involved in autism

(2017) Rui Chen et al.   Molecular Autism

Low Retinal Dehydrogenase 1 (RALDH1) Level in Prepubertal Boys with Autism Spectrum Disorder: A Possible Link to Dopamine Dysfunction?

(2017) Denis Pavăl et al.   Clinical Psychopharmacology and Neuroscience

De Novo Mutations of RERE Cause a Genetic Syndrome with Features that Overlap Those Associated with Proximal 1p36 Deletions

(2016) Brieana Fregeau et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Wnt signaling networks in autism spectrum disorder and intellectual disability

(2016) Vickie Kwan et al.   Journal of Neurodevelopmental Disorders

Prostaglandin E2promotes neural proliferation and differentiation and regulates Wnt target gene expression

(2016) Christine T. Wong et al.   JOURNAL OF NEUROSCIENCE RESEARCH

From molecules to behavior: An integrative theory of autism spectrum disorder

(2016) Alexandru-Ştefan Niculae et al.   MEDICAL HYPOTHESES

DIXDC1 contributes to psychiatric susceptibility by regulating dendritic spine and glutamatergic synapse density via GSK3 and Wnt/β-catenin signaling

(2016) P-M Martin et al.   MOLECULAR PSYCHIATRY

Augmented noncanonical BMP type II receptor signaling mediates the synaptic abnormality of fragile X syndrome

(2016) Risa Kashima et al.   Science Signaling

Dysregulated fibroblast growth factor (FGF) signaling in neurological and psychiatric disorders

(2016) Cortney A. Turner et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

DIXDC1 Phosphorylation and Control of Dendritic Morphology Are Impaired by Rare Genetic Variants

(2016) Vickie Kwan et al.   Cell Reports

Impaired learning and memory in CD38 null mutant mice

(2016) Somi Kim et al.   Molecular Brain

Angelman Syndrome Protein Ube3a Regulates Synaptic Growth and Endocytosis by Inhibiting BMP Signaling in Drosophila

(2016) Wenhua Li et al.   PLoS Genetics

Augmented noncanonical BMP type II receptor signaling mediates the synaptic abnormality of fragile X syndrome

(2016) Risa Kashima et al.   Science Signaling

Therapeutic Effect of a Synthetic RORα/γ Agonist in an Animal Model of Autism

(2015) Yongjun Wang et al.   ACS Chemical Neuroscience

Crosstalk between Wnt/β-catenin and Hedgehog/Gli signaling pathways in colon cancer and implications for therapy

(2015) Li Song et al.   CANCER BIOLOGY & THERAPY

Canonical and noncanonical Wnt signaling in neural stem/progenitor cells

(2015) Nora Bengoa-Vergniory et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Reduced cholesterol levels impair Smoothened activation in Smith–Lemli–Opitz syndrome

(2015) Robert Blassberg et al.   HUMAN MOLECULAR GENETICS

Whole-Exome Sequencing in a South American Cohort Links ALDH1A3, FOXN1 and Retinoic Acid Regulation Pathways to Autism Spectrum Disorders

(2015) Oscar A. Moreno-Ramos et al.   PLoS One

The autism-associated chromatin modifier CHD8 regulates other autism risk genes during human neurodevelopment

(2015) Justin Cotney et al.   Nature Communications

PDZ interaction of Vangl2 links PSD-95 and Prickle2 but plays only a limited role in the synaptic localisation of Vangl2

(2015) Tadahiro Nagaoka et al.   Scientific Reports

The autism-associated gene chromodomain helicase DNA-binding protein 8 (CHD8) regulates noncoding RNAs and autism-related genes

(2015) B Wilkinson et al.   Translational Psychiatry

The Fibroblast Growth Factor signaling pathway

(2015) David M. Ornitz et al.   Wiley Interdisciplinary Reviews-Developmental Biology

A new intellectual disability syndrome caused byCTNNB1haploinsufficiency

(2014) Estelle Dubruc et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Wnt signalling in neuronal differentiation and development

(2014) Nibaldo C. Inestrosa et al.   CELL AND TISSUE RESEARCH

Synaptic Activity-Regulated Wnt Signaling in Synaptic Plasticity, Glial Function and Chronic Pain

(2014) Shao-Jun Tang   CNS & Neurological Disorders-Drug Targets

Axon guidance and injury—lessons from Wnts and Wnt signaling

(2014) Keisuke Onishi et al.   CURRENT OPINION IN NEUROBIOLOGY

The Wnt cries many: Wnt regulation of neurogenesis through tissue patterning, proliferation, and asymmetric cell division

(2014) Holger Bielen et al.   Developmental Neurobiology

The discovery of integrated gene networks for autism and related disorders

(2014) Fereydoun Hormozdiari et al.   GENOME RESEARCH

De novo mutations in beta-catenin (CTNNB1) appear to be a frequent cause of intellectual disability: expanding the mutational and clinical spectrum

(2014) Alma Kuechler et al.   HUMAN GENETICS

Ankyrin-G regulates neurogenesis and Wnt signaling by altering the subcellular localization of β-catenin

(2014) O Durak et al.   MOLECULAR PSYCHIATRY

Adenomatous polyposis coli protein deletion leads to cognitive and autism-like disabilities

(2014) J L Mohn et al.   MOLECULAR PSYCHIATRY

Synaptic, transcriptional and chromatin genes disrupted in autism

(2014) Silvia De Rubeis et al.   NATURE

The contribution of de novo coding mutations to autism spectrum disorder

(2014) Ivan Iossifov et al.   NATURE

3p Interstitial Deletion Including PRICKLE2 in Identical Twins With Autistic Features

(2014) Akihisa Okumura et al.   PEDIATRIC NEUROLOGY

Autism Associated Gene, ENGRAILED2, and Flanking Gene Levels Are Altered in Post-Mortem Cerebellum

(2014) Jiyeon Choi et al.   PLoS One

Sonic hedgehog signaling in the postnatal brain

(2014) Arturo Álvarez-Buylla et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

A de novo convergence of autism genetics and molecular neuroscience

(2014) Niklas Krumm et al.   TRENDS IN NEUROSCIENCES

Retinoic acid signaling pathways in development and diseases

(2013) Bhaskar C. Das et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Coexpression Networks Implicate Human Midfetal Deep Cortical Projection Neurons in the Pathogenesis of Autism

(2013) A. Jeremy Willsey et al.   CELL

 -catenin regulates Pax3 and Cdx2 for caudal neural tube closure and elongation

(2013) T. Zhao et al.   DEVELOPMENT

Homozygous and heterozygous disruptions of ANK3: at the crossroads of neurodevelopmental and psychiatric disorders

(2013) Z. Iqbal et al.   HUMAN MOLECULAR GENETICS

Neurotrophin and Wnt signaling cooperatively regulate dendritic spine formation

(2013) Brian G. Hiester et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Disruption of the non-canonical Wnt gene PRICKLE2 leads to autism-like behaviors with evidence for hippocampal synaptic dysfunction

(2013) L P Sowers et al.   MOLECULAR PSYCHIATRY

The chromatin remodeller CHD8 is required for E2F-dependent transcription activation of S-phase genes

(2013) Alicia Subtil-Rodríguez et al.   NUCLEIC ACIDS RESEARCH

Crosstalk between Shh and TGF-β Signaling in Cyclosporine-Enhanced Cell Proliferation in Human Gingival Fibroblasts

(2013) Yi Chung et al.   PLoS One

WNT signaling in neuronal maturation and synaptogenesis

(2013) Silvana B. Rosso et al.   Frontiers in Cellular Neuroscience

Whole-genome sequencing in an autism multiplex family

(2013) Lingling Shi et al.   Molecular Autism

Genome-wide identification of transcriptional targets of RORA reveals direct regulation of multiple genes associated with autism spectrum disorder

(2013) Tewarit Sarachana et al.   Molecular Autism

A rare WNT1 missense variant overrepresented in ASD leads to increased Wnt signal pathway activation

(2013) P-M Martin et al.   Translational Psychiatry

Wnt/β-Catenin Signaling and Disease

(2012) Hans Clevers et al.   CELL

Wnt9b-dependent FGF signaling is crucial for outgrowth of the nasal and maxillary processes during upper jaw and lip development

(2012) Y.-R. Jin et al.   DEVELOPMENT

Retinoic acid signalling during development

(2012) M. Rhinn et al.   DEVELOPMENT

Crosstalk between Fgf and Wnt signaling in the zebrafish tailbud

(2012) Michael J. Stulberg et al.   DEVELOPMENTAL BIOLOGY

BMP-binding protein twisted gastrulation is required in mammary gland epithelium for normal ductal elongation and myoepithelial compartmentalization

(2012) Cynthia L. Forsman et al.   DEVELOPMENTAL BIOLOGY

The dynamic role of bone morphogenetic proteins in neural stem cell fate and maturation

(2012) Allison M. Bond et al.   Developmental Neurobiology

Dynamics of TGF-β/Smad signaling

(2012) Zhike Zi et al.   FEBS LETTERS

Crosstalk between TGF-β and hedgehog signaling in cancer

(2012) Delphine Javelaud et al.   FEBS LETTERS

Mutations ofANK3identified by exome sequencing are associated with autism susceptibility

(2012) Cheng Bi et al.   HUMAN MUTATION

Expression of Microphthalmia-associated Transcription Factor (MITF), Which Is Critical for Melanoma Progression, Is Inhibited by Both Transcription Factor GLI2 and Transforming Growth Factor-β

(2012) Marie-Jeanne Pierrat et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

De novo mutations revealed by whole-exome sequencing are strongly associated with autism

(2012) Stephan J. Sanders et al.   NATURE

Sporadic autism exomes reveal a highly interconnected protein network of de novo mutations

(2012) Brian J. O’Roak et al.   NATURE

Downregulating the Canonical Wnt/β-catenin Signaling Pathway Attenuates the Susceptibility to Autism-like Phenotypes by Decreasing Oxidative Stress

(2012) Yinghua Zhang et al.   NEUROCHEMICAL RESEARCH

Multiplex Targeted Sequencing Identifies Recurrently Mutated Genes in Autism Spectrum Disorders

(2012) B. J. O'Roak et al.   SCIENCE

Frizzled and LRP5/6 Receptors for Wnt/ -Catenin Signaling

(2012) B. T. MacDonald et al.   Cold Spring Harbor Perspectives in Biology

Age-Dependent Brain Gene Expression and Copy Number Anomalies in Autism Suggest Distinct Pathological Processes at Young Versus Mature Ages

(2012) Maggie L. Chow et al.   PLoS Genetics

A review of the evidence for the canonical Wnt pathway in autism spectrum disorders

(2012) Hans Kalkman   Molecular Autism

Neuropilins are positive regulators of Hedgehog signal transduction

(2011) R. T. Hillman et al.   GENES & DEVELOPMENT

Identification of direct downstream targets of Dlx5 during early inner ear development

(2011) Samin A. Sajan et al.   HUMAN MOLECULAR GENETICS

Synaptic Wnt signaling—a contributor to major psychiatric disorders?

(2011) Nathan D. Okerlund et al.   Journal of Neurodevelopmental Disorders

Unknown

(2011) Mathias Riebold et al.   MOLECULAR MEDICINE

Relationship Between Sonic Hedgehog Protein, Brain-Derived Neurotrophic Factor and Oxidative Stress in Autism Spectrum Disorders

(2011) Laila Y. Al-Ayadhi   NEUROCHEMICAL RESEARCH

Malondialdehyde, Bcl-2, Superoxide Dismutase and Glutathione Peroxidase may Mediate the Association of Sonic Hedgehog Protein and Oxidative Stress in Autism

(2011) Ahmad Ghanizadeh   NEUROCHEMICAL RESEARCH

Rare De Novo and Transmitted Copy-Number Variation in Autistic Spectrum Disorders

(2011) Dan Levy et al.   NEURON

Abnormal behavior in mice mutant for the Disc1 binding partner, Dixdc1

(2011) S Kivimäe et al.   Translational Psychiatry

Neuropilin-1 exerts co-receptor function for TGF-beta-1 on the membrane of cancer cells and enhances responses to both latent and active TGF-beta

(2010) Yelena Glinka et al.   CARCINOGENESIS

What causes autism? Exploring the environmental contribution

(2010) Philip J Landrigan   CURRENT OPINION IN PEDIATRICS

Fibroblast growth factor signaling in development of the cerebral cortex

(2010) Tomoko Iwata et al.   DEVELOPMENT GROWTH & DIFFERENTIATION

The canonical Wnt/ß-catenin signaling pathway regulates Fgf signaling for early facial development

(2010) Yongping Wang et al.   DEVELOPMENTAL BIOLOGY

Loss of WNT-TCF addiction and enhancement of HH-GLI1 signalling define the metastatic transition of human colon carcinomas

(2010) Frédéric Varnat et al.   EMBO Molecular Medicine

Global methylation profiling of lymphoblastoid cell lines reveals epigenetic contributions to autism spectrum disorders and a novel autism candidate gene, RORA, whose protein product is reduced in autistic brain

(2010) AnhThu Nguyen et al.   FASEB JOURNAL

Requirement of TGFβ Signaling for SMO-mediated Carcinogenesis

(2010) Qipeng Fan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A mechanism for vertebrate Hedgehog signaling: recruitment to cilia and dissociation of SuFu–Gli protein complexes

(2010) Hanna Tukachinsky et al.   JOURNAL OF CELL BIOLOGY

The Gata3 Transcription Factor Is Required for the Survival of Embryonic and Adult Sympathetic Neurons

(2010) K. Tsarovina et al.   JOURNAL OF NEUROSCIENCE

Distinct FGFs promote differentiation of excitatory and inhibitory synapses

(2010) Akiko Terauchi et al.   NATURE

Intronic Single Nucleotide Polymorphisms of Engrailed Homeobox 2 Modulate the Disease Vulnerability of Autism in a Han Chinese Population

(2010) Pinchen Yang et al.   NEUROPSYCHOBIOLOGY

Wnt signal transduction pathways

(2010) Yuko Komiya et al.   Organogenesis

Global Regulator SATB1 Recruits β-Catenin and Regulates TH2 Differentiation in Wnt-Dependent Manner

(2010) Dimple Notani et al.   PLOS BIOLOGY

Retinoic Acid from the Meninges Regulates Cortical Neuron Generation

(2009) Julie A. Siegenthaler et al.   CELL

Lrp6-mediated canonical Wnt signaling is required for lip formation and fusion

(2009) L. Song et al.   DEVELOPMENT

Wnt/β-Catenin Signaling: Components, Mechanisms, and Diseases

(2009) Bryan T. MacDonald et al.   DEVELOPMENTAL CELL

Reduced Level of Smoothened Suppresses Intestinal Tumorigenesis by Down-Regulation of Wnt Signaling

(2009) Sumimasa Arimura et al.   GASTROENTEROLOGY

Family-based studies indicate association ofEngrailed 2gene with autism in an Indian population

(2009) B. Sen et al.   GENES BRAIN AND BEHAVIOR

Association between autism and variants in the wingless-type MMTV integration site family member 2 ( WNT2) gene

(2009) Tetsuya Marui et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

CHD8 suppresses p53-mediated apoptosis through histone H1 recruitment during early embryogenesis

(2009) Masaaki Nishiyama et al.   NATURE CELL BIOLOGY

Prickle promotes neurite outgrowth via the Dishevelled dependent pathway in C1300 cells

(2009) Lisa Fujimura et al.   NEUROSCIENCE LETTERS

Common increase of GATA-3 level in PC-12 cells by three teratogens causing autism spectrum disorders

(2009) Ujjwal K. Rout et al.   NEUROSCIENCE RESEARCH

Roles of Noncanonical Wnt/PCP Pathway Genes in Neuronal Migration and Neurulation in Zebrafish

(2009) Hironori Wada et al.   Zebrafish

Retinoic Acid Synthesis and Signaling during Early Organogenesis

(2008) Gregg Duester   CELL

The DLX1and DLX2 genes and susceptibility to autism spectrum disorders

(2008) Xudong Liu et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Deciphering the function of canonical Wnt signals in development and disease: conditional loss- and gain-of-function mutations of  -catenin in mice

(2008) T. Grigoryan et al.   GENES & DEVELOPMENT

AnkyrinG is required for maintenance of the axon initial segment and neuronal polarity

(2008) Kristian L. Hedstrom et al.   JOURNAL OF CELL BIOLOGY

CHD8 Is an ATP-Dependent Chromatin Remodeling Factor That Regulates  -Catenin Target Genes

(2008) B. A. Thompson et al.   MOLECULAR AND CELLULAR BIOLOGY

Retinoic acid in development: towards an integrated view

(2008) Karen Niederreither et al.   NATURE REVIEWS GENETICS

Association of the Homeobox Transcription Factor Gene ENGRAILED 2 with Autistic Disorder in Chinese Children

(2008) Pinchen Yang et al.   NEUROPSYCHOBIOLOGY

Akt2 overexpression plays a critical role in the establishment of colorectal cancer metastasis

(2008) P. G. Rychahou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neuroanatomy of autism

(2008) David G. Amaral et al.   TRENDS IN NEUROSCIENCES

Heterogeneous association between engrailed-2 and autism in the CPEA network

(2007) Camille W. Brune et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS

Association of the ENGRAILED 2 (EN2) gene with autism in Chinese Han population

(2007) Lifang Wang et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS