Wnt signaling networks in autism spectrum disorder and intellectual disability

A de novo frameshift mutation in chromodomain helicase DNA-binding domain 8 (CHD8): A case report and literature review

(2016) Nancy Merner et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Deletion of CTNNB1 in inhibitory circuitry contributes to autism-associated behavioral defects

(2016) Fengping Dong et al.   HUMAN MOLECULAR GENETICS

Modeling synaptogenesis in schizophrenia and autism using human iPSC derived neurons

(2016) Christa W. Habela et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Early postnatal GABAA receptor modulation reverses deficits in neuronal maturation in a conditional neurodevelopmental mouse model of DISC1

(2016) A Saito et al.   MOLECULAR PSYCHIATRY

Prenatal β-catenin/Brn2/Tbr2 transcriptional cascade regulates adult social and stereotypic behaviors

(2016) H Belinson et al.   MOLECULAR PSYCHIATRY

DISC1 causes associative memory and neurodevelopmental defects in fruit flies

(2016) K Furukubo-Tokunaga et al.   MOLECULAR PSYCHIATRY

DIXDC1 contributes to psychiatric susceptibility by regulating dendritic spine and glutamatergic synapse density via GSK3 and Wnt/β-catenin signaling

(2016) P-M Martin et al.   MOLECULAR PSYCHIATRY

Chd8 mediates cortical neurogenesis via transcriptional regulation of cell cycle and Wnt signaling

(2016) Omer Durak et al.   NATURE NEUROSCIENCE

Unifying Views of Autism Spectrum Disorders: A Consideration of Autoregulatory Feedback Loops

(2016) Caitlin Mullins et al.   NEURON

Opposing actions of the synapse-associated protein of 97-kDa molecular weight (SAP97) and Disrupted in Schizophrenia 1 (DISC1) on Wnt/β-catenin signaling

(2016) M. Boccitto et al.   NEUROSCIENCE

Neocortical neurogenesis and the etiology of autism spectrum disorder

(2016) Alan Packer   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

DIXDC1 Phosphorylation and Control of Dendritic Morphology Are Impaired by Rare Genetic Variants

(2016) Vickie Kwan et al.   Cell Reports

Synaptic Wnt/GSK3βSignaling Hub in Autism

(2016) Mario O. Caracci et al.   NEURAL PLASTICITY

Mutations in DDX3X Are a Common Cause of Unexplained Intellectual Disability with Gender-Specific Effects on Wnt Signaling

(2015) Lot Snijders Blok et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Glutamate Synapses in Human Cognitive Disorders

(2015) Lenora Volk et al.   Annual Review of Neuroscience

Microglia function during brain development: New insights from animal models

(2015) Parizad M. Bilimoria et al.   BRAIN RESEARCH

Coordinated Spine Pruning and Maturation Mediated by Inter-Spine Competition for Cadherin/Catenin Complexes

(2015) Wen-Jie Bian et al.   CELL

Altered white matter connectivity as a neural substrate for social impairment in Autism Spectrum Disorder

(2015) Stephanie H. Ameis et al.   CORTEX

Common Mechanisms of Excitatory and Inhibitory Imbalance in Schizophrenia and Autism Spectrum Disorders

(2015) R. Gao et al.   CURRENT MOLECULAR MEDICINE

First glimpses of the neurobiology of autism spectrum disorder

(2015) Stephan J Sanders   CURRENT OPINION IN GENETICS & DEVELOPMENT

Autism and the synapse

(2015) Darius Ebrahimi-Fakhari et al.   CURRENT OPINION IN NEUROLOGY

Decreased aggression and increased repetitive behavior inPtenhaploinsufficient mice

(2015) A. E. Clipperton-Allen et al.   GENES BRAIN AND BEHAVIOR

Dysregulation of Mammalian Target of Rapamycin Signaling in Mouse Models of Autism

(2015) K. M. Huber et al.   JOURNAL OF NEUROSCIENCE

Pten Mutations Alter Brain Growth Trajectory and Allocation of Cell Types through Elevated  -Catenin Signaling

(2015) Y. Chen et al.   JOURNAL OF NEUROSCIENCE

Excess of rare, inherited truncating mutations in autism

(2015) Niklas Krumm et al.   NATURE GENETICS

Immune mediators in the brain and peripheral tissues in autism spectrum disorder

(2015) Myka L. Estes et al.   NATURE REVIEWS NEUROSCIENCE

From the genetic architecture to synaptic plasticity in autism spectrum disorder

(2015) Thomas Bourgeron   NATURE REVIEWS NEUROSCIENCE

Excitatory/Inhibitory Balance and Circuit Homeostasis in Autism Spectrum Disorders

(2015) Sacha B. Nelson et al.   NEURON

Balancing Proliferation and Connectivity in PTEN-associated Autism Spectrum Disorder

(2015) Amanda K. Tilot et al.   Neurotherapeutics

Interneuronal DISC1 regulates NRG1-ErbB4 signalling and excitatory–inhibitory synapse formation in the mature cortex

(2015) Saurav Seshadri et al.   Nature Communications

The autism-associated chromatin modifier CHD8 regulates other autism risk genes during human neurodevelopment

(2015) Justin Cotney et al.   Nature Communications

PDZ interaction of Vangl2 links PSD-95 and Prickle2 but plays only a limited role in the synaptic localisation of Vangl2

(2015) Tadahiro Nagaoka et al.   Scientific Reports

The Parvalbumin/Somatostatin Ratio Is Increased in Pten Mutant Mice and by Human PTEN ASD Alleles

(2015) Daniel Vogt et al.   Cell Reports

Genomic DISC1 Disruption in hiPSCs Alters Wnt Signaling and Neural Cell Fate

(2015) Priya Srikanth et al.   Cell Reports

CRISPR/Cas9-mediated heterozygous knockout of the autism gene CHD8 and characterization of its transcriptional networks in neurodevelopment

(2015) Ping Wang et al.   Molecular Autism

The autism-associated gene chromodomain helicase DNA-binding protein 8 (CHD8) regulates noncoding RNAs and autism-related genes

(2015) B Wilkinson et al.   Translational Psychiatry

Mutations and Modeling of the Chromatin Remodeler CHD8 Define an Emerging Autism Etiology

(2015) Rebecca A. Barnard et al.   Frontiers in Neuroscience

A new intellectual disability syndrome caused byCTNNB1haploinsufficiency

(2014) Estelle Dubruc et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Disruptive CHD8 Mutations Define a Subtype of Autism Early in Development

(2014) Raphael Bernier et al.   CELL

De novo mutations in beta-catenin (CTNNB1) appear to be a frequent cause of intellectual disability: expanding the mutational and clinical spectrum

(2014) Alma Kuechler et al.   HUMAN GENETICS

Pten haploinsufficient mice show broad brain overgrowth but selective impairments in autism-relevant behavioral tests

(2014) Amy E. Clipperton-Allen et al.   HUMAN MOLECULAR GENETICS

Dominant β-catenin mutations cause intellectual disability with recognizable syndromic features

(2014) Valter Tucci et al.   JOURNAL OF CLINICAL INVESTIGATION

Functionally distinct groups of inherited PTEN mutations in autism and tumour syndromes

(2014) Laura Spinelli et al.   JOURNAL OF MEDICAL GENETICS

Quantitative Phosphoproteomics of Murine Fmr1-KO Cell Lines Provides New Insights into FMRP-Dependent Signal Transduction Mechanisms

(2014) Katarina Matic et al.   JOURNAL OF PROTEOME RESEARCH

Ankyrin-G regulates neurogenesis and Wnt signaling by altering the subcellular localization of β-catenin

(2014) O Durak et al.   MOLECULAR PSYCHIATRY

De novo mutations in schizophrenia implicate chromatin remodeling and support a genetic overlap with autism and intellectual disability

(2014) S E McCarthy et al.   MOLECULAR PSYCHIATRY

Molecular and phenotypic abnormalities in individuals with germline heterozygous PTEN mutations and autism

(2014) T W Frazier et al.   MOLECULAR PSYCHIATRY

Synaptic, transcriptional and chromatin genes disrupted in autism

(2014) Silvia De Rubeis et al.   NATURE

The contribution of de novo coding mutations to autism spectrum disorder

(2014) Ivan Iossifov et al.   NATURE

Can we safely target the WNT pathway?

(2014) Michael Kahn   NATURE REVIEWS DRUG DISCOVERY

Psychiatric Risk Factor ANK3/Ankyrin-G Nanodomains Regulate the Structure and Function of Glutamatergic Synapses

(2014) Katharine R. Smith et al.   NEURON

CHD8regulates neurodevelopmental pathways associated with autism spectrum disorder in neural progenitors

(2014) Aarathi Sugathan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A de novo convergence of autism genetics and molecular neuroscience

(2014) Niklas Krumm et al.   TRENDS IN NEUROSCIENCES

Dysfunction of Wnt signaling and synaptic disassembly in neurodegenerative diseases

(2014) S. A. Purro et al.   Journal of Molecular Cell Biology

Overproduction of Upper-Layer Neurons in the Neocortex Leads to Autism-like Features in Mice

(2014) Wei-Qun Fang et al.   Cell Reports

Glycogen Synthase Kinase-3 Inhibitors Reverse Deficits in Long-term Potentiation and Cognition in Fragile X Mice

(2013) Aimee V. Franklin et al.   BIOLOGICAL PSYCHIATRY

Delayed myelination in a mouse model of fragile X syndrome

(2013) L. K. K. Pacey et al.   HUMAN MOLECULAR GENETICS

Homozygous and heterozygous disruptions of ANK3: at the crossroads of neurodevelopmental and psychiatric disorders

(2013) Z. Iqbal et al.   HUMAN MOLECULAR GENETICS

Prenatal Valproate Exposure and Risk of Autism Spectrum Disorders and Childhood Autism

(2013) Jakob Christensen et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

The non-canonical Wnt ligand Wnt5a rescues morphological deficits in Prickle2-deficient hippocampal neurons

(2013) L P Sowers et al.   MOLECULAR PSYCHIATRY

Disruption of the non-canonical Wnt gene PRICKLE2 leads to autism-like behaviors with evidence for hippocampal synaptic dysfunction

(2013) L P Sowers et al.   MOLECULAR PSYCHIATRY

AKT activation by N-cadherin regulates beta-catenin signaling and neuronal differentiation during cortical development

(2013) Jianing Zhang et al.   Neural Development

Dysregulation of synaptic plasticity precedes appearance of morphological defects in a Pten conditional knockout mouse model of autism

(2013) K. Takeuchi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

RNA Helicase DDX3 Is a Regulatory Subunit of Casein Kinase 1 in Wnt- -Catenin Signaling

(2013) C.-M. Cruciat et al.   SCIENCE

Wnts in adult brain: from synaptic plasticity to cognitive deficiencies

(2013) Carolina A. Oliva et al.   Frontiers in Cellular Neuroscience

A rare WNT1 missense variant overrepresented in ASD leads to increased Wnt signal pathway activation

(2013) P-M Martin et al.   Translational Psychiatry

The Pathophysiology of Fragile X (and What It Teaches Us about Synapses)

(2012) Asha L. Bhakar et al.   Annual Review of Neuroscience

The ANK3 Bipolar Disorder Gene Regulates Psychiatric-Related Behaviors That Are Modulated by Lithium and Stress

(2012) Melanie P. Leussis et al.   BIOLOGICAL PSYCHIATRY

Sequencing Chromosomal Abnormalities Reveals Neurodevelopmental Loci that Confer Risk across Diagnostic Boundaries

(2012) Michael E. Talkowski et al.   CELL

Brain region differences in regulation of Akt and GSK3 by chronic stimulant administration in mice

(2012) Marjelo A. Mines et al.   CELLULAR SIGNALLING

PTEN signaling in autism spectrum disorders

(2012) Jing Zhou et al.   CURRENT OPINION IN NEUROBIOLOGY

Examination of methylphenidate-mediated behavior regulation by glycogen synthase kinase-3 in mice

(2012) Marjelo A. Mines et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Patterns and rates of exonic de novo mutations in autism spectrum disorders

(2012) Benjamin M. Neale et al.   NATURE

De novo mutations revealed by whole-exome sequencing are strongly associated with autism

(2012) Stephan J. Sanders et al.   NATURE

Sporadic autism exomes reveal a highly interconnected protein network of de novo mutations

(2012) Brian J. O’Roak et al.   NATURE

Downregulating the Canonical Wnt/β-catenin Signaling Pathway Attenuates the Susceptibility to Autism-like Phenotypes by Decreasing Oxidative Stress

(2012) Yinghua Zhang et al.   NEUROCHEMICAL RESEARCH

Prenatal exposure to valproic acid increases the neural progenitor cell pool and induces macrocephaly in rat brain via a mechanism involving the GSK-3β/β-catenin pathway

(2012) Hyo Sang Go et al.   NEUROPHARMACOLOGY

Selective deletion of forebrain glycogen synthase kinase 3  reveals a central role in serotonin-sensitive anxiety and social behaviour

(2012) C. Latapy et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Multiplex Targeted Sequencing Identifies Recurrently Mutated Genes in Autism Spectrum Disorders

(2012) B. J. O'Roak et al.   SCIENCE

Wnt signaling during synaptic development and plasticity

(2011) Vivian Budnik et al.   CURRENT OPINION IN NEUROBIOLOGY

Synaptic microcircuit dysfunction in genetic models of neurodevelopmental disorders: focus on Mecp2 and Met

(2011) Gordon MG Shepherd et al.   CURRENT OPINION IN NEUROBIOLOGY

Inhibition of GSK3  improves hippocampus-dependent learning and rescues neurogenesis in a mouse model of fragile X syndrome

(2011) W. Guo et al.   HUMAN MOLECULAR GENETICS

Synaptic Wnt signaling—a contributor to major psychiatric disorders?

(2011) Nathan D. Okerlund et al.   Journal of Neurodevelopmental Disorders

Histone H1 Recruitment by CHD8 Is Essential for Suppression of the Wnt- -Catenin Signaling Pathway

(2011) M. Nishiyama et al.   MOLECULAR AND CELLULAR BIOLOGY

Common DISC1 Polymorphisms Disrupt Wnt/GSK3β Signaling and Brain Development

(2011) Karun K. Singh et al.   NEURON

The effects of neuropsychiatric drugs on glycogen synthase kinase-3 signaling

(2011) L.P. Sutton et al.   NEUROSCIENCE

Abnormal behavior in mice mutant for the Disc1 binding partner, Dixdc1

(2011) S Kivimäe et al.   Translational Psychiatry

Raphe-mediated signals control the hippocampal response to SRI antidepressants via miR-16

(2011) J M Launay et al.   Translational Psychiatry

Glycogen Synthase Kinase-3: A Promising Therapeutic Target for Fragile X Syndrome

(2011) Marjelo A. Mines et al.   Frontiers in Molecular Neuroscience

The Genetics of Autism Spectrum Disorders and Related Neuropsychiatric Disorders in Childhood

(2010) Paul Lichtenstein et al.   AMERICAN JOURNAL OF PSYCHIATRY

Confirmation study of PTEN mutations among individuals with autism or developmental delays/mental retardation and macrocephaly

(2010) Kim L. McBride et al.   Autism Research

Prenatal Interaction of Mutant DISC1 and Immune Activation Produces Adult Psychopathology

(2010) Bagrat Abazyan et al.   BIOLOGICAL PSYCHIATRY

Dixdc1 Is a Critical Regulator of DISC1 and Embryonic Cortical Development

(2010) Karun K. Singh et al.   NEURON

GSK3 Influences Social Preference and Anxiety-Related Behaviors during Social Interaction in a Mouse Model of Fragile X Syndrome and Autism

(2010) Marjelo A. Mines et al.   PLoS One

MiR-16 Targets the Serotonin Transporter: A New Facet for Adaptive Responses to Antidepressants

(2010) A. Baudry et al.   SCIENCE

Lithium ameliorates altered glycogen synthase kinase-3 and behavior in a mouse model of Fragile X syndrome

(2009) Christopher J. Yuskaitis et al.   BIOCHEMICAL PHARMACOLOGY

Disrupted in Schizophrenia 1 Regulates Neuronal Progenitor Proliferation via Modulation of GSK3β/β-Catenin Signaling

(2009) Yingwei Mao et al.   CELL

Haploinsufficiency forPtenandSerotonin transportercooperatively influences brain size and social behavior

(2009) Damon T. Page et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Wnt Signaling in Neural Circuit Assembly

(2008) Patricia C. Salinas et al.   Annual Review of Neuroscience

CHD8 Is an ATP-Dependent Chromatin Remodeling Factor That Regulates  -Catenin Target Genes

(2008) B. A. Thompson et al.   MOLECULAR AND CELLULAR BIOLOGY

Elevated glycogen synthase kinase-3 activity in Fragile X mice: Key metabolic regulator with evidence for treatment potential

(2008) Wenzhong William Min et al.   NEUROPHARMACOLOGY