期刊
DEVELOPMENTAL NEUROBIOLOGY
卷 72, 期 7, 页码 1068-1084出版社
WILEY-BLACKWELL
DOI: 10.1002/dneu.22022
关键词
BMP; neural stem cells; patterning; neurogenesis; gliogenesis
资金
- NCI NIH HHS [U54 CA151880] Funding Source: Medline
- NINDS NIH HHS [R01 NS020778, R01 NS020013] Funding Source: Medline
The bone morphogenetic proteins (BMPs) are a group of powerful morphogens that are critical for development of the nervous system. The effects of BMP signaling on neural stem cells are myriad and dynamic, changing with each stage of development. During early development inhibition of BMP signaling differentiates neuroectoderm from ectoderm, and BMP signaling helps to specify neural crest. Thus modulation of BMP signaling underlies formation of both the central and peripheral nervous systems. BMPs secreted from dorsal structures then form a gradient which helps pattern the dorsalventral axis of the developing spinal cord and brain. During forebrain development BMPs sequentially induce neurogenesis and then astrogliogenesis and participate in neurite outgrowth from immature neurons. BMP signaling also plays a critical role in maintaining adult neural stem cell niches in the subventricular zone (SVZ) and subgranular zone (SGZ). BMPs are able to exert such diverse effects through closely regulated temporospatial expression and interaction with other signaling pathways. (C) 2012 Wiley Periodicals, Inc. Develop Neurobiol 72: 10681084, 2012
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