Review
Biochemistry & Molecular Biology
Diana Wu, Lilian U. Thompson, Elena M. Comelli
Summary: Breast cancer, the second most common cancer in women after skin cancer, can be influenced by mammary gland development. miRNAs play a key role in both mammary development and breast cancer, and studying their role in development may provide insights into potential targets for breast cancer treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Oncology
Madison N. Wicker, Kay-Uwe Wagner
Summary: Cellular plasticity, the ability of cells to change their identity, plays a crucial role in mammary gland development and breast cancer progression. This review provides a comprehensive overview of the factors and mechanisms that promote cellular plasticity in the mammary gland. It discusses changes in cell identity during normal development, the role of the gestation cycle, and highlights the importance of the microenvironment and extracellular matrix. The review also explores cellular reprogramming during mammary tumorigenesis, focusing on the origin of basal-like breast cancers and the role of oncogenic signaling networks. Additionally, recent advances in genetically engineered models to study cellular plasticity in vivo are discussed.
Review
Biochemistry & Molecular Biology
Mariam Rusidze, Marine Adlanmerini, Elodie Chantalat, I. Raymond-Letron, Surya Cayre, Jean-Francois Arnal, Marie-Ange Deugnier, Francoise Lenfant
Summary: This review discusses the role of ER alpha in mammary gland development and breast cancer progression, highlighting both the classical nuclear genomic and membrane non-genomic actions of ER alpha in regulating mammary development at different stages. It also provides an overview of the characteristics of luminal cell lineage expressing ER alpha and the impact of ER alpha signaling in transgenic mouse models, emphasizing its pivotal role in mammary gland morphogenesis and function as well as its implication in tumorigenesis. Additionally, the review covers the main features of ER alpha-positive luminal breast cancers and their modeling in mice.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Shinnosuke Ono, Atsushi Yamada, Junichi Tanaka, Akane Yukimori, Kiyohito Sasa, Kenji Mishima, Takahiro Funatsu, Ryutaro Kamijo
Summary: Research on salivary gland development and related mechanisms is crucial for the treatment of salivary diseases. This study investigated the role of BMP-2 in salivary gland formation using an organ culture system. The results suggest that BMP-2 suppresses salivary gland formation, particularly acinar differentiation, through the Smad pathway.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Veterinary Sciences
Aolei Chen, Shaotang Ye, Jiahui Zheng, Jichao Li, Zejia Chen, Yashan Zhang, Shoujun Li
Summary: In this study, a cancerous HER2-enriched myoepithelial cell line from canine mammary tumor and a mammosphere developed from myoepithelial cells were successfully established. This novel cell line and its associated mammospheres could be used as a model to investigate the role of myoepithelial cells in the development of mammary tumors.
BMC VETERINARY RESEARCH
(2023)
Review
Cell Biology
Elena Spina, Pamela Cowin
Summary: Embryonic mammary gland development involves multiple steps, including the formation of mammary placodes and mammary buds, as well as the development of ductal trees. Studies have identified factors and pathways that influence these steps, and there is a deeper understanding of the characteristics of mammary stem cells and progenitor cells.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Swarajit Kumar Biswas, Saswati Banerjee, Ginger Wendolyn Baker, Chieh-Yin Kuo, Indrajit Chowdhury
Summary: The mammary gland, a compound and branched structure, plays a crucial role in mammalian reproduction by producing milk. Its development involves hormonal regulation and different stages of morphogenesis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Nguyen Xuan Thang, Dong Wook Han, Chanhyeok Park, Hyeonji Lee, Hyeonwoo La, Seonho Yoo, Heeji Lee, Sang Jun Uhm, Hyuk Song, Jeong Tae Do, Kyoung Sik Park, Youngsok Choi, Kwonho Hong
Summary: This study investigated the relationship between INO80 expression and breast cancer sub-classification and progression using weighted gene co-expression network analysis (WCGNA). The findings suggest that INO80 repression is associated with increased risk of breast carcinogenesis and differential responsiveness of estrogen receptors.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Uijin Kim, Suyeon Kim, Nahyun Kim, Ha Youn Shin
Summary: The activation of mammary-specific super-enhancers relies on protein-protein interactions between mammary-enriched transcription factors, and ELF5 and STAT5A play key roles in the activation of the super-enhancers.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Karolina Kowalska, Dominika Ewa Habrowska-Gorczynska, Marta Justyna Koziel, Kinga Anna Urbanek, Kamila Dominska, Agnieszka Wanda Piastowska-Ciesielska
Summary: Mycotoxins are common food and feed pollutants, with potential toxicity. This study found that AOH significantly affects cell viability and motility, inducing oxidative stress, DNA damage, and cell cycle arrest.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, General & Internal
Zhihao Zhang, Yueyuan Wang, Xiao Xie, Jingyu Peng, Jinghui Hong, Lirong Bi, Ming Yang
Summary: Adenomyoepithelioma (AME) is a rare tumor with controversial treatment approaches due to limited high-quality data and prospective studies. Simple mastectomy is considered an acceptable treatment option for this tumor.
Review
Cell Biology
Jakub Sumbal, Denisa Belisova, Zuzana Koledova
Summary: This article summarizes key studies that unravel the roles of fibroblasts in mammary gland development. Additionally, it discusses the origin, heterogeneity, and plasticity of mammary fibroblasts during mammary development and cancer progression.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2021)
Article
Endocrinology & Metabolism
Georgia Colleluori, Jessica Perugini, Giorgio Barbatelli, Saverio Cinti
Summary: The mammary gland is an exocrine gland responsible for milk production in female mammals, composed mainly of epithelial cells and adipocytes. It displays highly plastic properties during different stages of the lactation cycle and requires close association with adipocytes for proper development. The role of adipocytes in mammary gland development and diseases like obesity and breast cancer deserves further investigation.
REVIEWS IN ENDOCRINE & METABOLIC DISORDERS
(2021)
Article
Biology
Kohei Saeki, Gregory Chang, Noriko Kanaya, Xiwei Wu, Jinhui Wang, Lauren Bernal, Desiree Ha, Susan L. Neuhausen, Shiuan Chen
Summary: The study presents an integrated mammary cell gene expression atlas derived from mouse and human single-cell RNA-sequence data, characterizing key life stages of mammary gland remodeling and inferring cells of origin for various breast cancer subtypes using breast cancer expression data.
COMMUNICATIONS BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Kiley Graim, Dmitriy Gorenshteyn, David G. Robinson, Nicholas J. Carriero, James A. Cahill, Rumela Chakrabarti, Michael H. Goldschmidt, Amy C. Durham, Julie Funk, John D. Storey, Vessela N. Kristensen, Chandra L. Theesfeld, Karin U. Sorenmo, Olga G. Troyanskaya
Summary: Studying canine mammary tumors can model molecular changes in human breast cancer, improving diagnostics and treatments. Utilizing multiple canine tumor samples reveals specific biological pathways of malignant tumors compared to benign and normal tissues. Research indicates that multiple histological samples per patient are crucial for capturing disease progression-related features in human breast cancer.
Article
Developmental Biology
Mary Taglienti, Daniel Graf, Valerie Schumacher, Jordan A. Kreidberg
Summary: The mammalian kidney is composed of nephrons, which are formed through mesenchymal-to-epithelial transformation by nephron progenitor cells. Bmp7 plays a major role in determining nephron number and driving their proliferation, ultimately contributing to the development of a mature kidney.
Editorial Material
Immunology
Consolato M. Sergi
Article
Surgery
Joseph de Nanassy, David Mack, Marcos Bettolli, Consolato M. Sergi
Summary: We report a case of a pediatric patient with Crohn disease who presented with a non-Meckel diverticulum in the colonic wall of the cecum. This is the first report of such a diverticulum in a child with Crohn disease and we examine the underlying mechanics. The diverticulum formed at the site of maximum stricture and weakest point in the bowel wall due to the inflammatory bowel disease. The time interval between diagnosis of ileocecal stricture and surgery was important for the development of this diverticulum. Continued follow-up in adulthood is necessary due to the increased risk of intestinal diverticular disease and neoplasms in patients with Crohn disease.
JOURNAL OF SURGICAL CASE REPORTS
(2022)
Article
Religion
Consolato M. Sergi, Tomy Mullur
Summary: Despite advancements in technology and medical care, the reasons for perinatal loss can still remain a mystery. It is important for medical professionals to prioritize culturally sensitive discussions, but religious and spiritual beliefs often get overlooked. This article highlights the significance of spiritual and theological responses in helping parents cope with stillbirth and emphasizes the critical role of chaplains in supporting both families and physicians.
JOURNAL OF PASTORAL CARE & COUNSELING
(2022)
Article
Oncology
Jayanthi Vijayakumar, Tufia Haddad, Kalpna Gupta, Janet Sauers, Douglas Yee
Summary: The clinical activity of naltrexone in patients with ER-positive metastatic breast cancer was evaluated. The results showed that naltrexone exhibited modest activity in stabilizing or reducing tumor SUVmax values in this short study. However, further development of the drug in hormone refractory breast cancer is not supported.
INVESTIGATIONAL NEW DRUGS
(2023)
Article
Oncology
Irene Donato, Kiran K. Velpula, Andrew J. Tsung, Jack A. Tuszynski, Consolato M. Sergi
Summary: This study proposes a mathematical and computational approach to diagnose neuroblastoma by calculating image entropy, fractal dimension, and lacunarity. The method is able to automatically predict tumor malignancy and may challenge the current classification of neuroblastoma.
Review
Dentistry, Oral Surgery & Medicine
Daniela M. Roth, Jeremie Oliver Pina, Melissa MacPherson, Curtis Budden, Daniel Graf
Summary: This article reviews the biological causes of widened cranial sutures and persistent fontanelles in craniofacial syndromes, exploring the roles of progenitor cell differentiation, extracellular matrix production, mineralization, and bone resorption. It highlights the gaps in understanding complex craniofacial disorders and calls for further research integrating genetics, cellular biology, and clinical pillars of health science.
CLEFT PALATE CRANIOFACIAL JOURNAL
(2023)
Article
Biochemistry & Molecular Biology
Bhumika Rajoria, Xihong Zhang, Douglas Yee
Summary: The Insulin-like Growth Factor (IGF) system has long been studied in breast cancer progression, but targeting it has not been successful due to the complexity and homology of its receptors. This study examined the metabolic phenotype of breast cancer cells upon stimulation with IGF-1 and insulin. The results showed that IGF-1R, but not IR, regulates ATP production, providing evidence of the relationship between metabolic dysfunction, cancer, and the IGF axis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Medicine, General & Internal
Josef Hager, Consolato M. Sergi
Summary: Factors such as population migration, tourism, dog translocations, and poor hygiene practices contribute to the spread of echinococcosis. Prompt diagnosis of cystic echinococcosis (CE) should be considered when a cyst-like mass is found in the liver or lung of individuals with a history of exposure to sheepdogs in endemic areas. Routine imaging techniques and serologic investigations are used for detection and confirmation. Treatment options for pediatric echinococcosis include drug therapy and surgical interventions.
Editorial Material
Medicine, General & Internal
Consolato M. Sergi
Summary: Road accidents involving dangerous chemical compounds pose a hazard to public health worldwide. This commentary briefly reviews a recent event in East Palestine, Ohio and discusses one of the chemicals involved, which has a predisposition to initiate a carcinogenic process. The author, as a consultant for the International Agency for Research on Cancer, has reviewed numerous chemical compounds.
Review
Medicine, General & Internal
Consolato M. Sergi, Deborah Spencer, Taher Al-Jishi
Summary: This article summarizes the most frequent findings discussed at multidisciplinary team (MDT) meetings, including pathological findings of stillbirth and the importance of the placenta.
JOURNAL OF LABORATORY PHYSICIANS
(2023)
Article
Endocrinology & Metabolism
Xihong Zhang, Sidhant Varma, Douglas Yee
Summary: Inhibition of IRS-1 protein can suppress both IGFR-IR and IR, leading to inhibition of growth and regulation in hormone-dependent breast cancer cells. This study reveals the crucial role of IRS-1 in endocrine responsive breast cancer.
Article
Genetics & Heredity
Michael A. Carpenter, Nuri A. Temiz, Mahmoud A. Ibrahim, Matthew C. Jarvis, Margaret R. Brown, Prokopios P. Argyris, William L. Brown, Gabriel J. Starrett, Douglas Yee, Reuben S. Harris
Summary: The single-stranded DNA cytosine deamination by APOBEC3 enzymes is a significant source of mutation in cancer, and both APOBEC3A and APOBEC3B contribute to the overall mutation landscape.
Letter
Obstetrics & Gynecology
Consolato M. Sergi, Tomy Mullur
ARCHIVES OF GYNECOLOGY AND OBSTETRICS
(2023)
Review
Orthopedics
Pranidhi Baddam, Francy Bayona-Rodriguez, Sandra M. Campbell, Hamdy El-Hakim, Daniel Graf
Summary: This scoping review consolidates the existing knowledge on nasal septum cartilage (NSC) properties and identifies the gaps in knowledge and research questions for future investigations. The growth, extracellular matrix, and mechanical properties of NSC are not uniform, varying with age and location. Most articles focus on studying the growth properties of NSC, while the interrelationship between multiple cartilage properties is rarely explored. It emphasizes the need for understanding the intersection of various cartilage properties and using standardized assessment protocols to describe NSC.
Review
Developmental Biology
Cheng Shi, Pengfei Jiao, Zhiyi Chen, Lan Ma, Siyue Yao
Summary: This review discusses the molecular etiology of congenital craniofacial abnormalities, with a focus on the role and mechanism of noncoding RNAs in regulating craniofacial development. Aberrant expression of noncoding RNAs has been implicated in the pathogenesis of craniofacial abnormalities, providing potential therapeutic targets.
DEVELOPMENTAL BIOLOGY
(2024)
Article
Developmental Biology
Hideru Togashi, Steven Ray Davis, Makoto Sato
Summary: Tile patterns, regulated by cell adhesion molecules, are regular arrangements of cells that play important functional roles in multicellular organisms. The physical constraints and cell adhesion regulate both cell shape and tissue morphogenesis.
DEVELOPMENTAL BIOLOGY
(2024)
Article
Developmental Biology
Armen Khanbabei, Lina Segura, Cynthia Petrossian, Aaron Lemus, Ithan Cano, Courtney Frazier, Armen Halajyan, Donnie Ca, Mariano Loza-Coll
Summary: This article investigates the genetic regulatory mechanisms of Drosophila intestinal stem cells. The study found that most target genes co-regulated by Esg and STAT show a consistent gene expression pattern. However, manipulating these validated targets in vivo rarely replicated the effects of manipulating Esg and STAT, suggesting the presence of complex genetic interactions among the downstream targets of these two master regulator genes.
DEVELOPMENTAL BIOLOGY
(2024)
Article
Developmental Biology
Bayley J. Waters, Zoe R. Birman, Matthew R. Wagner, Julia Lemanski, Barak Blum
Summary: Researchers found that conditional deletion of Robo2 in adult mice led to a significant loss of islet architecture without affecting beta cell identity or function, suggesting that Robo2 plays a role in actively maintaining adult islet architecture. Understanding the factors required for islet architecture maintenance is crucial for developing future diabetes therapies.
DEVELOPMENTAL BIOLOGY
(2024)
Article
Developmental Biology
Rhiannon Clements, Tyler Smith, Luke Cowart, Jennifer Zhumi, Alan Sherrod, Aidan Cahill, Ginger L. Hunter
Summary: Cell protrusions play a crucial role in regulating cell activities during development. By studying the regulation mechanism in fruit fly sensory bristle patterning, it was found that Myosin XV is essential for the dynamics of signaling filopodia and promotes long-range Notch signaling.
DEVELOPMENTAL BIOLOGY
(2024)
Article
Developmental Biology
Margaret Keating, Ryan Hagle, Daniel Osorio-Mendez, Anjelica Rodriguez-Parks, Sarah I. Almutawa, Junsu Kang
Summary: Knock-in reporter (KI) animals are essential for studying gene expression in biomedical research. This study developed a new strategy using minicircle technology and a minimal promoter to enhance knock-in events and establish stable KI transgenic reporter lines. The study also highlighted the importance of selecting the proper KI line due to potential inappropriate influence of genome editing on reporter gene expression.
DEVELOPMENTAL BIOLOGY
(2024)
Article
Developmental Biology
Christian Altbuerger, Meta Rath, Daniel Armbruster, Wolfgang Driever
Summary: This study reveals that Neurog1 and Olig2 transcription factors have differential requirements for the development of dopaminergic neurons, and they integrate local patterning signals and Notch neurogenic selection signaling to specify the progenitor population and initiate neurogenesis and differentiation.
DEVELOPMENTAL BIOLOGY
(2024)