Article
Cell Biology
Yajun Xie, Aaron T. Kuan, Wengang Wang, Zachary T. Herbert, Olivia Mosto, Olubusola Olukoya, Manal Adam, Steve Vu, Minsu Kim, Diana Tran, Nicolas Gomez, Claire Charpentier, Ingie Sorour, Tiara E. Lacey, Michael Y. Tolstorukov, Bernardo L. Sabatini, Wei-Chung Allen Lee, Corey C. Harwell
Summary: Neuron-glia interactions, particularly through the Sonic hedgehog (Shh) pathway, play a crucial role in coordinating synaptic connectivity in the cortex. Shh signaling in cortical astrocytes regulates synaptic development, astrocyte morphology, and excitatory synapse formation, ultimately shaping circuit assembly and function during development. Loss of Shh in layer V neurons affects astrocyte complexity and synaptic coverage, while activation of Shh signaling in astrocytes promotes cortical synapse formation.
Article
Biochemistry & Molecular Biology
Su Woong Jung, Su-Mi Kim, Arum Kim, Seon Hwa Park, Ju-Young Moon, Sang-Ho Lee
Summary: The midbody plays a crucial role in the transition of fibroblasts into myofibroblasts by mediating TGF-beta/Smad signaling. The pathway related to microtubules is implicated in kidney fibrosis, and blocking microtubule dynamics can improve kidney fibrosis.
Article
Cell Biology
Jun Zhou, Yasamin Dabiri, Rodrigo A. Gama-Brambila, Shahrouz Ghafoory, Mukaddes Altinbay, Arianeb Mehrabi, Mohammad Golriz, Biljana Blagojevic, Stefanie Reuter, Kang Han, Anna Seidel, Ivan Dikic, Stefan Wolfl, Xinlai Cheng
Summary: The study identifies pVHL as an E3 ligase for SMAD3 ubiquitination, which interacts with SMAD3 triggering its degradation, negatively regulating the TGF-beta/SMAD3 signaling pathway. Loss of pVHL in Drosophila leads to up-regulation of TGF-beta targets and a downward wing blade phenotype, rescued by inhibition of SMAD activity. The ectopic veinlets and reduced wing growth observed in Drosophila upon pVHL expression mirrors the effects seen with loss of TGF-beta/SMAD signaling.
JOURNAL OF CELL BIOLOGY
(2021)
Article
Dentistry, Oral Surgery & Medicine
Shunhui Yin, Fengmei Jia, Liquan Ran, Liangkun Xie, Zhiyao Wu, Yeming Zhan, Yan Zhang, Mingzhu Zhang
Summary: This study investigates the effects of exosomes derived from idiopathic gingival fibroma fibroblasts on the proliferation and apoptosis of normal gingival fibroblasts. The results demonstrate that these exosomes play a role in regulating the proliferation and apoptosis of gingival fibroblasts.
Article
Oncology
Bei Pu, Xu Zhang, Tengfeng Yan, Yuntao Li, Baohui Liu, Zhihong Jian, Omer Kamal Mahgoub, Lijuan Gu, Xiaoxing Xiong, Ning Zou
Summary: Recent studies have shown that MICAL2 plays a role in promoting proliferation and migration of glioblastoma through the TGF-beta/p-Smad2/EMT-like signaling pathway. Knockdown of MICAL2 can inhibit the growth and invasion abilities of glioblastoma cells. High MICAL2 expression predicts poor prognosis in GBM patients, making it a potential therapeutic target.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Edyta Dzialo, Marcin Czepiel, Karolina Tkacz, Maciej Siedlar, Gabriela Kania, Przemyslaw Blyszczuk
Summary: The study revealed that WNT/beta-catenin signaling promotes the transition of cardiac fibroblasts to myofibroblasts by enhancing IL-11 production in TGF-beta-mediated pathways, while non-canonical WNT5a co-activation suppressed TGF-beta-induced collagen I production.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Medicine, Research & Experimental
Jitang Chen, Ze-yang Ding, Si Li, Sha Liu, Chen Xiao, Zifu Li, Bi-xiang Zhang, Xiao-ping Chen, Xiangliang Yang
Summary: Targeting TGF beta signaling for cancer therapy presents challenges and opportunities, as inhibitors can enhance chemotherapy efficacy but must also consider the dual role of TGF beta in normal tissues and tumors to avoid unwanted side effects.
Article
Environmental Sciences
Shiwen Liu, Yumeng Hu, Yue Wang, Yeqing Sun, Shu-Lan Qin, Dan Xu
Summary: The study found that endosulfan may cause excessive cell proliferation and accumulation of extracellular matrix in human renal mesangial cells through the TGF-β/Smad signaling pathway, as well as induce oxidative stress and inflammation.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Cell Biology
Nongthombam Boby, Alyssa Ransom, Barcley T. Pace, Kelsey M. Williams, Christopher Mabee, Arpita Das, Sudesh K. Srivastav, Edith Porter, Bapi Pahar
Summary: Increased production of TGF-beta was observed in intestinal CD3(-)CD20(-)CD68(+) cells from SIV-infected rhesus macaques, which negatively correlated with the frequency of jejunum CD4(+) T cells. Disruption of a negative feedback loop mediated by SMAD7 may enhance TGF-beta production and SMAD-dependent signaling in SIV infection.
Review
Cell Biology
Maoduo Zhang, Ying Yi Zhang, Yongze Chen, Jia Wang, Qiang Wang, Hezhe Lu
Summary: The TGF-beta pathway in cancer has dual roles and is considered a potential new avenue for cancer therapy, but its functions and mechanisms of action require further investigation.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Neurosciences
Ana M. Hernandez-Vega, Ignacio Camacho-Arroyo
Summary: The study demonstrates that E2 and TGF-β signaling pathways interact through ER-α and Smad2/3 mediators in human GBM cells and inhibit EMT activation induced by both factors alone.
Article
Biotechnology & Applied Microbiology
Jincheng Wu, Pei Yu, Huling Lv, Shuang Yang, Zhe Wu
Summary: The study investigated the effect of different nanostructured zirconia surface topographies on macrophage phenotypes, with blank-machined zirconia surfaces showing superior cell proliferation and adhesion. It was found that RAW264.7 cells polarized towards both inflammatory and anti-inflammatory macrophages on all nanostructured zirconia surfaces, with a higher expression of M2 macrophage phenotype on BMZ surfaces. Additionally, conditioned media from RAW264.7 culture on these surfaces inhibited cell apoptosis to human gingival fibroblasts while promoting fibroblast proliferation and secretion.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Oncology
Yanyan Feng, Chuanyu Sun, Lifeng Zhang, Hongyuan Wan, Hangsheng Zhou, Yongquan Chen, Lijie Zhu, Guowei Xia, Yuanyuan Mi
Summary: The coatomer protein complex subunit beta 2 (COPB2) plays an important role in prostate cancer by promoting the proliferation and invasion of cancer cells through the regulation of the MAPK/TGF-beta signaling pathway. COPB2 could potentially serve as a new biomarker for diagnosis and monitoring of prostate cancer.
FRONTIERS IN ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Leonardo Martini, Seung Han Baek, Ian Lo, Benjamin A. Raby, Edwin K. Silverman, Scott T. Weiss, Kimberly Glass, Arda Halu
Summary: The versatility of cellular response arises from the communication and crosstalk of signaling pathways in a complex network. This study presents a network-based statistical approach called MuXTalk that models the unique ways in which signaling and regulatory interactions can interface. Using statistically over-represented multilinks as proxies of crosstalk, crosstalk among 60 signaling pathways is inferred, expanding currently available crosstalk databases significantly.
NUCLEIC ACIDS RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
Jeff Yat-Fai Chung, Max Kam-Kwan Chan, Jane Siu-Fan Li, Alex Siu-Wing Chan, Philip Chiu-Tsun Tang, Kam-Tong Leung, Ka-Fai To, Hui-Yao Lan, Patrick Ming-Kuen Tang
Summary: TGF-beta signaling plays crucial roles in inflammatory diseases by regulating immunocytes in tissue fibrosis and accelerating tumor development in cancer. The pleiotropic nature of TGF-beta signaling in generating fibrotic TME, containing CAFs and matrix proteins, remains largely unclear, despite recent studies demonstrating its clinical implications in cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Dentistry, Oral Surgery & Medicine
Yu-Tang Chin, Hsiao-Pei Tu, Chi-Yu Lin, Po-Jan Kuo, Hsien-Chung Chiu, Shao-Hsien Liu, Sheng-Yang Lee, Earl Fu
Summary: The study demonstrated the significance of reactive oxygen species (ROS) in the development of gingival overgrowth (GO) and proposed an antioxidant strategy to prevent or reduce GO. Antioxidants, including vitamin E and sulforaphane, were found to ameliorate CsA-induced pathological and morphological alterations in GO without interfering with CsA's immunosuppressive effects. This research provides valuable insights for clinicians in devising better prevention strategies for patients susceptible to GO.
JOURNAL OF PERIODONTAL RESEARCH
(2021)
Article
Dentistry, Oral Surgery & Medicine
Min-Chia Chen, Hsien-Chung Chiu, Po-Jan Kuo, Cheng-Yang Chiang, Martin M. Fu, Earl Fu
Summary: The study found that implanting a 900mm pore size 3D-printed PCL scaffold can facilitate new bone formation in critical-size calvarial defects, while adding PRF did not provide additional advantages.
JOURNAL OF DENTAL SCIENCES
(2021)
Article
Dentistry, Oral Surgery & Medicine
Tzu-Ying Chen, Po-Jan Kuo, Chi-Yu Lin, Tsung-Fu Hung, Hsien-Chung Chiu, Cheng-Yang Chiang, Kuang-Chung Shih, Earl Fu
Summary: Through the CyPA pathway, both LPS and hGF could enhance the MMP-9 expression in U937 cells. The results showed that extra-supplied CyPA increased MMP-9 mRNA and enzyme activity, while the CyPA inhibitor, cyclosporine A, suppressed the LPS- and co-culture-enhanced MMP-9. Additionally, MAP kinase inhibitors (PD98059 and SP600125) also suppressed the CyPA-enhanced MMP-9 in U937 cells.
JOURNAL OF PERIODONTOLOGY
(2022)
Article
Biology
Yi Chung, Yi-Ting Hsiao, Wen-Ching Huang
Summary: The study revealed the negative effects of overtraining on both physiological and psychological aspects, such as imbalanced energy expenditure, exacerbated inflammatory response, increased anxiety status, elevated inflammatory cytokines and immune cells, and decreased food intake. This highlights the importance of addressing the maladaptation of overtraining and using an animal model to explore effective strategies for treatment and prevention in future studies.
Article
Dentistry, Oral Surgery & Medicine
Martin M. Fu, Rebecca Y. Chen, Min-Wen Fu, Huan-Chen Kao, Huan-Chiao Kao, Hsun-Liang Chan, Earl Fu, Tony Szu-Hsien Lee
Summary: This study compared the life satisfaction among different dentist groups in Taiwan and found that US-trained specialists were more likely to be satisfied with their lives, while career-related factors had little impact on life satisfaction.
INTERNATIONAL DENTAL JOURNAL
(2022)
Article
Dentistry, Oral Surgery & Medicine
Martin M. Fu, Wu-Chien Chien, Chi-Hsiang Chung, Wei-Cheng Lee, Hsiao-Pei Tu, Earl Fu
Summary: The study suggests that patients with periodontitis may have an increased risk of developing benign colorectal tumors, but not malignant ones.
JOURNAL OF PERIODONTAL RESEARCH
(2022)
Article
Environmental Sciences
Yi Chung, Hsin-Hui Huang
Summary: The study indicates that cognitive interventions, such as gender equality curriculum, help break gender stereotypes in kindergarten children. Children in the experimental group who participated in the gender equality curriculum were more likely to choose non-stereotypical relationships in picture classification tasks, while children in the control group were more inclined to maintain gender stereotype relationship choices.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Article
Dentistry, Oral Surgery & Medicine
Suzanne Ying-Shan Su, Wu-Chien Chien, Chi-Hsiang Chung, Wan-Fu Su, Earl Fu
Summary: This study suggests an association between periodontitis and tinnitus.
JOURNAL OF CLINICAL PERIODONTOLOGY
(2022)
Article
Dentistry, Oral Surgery & Medicine
Ling-Yu Liang, Ming-Che Tsai, Kuang-Chung Shih, Shiu-Ming Huang, Donald E. Morisky, Earl Fu
Summary: The study estimated the tooth lifespan and burden of tooth loss in Taiwan using National Health Insurance data. It found an increasing trend in tooth extraction rate with age, varied ASTER-T among different tooth types, and the maximum YLDs-T for first molars.
JOURNAL OF DENTAL SCIENCES
(2022)
Article
Nutrition & Dietetics
Syun-Hui Tsai, Yu-Hwei Tseng, Wen-Fei Chiou, Shih-Ming Chen, Yi Chung, Wen-Chi Wei, Wen-Ching Huang
Summary: This study explored the effects of whole-body vibration (WBV) and excessive fructose consumption on menopausal women. The results showed that WBV can improve obesity, glucose intolerance, and inflammation, while excessive fructose intake negatively affects menopausal health.
FRONTIERS IN NUTRITION
(2022)
Article
Food Science & Technology
Yi Chung, Jia-Ling Wu, Wen-Ching Huang
Summary: Insufficient or disrupted sleep can be caused by night shifts, work pressure, and irregular lifestyles. This study used mice to investigate the effects of sleep deprivation on various physiological and psychological aspects, and whether a prebiotics mixture could mitigate those effects. The results showed that sleep deprivation caused intestinal inflammation, decreased intestinal permeability, and affected gene expression. However, supplementing with prebiotics improved these effects, as well as blood sugar homeostasis and exercise performance.
FOOD RESEARCH INTERNATIONAL
(2023)
Article
Endocrinology & Metabolism
Wu-Chien Chien, Earl Fu, Chi-Hsiang Chung, Chia-Mao Cheng, Hsiao-Pei Tu, Wei-Cheng Lee, Wei-Liang Chen, Kuang-Chung Shih
Summary: This study used the National Health Insurance Research Database of Taiwan to find that periodontitis patients are more likely to develop type 2 diabetes, while patients with diabetes are more likely to have severe periodontitis.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Dentistry, Oral Surgery & Medicine
Ying-Wu Chen, Ming-Lun Lee, Cheng-Yang Chiang, Earl Fu
Summary: This study examined the effects of Bifidobacterium and Lactobacillus on periodontitis using a rat model. The results showed that the combination of these probiotics enhanced IL-10 levels and ameliorated the symptoms of periodontitis. Single-use of probiotics also had some alleviating effects.
JOURNAL OF DENTAL SCIENCES
(2023)
Article
Dentistry, Oral Surgery & Medicine
Earl Fu, Chan-Yen Kuo, Yi-Jan Hsia, Yiao-Mien Huang, Hui-Hwa Tseng, Min-Wen Fu, Kuang-Chung Shih
Summary: This study aimed to investigate the temporal pattern of ferroptosis in ligation-induced rat periodontitis and the effect of ferrostatin-1 on the model. The results revealed the role of ferroptosis via the system Xc/Gpx4 pathway in experimental periodontitis and suggested it as a potential regulatory strategy.
JOURNAL OF PERIODONTAL RESEARCH
(2023)
Correction
Biology
Yi Chung, Yi-Ting Hsiao, Wen-Ching Huang
