Review
Biochemistry & Molecular Biology
Caterina Anania, Giulia Brindisi, Ivana Martinelli, Edoardo Bonucci, Miriam D'Orsi, Sara Ialongo, Anna Nyffenegger, Tonia Raso, Mattia Spatuzzo, Giovanna De Castro, Anna Maria Zicari, Carlo Carraro, Maria Grazia Piccioni, Francesca Olivero
Summary: Atopic dermatitis is a chronic inflammatory skin disorder with increasing prevalence in children and adults. The potential role of probiotics in preventing atopic dermatitis has generated considerable interest, as they can modulate systemic inflammation and immune responses. However, the molecular mechanisms and efficacy of probiotics in anti-allergic effects are still unclear and controversial.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Microbiology
Hsin-Yu Chen, Yung-Tsung Chen, Kuan-Yi Li, Hsiao-Wen Huang, Yu-Chun Lin, Ming-Ju Chen
Summary: Through experiments in a house dust mite (HDM) extraction-induced atopic dermatitis (AD) mouse model, it was found that administration of a mixture of heat-killed Lactococcus lactis subsp. cremoris MP01 and Lactobacillus paracasei subsp. paracasei MP02 relieved AD symptoms, decreased serum IgE concentration, and rebalanced the population of Th1/Th2 cells in the spleen.
Article
Biochemistry & Molecular Biology
Manami Toriyama, Defri Rizaldy, Motoki Nakamura, Yukiko Atsumi, Michinori Toriyama, Fumitaka Fujita, Fumihiro Okada, Akimichi Morita, Hiroshi Itoh, Ken J. Ishii
Summary: Atopic dermatitis is a common allergic skin disorder affecting up to 10% of adults in developed countries. This study reveals the presence of a previously unknown primary cilium-like structure in dendritic cells (DCs) and Langerhans cells (LCs), which becomes aberrantly expressed in AD patients. These findings suggest a potential role of the primary cilium in the pathogenesis of AD and may provide a new target for its treatment.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2023)
Article
Allergy
Pierre Marschall, Ruicheng Wei, Justine Segaud, Wenjin Yao, Pierre Hener, Beatriz Falcon German, Pierre Meyer, Cecile Hugel, Grace Ada Da Silva, Reinhard Braun, Daniel H. Kaplan, Mei Li
Summary: This study explores the dual functionality of Langerhans cells (LCs) in TSLP-promoted TFH and T(H)2 differentiation in atopic dermatitis (AD) pathogenesis, demonstrating that LCs play different roles in different mouse models of AD, promoting TFH/GC response in one model and inhibiting it in another.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2021)
Article
Microbiology
Chi Tung Choy, Pui Ling Kella Siu, Junwei Zhou, Chi Ho Wong, Yuk Wai Lee, Ho Wang Chan, Joseph Chi Ching Tsui, Claudia Jun Yi Lo, Steven King Fan Loo, Stephen Kwok Wing Tsui
Summary: This study focused on pediatric atopic dermatitis (AD) patients in southern China and used targeted 16S rRNA sequencing and bioinformatic analysis to investigate the impact of orally administered probiotics on the gut microbiome. After an 8-week course of probiotics, a significant improvement in the Eczema Area and Severity Index (EASI) was observed, with no adverse effects. The relative abundances of key microbial drivers also increased. The study provides preliminary evidence supporting targeted probiotic supplementation for childhood AD management.
Review
Medicine, Research & Experimental
Camila Stofella Sodre, Mayra Stambovsky Vieira, Juliany Lima Estefan, Cristiane Moraes, Fernanda Sampaio Cavalcante, Katia Regina Netto dos Santos, Dennis de Carvalho Ferreira
Summary: A literature review found that probiotics have the potential to improve symptoms of atopic dermatitis in adult patients, reducing itchiness and severity as measured by SCORAD. However, there is still controversy and divergence regarding the actual benefits of probiotics in this context.
EUROPEAN JOURNAL OF MEDICAL RESEARCH
(2022)
Review
Immunology
Chunjiao Zheng, Yuling Shi, Ying Zou
Summary: The use of immune checkpoint inhibitors (ICIs) in cancer treatment may lead to progressive atopic dermatitis (AD) by affecting T cell reactivation. T cell co-signaling pathways play a critical role in the pathogenesis of AD, determining the magnitude of the T cell response to antigens. Understanding these pathways is important for investigating the mechanism and treatment of AD.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Immunology
Zhifeng Fang, Lingzhi Li, Hao Zhang, Jianxin Zhao, Wenwei Lu, Wei Chen
Summary: Atopic dermatitis (AD) is increasing in urban areas, and recent advances show that the development of AD is associated with gut microbiota and skin microbiome. Probiotics can improve AD by enhancing the intestinal environment and balancing immune responses, offering an alternative for prevention and treatment. Studies suggest that targeting gut microbiota with probiotics may help alleviate AD by boosting epidermal barrier and regulating immune signaling.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Bo-Rui Chen, Kung-Ting Hsu, Tsung-Lin Li, Yi-Lin Chan, Chang-Jer Wu
Summary: The study demonstrates that fucoidan derived from Cladosiphon okamuranus inhibits nitric oxide production, reduces immunocyte proliferation, decreases epidermal hyperplasia and eosinophilic infiltration, regulates systemic immunity, promotes skin repair, and alleviates itching symptoms. Additionally, it up-regulates TGF-beta 1 level and down-regulates AD-associated cytokines, effectively improving atopic dermatitis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Nutrition & Dietetics
Paula Danielle Santa Maria Albuquerque de Andrade, Jorgete Silva, Vanessa Carregaro, Lais Amorim Sacramento, Luciana Rodrigues Roberti, Davi Casale Aragon, Fabio Carmona, Persio Roxo-Junior
Summary: This study evaluated the clinical efficacy of a mixture of Lactobacillus and Bifidobacterium probiotics in children and adolescents with atopic dermatitis. The results showed that this probiotic mixture significantly reduced skin symptoms and the need for immunosuppressants.
FRONTIERS IN NUTRITION
(2022)
Article
Nutrition & Dietetics
Bozena Cukrowska, Aldona Ceregra, Elzbieta Maciorkowska, Barbara Surowska, Maria Agnieszka Zegadlo-Mylik, Ewa Konopka, Ilona Trojanowska, Magdalena Zakrzewska, Joanna Beata Bierla, Mateusz Zakrzewski, Ewelina Kanarek, Ilona Motyl
Summary: Probiotics were found to significantly improve the severity of AD symptoms in children under 2 years old with both AD and CMP allergy, with the effect still noticeable after three months. Probiotics had a main effect on patients sensitized to allergens, but this effect diminished after nine months. Further research is needed to assess the impact of probiotic supplementation on immune tolerance development.
Article
Allergy
Lennart M. Roesner, Ahmed K. Farag, Rebecca Pospich, Stephan Traidl, Thomas Werfel
Summary: This study compares T cells from lesional skin and blood of patients with atopic dermatitis (AD) and psoriasis, and finds that analyzing the T-cell receptor (TCR) sequences that drive skin-homing T cells helps to clarify the extent to which these infiltrating T cells are antigen-specific.
Article
Plant Sciences
Se Hoon Lee, Jeesuk Yu, Sang Hyun Cho
Summary: The study indicated that a combination of Panax ginseng extract and probiotics has a preventive effect on AD-like skin lesions in mice, reducing transepidermal water loss, serum IgE level, and expression of inflammatory cytokines in the skin.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Review
Pharmacology & Pharmacy
Sabina Fijan, Nina Kolc, Metka Hrasovec, Gro Jamtvedt, Maja Sikic Pogacar, Dusanka Micetic Turk, Uros Maver
Summary: This study evaluated the effect of single-strain probiotic lactobacilli on treating children's atopic dermatitis. The results showed that certain strains were more effective in reducing the severity of atopic dermatitis, and treatment time and patient age also played a role.
Article
Allergy
Juan Manuel Leyva-Castillo, Mrinmoy Das, Emilie Artru, Juhan Yoon, Claire Galand, Raif S. Geha
Summary: The study found that IL-13 released by cutaneous MCs in response to mechanical skin injury inhibits the T(H)1 cell response to cutaneous antigen exposure in AD.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Bong Sun Kim, Cheol-Heui Yun, Seung Hyun Han, Ki-Duk Song, Seok-Seong Kang
Summary: The study demonstrates that the lipoteichoic acid (LTA) of Lactobacillus plantarum can effectively inhibit Salmonella flagellin-induced IL-8 production in porcine peripheral blood mononuclear cells, highlighting its crucial role in enhancing anti-inflammatory responses.
PROBIOTICS AND ANTIMICROBIAL PROTEINS
(2021)
Review
Nutrition & Dietetics
Bon-Hee Gu, Myunghoo Kim, Cheol-Heui Yun
Summary: The gastrointestinal tract contains various immune cells that regulate the balance of tolerance and activation in response to environmental conditions. Dietary components are converted into gut metabolites that significantly impact intestinal immunity.
Article
Immunology
Gil-Woo Lee, Sung-Woo Lee, Juhee Kim, Young-Jun Ju, Hee-Ok Kim, Cheol-Heui Yun, Jae-Ho Cho
Summary: The study identified unique immune contexts in Jak3 (-/-) mice, resulting in IL-2-driven T cell expansion, with potential clinical implications for designing treatment strategies.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Seonggeun Han, Jaewon Kim, Youngseok Lee, Junhyuk Bang, Cheol Gyun Kim, Junhwa Choi, Jinki Min, Inho Ha, Yeosang Yoon, Cheol-Heui Yun, Mutya Cruz, Benjamin J. Wiley, Seung Hwan Ko
Summary: We introduce a transparent and self-sterilizable air filter fabricated using copper nanowires. The filter allows visible light penetration, enabling ease of communication, while effectively capturing particulate matter and exhibiting thermal antibacterial efficacy. It shows high reusability and stability after repeated uses. The results suggest that this filter can serve as an alternative antimicrobial air filter for current and future pandemic situations.
Article
Multidisciplinary Sciences
Narae Kim, Min Jeong Gu, Yoon-Chul Kye, Young-Jun Ju, Rira Hong, Do Bin Ju, Young Jin Pyung, Seung Hyun Han, Byung-Chul Park, Cheol-Heui Yun
Summary: This study evaluated the effect of phage EK99P-1 on ETEC K99-infected porcine intestinal epithelial cells. The results showed that phage EK99P-1 prevented barrier disruption and decreased inflammatory responses caused by ETEC K99. In addition, it also modulated the immune cell inflammatory response by regulating the intestinal barrier and cytokines.
SCIENTIFIC REPORTS
(2022)
Article
Reproductive Biology
Jisoo Han, Inkyu Yoo, Soohyung Lee, Yugyeong Cheon, Cheol-Heui Yun, Hakhyun Ka
Summary: The expression of IL10 and IL12 in the endometrium of pigs shows a specific pattern during pregnancy. IL10 may provide anti-inflammatory conditions for maternal immune tolerance.
BIOLOGY OF REPRODUCTION
(2022)
Editorial Material
Agriculture, Dairy & Animal Science
Cheol-Heui Yun
Review
Materials Science, Multidisciplinary
Mohammad Ariful Islam, Tae-Eun Park, Jannatul Firdous, Hui-Shan Li, Zuly Jimenez, Michael Lim, Jeong-Won Choi, Cheol-Heui Yun, Chong-Su Cho
Summary: Regulating cellular uptake pathways using engineered materials is an important strategy for efficient gene transfer. In this review, the authors discuss the characteristics of gene carriers that affect their uptake, as well as strategies for regulating cellular uptake to improve gene delivery efficacy.
PROGRESS IN MATERIALS SCIENCE
(2022)
Review
Cell & Tissue Engineering
Young Jin Pyung, Da-Jeong Park, Cheol Gyun Kim, Cheol-Heui Yun
Summary: Tissue damage activates immune responses in the lungs, involving both innate and adaptive immune cells. Macrophages and ILC2s are important innate immune cells involved in tissue remodeling, while resident memory T cells control prolonged disease and tissue damage. Understanding the immunological perspective of lung tissue remodeling and damage control is crucial for stakeholders in this field.
TISSUE ENGINEERING AND REGENERATIVE MEDICINE
(2023)
Article
Cell Biology
Ok-Jin Park, Ye-Eun Ha, Ju-Ri Sim, Dongwook Lee, Eun-Hye Lee, Sun-Young Kim, Cheol-Heui Yun, Seung Hyun Han
Summary: In this study, it was found that the combined effect of short-chain fatty acids (SCFAs) and lipoteichoic acid (LTA) from Enterococcus faecalis can enhance inflammasome activation and IL-1 beta production in macrophages, potentially contributing to dental inflammatory diseases such as apical periodontitis.
CELL DEATH DISCOVERY
(2023)
Article
Communication
Yera Hur, Cheol-Heui Yun
Summary: This study aimed to examine the current status of research and publication ethics training in Korean academic organizations and identify ways to strengthen the training. The results showed that more than half of the academic organizations provided training programs, with humanities and social sciences organizations offering more training. The training was mainly conducted in lecture format, and academic organizations preferred case-based discussion methods with expert instructors.
Article
Immunology
Young-Jun Ju, Kyung-Min Lee, Girak Kim, Yoon-Chul Kye, Han Wool Kim, Hyuk Chu, Byung-Chul Park, Jae-Ho Cho, Pahn-Shick Chang, Seung Hyun Han, Cheol-Heui Yun
Summary: This study evaluated the effects of short-term fasting on intestinal dendritic cells (DCs) and their impact on protective immunity. Short-term fasting increased the number of CD103(+)CD11b(-) DCs in the intestine, which showed signs of proliferation and migration. Short-term-fasted mice had reduced bacterial burden and improved survival after infection with Listeria monocylogenes (LM).
Correction
Communication
Cheol-Heui Yun
Proceedings Paper
Engineering, Electrical & Electronic
Payam Hosseinzadeh Kasani, Sara Hosseinzadeh Kasani, Han Wool Kim, Kee Hyun Cho, Jae-Won Jang, Cheol-Heui Yun
Summary: The presence of anti-nuclear autoantibodies in human serum is linked to autoimmune diseases, with the gold standard for testing being indirect immunofluorescence imaging on HEp-2 cells. Accurate classification of HEp-2 cells is crucial for diagnosing immune system diseases. Developing computer-aided diagnosis systems for ANA analysis is necessary to improve disease diagnosis and treatment planning for patients.
12TH INTERNATIONAL CONFERENCE ON ICT CONVERGENCE (ICTC 2021): BEYOND THE PANDEMIC ERA WITH ICT CONVERGENCE INNOVATION
(2021)
Proceedings Paper
Engineering, Electrical & Electronic
Payam Hosseinzadeh Kasani, Sara Hosseinzadeh Kasani, Yeshin Kim, Cheol-Heui Yun, Seong Hye Choi, Jae-Won Jang
Summary: Dementia, particularly Alzheimer's disease, has a significant impact on global healthcare and early and accurate diagnosis is crucial for effective treatment. Developing computer-aided diagnosis systems using machine learning models can provide efficient clinical classification and support clinical decision making.
12TH INTERNATIONAL CONFERENCE ON ICT CONVERGENCE (ICTC 2021): BEYOND THE PANDEMIC ERA WITH ICT CONVERGENCE INNOVATION
(2021)