Article
Endocrinology & Metabolism
Yang Sun, Ye Lv, Hui-Wen Ren, Guan-Yu Wang, Li-Na Xuan, Yi-Yang Luo, Zhi-Lin Luan
Summary: The study found a significant association between MAP3K4 and schizophrenia in the Northeast Chinese Han population, with certain SNPs showing strong correlation with the disease.
METABOLIC BRAIN DISEASE
(2022)
Article
Nutrition & Dietetics
Yu-Min Huang, Weu Wang, Po-Pin Hsieh, Hsin-Hung Chen
Summary: The genetic effect of obesity plays a significant role in the development of an obesogenic environment. Genes rs712221 and rs2016520 are associated with obesity and show a synergistic effect, increasing the risk of obesity.
Article
Biochemistry & Molecular Biology
Maria Radanova, Mariya Levkova, Galya Mihaylova, Rostislav Manev, Margarita Maneva, Rossen Hadgiev, Nikolay Conev, Ivan Donev
Summary: There is a growing interest in studying single nucleotide polymorphisms (SNPs) in microRNA (miRNA) genes, as they may be associated with susceptibility, prognosis, and treatment response in colorectal cancer (CRC). These miRNA-SNPs could serve as non-invasive biomarkers for early detection of CRC. However, contradictory findings have been reported when different research groups investigated the same SNP in a gene for a specific miRNA, highlighting the need for more case-control studies involving participants from different ethnic backgrounds. According to our review, three miRNA-SNPs - miR-146a rs2910164, miR-27a rs895819, and miR-608 rs4919510 - appear to be promising prognostic, diagnostic, and predictive biomarkers for CRC.
Article
Medicine, General & Internal
Antonia Msafiri Makene, Jun-Lin Liu
Summary: This study identified multiple polymorphic loci in the CARD14 gene associated with susceptibility to psoriasis and confirmed the significant correlation of several loci with the development of psoriasis. Bioinformatic analysis further demonstrated the impact of these loci on gene function and identified two protective haplotypes for the disease.
Article
Agronomy
Mohammad Wali Salari, Patrick Obia Ongom, Rima Thapa, Henry T. Nguyen, Tri D. Vuong, Katy Martin Rainey
Summary: This study investigated the genetic control of sucrose, raffinose, and stachyose in soybeans, identifying several quantitative trait loci (QTLs) on chromosomes 1, 3, and 6. These QTLs explain variance in the levels of these carbohydrates, with potential candidate genes involved in seed development and plant growth.
Article
Biochemistry & Molecular Biology
Allison Duncan, Darryl Nousome, Randy Ricks, Huai-Ching Kuo, Lakshmi Ravindranath, Albert Dobi, Jennifer Cullen, Shiv Srivastava, Gregory T. Chesnut, Gyorgy Petrovics, Indu Kohaar
Summary: Growing evidence suggests that genetics plays a role in prostate cancer susceptibility and severity. This study investigated the association between TP53 gene SNPs and clinico-pathological features of prostate cancer in African American (AA) and Caucasian (CA) men. The results showed ancestral differences in allele frequencies, with the TP53 Arg72Pro SNP associated with a shorter time to biochemical recurrence.
Article
Genetics & Heredity
Mao Li, Hejiang Wei, Shuyi Zhong, Yanhui Cheng, Simin Wen, Dayan Wang, Yuelong Shu
Summary: This study investigated the association of leptin gene, leptin receptor gene, and peroxisome proliferator activated receptor gamma gene polymorphisms with humoral immune response to influenza vaccine. The results showed that PPARG rs17793951 variants were significantly associated with immune response to influenza vaccine. Gender differences were found in the association of LEPR and PPARG variants with immune response to influenza vaccine.
FRONTIERS IN GENETICS
(2021)
Article
Plant Sciences
Xi-ou Xiao, Ning Zhang, Hui Jin, Huaijun Si
Summary: This study evaluated the genetic diversity and population structure of 135 autotetraploid potatoes using SLAF-seq methods. Analysis of 3,397,137 high-quality SNPs revealed that the classification of these potatoes based on SNP profiles did not correlate with their geographical origins. Furthermore, 71 PARMS-SNP markers were successfully used to analyze 190 autotetraploid potato varieties. Overall, these novel SNP markers provide a solid foundation for potato genetic diversity analysis, DUS testing, and plant variety protection.
Article
Immunology
Ding-Ping Chen, Ying-Hao Wen, Wei-Tzu Lin, Fang-Ping Hsu, Kuang-Hui Yu
Summary: This study investigated the association between RA and single-nucleotide polymorphisms (SNPs) of co-stimulatory or co-inhibitory molecules. The results showed that there were 13 SNPs associated with RA, which may play an important role in immune regulation and require further research into the pathogenesis of RA.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Ravita Kumari, Shikha Tiwari, Mahendra Atlani, Athira Anirudhan, Sudhir K. Goel, Ashok Kumar
Summary: The prevalence of chronic kidney disease of unknown etiology (CKDu) is increasing globally, including in the Indian population. This study analyzed the association between single nucleotide polymorphisms (SNPs) in three genes and the susceptibility to CKDu. The results showed that certain genetic variants in KCNA10 and SLC13A3 genes were significantly associated with CKDu susceptibility. These findings suggest that genetic factors play a role in the predisposition to CKDu.
BIOCHEMICAL GENETICS
(2023)
Article
Agriculture, Dairy & Animal Science
Peng Wang, Wentao Li, Ziyi Liu, Xiaoyun He, Rong Lan, Yufang Liu, Mingxing Chu
Summary: This study analyzed the association between PPP2R5C and SLC39A5 gene polymorphisms and litter size in Yunshang black goats. The results showed that the polymorphisms PPP2R5C g.65977743C>T and SLC39A5 g.50676693T>C were significantly associated with the litter size of the third parity in Yunshang black goats. Further experiments confirmed that individuals with CC genotype of PPP2R5C and TT genotype of SLC39A5 had higher expression of these genes in goat ovarian tissues. These findings provide new insights into candidate gene selection for marker-assisted selection in goats.
Article
Biochemistry & Molecular Biology
Danial Jahantigh, Saeedeh Ghazaey Zidanloo, Seyedeh Zahra Moossavi, Forough Forghani
Summary: Functional single nucleotide polymorphisms (SNPs) in the IL-12B gene can significantly affect protein expression or modify its functions, potentially leading to immune disorders. The relationship between common IL-12B SNPs and the risk of preeclampsia (PE) has been unclear. A case-control study genotyped 253 PE patients and 250 healthy subjects for IL-12B rs3212227 and IL-12B rs6887695 SNPs. In-silico analysis was also conducted to assess the potential functions of these polymorphisms. The results showed an association between the rs3212227 variation in the IL-12B gene and susceptibility to PE. The rs6887695 SNP correlated negatively with PE development and had a protective effect on PE risk. The study also found certain haplotypes of IL-12B to be more prevalent in PE patients.
Article
Fisheries
Baohua Duan, Tongxu Kang, Haifu Wan, Shumei Mu, Yueqiang Guan, Weibiao Liu, Zejian Li, Yang Tian, Yuqin Ren, Xianjiang Kang
Summary: The SIF gene in the swimming crab (Portunus trituberculatus) was investigated to understand its biological function. The study found that the SIF gene had higher expression in the fast-growing group compared to the slow-growing group, and it was ubiquitously expressed in various tissues, with the highest expression in the heart. Additionally, four SNPs in the SIF gene were found to be significantly associated with growth traits in the swimming crab.
AQUACULTURE REPORTS
(2023)
Article
Medicine, General & Internal
Imaniar Noor Faridah, Haafizah Dania, Rita Maliza, Wan-Hsuan Chou, Wen-Hung Wang, Yen-Hsu Chen, Dyah Aryani Perwitasari, Wei-Chiao Chang
Summary: Dengue is a global arboviral disease that has become a major public health concern. This study investigated the associations of variations in the MICB and PLCE1 genes with dengue severity and thrombocytopenia in Indonesian and Taiwanese populations. The results showed associations between MICB rs3132468 and dengue shock syndrome (DSS), as well as between PLCE1 rs3740360 and secondary dengue hemorrhagic fever (DHF) in Indonesian patients.
Article
Environmental Sciences
Huimin Wang, Guangzhi Yang, Dawei Sun, Boshen Wang, Hao Chen, Mengyao Chen, Baoli Zhu
Summary: The study found an association between genetic polymorphisms rs10499080 and rs6568819 within the HDAC2 gene and the risk of NIHL, indicating that workers exposed to noise with HDAC2 have a lower risk of NIHL.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Clinical Neurology
Ziqi Wang, Jun Li, Tian Zhang, Tianlan Lu, Han Wang, Meixiang Jia, Jing Liu, Jun Xiong, Dai Zhang, Lifang Wang
Summary: The study identified a significant association between rs363018 in SNAP25 and autism in the Han Chinese population, suggesting that SNAP25 may be a susceptibility gene for autism.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2021)
Article
Neurosciences
Qianqian Li, Jun Yan, Jinmin Liao, Xiao Zhang, Lijun Liu, Xiaoyu Fu, Hao Yang Tan, Dai Zhang, Hao Yan
Summary: This study found that stress exacerbated the symptoms of OCD patients and impaired their working memory. Healthy controls showed less brain area activation during the task, while patients did not exhibit this. This indicates that the neural response of patients to stress differs from that of healthy controls.
NEUROSCIENCE BULLETIN
(2021)
Article
Psychiatry
Hui-Juan Li, Chen Zhang, Li Hui, Dong-Sheng Zhou, Yi Li, Chu-Yi Zhang, Chuang Wang, Lu Wang, Wenqiang Li, Yongfeng Yang, Na Qu, Jinsong Tang, Ying He, Jun Zhou, Zihao Yang, Xingxing Li, Jun Cai, Lu Yang, Jun Chen, Weixing Fan, Wei Tang, Wenxin Tang, Qiu-Fang Jia, Weiqing Liu, Chuanjun Zhuo, Xueqin Song, Fang Liu, Yan Bai, Bao-Liang Zhong, Shu-Fang Zhang, Jing Chen, Bin Xia, Luxian Lv, Zhongchun Liu, Shaohua Hu, Xiao-Yan Li, Jie-Wei Liu, Xin Cai, Yong-Gang Yao, Yuyanan Zhang, Hao Yan, Suhua Chang, Jing-Ping Zhao, Wei-Hua Yue, Xiong-Jian Luo, Xiaogang Chen, Xiao Xiao, Yiru Fang, Ming Li
Summary: This study identified novel risk loci for bipolar disorder in the Han Chinese population and found evidence of shared genetic risk of BD between Han Chinese and European populations through genetic correlation estimation and polygenic risk score analyses.
Article
Behavioral Sciences
Stephen Faraone, Tobias Banaschewski, David Coghill, Yi Zheng, Joseph Biederman, Mark A. Bellgrove, Jeffrey H. Newcorn, Martin Gignac, Nouf M. Al Saud, Iris Manor, Luis Augusto Rohde, Li Yang, Samuele Cortese, Doron Almagor, Mark A. Stein, Turki H. Albatti, Haya F. Aljoudi, Mohammed M. J. Alqahtani, Philip Asherson, Lukoye Atwoli, Sven Bolte, Jan K. Buitelaar, Cleo L. Crunelle, David Daley, Soren Dalsgaard, Manfred Doepfner, Stacey Espinet, Michael Fitzgerald, Barbara Franke, Manfred Gerlach, Jan Haavik, Catharina A. Hartman, Cynthia M. Hartung, Stephen P. Hinshaw, Pieter J. Hoekstra, Chris Hollis, Scott H. Kollins, J. J. Sandra Kooij, Jonna Kuntsi, Henrik Larsson, Tingyu Li, Jing Liu, Eugene Merzon, Gregory Mattingly, Paulo Mattos, Suzanne McCarthy, Amori Yee Mikami, Brooke S. G. Molina, Joel T. Nigg, Diane Purper-Ouakil, Olayinka O. Omigbodun, Guilherme Polanczyk, Yehuda Pollak, Alison S. Poulton, Ravi Philip Rajkumar, Andrew Reding, Andreas Reif, Katya Rubia, Julia Rucklidge, Marcel Romanos, J. Antoni Ramos-Quiroga, Arnt Schellekens, Anouk Scheres, Renata Schoeman, Julie B. Schweitzer, Henal Shah, Mary Solanto, Edmund Sonuga-Barke, Cesar Soutullo, Hans-Christoph Steinhausen, James M. Swanson, Anita Thapar, Gail Tripp, Geurt van de Glind, Wim van den Brink, Saskia Van der Oord, Andre Venter, Benedetto Vitiello, Susanne Walitza, Yufeng Wang
Summary: This study curated 208 empirically supported statements about ADHD based on strong evidence. These statements were endorsed by 80 authors from 27 countries and 6 continents, as well as 366 readers who agreed with the contents of the document. The meta-analysis findings provide firm statements about the nature, course, outcome causes, and treatments of ADHD, which can help reduce misconceptions and stigma.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2021)
Article
Pediatrics
Yajing Sun, Xue Li, Lingzi Xu, Zenghui Ma, Yulu Yang, Tingni Yin, Zilin Gao, Xiaoyun Gong, Lei Li, Qinyi Liu, Xinzhou Tang, Jing Liu
Summary: Adolescents with autism exhibit more health-related risky behaviors compared to neurotypical adolescents, with factors such as anxiety, depression, low self-esteem, low IQ score, low ToM test score, increasing age, and communication disorder identified as risk factors for these behaviors. It is important to pay attention to the emotional state, self-esteem, cognitive function, and communication levels of autistic adolescents with health-related risky behaviors.
CHILD AND ADOLESCENT PSYCHIATRY AND MENTAL HEALTH
(2021)
Article
Medicine, General & Internal
Ya-Jing Sun, Ling-Zi Xu, Zeng-Hui Ma, Yu-Lu Yang, Ting-Ni Yin, Xiao-Yun Gong, Zi-Lin Gao, Yan-Ling Liu, Jing Liu
Summary: This study investigated health-related risky behaviors in adolescents with high-functioning autism (HFA) and found that factors such as poor emotional experience, depression, low intelligence score, low Theory of Mind test score, and poor adaptation to school life were risk factors for these behaviors. Adolescents with HFA were more likely to engage in health-related risky behaviors.
WORLD JOURNAL OF CLINICAL CASES
(2021)
Article
Pediatrics
Xiaoyun Gong, Xue Li, Qiandong Wang, Sio Pan Hoi, Tingni Yin, Liyang Zhao, Fanchao Meng, Xuerong Luo, Jing Liu
Summary: The study found that children with Autism Spectrum Disorder (ASD) pay less attention to social stimuli and prefer nonsocial stimuli. Preference for dynamic social images increased with age in ASD children. There was no association between visual preference and IQ in ASD children, while the severity of social interaction deficits was negatively correlated with preference for dynamic social images.
TRANSLATIONAL PEDIATRICS
(2021)
Article
Psychology, Developmental
Zeng-Hui Ma, Bin Lu, Xue Li, Ting Mei, Yan-Qing Guo, Liu Yang, Hui Wang, Xin-Zhou Tang, Zhao-Zheng Ji, Jing-Ran Liu, Ling-Zi Xu, Yu-Lu Yang, Qing-Jiu Cao, Chao-Gan Yan, Jing Liu
Summary: The study revealed that individuals with autism spectrum disorder exhibit atypical developmental changes in cortico-striatal intrinsic functional connectivity, with connectivity increasing with age, while typically developing individuals show either decreasing or constant connectivity with age. Significant correlations were found between these connectivity changes and specific autistic behaviors.
Article
Psychiatry
Yajing Sun, Zhifei Kong, Yuqing Song, Jing Liu, Xilin Wang
Summary: This study explored the validity and reliability of PHQ-9 for screening depression among patients with neurological disorders and identified factors influencing such patients. The results demonstrated good reliability and validity of PHQ-9 in the Chinese population. Unemployment was found to be a significant risk factor for depression in patients with neurological disorders.
Article
Pediatrics
Hui Wang, Zeng-Hui Ma, Ling-Zi Xu, Liu Yang, Zhao-Zheng Ji, Xin-Zhou Tang, Jing-Ran Liu, Xue Li, Qing-Jiu Cao, Jing Liu
Summary: This study found that individuals with autism spectrum disorder showed different atypical regional gray matter volumetric changes in childhood, adolescence, and adulthood compared to their typically developing peers, highlighting the importance of considering developmental stages of the brain when exploring brain structural atypicalities in autism.
CHILD AND ADOLESCENT PSYCHIATRY AND MENTAL HEALTH
(2022)
Article
Psychology, Developmental
Yixiao Hu, Qianhan Xiong, Qiandong Wang, Ci Song, Duo Wang, Haoyang Lu, Wanjun Shi, Ying Han, Jing Liu, Xue Li, Li Yi
Summary: The study explored the early development of social attention in toddlers at high familial risk (HR) for autism spectrum disorder (ASD). It found that HR toddlers showed a decrease in social preference with age, while LR toddlers did not. Both groups exhibited significant social habituation, but HR toddlers habituated slightly slower as age increased, indicating atypical social attention as an early characteristic of toddlers at high familial risk for ASD.
INFANT BEHAVIOR & DEVELOPMENT
(2022)
Article
Clinical Neurology
Yilu Zhao, Li Yang, Gaolang Gong, Qingjiu Cao, Jing Liu
Summary: The study revealed atypical white matter patterns in ASD, ADHD, and other NDDs. Shared microstructural abnormalities in the splenium of the CC were possibly present in ASD and ADHD. No consistent abnormalities were detected in specific learning disorder, motor disorder, or communication disorder.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2022)
Article
Genetics & Heredity
Ziqi Wang, Tianlan Lu, Xianjing Li, Miaomiao Jiang, Meixiang Jia, Jing Liu, Dai Zhang, Jun Li, Lifang Wang
Summary: This study investigated the dysregulation of miRNAs in autism in the Han Chinese population. The results showed that 10 miRNAs were significantly differentially expressed in patients with autism, and their targets were related to neurodevelopment, brain functions, and autism.
FRONTIERS IN GENETICS
(2022)
Article
Pediatrics
Ting Mei, Zeng-Hui Ma, Yan-Qing Guo, Bin Lu, Qing-Jiu Cao, Xiao Chen, Liu Yang, Hui Wang, Xin-Zhou Tang, Zhao-Zheng Ji, Jing-Ran Liu, Ling-Zi Xu, Li-Qi Wang, Yu-Lu Yang, Xue Li, Chao-Gan Yan, Jing Liu
Summary: The study found that individuals with autism showed significantly higher ALFF in the dorsal striatum in childhood and remarkably lower ALFF in adulthood, with no significant differences in adolescence. Abnormal ALFF amplitudes were specific to the slow-4 frequency band.
TRANSLATIONAL PEDIATRICS
(2022)
Article
Education & Educational Research
Xinzhou Tang, Zihui Hua, Jiayin Xing, Li Yi, Zhaozheng Ji, Liyang Zhao, Xing Su, Tingni Yin, Ran Wei, Xue Li, Jing Liu
Summary: Verbal fluency tasks can be valuable in predicting diagnoses and symptoms of autism spectrum disorder (ASD) and comorbid ASD and attention-deficit/hyperactivity disorder (ADHD) in children and adolescents. This study found that both ASD and ASD + ADHD groups showed deficits in verbal fluency compared to typically developing individuals. The number of correct word items produced during the task predicted ADHD symptoms and differentiated the ASD and ASD + ADHD groups from the typically developing group. The number of repetitive items and errors differentiated the ASD + ADHD group from the typically developing group and predicted symptoms related to language and social and self-help in ASD.
READING AND WRITING
(2023)