Article
Endocrinology & Metabolism
Yang Sun, Ye Lv, Hui-Wen Ren, Guan-Yu Wang, Li-Na Xuan, Yi-Yang Luo, Zhi-Lin Luan
Summary: The study found a significant association between MAP3K4 and schizophrenia in the Northeast Chinese Han population, with certain SNPs showing strong correlation with the disease.
METABOLIC BRAIN DISEASE
(2022)
Article
Geriatrics & Gerontology
Yanfei Wei, Shuzhen Liu, Jiansheng Cai, Xu Tang, Junling Zhang, Min Xu, Qiumei Liu, Chunmei Wei, Xiaoting Mo, Shenxiang Huang, Yinxia Lin, Tingyu Mai, Dechan Tan, Tingyu Luo, Ruoyu Gou, Huaxiang Lu, Jian Qin, Zhiyong Zhang
Summary: The study revealed that TFEB gene polymorphisms and their haplotypes could potentially impact cognitive function among the rural Chinese population.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Article
Genetics & Heredity
Jie Wei, Huan Zhang, Xiaoya Ma, Yujie Li, Wenqian Zhou, Jinping Guo, Tianbo Jin, Mingjun Hu
Summary: This study investigated the association between single nucleotide polymorphisms (SNPs) of the OR51E1 gene and glioma susceptibility in the Chinese Han population. The results showed that polymorphisms rs10768148, rs7102992, and rs10500608 were associated with glioma risk in the overall sample. Stratified analyses based on gender and age revealed specific SNP-glioma associations. Additionally, synergistic and redundant relationships between certain SNPs were identified. Overall, this study provides a basis for assessing glioma risk-associated variants in the Chinese Han population.
Article
Immunology
Chenxi Liu, Songxin Yan, Haizhen Chen, Ziyan Wu, Liubing Li, Linlin Cheng, Haolong Li, Yongzhe Li
Summary: This study found that the GTF2I rs117026326 and rs73366469 SNPs were strongly associated with SSc in the Chinese Han population, while NFKB1 rs1599961 showed a suggestive association with SSc. However, TYK2 rs2304256 was not significantly associated with SSc in this particular population.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Medicine, General & Internal
Xu Liu, Kelaier Yang, Zhangfu Li, Jikui Liu
Summary: The study evaluated the association between MMP2 gene SNPs and risk of colorectal cancer (CRC). It found that rs243849 was associated with a decreased risk of CRC, while rs1053605 was associated with an increased risk. Additionally, the effects of these SNPs varied in different lifestyle and age groups. These findings suggest that MMP2 gene polymorphisms may be useful for predicting CRC progression.
INTERNATIONAL JOURNAL OF GENERAL MEDICINE
(2022)
Article
Medicine, General & Internal
Guanghui Tong, Weiwei Tong, Ran He, Zhigang Cui, Sixuan Li, Baosen Zhou, Zhihua Yin
Summary: This study found that rs3200401 in the lncRNA MALAT1 gene is associated with the susceptibility of non-small cell lung cancer and lung squamous cell carcinoma. However, there is no significant association between rs619586 and lung cancer susceptibility. The study also discovered interactions between genes and cigarette smoking.
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
(2022)
Article
Medicine, General & Internal
Antonia Msafiri Makene, Jun-Lin Liu
Summary: This study identified multiple polymorphic loci in the CARD14 gene associated with susceptibility to psoriasis and confirmed the significant correlation of several loci with the development of psoriasis. Bioinformatic analysis further demonstrated the impact of these loci on gene function and identified two protective haplotypes for the disease.
Article
Environmental Sciences
Huimin Wang, Guangzhi Yang, Dawei Sun, Boshen Wang, Hao Chen, Mengyao Chen, Baoli Zhu
Summary: The study found an association between genetic polymorphisms rs10499080 and rs6568819 within the HDAC2 gene and the risk of NIHL, indicating that workers exposed to noise with HDAC2 have a lower risk of NIHL.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Multidisciplinary Sciences
Lining Si, Haiyuan Wang, Rong Wang, Lhachen Tsering, Qifu Long, Yahui Jiang, Yun Yi, Yanli Zhao
Summary: High altitude pulmonary edema (HAPE) is a common and harmful respiratory disease in high altitude areas. In a case-control study conducted in Northwest China, we found that certain CYP4F2 gene polymorphisms were associated with HAPE susceptibility in the Chinese Han population. Specifically, rs3093193 reduced the risk of HAPE, while rs12459936 increased the susceptibility. Age and gender stratification analysis revealed further correlations between these gene polymorphisms and HAPE risk. Our study provides valuable insights into the genetic factors influencing HAPE risk in the Chinese Han population.
Article
Clinical Neurology
Ziqi Wang, Jun Li, Tian Zhang, Tianlan Lu, Han Wang, Meixiang Jia, Jing Liu, Jun Xiong, Dai Zhang, Lifang Wang
Summary: The study identified a significant association between rs363018 in SNAP25 and autism in the Han Chinese population, suggesting that SNAP25 may be a susceptibility gene for autism.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2021)
Article
Pediatrics
Yanqing Liu, Wen Fu, Kai Fu, Xiaoyu Zuo, Wei Jia, Ning Wang, Yan Zhang, Guochang Liu, Fuming Deng
Summary: This study investigated the association between HAAO gene polymorphism rs3816183 T>C and hypospadias in a cohort of Chinese children. The results showed that the rs3816183[T] polymorphism is associated with increased risk of anterior/middle hypospadias. However, the overall risk of hypospadias could not be confirmed.
FRONTIERS IN PEDIATRICS
(2022)
Article
Biochemistry & Molecular Biology
Fang Luo, PinAng Zou, Yinqian Liao, Jiaze Luo, Dan Luo, Kuan Hu, KaiXuan Zhang, BaoGuo Wang
Summary: This study found an association between TAP gene polymorphisms and TB susceptibility, particularly the SNPs rs1135216 and rs3819721. The risk of developing tuberculosis increases with the number of risk alleles.
MOLECULAR GENETICS AND GENOMICS
(2022)
Article
Biochemistry & Molecular Biology
Lingfeng Zha, Jiangtao Dong, Qianwen Chen, Yuhua Liao, Hongsong Zhang, Tian Xie, Tingting Tang, Ni Xia, Min Zhang, Jiao Jiao, Yingchao Zhou, Jianfei Wu, Xiangping Yang, Chengqi Xu, Qing K. Wang, Xin Tu, Xiang Cheng, Shaofang Nie
Summary: The study found that IL9 may play a causal role in CAD by interacting with traditional risk factors, particularly the CGAT haplotype and specific genotypes that have a significant impact on the risk of CAD.
Article
Oncology
Weihong Xiong, Zhumei Li, Xiangfa Zeng, Jun Cui, Zhiming Cheng, Xiaoying Yang, Yipeng Ding
Summary: This study found that ANXA6 gene variants are associated with susceptibility to head and neck cancer in the Chinese Han population, suggesting that ANXA6 may serve as a potential biomarker for prognosis and diagnosis of head and neck cancer.
FRONTIERS IN ONCOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Hanyi Zhang, Siyao Deng, Jiayu Zhang, Guiquan Zhu, Jie Zhou, Wenjing Ye, Qingwei Wang, Yi Wang, Bingwen Zou, Peng Zhang, Shichuan Zhang, Jinyi Lang, Shun Lu
Summary: Genetic variants in genes involved in the LMP1 signaling pathway, particularly the NFKBIA promoter SNP rs2233409, may be moderately associated with the risk of nasopharyngeal carcinoma (NPC). Further studies with larger sample sizes and functional analysis are needed to confirm these findings.