New concepts in opioid analgesia

The novel μ-opioid receptor agonist PZM21 depresses respiration and induces tolerance to antinociception

(2018) Rob Hill et al.   BRITISH JOURNAL OF PHARMACOLOGY

Pharmacogenomics of GPCR Drug Targets

(2018) Alexander S. Hauser et al.   CELL

Progress in understanding mechanisms of opioid-induced gastrointestinal adverse effects and respiratory depression

(2018) Mohammad Zafar Imam et al.   NEUROPHARMACOLOGY

Analgesic Effects of A Novel Ph-Dependent μ-Opioid Receptor Agonist in Models of Neuropathic and Abdominal Pain

(2018) Antonio Rodriguez-Gaztelumendi et al.   PAIN

Opioid receptor signaling, analgesic and side effects induced by a computationally designed pH-dependent agonist

(2018) Viola Spahn et al.   Scientific Reports

Preclinical efficacy studies in investigator brochures: Do they enable risk–benefit assessment?

(2018) Susanne Wieschowski et al.   PLOS BIOLOGY

Targeting delta opioid receptors for pain treatment: drugs in phase I and II clinical development

(2017) Viola Spahn et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

New Data on Opioid Use and Prescribing in the United States

(2017) Anne Schuchat et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Effects of acute and repeated treatment with the biased mu opioid receptor agonist TRV130 (oliceridine) on measures of antinociception, gastrointestinal function, and abuse liability in rodents

(2017) Ahmad A Altarifi et al.   JOURNAL OF PSYCHOPHARMACOLOGY

Loss of μ opioid receptor signaling in nociceptors, but not microglia, abrogates morphine tolerance without disrupting analgesia

(2017) Gregory Corder et al.   NATURE MEDICINE

Breaking barriers to novel analgesic drug development

(2017) Ajay S. Yekkirala et al.   NATURE REVIEWS DRUG DISCOVERY

Opioid misuse in gastroenterology and non-opioid management of abdominal pain

(2017) Eva Szigethy et al.   Nature Reviews Gastroenterology & Hepatology

Brain imaging tests for chronic pain: medical, legal and ethical issues and recommendations

(2017) Karen D. Davis et al.   Nature Reviews Neurology

Drug Companies’ Liability for the Opioid Epidemic

(2017) Rebecca L. Haffajee et al.   NEW ENGLAND JOURNAL OF MEDICINE

Addressing the Opioid Epidemic — Opportunities in the Postmarketing Setting

(2017) Bruce M. Psaty et al.   NEW ENGLAND JOURNAL OF MEDICINE

Abuse-Deterrent Opioid Formulations — Putting the Potential Benefits into Perspective

(2017) William C. Becker et al.   NEW ENGLAND JOURNAL OF MEDICINE

A nontoxic pain killer designed by modeling of pathological receptor conformations

(2017) V. Spahn et al.   SCIENCE

Designing Safer Analgesics via μ-Opioid Receptor Pathways

(2017) H.C. Stephen Chan et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Polyglycerol-opioid conjugate produces analgesia devoid of side effects

(2017) Sara González-Rodríguez et al.   eLife

Species differences in the effects of the κ-opioid receptor antagonist zyklophin

(2016) Sunil Sirohi et al.   ALCOHOL

G-protein–gated Inwardly Rectifying Potassium Channels Modulate Respiratory Depression by Opioids

(2016) Gaspard Montandon et al.   ANESTHESIOLOGY

Opioid Receptors

(2016) Christoph Stein   Annual Review of Medicine

Leukocyte opioid receptors mediate analgesia via Ca 2+ -regulated release of opioid peptides

(2016) Melih Ö. Celik et al.   BRAIN BEHAVIOR AND IMMUNITY

Gradual withdrawal of remifentanil infusion may prevent opioid-induced hyperalgesia † †This Article is accompanied by Editorial Aew050.

(2016) M Comelon et al.   BRITISH JOURNAL OF ANAESTHESIA

CDC Guideline for Prescribing Opioids for Chronic Pain—United States, 2016

(2016) Deborah Dowell et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Will peripherally restricted kappa-opioid receptor agonists (pKORAs) relieve pain with less opioid adverse effects and abuse potential?

(2016) A. Albert-Vartanian et al.   JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS

Management of Postoperative Pain: A Clinical Practice Guideline From the American Pain Society, the American Society of Regional Anesthesia and Pain Medicine, and the American Society of Anesthesiologists' Committee on Regional Anesthesia, Executive Committee, and Administrative Council

(2016) Roger Chou et al.   JOURNAL OF PAIN

Synthetic and Receptor Signaling Explorations of the Mitragyna Alkaloids: Mitragynine as an Atypical Molecular Framework for Opioid Receptor Modulators

(2016) Andrew C. Kruegel et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A randomized, phase 2 study investigating TRV130, a biased ligand of the μ-opioid receptor, for the intravenous treatment of acute pain

(2016) Eugene R. Viscusi et al.   PAIN

Postoperative Opioid-induced Respiratory Depression

(2015) Lorri A. Lee et al.   ANESTHESIOLOGY

Single Amino Acid Variation Underlies Species-Specific Sensitivity to Amphibian Skin-Derived Opioid-like Peptides

(2015) Eyal Vardy et al.   CHEMISTRY & BIOLOGY

Intestinal inflammation and pain management

(2015) Lilian Basso et al.   CURRENT OPINION IN PHARMACOLOGY

Intraoperative Use of Remifentanil for TIVA: Postoperative Pain, Acute Tolerance, and Opioid-Induced Hyperalgesia

(2015) Martin S. Angst   JOURNAL OF CARDIOTHORACIC AND VASCULAR ANESTHESIA

Reproducibility: Standardize antibodies used in research

(2015) Andrew Bradbury et al.   NATURE

Rates of opioid misuse, abuse, and addiction in chronic pain

(2015) Kevin E. Vowles et al.   PAIN

Opioid-induced hyperalgesia in patients after surgery: a systematic review and a meta-analysis

(2014) D. Fletcher et al.   BRITISH JOURNAL OF ANAESTHESIA

Analgesic efficacy of opioids in chronic pain: recent meta-analyses

(2014) H Reinecke et al.   BRITISH JOURNAL OF PHARMACOLOGY

Identifying ligand-specific signalling within biased responses: focus on δ opioid receptor ligands

(2014) I Charfi et al.   BRITISH JOURNAL OF PHARMACOLOGY

β-Arrestin-2-Biased Agonism of Delta Opioid Receptors Sensitizes Transient Receptor Potential Vanilloid Type 1 (TRPV1) in Primary Sensory Neurons

(2014) Matthew P Rowan et al.   Molecular Pain

Peripheral gating of pain signals by endogenous lipid mediators

(2014) Daniele Piomelli et al.   NATURE NEUROSCIENCE

Peripheral opioid receptor blockade increases postoperative morphine demands—A randomized, double-blind, placebo-controlled trial

(2014) Christina Jagla et al.   PAIN

Peripheral input and its importance for central sensitization

(2013) Ralf Baron et al.   ANNALS OF NEUROLOGY

Single-Dose Intra-Articular Morphine After Arthroscopic Knee Surgery: A Meta-Analysis of Randomized Placebo-Controlled Studies

(2013) Chao Zeng et al.   ARTHROSCOPY-THE JOURNAL OF ARTHROSCOPIC AND RELATED SURGERY

Targeting novel peripheral mediators for the treatment of chronic pain

(2013) N Richards et al.   BRITISH JOURNAL OF ANAESTHESIA

The K+channel GIRK2 is both necessary and sufficient for peripheral opioid-mediated analgesia

(2013) Dinah Nockemann et al.   EMBO Molecular Medicine

Opioids, sensory systems and chronic pain

(2013) Christoph Stein   EUROPEAN JOURNAL OF PHARMACOLOGY

Sequestered naltrexone in sustained release morphine or oxycodone – a way to inhibit illicit use?

(2013) Robert B Raffa et al.   Expert Opinion On Drug Safety

First Clinical Experience With TRV130: Pharmacokinetics and Pharmacodynamics in Healthy Volunteers

(2013) David G. Soergel et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Vascular and upper gastrointestinal effects of non-steroidal anti-inflammatory drugs: meta-analyses of individual participant data from randomised trials

(2013)   LANCET

Classification and definition of misuse, abuse, and related events in clinical trials: ACTTION systematic review and recommendations

(2013) Shannon M. Smith et al.   PAIN

Opioid withdrawal increases transient receptor potential vanilloid 1 activity in a protein kinase A-dependent manner

(2013) Viola Spahn et al.   PAIN

How are topical opioids used to manage painful cutaneous lesions in palliative care? A critical review

(2013) Tanya Graham et al.   PAIN

µ-opioid receptor gene variantOPRM1118 A>G: a summary of its molecular and clinical consequences for pain

(2013) Carmen Walter et al.   PHARMACOGENOMICS

Functional Characteristics of the Naked Mole Rat μ-Opioid Receptor

(2013) Melanie Busch-Dienstfertig et al.   PLoS One

Anti-Inflammatory Therapy in Chronic Disease: Challenges and Opportunities

(2013) I. Tabas et al.   SCIENCE

Opioid receptors: toward separation of analgesic from undesirable effects

(2013) Ping-Yee Law et al.   TRENDS IN BIOCHEMICAL SCIENCES

Targeting inflammation and wound healing by opioids

(2013) Christoph Stein et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Consequences of the 118A>G polymorphism in the OPRM1 gene: translation from bench to bedside?

(2013) Elisa Mura et al.   Journal of Pain Research

Regulation of CaV2 calcium channels by G protein coupled receptors

(2012) Gerald W. Zamponi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Pain inhibition by blocking leukocytic and neuronal opioid peptidases in peripheral inflamed tissue

(2012) Anja Schreiter et al.   FASEB JOURNAL

Inhibiting the breakdown of endogenous opioids and cannabinoids to alleviate pain

(2012) Bernard P. Roques et al.   NATURE REVIEWS DRUG DISCOVERY

Modulating Pain in the Periphery

(2012) Srinivasa N. Raja   REGIONAL ANESTHESIA AND PAIN MEDICINE

Dual Peripheral Actions of Immune Cells in Neuropathic Pain

(2011) Halina Machelska   ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS

Predictive validity of behavioural animal models for chronic pain

(2011) Odd-Geir Berge   BRITISH JOURNAL OF PHARMACOLOGY

Modulation of Peripheral Sensory Neurons by the Immune System: Implications for Pain Therapy

(2011) C. Stein et al.   PHARMACOLOGICAL REVIEWS

Emerging roles for G protein-gated inwardly rectifying potassium (GIRK) channels in health and disease

(2010) Christian Lüscher et al.   NATURE REVIEWS NEUROSCIENCE

The necessity of animal models in pain research

(2010) Jeffrey S. Mogil et al.   PAIN

Coexpression of  - and  -opioid receptors in nociceptive sensory neurons

(2010) H.-B. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cellular and Molecular Mechanisms of Pain

(2009) Allan I. Basbaum et al.   CELL

Peripheral Non-Viral MIDGE Vector-Driven Delivery of β-Endorphin in Inflammatory Pain

(2009) Halina Machelska et al.   Molecular Pain

Do Opioids Induce Hyperalgesia in Humans? An Evidence-Based Structured Review

(2009) David A. Fishbain et al.   PAIN MEDICINE

Pain and the immune system

(2008) H.L. Rittner et al.   BRITISH JOURNAL OF ANAESTHESIA

Opioids and the control of respiration

(2008) K.T.S. Pattinson   BRITISH JOURNAL OF ANAESTHESIA

 -Opioid Receptor-Mediated Depression of the Hypothalamic Hypocretin/Orexin Arousal System

(2008) Y. Li et al.   JOURNAL OF NEUROSCIENCE

Morphine-6-glucuronide (M6G) for postoperative pain relief

(2007) Albert Dahan et al.   EUROPEAN JOURNAL OF PAIN