Will peripherally restricted kappa-opioid receptor agonists (pKORAs) relieve pain with less opioid adverse effects and abuse potential?

What Are the Potential Sites of Protein Arylation by N-Acetyl-p-benzoquinone Imine (NAPQI)?

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Emerging targets in treating pain

(2015) David S. Chang et al.   Current Opinion in Anesthesiology

Kappa Opioid Receptor-Induced Aversion Requires p38 MAPK Activation in VTA Dopamine Neurons

(2015) J. M. Ehrich et al.   JOURNAL OF NEUROSCIENCE

NSAIDs and Cardiovascular Diseases: Role of Reactive Oxygen Species

(2015) Rajeshwary Ghosh et al.   Oxidative Medicine and Cellular Longevity

Global Fertility and Population Trends

(2015) John Bongaarts   SEMINARS IN REPRODUCTIVE MEDICINE

Tu1405 The Kappa-Opioid Receptor Agonist Asimadoline Remains Peripherally Restricted at Supra-Therapeutic Plasma Exposures

(2015) Gareth A. Hicks et al.   GASTROENTEROLOGY

Gender, Variation in Opioid Receptor Genes and Sensitivity to Experimental Pain

(2013) Hiroe Sato et al.   Molecular Pain

Targeting pain and inflammation by peripherally acting opioids

(2013) Christoph Stein   Frontiers in Pharmacology

The prevalence of chronic pain with an analysis of countries with a Human Development Index less than 0.9: a systematic review without meta-analysis

(2012) Raga A. Elzahaf et al.   CURRENT MEDICAL RESEARCH AND OPINION

Non-Analgesic Effects of Opioids: Peripheral Opioid Receptors as Promising Targets for Future Anti-Pruritic Therapies

(2012) Adam Reich et al.   CURRENT PHARMACEUTICAL DESIGN

Pain inhibition by blocking leukocytic and neuronal opioid peptidases in peripheral inflamed tissue

(2012) Anja Schreiter et al.   FASEB JOURNAL

The Economic Costs of Pain in the United States

(2012) Darrell J. Gaskin et al.   JOURNAL OF PAIN

Stimulation of Peripheral Kappa Opioid Receptors Inhibits Inflammatory Hyperalgesia via Activation of the PI3Kγ/AKT/nNOS/NO Signaling Pathway

(2012) Thiago M Cunha et al.   Molecular Pain

Effects of peripheral κ opioid receptor activation on inflammatory mechanical hyperalgesia in male and female rats

(2012) Q-Schick Auh et al.   NEUROSCIENCE LETTERS

Opioids: a two-faced Janus

(2011) Karsten Ahlbeck   CURRENT MEDICAL RESEARCH AND OPINION

The role of nociceptin and dynorphin in chronic pain: Implications of neuro–glial interaction

(2011) Joanna Mika et al.   NEUROPEPTIDES

What do we (not) know about how paracetamol (acetaminophen) works?

(2010) K. Toussaint et al.   JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS

The Prevalence of Chronic Pain in United States Adults: Results of an Internet-Based Survey

(2010) Catherine B. Johannes et al.   JOURNAL OF PAIN

The Therapeutic Potential of κ-Opioids for Treatment of Pain and Addiction

(2010) Charles Chavkin   NEUROPSYCHOPHARMACOLOGY

Kappa opioids and the modulation of pain

(2010) Bronwyn Kivell et al.   PSYCHOPHARMACOLOGY

Kinase cascades and ligand-directed signaling at the kappa opioid receptor

(2010) Michael R. Bruchas et al.   PSYCHOPHARMACOLOGY

Peptide Kappa Opioid Receptor Ligands: Potential for Drug Development

(2009) Jane V. Aldrich et al.   AAPS Journal

Analgesic Efficacy of Peripheral κ-Opioid Receptor Agonist CR665 Compared to Oxycodone in a Multi-modal, Multi-tissue Experimental Human Pain Model

(2009) Lars Arendt-Nielsen et al.   ANESTHESIOLOGY

Delta and Kappa Opioid Receptors as Suitable Drug Targets for Pain

(2009) Todd W. Vanderah   CLINICAL JOURNAL OF PAIN

Peripheral mechanisms of opioid analgesia

(2009) Christoph Stein et al.   CURRENT OPINION IN PHARMACOLOGY

Structure and function of the blood–brain barrier

(2009) N. Joan Abbott et al.   NEUROBIOLOGY OF DISEASE

Novel d-amino acid tetrapeptides produce potent antinociception by selectively acting at peripheral κ-opioid receptors,

(2008) Todd W. Vanderah et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Opioids and the treatment of chronic pain: Controversies, current status, and future directions.

(2008) Andrew Rosenblum et al.   EXPERIMENTAL AND CLINICAL PSYCHOPHARMACOLOGY

Effect of a κ-opioid agonist, i.v. JNJ-38488502, on sensation of colonic distensions in healthy male volunteers

(2008) b. n. floyd et al.   NEUROGASTROENTEROLOGY AND MOTILITY