Peripheral gating of pain signals by endogenous lipid mediators

Biosynthetic Pathways of Bioactive N-Acylethanolamines in Brain

(2013) Kazuhito Tsuboi et al.   CNS & Neurological Disorders-Drug Targets

Metabolism of endocannabinoids and relatedN-acylethanolamines: Canonical and alternative pathways

(2013) Natsuo Ueda et al.   FEBS Journal

Cannabinoid receptor 1 controls human mucosal-type mast cell degranulation and maturation in situ

(2013) Koji Sugawara et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Bilateral Changes of Cannabinoid Receptor Type 2 Protein and mRNA in the Dorsal Root Ganglia of a Rat Neuropathic Pain Model

(2013) Ivana Hradilová Svíženská et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

Substrate-selective COX-2 inhibition decreases anxiety via endocannabinoid activation

(2013) Daniel J Hermanson et al.   NATURE NEUROSCIENCE

Increased anandamide uptake by sensory neurons contributes to hyperalgesia in a model of cancer pain

(2013) Iryna A. Khasabova et al.   NEUROBIOLOGY OF DISEASE

More surprises lying ahead. The endocannabinoids keep us guessing

(2013) Daniele Piomelli   NEUROPHARMACOLOGY

CB1 cannabinoid receptor agonist prevents NGF-induced sensitization of TRPV1 in sensory neurons

(2013) Thomas S. McDowell et al.   NEUROSCIENCE LETTERS

A novel biological role for the phospholipid lysophosphatidylinositol in nociceptive sensitization via activation of diverse G-protein signalling pathways in sensory nerves in vivo

(2013) Vijayan Gangadharan et al.   PAIN

Impact of Soluble Epoxide Hydrolase and Epoxyeicosanoids on Human Health

(2012) Christophe Morisseau et al.   Annual Review of Pharmacology and Toxicology

Characterisation of cannabinoid 1 receptor expression in the perikarya, and peripheral and spinal processes of primary sensory neurons

(2012) Gabor Veress et al.   Brain Structure & Function

The Endocannabinoid System and Pain

(2012) Josee Guindon et al.   CNS & Neurological Disorders-Drug Targets

Changes in Cannabinoid Receptor Subtype 1 Activity and Interaction with Metabotropic Glutamate Subtype 5 Receptors in the Periaqueductal Gray- Rostral Ventromedial Medulla Pathway in a Rodent Neuropathic Pain Model

(2012) Enza Palazzo et al.   CNS & Neurological Disorders-Drug Targets

Examining the safety of PPAR agonists – current trends and future prospects

(2012) Michele Bortolini et al.   Expert Opinion On Drug Safety

PPARα as a therapeutic target in inflammation-associated diseases

(2012) Philippe Gervois et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Peroxisome Proliferator-Activated Receptor   Mediates Acute Effects of Palmitoylethanolamide on Sensory Neurons

(2012) I. A. Khasabova et al.   JOURNAL OF NEUROSCIENCE

Activation of Type 5 Metabotropic Glutamate Receptors and Diacylglycerol Lipase-  Initiates 2-Arachidonoylglycerol Formation and Endocannabinoid-Mediated Analgesia

(2012) L. C. Gregg et al.   JOURNAL OF NEUROSCIENCE

GPR55 and GPR35 and their relationship to cannabinoid and lysophospholipid receptors

(2012) Pingwei Zhao et al.   LIFE SCIENCES

Endocannabinoid Signaling and Synaptic Function

(2012) Pablo E. Castillo et al.   NEURON

Antinociceptive effects of the N-acylethanolamine acid amidase inhibitor ARN077 in rodent pain models

(2012) Oscar Sasso et al.   PAIN

Peripheral FAAH inhibition causes profound antinociception and protects against indomethacin-induced gastric lesions

(2012) Oscar Sasso et al.   PHARMACOLOGICAL RESEARCH

Discovery of Prostamide F2α and Its Role in Inflammatory Pain and Dorsal Horn Nociceptive Neuron Hyperexcitability

(2012) Luisa Gatta et al.   PLoS One

Cannabinoids Inhibit Acid-Sensing Ion Channel Currents in Rat Dorsal Root Ganglion Neurons

(2012) Yu-Qiang Liu et al.   PLoS One

Acute augmentation of epoxygenated fatty acid levels rapidly reduces pain-related behavior in a rat model of type I diabetes

(2012) B. Inceoglu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Anti-inflammatory lipoxin A4 is an endogenous allosteric enhancer of CB1 cannabinoid receptor

(2012) F. A. Pamplona et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Spinal 12-lipoxygenase-derived hepoxilin A3 contributes to inflammatory hyperalgesia via activation of TRPV1 and TRPA1 receptors

(2012) A. M. Gregus et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Alteration of neuropathic and visceral pain in female C57BL/6J mice lacking the PPAR-α gene

(2012) Jessica Ruiz-Medina et al.   PSYCHOPHARMACOLOGY

β-Lactones Inhibit N-acylethanolamine Acid Amidase by S-Acylation of the Catalytic N-Terminal Cysteine

(2012) Andrea Armirotti et al.   ACS Medicinal Chemistry Letters

Proinflammatory Stimuli Control N-Acylphosphatidylethanolamine-Specific Phospholipase D Expression in Macrophages

(2011) C. Zhu et al.   MOLECULAR PHARMACOLOGY

Increasing 2-arachidonoyl glycerol signaling in the periphery attenuates mechanical hyperalgesia in a model of bone cancer pain

(2011) Iryna A. Khasabova et al.   PHARMACOLOGICAL RESEARCH

Modulation of Peripheral Sensory Neurons by the Immune System: Implications for Pain Therapy

(2011) C. Stein et al.   PHARMACOLOGICAL REVIEWS

Is lipid signaling through cannabinoid 2 receptors part of a protective system?

(2011) P. Pacher et al.   PROGRESS IN LIPID RESEARCH

Emerging roles of resolvins in the resolution of inflammation and pain

(2011) Ru-Rong Ji et al.   TRENDS IN NEUROSCIENCES

Specialized pro-resolving lipid mediators in the inflammatory response: An update

(2010) Gerard Bannenberg et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

N-palmitoyl-ethanolamine: Biochemistry and new therapeutic opportunities

(2010) Stefania Petrosino et al.   BIOCHIMIE

Peripheral antinociceptive effects of inhibitors of monoacylglycerol lipase in a rat model of inflammatory pain

(2010) Josée Guindon et al.   BRITISH JOURNAL OF PHARMACOLOGY

Resolvins RvE1 and RvD1 attenuate inflammatory pain via central and peripheral actions

(2010) Zhen-Zhong Xu et al.   NATURE MEDICINE

Anandamide suppresses pain initiation through a peripheral endocannabinoid mechanism

(2010) Jason R Clapper et al.   NATURE NEUROSCIENCE

Resolvin D1 binds human phagocytes with evidence for proresolving receptors

(2010) S. Krishnamoorthy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cellular and Molecular Mechanisms of Pain

(2009) Allan I. Basbaum et al.   CELL

Characterization of Monoacylglycerol Lipase Inhibition Reveals Differences in Central and Peripheral Endocannabinoid Metabolism

(2009) Jonathan Z. Long et al.   CHEMISTRY & BIOLOGY

Central administration of palmitoylethanolamide reduces hyperalgesia in mice via inhibition of NF-κB nuclear signalling in dorsal root ganglia

(2009) Giuseppe D'Agostino et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Localization of the Endocannabinoid-Degrading Enzyme Fatty Acid Amide Hydrolase in Rat Dorsal Root Ganglion Cells and Its Regulation after Peripheral Nerve Injury

(2009) I. J. Lever et al.   JOURNAL OF NEUROSCIENCE

Synergy between Enzyme Inhibitors of Fatty Acid Amide Hydrolase and Cyclooxygenase in Visceral Nociception

(2009) P. S. Naidu et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Activation of peroxisome proliferator-activated receptor γ in brain inhibits inflammatory pain, dorsal horn expression of Fos, and local edema

(2009) J. Morgenweck et al.   NEUROPHARMACOLOGY

Activation of TRPV1 in the spinal cord by oxidized linoleic acid metabolites contributes to inflammatory hyperalgesia

(2009) A. M. Patwardhan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Selective N-acylethanolamine-hydrolyzing acid amidase inhibition reveals a key role for endogenous palmitoylethanolamide in inflammation

(2009) C. Solorzano et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Modulation of the anti-nociceptive effects of 2-arachidonoyl glycerol by peripherally administered FAAH and MGL inhibitors in a neuropathic pain model

(2008) J Desroches et al.   BRITISH JOURNAL OF PHARMACOLOGY

Prostaglandin E2 glycerol ester, an endogenous COX-2 metabolite of 2-arachidonoylglycerol, induces hyperalgesia and modulates NFκB activity

(2008) S Shu-Jung Hu et al.   BRITISH JOURNAL OF PHARMACOLOGY

Cyclooxygenases: structural and functional insights

(2008) Carol A. Rouzer et al.   JOURNAL OF LIPID RESEARCH

A Decrease in Anandamide Signaling Contributes to the Maintenance of Cutaneous Mechanical Hyperalgesia in a Model of Bone Cancer Pain

(2008) I. A. Khasabova et al.   JOURNAL OF NEUROSCIENCE

Cannabinoid receptor CB2 localisation and agonist-mediated inhibition of capsaicin responses in human sensory neurons

(2008) Uma Anand et al.   PAIN

Role of ionotropic cannabinoid receptors in peripheral antinociception and antihyperalgesia

(2008) Armen N. Akopian et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Characterisation of the cannabinoid receptor system in synovial tissue and fluid in patients with osteoarthritis and rheumatoid arthritis

(2008) Denise Richardson et al.   ARTHRITIS RESEARCH & THERAPY

Cannabinoid CB2receptors: a therapeutic target for the treatment of inflammatory and neuropathic pain

(2007) J Guindon et al.   BRITISH JOURNAL OF PHARMACOLOGY

The peripheral cannabinoid receptor knockout mice: an update

(2007) N E Buckley   BRITISH JOURNAL OF PHARMACOLOGY