Inhibiting the breakdown of endogenous opioids and cannabinoids to alleviate pain

The Endocannabinoid System and Pain

(2012) Josee Guindon et al.   CNS & Neurological Disorders-Drug Targets

The discovery and development of inhibitors of fatty acid amide hydrolase (FAAH)

(2011) Katerina Otrubova et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Immune cell–derived opioids protect against neuropathic pain in mice

(2011) Dominika Labuz et al.   JOURNAL OF CLINICAL INVESTIGATION

Mechanistic and Pharmacological Characterization of PF-04457845: A Highly Potent and Selective Fatty Acid Amide Hydrolase Inhibitor That Reduces Inflammatory and Noninflammatory Pain

(2011) K. Ahn et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

A catalytically silent FAAH-1 variant drives anandamide transport in neurons

(2011) Jin Fu et al.   NATURE NEUROSCIENCE

Endogenous Opioids as Physiological Antidepressants: Complementary Role of Delta Receptors and Dopamine

(2011) Emily M Jutkiewicz et al.   NEUROPSYCHOPHARMACOLOGY

Cellular Mechanisms Underlying the Interaction between Cannabinoid and Opioid System

(2010) D. Parolaro et al.   CURRENT DRUG TARGETS

Crystal Structure of Fatty Acid Amide Hydrolase Bound to the Carbamate Inhibitor URB597: Discovery of a Deacylating Water Molecule and Insight into Enzyme Inactivation

(2010) Mauro Mileni et al.   JOURNAL OF MOLECULAR BIOLOGY

Shared Mechanisms for Opioid Tolerance and a Transition to Chronic Pain

(2010) E. K. Joseph et al.   JOURNAL OF NEUROSCIENCE

Anandamide suppresses pain initiation through a peripheral endocannabinoid mechanism

(2010) Jason R Clapper et al.   NATURE NEUROSCIENCE

Mu and delta opioid receptors on nociceptors attenuate mechanical hyperalgesia in rat

(2010) E.K. Joseph et al.   NEUROSCIENCE

Dysfunction of endogenous pain inhibition during exercise with painful muscles in patients with shoulder myalgia and fibromyalgia

(2010) Lisa Lannersten et al.   PAIN

Local application of the endocannabinoid hydrolysis inhibitor URB597 reduces nociception in spontaneous and chemically induced models of osteoarthritis

(2010) Niklas Schuelert et al.   PAIN

Coexpression of  - and  -opioid receptors in nociceptive sensory neurons

(2010) H.-B. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Discovery of PF-04457845: A Highly Potent, Orally Bioavailable, and Selective Urea FAAH Inhibitor

(2010) Douglas S. Johnson et al.   ACS Medicinal Chemistry Letters

The Role of the Endogenous Cannabinoid System in Peripheral Analgesia

(2010) Josee Guindon et al.   Current Molecular Pharmacology

Targeting Fatty Acid Amide Hydrolase (FAAH) to Treat Pain and Inflammation

(2009) Joel E. Schlosburg et al.   AAPS Journal

Structure of aminopeptidase N fromEscherichia colicomplexed with the transition-state analogue aminophosphinic inhibitor PL250

(2009) Marie-Claude Fournié-Zaluski et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Neprilysin Null Mice Develop Exaggerated Pulmonary Vascular Remodeling in Response to Chronic Hypoxia

(2009) Edward C. Dempsey et al.   AMERICAN JOURNAL OF PATHOLOGY

Cellular and Molecular Mechanisms of Pain

(2009) Allan I. Basbaum et al.   CELL

From endocannabinoid profiling to ‘endocannabinoid therapeutics’

(2009) Alessia Ligresti et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Cannabinoid–opioid interactions during neuropathic pain and analgesia

(2009) Ittai Bushlin et al.   CURRENT OPINION IN PHARMACOLOGY

Opiates as Antidepressants

(2009) Esther Berrocoso et al.   CURRENT PHARMACEUTICAL DESIGN

Synergy between Enzyme Inhibitors of Fatty Acid Amide Hydrolase and Cyclooxygenase in Visceral Nociception

(2009) P. S. Naidu et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Blockade of Endocannabinoid-Degrading Enzymes Attenuates Neuropathic Pain

(2009) S. G. Kinsey et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Involvement of enkephalins in the inhibition of osteosarcoma-induced thermal hyperalgesia evoked by the blockade of peripheral P2X3 receptors

(2009) Sara González-Rodríguez et al.   NEUROSCIENCE LETTERS

The endocannabinoid system of the skin in health and disease: novel perspectives and therapeutic opportunities

(2009) Tamás Bíró et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Altered Striatal Activation Predicting Real-World Positive Affect in Adolescent Major Depressive Disorder

(2008) Erika E. Forbes et al.   AMERICAN JOURNAL OF PSYCHIATRY

Biochemical and Biological Properties of 4-(3-phenyl-[1,2,4] thiadiazol-5-yl)-piperazine-1-carboxylic acid phenylamide, a Mechanism-Based Inhibitor of Fatty Acid Amide Hydrolase

(2008) Mark J. Karbarz et al.   ANESTHESIA AND ANALGESIA

Aminopeptidase N (APN)/CD13 inhibitor, Ubenimex, enhances radiation sensitivity in human cervical cancer

(2008) Hirohisa Tsukamoto et al.   BMC CANCER

The μ-opioid receptor agonist morphine, but not agonists at δ- or κ-opioid receptors, induces peripheral antinociception mediated by cannabinoid receptors

(2008) D da Fonseca Pacheco et al.   BRITISH JOURNAL OF PHARMACOLOGY

A physiological role for endocannabinoid-derived products of cyclooxygenase-2-mediated oxidative metabolism

(2008) J Guindon et al.   BRITISH JOURNAL OF PHARMACOLOGY

Adverse effects of medical cannabinoids: a systematic review

(2008) T. Wang et al.   CANADIAN MEDICAL ASSOCIATION JOURNAL

Enzymatic Pathways That Regulate Endocannabinoid Signaling in the Nervous System

(2008) Kay Ahn et al.   CHEMICAL REVIEWS

Enkephalinase Inhibitors: Potential Agents for the Management of Pain

(2008) V. Thanawala et al.   CURRENT DRUG TARGETS

Modulation of opioids via protection of anandamide degradation by fatty acid amide hydrolase

(2008) Victoria L. Haller et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Inhibition of osteosarcoma-induced thermal hyperalgesia in mice by the orally active dual enkephalinase inhibitor PL37. Potentiation by gabapentin

(2008) Luis Menéndez et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Antinociceptive and anti-allodynic effects of oral PL37, a complete inhibitor of enkephalin-catabolizing enzymes, in a rat model of peripheral neuropathic pain induced by vincristine

(2008) Karine Thibault et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Extracellular Biotransformation of β-Endorphin in Rat Striatum and Cerebrospinal Fluid

(2008) B. Reed et al.   JOURNAL OF NEUROENDOCRINOLOGY

A Decrease in Anandamide Signaling Contributes to the Maintenance of Cutaneous Mechanical Hyperalgesia in a Model of Bone Cancer Pain

(2008) I. A. Khasabova et al.   JOURNAL OF NEUROSCIENCE

The future of pain

(2008) Ronald Melzack   NATURE REVIEWS DRUG DISCOVERY

Targeting the endocannabinoid system: to enhance or reduce?

(2008) Vincenzo Di Marzo   NATURE REVIEWS DRUG DISCOVERY

Prodrugs: design and clinical applications

(2008) Jarkko Rautio et al.   NATURE REVIEWS DRUG DISCOVERY

Inhibition of fatty acid amide hydrolase and cyclooxygenase-2 increases levels of endocannabinoid related molecules and produces analgesia via peroxisome proliferator-activated receptor-alpha in a model of inflammatory pain

(2008) Maulik D. Jhaveri et al.   NEUROPHARMACOLOGY

Pain-related effects of trait anger expression: Neural substrates and the role of endogenous opioid mechanisms

(2008) Stephen Bruehl et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Peripheral mechanisms underlying the essential role of P2X3,2/3 receptors in the development of inflammatory hyperalgesia

(2008) Maria Cláudia G. Oliveira et al.   PAIN

The pro-nociceptive effects of remifentanil or surgical injury in mice are associated with a decrease in delta-opioid receptor mRNA levels: Prevention of the nociceptive response by on-site delivery of enkephalins

(2008) David Cabañero et al.   PAIN

Structure-guided inhibitor design for human FAAH by interspecies active site conversion

(2008) M. Mileni et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Cell and Molecular Basis of Mechanical, Cold, and Inflammatory Pain

(2008) B. Abrahamsen et al.   SCIENCE

The moonlighting enzyme CD13: old and new functions to target

(2008) Paola Mina-Osorio   TRENDS IN MOLECULAR MEDICINE

Role of ionotropic cannabinoid receptors in peripheral antinociception and antihyperalgesia

(2008) Armen N. Akopian et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Effect of bradykinin metabolism inhibitors on evoked hypotension in rats: rank efficacy of enzymes associated with bradykinin-mediated angioedema

(2007) R M Fryer et al.   BRITISH JOURNAL OF PHARMACOLOGY

The complications of promiscuity: endocannabinoid action and metabolism

(2007) S P H Alexander et al.   BRITISH JOURNAL OF PHARMACOLOGY

Cannabinoids go nuclear: evidence for activation of peroxisome proliferator-activated receptors

(2007) S E O'Sullivan   BRITISH JOURNAL OF PHARMACOLOGY

Inhibition of fatty acid amide hydrolase produces analgesia by multiple mechanisms

(2006) Leon Chang et al.   BRITISH JOURNAL OF PHARMACOLOGY

75 years of opioid research: the exciting but vain quest for the Holy Grail

(2006) Alistair D Corbett et al.   BRITISH JOURNAL OF PHARMACOLOGY

Levels, Metabolism, and Pharmacological Activity of Anandamide in CB1 Cannabinoid Receptor Knockout Mice

(2003) Vincenzo Di Marzo et al.   JOURNAL OF NEUROCHEMISTRY