Identifying ligand-specific signalling within biased responses: focus on δ opioid receptor ligands

Molecular control of δ-opioid receptor signalling

(2014) Gustavo Fenalti et al.   NATURE

Efficacy and ligand bias at the μ-opioid receptor

(2013) E Kelly   BRITISH JOURNAL OF PHARMACOLOGY

The Concise Guide to PHARMACOLOGY 2013/14: G Protein-Coupled Receptors

(2013) Stephen P.H. Alexander et al.   BRITISH JOURNAL OF PHARMACOLOGY

The Dynamic Process of β2-Adrenergic Receptor Activation

(2013) Rie Nygaard et al.   CELL

Ligand- and cell-dependent determinants of internalization and cAMP modulation by delta opioid receptor (DOR) agonists

(2013) Iness Charfi et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Signalling bias in new drug discovery: detection, quantification and therapeutic impact

(2013) Terry Kenakin et al.   NATURE REVIEWS DRUG DISCOVERY

Measurements of ligand bias and functional affinity

(2013) Terry Kenakin et al.   NATURE REVIEWS DRUG DISCOVERY

Quantifying biased agonism: understanding the links between affinity and efficacy

(2013) Sudarshan Rajagopal   NATURE REVIEWS DRUG DISCOVERY

Label-free cell phenotypic assessment of the biased agonism and efficacy of agonists at the endogenous muscarinic M3 receptors

(2013) Huayun Deng et al.   JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS

Differential Association of Receptor-G   Complexes with  -Arrestin2 Determines Recycling Bias and Potential for Tolerance of Delta Opioid Receptor Agonists

(2012) N. Audet et al.   JOURNAL OF NEUROSCIENCE

Where have all the active receptor states gone?

(2012) H Ongun Onaran et al.   Nature Chemical Biology

A Simple Method for Quantifying Functional Selectivity and Agonist Bias

(2011) Terry Kenakin et al.   ACS Chemical Neuroscience

Delta opioid receptor analgesia

(2011) Claire Gavériaux-Ruff et al.   BEHAVIOURAL PHARMACOLOGY

Biased signalling and allosteric machines: new vistas and challenges for drug discovery

(2011) Terry P Kenakin   BRITISH JOURNAL OF PHARMACOLOGY

Quantifying Ligand Bias at Seven-Transmembrane Receptors

(2011) S. Rajagopal et al.   MOLECULAR PHARMACOLOGY

Conformational changes in the G protein Gs induced by the β2 adrenergic receptor

(2011) Ka Young Chung et al.   NATURE

Structure of a nanobody-stabilized active state of the β2 adrenoceptor

(2011) Søren G. F. Rasmussen et al.   NATURE

Crystal structure of the β2 adrenergic receptor–Gs protein complex

(2011) Søren G. F. Rasmussen et al.   NATURE

Genetic ablation of delta opioid receptors in nociceptive sensory neurons increases chronic pain and abolishes opioid analgesia

(2011) Claire Gaveriaux-Ruff et al.   PAIN

Functional Selectivity at the  -Opioid Receptor: Implications for Understanding Opioid Analgesia and Tolerance

(2011) K. M. Raehal et al.   PHARMACOLOGICAL REVIEWS

Phosphorylation Barcoding as a Mechanism of Directing GPCR Signaling

(2011) S. B. Liggett   Science Signaling

Being mindful of seven-transmembrane receptor ‘guests’ when assessing agonist selectivity

(2010) Terry Kenakin   BRITISH JOURNAL OF PHARMACOLOGY

Morphine-like Opiates Selectively Antagonize Receptor-Arrestin Interactions

(2010) Paola Molinari et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Serine 363 of the  -opioid receptor is crucial for adopting distinct pathways to activate ERK1/2 in response to stimulation with different ligands

(2010) C. Xu et al.   JOURNAL OF CELL SCIENCE

SK-N-BE: A Human Neuroblastoma Cell Line Containing Two Subtypes of δ-Opioid Receptors

(2010) Jocelyne Polastron et al.   JOURNAL OF NEUROCHEMISTRY

Ligand-Directed Trafficking of the  -Opioid Receptor In Vivo: Two Paths Toward Analgesic Tolerance

(2010) A. A. A. Pradhan et al.   JOURNAL OF NEUROSCIENCE

Seven Transmembrane Receptors as Shapeshifting Proteins: The Impact of Allosteric Modulation and Functional Selectivity on New Drug Discovery

(2010) T. Kenakin et al.   PHARMACOLOGICAL REVIEWS

Introduction: Recommendations for the Diagnosis, Assessment, and Treatment of Neuropathic Pain

(2009) Robert H. Dworkin   AMERICAN JOURNAL OF MEDICINE

G Protein independent phosphorylation and internalization of the δ-opioid receptor

(2009) Faye A. Bradbury et al.   JOURNAL OF NEUROCHEMISTRY

Use of plasmon waveguide resonance (PWR) spectroscopy for examining binding, signaling and lipid domain partitioning of membrane proteins

(2009) Victor J. Hruby et al.   LIFE SCIENCES

Differential noxious and motor tolerance of chronic delta opioid receptor agonists in rodents

(2009) H. Beaudry et al.   NEUROSCIENCE

In Vivo Delta Opioid Receptor Internalization Controls Behavioral Effects of Agonists

(2009) Amynah A. A. Pradhan et al.   PLoS One

Different kinases desensitize the human δ-opioid receptor (hDOP-R) in the neuroblastoma cell line SK-N-BE upon peptidic and alkaloid agonists

(2008) Nicolas Marie et al.   CELLULAR SIGNALLING

Bioluminescence Resonance Energy Transfer Assays Reveal Ligand-specific Conformational Changes within Preformed Signaling Complexes Containing δ-Opioid Receptors and Heterotrimeric G Proteins

(2008) Nicolas Audet et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Kappa opioids promote the proliferation of astrocytes via Gβγ and β-arrestin 2-dependent MAPK-mediated pathways

(2008) Gregory P. McLennan et al.   JOURNAL OF NEUROCHEMISTRY

Role of Src in ligand-specific regulation of δ-opioid receptor desensitization and internalization

(2008) Min-Hua Hong et al.   JOURNAL OF NEUROCHEMISTRY