Lipid-mediated muscle insulin resistance: different fat, different pathways?

Training status diverges muscle diacylglycerol accumulation during free fatty acid elevation

(2014) Lisa S. Chow et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Acylcarnitines activate proinflammatory signaling pathways

(2014) Jennifer M. Rutkowsky et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Discovery of a Class of Endogenous Mammalian Lipids with Anti-Diabetic and Anti-inflammatory Effects

(2014) Mark M. Yore et al.   CELL

Tissue-Specific Differences in the Development of Insulin Resistance in a Mouse Model for Type 1 Diabetes

(2014) Tomas Jelenik et al.   DIABETES

Human Muscle Fiber Type–Specific Insulin Signaling: Impact of Obesity and Type 2 Diabetes

(2014) Peter H. Albers et al.   DIABETES

Role of diacylglycerol activation of PKCθ in lipid-induced muscle insulin resistance in humans

(2014) Julia Szendroedi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

New insights on glucosylated lipids: Metabolism and functions

(2013) Yohei Ishibashi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

From fatty-acid sensing to chylomicron synthesis: Role of intestinal lipid-binding proteins

(2013) Marjorie Buttet et al.   BIOCHIMIE

Mechanisms Underlying the Onset of Oral Lipid-Induced Skeletal Muscle Insulin Resistance in Humans

(2013) B. Nowotny et al.   DIABETES

Reduction of non-esterified fatty acids improves insulin sensitivity and lowers oxidative stress, but fails to restore oxidative capacity in type 2 diabetes: a randomised clinical trial

(2013) Esther Phielix et al.   DIABETOLOGIA

Distinct patterns of tissue-specific lipid accumulation during the induction of insulin resistance in mice by high-fat feeding

(2013) N. Turner et al.   DIABETOLOGIA

Mouse strain-dependent variation in obesity and glucose homeostasis in response to high-fat feeding

(2013) M. K. Montgomery et al.   DIABETOLOGIA

A sustained increase in plasma NEFA upregulates the Toll-like receptor network in human muscle

(2013) Sophie E. Hussey et al.   DIABETOLOGIA

High-Fat Diet-Mediated Lipotoxicity and Insulin Resistance Is Related to Impaired Lipase Expression in Mouse Skeletal Muscle

(2013) Pierre-Marie Badin et al.   ENDOCRINOLOGY

Ceramides and Glucosylceramides Are Independent Antagonists of Insulin Signaling

(2013) Jose A. Chavez et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Reduced skeletal muscle oxidative capacity and elevated ceramide but not diacylglycerol content in severe obesity

(2013) P.M. Coen et al.   Obesity

Lipid Droplets and Cellular Lipid Metabolism

(2012) Tobias C. Walther et al.   Annual Review of Biochemistry

Mitochondrial Plasticity in Obesity and Diabetes Mellitus

(2012) Tomas Jelenik et al.   ANTIOXIDANTS & REDOX SIGNALING

Mechanisms for Insulin Resistance: Common Threads and Missing Links

(2012) Varman T. Samuel et al.   CELL

Lipid-Induced Mitochondrial Stress and Insulin Action in Muscle

(2012) Deborah M. Muoio et al.   Cell Metabolism

Diacylglycerol Activation of Protein Kinase Cε and Hepatic Insulin Resistance

(2012) François R. Jornayvaz et al.   Cell Metabolism

Inflammation and Lipid Signaling in the Etiology of Insulin Resistance

(2012) Christopher K. Glass et al.   Cell Metabolism

Acylcarnitines

(2012) Marieke G. Schooneman et al.   DIABETES

Overexpression of Sphingosine Kinase 1 Prevents Ceramide Accumulation and Ameliorates Muscle Insulin Resistance in High-Fat Diet-Fed Mice

(2012) C. R. Bruce et al.   DIABETES

Toll-like Receptor 4 Deficiency Promotes the Alternative Activation of Adipose Tissue Macrophages

(2012) J. S. Orr et al.   DIABETES

A Lipidomics Analysis of the Relationship Between Dietary Fatty Acid Composition and Insulin Sensitivity in Young Adults

(2012) C. L. Kien et al.   DIABETES

Localisation and composition of skeletal muscle diacylglycerol predicts insulin resistance in humans

(2012) B. C. Bergman et al.   DIABETOLOGIA

Early Mitochondrial Adaptations in Skeletal Muscle to Diet-Induced Obesity Are Strain Dependent and Determine Oxidative Stress and Energy Expenditure But Not Insulin Sensitivity

(2012) Sihem Boudina et al.   ENDOCRINOLOGY

Insulin Resistance and Cancer Risk: An Overview of the Pathogenetic Mechanisms

(2012) Biagio Arcidiacono et al.   Experimental Diabetes Research

Fetuin-A acts as an endogenous ligand of TLR4 to promote lipid-induced insulin resistance

(2012) Durba Pal et al.   NATURE MEDICINE

Ectopic Fat and Insulin Resistance: Pathophysiology and Effect of Diet and Lifestyle Interventions

(2012) M. Snel et al.   International Journal of Endocrinology

Inflammatory Mechanisms in Obesity

(2011) Margaret F. Gregor et al.   Annual Review of Immunology

Skeletal Muscle Triglycerides, Diacylglycerols, and Ceramides in Insulin Resistance: Another Paradox in Endurance-Trained Athletes?

(2011) F. Amati et al.   DIABETES

Fatty acids acutely enhance insulin-induced oxidative stress and cause insulin resistance by increasing mitochondrial reactive oxygen species (ROS) generation and nuclear factor-κB inhibitor (IκB)–nuclear factor-κB (NFκB) activation in rat muscle, in the absence of mitochondrial dysfunction

(2011) R. Barazzoni et al.   DIABETOLOGIA

Sphingolipids: agents provocateurs in the pathogenesis of insulin resistance

(2011) C. Lipina et al.   DIABETOLOGIA

Many Ceramides

(2011) Yusuf A. Hannun et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lipid-induced insulin resistance mediated by the proinflammatory receptor TLR4 requires saturated fatty acid–induced ceramide biosynthesis in mice

(2011) William L. Holland et al.   JOURNAL OF CLINICAL INVESTIGATION

Ceramides as modulators of cellular and whole-body metabolism

(2011) Benjamin T. Bikman et al.   JOURNAL OF CLINICAL INVESTIGATION

Comparison of 5 intravenous lipid emulsions and their effects on hepatic steatosis in a murine model

(2011) Jonathan A. Meisel et al.   JOURNAL OF PEDIATRIC SURGERY

Skeletal Muscle Fatty Acid Handling in Insulin Resistant Men

(2011) Anneke M.J. van Hees et al.   Obesity

Chain length-specific properties of ceramides

(2011) Sabine Grösch et al.   PROGRESS IN LIPID RESEARCH

GPR120 Is an Omega-3 Fatty Acid Receptor Mediating Potent Anti-inflammatory and Insulin-Sensitizing Effects

(2010) Da Young Oh et al.   CELL

Lipid-Induced Insulin Resistance Affects Women Less Than Men and Is Not Accompanied by Inflammation or Impaired Proximal Insulin Signaling

(2010) L. D. Hoeg et al.   DIABETES

Saturated- and n-6 Polyunsaturated-Fat Diets Each Induce Ceramide Accumulation in Mouse Skeletal Muscle: Reversal and Improvement of Glucose Tolerance by Lipid Metabolism Inhibitors

(2010) G. Frangioudakis et al.   ENDOCRINOLOGY

Increased intramuscular lipid synthesis and low saturation relate to insulin sensitivity in endurance-trained athletes

(2010) Bryan C. Bergman et al.   JOURNAL OF APPLIED PHYSIOLOGY

A High-Fat Diet Elicits Differential Responses in Genes Coordinating Oxidative Metabolism in Skeletal Muscle of Lean and Obese Individuals

(2010) K. E. Boyle et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

The Effects of Long- or Medium-Chain Fat Diets on Glucose Tolerance and Myocellular Content of Lipid Intermediates in Rats

(2010) Johan De Vogel-van den Bosch et al.   Obesity

Membrane Fatty Acid Transporters as Regulators of Lipid Metabolism: Implications for Metabolic Disease

(2010) Jan F. C. Glatz et al.   PHYSIOLOGICAL REVIEWS

Lipid and insulin infusion-induced skeletal muscle insulin resistance is likely due to metabolic feedback and not changes in IRS-1, Akt, or AS160 phosphorylation

(2009) Andrew J. Hoy et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Insulin Resistance Is Associated With Higher Intramyocellular Triglycerides in Type I but Not Type II Myocytes Concomitant With Higher Ceramide Content

(2009) P. M. Coen et al.   DIABETES

Skeletal Muscle Insulin Resistance Is the Primary Defect in Type 2 Diabetes

(2009) R. A. DeFronzo et al.   DIABETES CARE

Skeletal Muscle Lipogenic Protein Expression Is Not Different between Lean and Obese Individuals: A Potential Factor in Ceramide Accumulation

(2009) A. Brianne Thrush et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Influence of Gender, Obesity, and Muscle Lipase Activity on Intramyocellular Lipids in Sedentary Individuals

(2009) Cedric Moro et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Mitochondrial H2O2 emission and cellular redox state link excess fat intake to insulin resistance in both rodents and humans

(2009) Ethan J. Anderson et al.   JOURNAL OF CLINICAL INVESTIGATION

Diabetes mellitus is associated with increased intramyocellular triglyceride, but not diglyceride, content in obese humans

(2009) Costas A. Anastasiou et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Identification of a Lipokine, a Lipid Hormone Linking Adipose Tissue to Systemic Metabolism

(2008) Haiming Cao et al.   CELL

Mitochondrial Overload and Incomplete Fatty Acid Oxidation Contribute to Skeletal Muscle Insulin Resistance

(2008) Timothy R. Koves et al.   Cell Metabolism

Ectopic lipids and organ function

(2008) Julia Szendroedi et al.   CURRENT OPINION IN LIPIDOLOGY

Human skeletal muscle ceramide content is not a major factor in muscle insulin sensitivity

(2008) M. Skovbro et al.   DIABETOLOGIA