Sphingolipids: agents provocateurs in the pathogenesis of insulin resistance

Sphingomyelinase stimulates oxidant signaling to weaken skeletal muscle and promote fatigue

(2010) Leonardo F. Ferreira et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Cellular depletion of atypical PKCλ is associated with enhanced insulin sensitivity and glucose uptake in L6 rat skeletal muscle cells

(2010) Clare Stretton et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Lipid-induced insulin resistance is prevented in lean and obese myotubes by AICAR treatment

(2010) Benjamin T. Bikman et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Ceramide channels and their role in mitochondria-mediated apoptosis

(2010) Marco Colombini   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Caveolae, caveolins, and cavins: complex control of cellular signalling and inflammation

(2010) J. H. Chidlow et al.   CARDIOVASCULAR RESEARCH

Inhibition of De Novo Ceramide Synthesis Reverses Diet-Induced Insulin Resistance and Enhances Whole-Body Oxygen Consumption

(2010) J. R. Ussher et al.   DIABETES

Ceramide-rich platforms in transmembrane signaling

(2010) Branka Stancevic et al.   FEBS LETTERS

Increased Mitochondrial Fatty Acid Oxidation Is Sufficient to Protect Skeletal Muscle Cells from Palmitate-induced Apoptosis

(2010) Carole Henique et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Effect of high fat diet enriched with unsaturated and diet rich in saturated fatty acids on sphingolipid metabolism in rat skeletal muscle

(2010) Agnieszka Blachnio-Zabielska et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Caveolins sequester FA on the cytoplasmic leaflet of the plasma membrane, augment triglyceride formation, and protect cells from lipotoxicity

(2010) J. R. Simard et al.   JOURNAL OF LIPID RESEARCH

Role of Sphingolipid Mediator Ceramide in Obesity and Renal Injury in Mice Fed a High-Fat Diet

(2010) K. M. Boini et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

High fat diet induces ceramide and sphingomyelin formation in rat’s liver nuclei

(2010) Grzegorz Chocian et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Receptor-mediated activation of ceramidase activity initiates the pleiotropic actions of adiponectin

(2010) William L Holland et al.   NATURE MEDICINE

Central role of ceramide biosynthesis in body weight regulation, energy metabolism, and the metabolic syndrome

(2009) Guang Yang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Ceramide 1-phosphate inhibits serine palmitoyltransferase and blocks apoptosis in alveolar macrophages

(2009) María H. Granado et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Intramuscular triacylglycerol and insulin resistance: Guilty as charged or wrongly accused?

(2009) Deborah M. Muoio   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Sphingomyelinases: their regulation and roles in cardiovascular pathophysiology

(2009) Catherine Pavoine et al.   CARDIOVASCULAR RESEARCH

Plasma Membrane Subdomain Compartmentalization Contributes to Distinct Mechanisms of Ceramide Action on Insulin Signaling

(2009) C. M. Blouin et al.   DIABETES

Exercise-induced alterations in intramyocellular lipids and insulin resistance: the athlete's paradox revisited

(2008) John J. Dubé et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Targeting of PKCζ and PKB to caveolin-enriched microdomains represents a crucial step underpinning the disruption in PKB-directed signalling by ceramide

(2008) Eric Hajduch et al.   BIOCHEMICAL JOURNAL

Modulating serine palmitoyl transferase (SPT) expression and activity unveils a crucial role in lipid-induced insulin resistance in rat skeletal muscle cells

(2008) Maria L. Watson et al.   BIOCHEMICAL JOURNAL

Overexpression of Carnitine Palmitoyltransferase-1 in Skeletal Muscle Is Sufficient to Enhance Fatty Acid Oxidation and Improve High-Fat Diet-Induced Insulin Resistance

(2008) C. R. Bruce et al.   DIABETES

Human skeletal muscle ceramide content is not a major factor in muscle insulin sensitivity

(2008) M. Skovbro et al.   DIABETOLOGIA

Acid Sphingomyelinase Deficiency Prevents Diet-induced Hepatic Triacylglycerol Accumulation and Hyperglycemia in Mice

(2008) Gergana M. Deevska et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Blocking VLDL secretion causes hepatic steatosis but does not affect peripheral lipid stores or insulin sensitivity in mice

(2008) Kaori Minehira et al.   JOURNAL OF LIPID RESEARCH

Tlr-4 Deficiency Selectively Protects Against Obesity Induced by Diets High in Saturated Fat

(2008) Jeremy E. Davis et al.   Obesity

Circulating levels of ganglioside GM3 in metabolic syndrome: A pilot study

(2008) Takashige Sato et al.   Obesity Research & Clinical Practice

Type I Gaucher Disease, a Glycosphingolipid Storage Disorder, Is Associated with Insulin Resistance

(2007) Mirjam Langeveld et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM