The other side of the coin: The tumor-suppressive aspect of oncogenes and the oncogenic aspect of tumor-suppressive genes, such as those along the CCND–CDK4/6–RB axis

Natural Antisense Transcript: A Concomitant Engagement with Protein-Coding Transcript

(2015)   Oncotarget

Unexpected Outcomes of CDK4/6 Inhibition

(2015) Yoon Jong Choi et al.   Oncotarget

Apoptosis in Living Animals Is Assisted by Scavenger Cells and Thus May Not Mainly Go through the Cytochrome C-Caspase Pathway

(2014) Bingya Liu et al.   Journal of Cancer

New Roles of Cyclin D1

(2013) Richard G. Pestell   AMERICAN JOURNAL OF PATHOLOGY

Metabolic control in cancer cells

(2013) Lluis Fajas   ANNALES D ENDOCRINOLOGIE

Cell Cycle Regulators Guide Mitochondrial Activity in Radiation-Induced Adaptive Response

(2013) Aris T. Alexandrou et al.   ANTIOXIDANTS & REDOX SIGNALING

Invasive cells in animals and plants: searching for LECA machineries in later eukaryotic life

(2013) Katarína Vaškovičová et al.   Biology Direct

Non-canonical p53 signaling to promote invasion

(2013) Paul Dent   CANCER BIOLOGY & THERAPY

Three steps to the immortality of cancer cells: senescence, polyploidy and self-renewal

(2013) Jekaterina Erenpreisa et al.   Cancer Cell International

The Dormancy Dilemma: Quiescence versus Balanced Proliferation

(2013) Alan Wells et al.   CANCER RESEARCH

Valproic acid inhibits the proliferation of cancer cells by re-expressing cyclin D2

(2013) Daria Witt et al.   CARCINOGENESIS

Cyclin D1 overexpression perturbs DNA replication and induces replication-associated DNA double-strand breaks in acquired radioresistant cells

(2013) Tsutomu Shimura et al.   CELL CYCLE

Cyclin-dependent kinase 4 may be expressed as multiple proteins and have functions that are independent of binding to CCND and RB and occur at the S and G2/M phases of the cell cycle

(2013) Yuan Sun et al.   CELL CYCLE

CDK4/6-inhibiting drug substitutes for p21 and p16 in senescence: Duration of cell cycle arrest and MTOR activity determine geroconversion

(2013) Olga V. Leontieva et al.   CELL CYCLE

Tumor-suppressive effects of CDK8 in endometrial cancer cells

(2013) Weiting Gu et al.   CELL CYCLE

Cell cycle regulators cyclin D1 and CDK4/6 have estrogen receptor-dependent divergent functions in breast cancer migration and stem cell-like activity

(2013) Rebecca Lamb et al.   CELL CYCLE

The role of cyclin D1 in response to long-term exposure to ionizing radiation

(2013) Tsutomu Shimura et al.   CELL CYCLE

S6K in geroconversion

(2013) Olga V. Leontieva et al.   CELL CYCLE

Immortality of cancers

(2013) Peter Duesberg et al.   CELL CYCLE

MEK drives cyclin D1 hyperelevation during geroconversion

(2013) O V Leontieva et al.   CELL DEATH AND DIFFERENTIATION

Titin Is a Major Human Disease Gene

(2013) Martin M. LeWinter et al.   CIRCULATION

Molecular Pathways: How Can BRCA-Mutated Tumors Become Resistant to PARP Inhibitors?

(2013) Peter Bouwman et al.   CLINICAL CANCER RESEARCH

The Cell-Cycle Regulator CDK4: An Emerging Therapeutic Target in Melanoma

(2013) K. E. Sheppard et al.   CLINICAL CANCER RESEARCH

Tumor suppressor activity of the ERK/MAPK pathway by promoting selective protein degradation

(2013) X. Deschenes-Simard et al.   GENES & DEVELOPMENT

Significance of Population Size on the Fixation of Nonsynonymous Mutations in Genes Under Varying Levels of Selection Pressure

(2013) S. Subramanian   GENETICS

The humankind genome: from genetic diversity to the origin of human diseases

(2013) Jose E. Belizário   GENOME

Phase II Trial of the CDK4 Inhibitor PD0332991 in Patients With Advanced CDK4-Amplified Well-Differentiated or Dedifferentiated Liposarcoma

(2013) Mark A. Dickson et al.   JOURNAL OF CLINICAL ONCOLOGY

Rethinking the war on cancer

(2013) Douglas Hanahan   LANCET

A key role for mitochondrial gatekeeper pyruvate dehydrogenase in oncogene-induced senescence

(2013) Joanna Kaplon et al.   NATURE

Blockbuster dreams for Pfizer's CDK inhibitor

(2013) Malini Guha   NATURE BIOTECHNOLOGY

Intermolecular domain swapping induces intein-mediated protein alternative splicing

(2013) A Sesilja Aranko et al.   Nature Chemical Biology

Overexpression of Cdk6 and Ccnd1 in chondrocytes inhibited chondrocyte maturation and caused p53-dependent apoptosis without enhancing proliferation

(2013) K Ito et al.   ONCOGENE

Targeting cell cycle and hormone receptor pathways in cancer

(2013) C E S Comstock et al.   ONCOGENE

Signaling through cyclin D-dependent kinases

(2013) Y J Choi et al.   ONCOGENE

Characterization of Growth Suppressive Functions of a Splice Variant of Cyclin D2

(2013) Karim Wafa et al.   PLoS One

p16 Stimulates CDC42-Dependent Migration of Hepatocellular Carcinoma Cells

(2013) Ya-Wen Chen et al.   PLoS One

PD-0332991, a CDK4/6 Inhibitor, Significantly Prolongs Survival in a Genetically Engineered Mouse Model of Brainstem Glioma

(2013) Kelly L. Barton et al.   PLoS One

Possible Formation of Mitochondrial-RNA Containing Chimeric or Trimeric RNA Implies a Post-Transcriptional and Post-Splicing Mechanism for RNA Fusion

(2013) Wei Yang et al.   PLoS One

Tumor suppressor p16INK4A is necessary for survival of cervical carcinoma cell lines

(2013) M. E. McLaughlin-Drubin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Silencing CDK4 radiosensitizes breast cancer cells by promoting apoptosis

(2013) Katie R Hagen et al.   Cell Division

A Double-Edged Sword: How Oncogenes and Tumor Suppressor Genes Can Contribute to Chromosomal Instability

(2013) Bernardo Orr et al.   Frontiers in Oncology

Re-thinking cell cycle regulators: the cross-talk with metabolism

(2013) Lluis Fajas   Frontiers in Oncology

A possible usage of a CDK4 inhibitor for breast cancer stem cell-targeted therapy

(2012) Yu Kyeong Han et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Selective CDK4/6 inhibition with tumor responses by PD0332991 in patients with mantle cell lymphoma

(2012) J. P. Leonard et al.   BLOOD

The Requirement for Cyclin D Function in Tumor Maintenance

(2012) Yoon Jong Choi et al.   CANCER CELL

Proteomic Identification of a Direct Role for Cyclin D1 in DNA Damage Repair

(2012) S. Jirawatnotai et al.   CANCER RESEARCH

Therapeutic response to CDK4/6 inhibition in breast cancer defined by ex vivo analyses of human tumors

(2012) Jeffry L. Dean et al.   CELL CYCLE

Hyper-mitogenic drive coexists with mitotic incompetence in senescent cells

(2012) Olga V. Leontieva et al.   CELL CYCLE

CDK4/6 inhibition antagonizes the cytotoxic response to anthracycline therapy

(2012) A. Kathleen McClendon et al.   CELL CYCLE

Drosophila cyclin D/Cdk4 regulates mitochondrial biogenesis and aging and sensitizes animals to hypoxic stress

(2012) Amalia Icreverzi et al.   CELL CYCLE

Switch of FANCL, a key FA-BRCA component, between tumor suppressor and promoter by alternative splicing

(2012) Chengfu Yuan et al.   CELL CYCLE

Recent progress in intein research: from mechanism to directed evolution and applications

(2012) Gerrit Volkmann et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Trespassing cancer cells: ‘fingerprinting’ invasive protrusions reveals metastatic culprits

(2012) Richard L Klemke   CURRENT OPINION IN CELL BIOLOGY

Quantifying harmful mutations in human populations

(2012) Sankar Subramanian   EUROPEAN JOURNAL OF HUMAN GENETICS

Cyclin D3 coordinates the cell cycle during differentiation to regulate erythrocyte size and number

(2012) V. G. Sankaran et al.   GENES & DEVELOPMENT

Modification of the DNA Damage Response by Therapeutic CDK4/6 Inhibition

(2012) Jeffry L. Dean et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Rational design of the survivin/CDK4 complex by combining protein–protein docking and molecular dynamics simulations

(2012) Jana Selent et al.   JOURNAL OF MOLECULAR MODELING

Multiple Roles of Cyclin-Dependent Kinase 4/6 Inhibitors in Cancer Therapy

(2012) Patrick J. Roberts et al.   JNCI-Journal of the National Cancer Institute

Reduced expression of cyclin D2 is associated with poor recurrence-free survival independent of cyclin D1 in stage III non-small cell lung cancer

(2012) Eunkyung Ko et al.   LUNG CANCER

Cdk4/6 Inhibition Induces Epithelial-Mesenchymal Transition and Enhances Invasiveness in Pancreatic Cancer Cells

(2012) F. Liu et al.   MOLECULAR CANCER THERAPEUTICS

Presenting ENCODE

(2012) Magdalena Skipper et al.   NATURE

p53 mutations in cancer

(2012) Patricia A. J. Muller et al.   NATURE CELL BIOLOGY

p16-Cdk4-Rb axis controls sensitivity to a cyclin-dependent kinase inhibitor PD0332991 in glioblastoma xenograft cells

(2012) L. Cen et al.   NEURO-ONCOLOGY

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

(2012) Milana Frenkel-Morgenstern et al.   NUCLEIC ACIDS RESEARCH

ENCODE Project Writes Eulogy for Junk DNA

(2012) E. Pennisi   SCIENCE

Effects of an Indolocarbazole-Derived CDK4 Inhibitor on Breast Cancer Cells

(2012) Yuan Sun et al.   Journal of Cancer

Unexpected Reduction of Skin Tumorigenesis on Expression of Cyclin-Dependent Kinase 6 in Mouse Epidermis

(2011) Xian Wang et al.   AMERICAN JOURNAL OF PATHOLOGY

Coding vs non-coding: Translatability of short ORFs found in putative non-coding transcripts

(2011) Yuji Kageyama et al.   BIOCHIMIE

Cyclin D1, Id1 and EMT in breast cancer

(2011) Nicholas P Tobin et al.   BMC CANCER

c-Myc induction of programmed cell death may contribute to carcinogenesis

(2011) Chenguang Wang et al.   CANCER BIOLOGY & THERAPY

A Systematic Screen for CDK4/6 Substrates Links FOXM1 Phosphorylation to Senescence Suppression in Cancer Cells

(2011) Lars Anders et al.   CANCER CELL

Regulation of Sp1 by cell cycle related proteins

(2011) Alicia Tapias et al.   CELL CYCLE

Cyclin D3 is dispensable for human diffuse large B-cell lymphoma survival and growth: evidence for redundancy with cyclin E

(2011) Maria R. Gumina et al.   CELL CYCLE

Rb inactivation in cell cycle and cancer: The puzzle of highly regulated activating phosphorylation of CDK4 versus constitutively active CDK-activating kinase

(2011) Sabine Paternot et al.   CELL CYCLE

Reviewing once more the c-myc and Ras collaboration

(2011) Chenguang Wang et al.   CELL CYCLE

Multiple pathways counteract cell death induced by RB1 loss: Implications for cancer

(2011) Giovanni Ciavarra et al.   CELL CYCLE

Biological functions of p53 isoforms through evolution: lessons from animal and cellular models

(2011) V Marcel et al.   CELL DEATH AND DIFFERENTIATION

Phase I, Dose-Escalation Trial of the Oral Cyclin-Dependent Kinase 4/6 Inhibitor PD 0332991, Administered Using a 21-Day Schedule in Patients with Advanced Cancer

(2011) K. T. Flaherty et al.   CLINICAL CANCER RESEARCH

Newly identified aspects of tumor suppression by RB

(2011) P. Viatour et al.   Disease Models & Mechanisms

Killing the second messenger: targeting loss of cell cycle control in endocrine-resistant breast cancer

(2011) C. A. Lange et al.   ENDOCRINE-RELATED CANCER

Therapeutically activating RB: reestablishing cell cycle control in endocrine therapy-resistant breast cancer

(2011) C. Thangavel et al.   ENDOCRINE-RELATED CANCER

The Giant Protein Titin: A Regulatory Node That Integrates Myocyte Signaling Pathways

(2011) Martina Krüger et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cyclin D3 promotes myogenic differentiation and Pax7 transcription

(2011) Ritika Gurung et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Point mutation instability (PIN) mutator phenotype as model for true back mutations seen in hereditary tyrosinemia type 1 – a hypothesis

(2011) Etresia van Dyk et al.   JOURNAL OF INHERITED METABOLIC DISEASE

Acquired Radioresistance of Cancer and the AKT/GSK3β/cyclin D1 Overexpression Cycle

(2011) Tsutomu SHIMURA   JOURNAL OF RADIATION RESEARCH

Fixation of Deleterious Mutations at Critical Positions in Human Proteins

(2011) S. Subramanian   MOLECULAR BIOLOGY AND EVOLUTION

RB deletion disrupts coordination between DNA replication licensing and mitotic entry in vivo

(2011) Ryan J. Bourgo et al.   MOLECULAR BIOLOGY OF THE CELL

Selective anticancer activity of a hexapeptide with sequence homology to a non-kinase domain of Cyclin Dependent Kinase 4

(2011) Hilmar M Warenius et al.   Molecular Cancer

A function for cyclin D1 in DNA repair uncovered by protein interactome analyses in human cancers

(2011) Siwanon Jirawatnotai et al.   NATURE

Cyclin D1 multitasks

(2011) Jiri Bartek et al.   NATURE

Harnessing synthetic lethal interactions in anticancer drug discovery

(2011) Denise A. Chan et al.   NATURE REVIEWS DRUG DISCOVERY

Exome sequencing as a tool for Mendelian disease gene discovery

(2011) Michael J. Bamshad et al.   NATURE REVIEWS GENETICS

Elimination of Proliferating Cells Unmasks the Shift from Senescence to Quiescence Caused by Rapamycin

(2011) Olga V. Leontieva et al.   PLoS One

Structural and Functional Analysis of Cyclin D1 Reveals p27 and Substrate Inhibitor Binding Requirements

(2010) Shu Liu et al.   ACS Chemical Biology

Down-Regulation of the Oncogene Cyclin D1 Increases Migratory Capacity in Breast Cancer and Is Linked to Unfavorable Prognostic Features

(2010) Sophie Lehn et al.   AMERICAN JOURNAL OF PATHOLOGY

The p76Rb and p100Rb truncated forms of the Rb protein exert antagonistic roles on cell death regulation in human cell lines

(2010) Nathalie Le Floch et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Cyclin D1/Cyclin-Dependent Kinase 4 Interacts with Filamin A and Affects the Migration and Invasion Potential of Breast Cancer Cells

(2010) Z. Zhong et al.   CANCER RESEARCH

Secondary mutations of BRCA1/2 and drug resistance

(2010) Kiranjit K. Dhillon et al.   CANCER SCIENCE

Cyclin independent role for cdk4/6 during B-cell lymphoma survival

(2010) E. Charles Snow   CELL CYCLE

p16Ink4A, not only a G1inhibitor?

(2010) Vjekoslav Dulić   CELL CYCLE

S-phase lengthening induced by p16INK4aoverexpression in malignant cells with wild-type pRb and p53

(2010) Wei Wen Chien et al.   CELL CYCLE

Absence of pRb facilitates E2F1-induced apoptosis in breast cancer cells

(2010) Baohua Sun et al.   CELL CYCLE

Apoptosis and aging: increased resistance to apoptosis enhances the aging process

(2010) Antero Salminen et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Methylated cyclin D2 gene circulating in the blood as a prognosis predictor of hepatocellular carcinoma

(2010) Masahito Tsutsui et al.   CLINICA CHIMICA ACTA

The essence of senescence

(2010) T. Kuilman et al.   GENES & DEVELOPMENT

MUT-TP53 2.0: a novel versatile matrix for statistical analysis of TP53 mutations in human cancera

(2010) Thierry Soussi et al.   HUMAN MUTATION

Parkin Enhances the Expression of Cyclin-dependent Kinase 6 and Negatively Regulates the Proliferation of Breast Cancer Cells

(2010) Shiam-Peng Tay et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Titin Diversity—Alternative Splicing Gone Wild

(2010) Wei Guo et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Mitigation of hematologic radiation toxicity in mice through pharmacological quiescence induced by CDK4/6 inhibition

(2010) Søren M. Johnson et al.   JOURNAL OF CLINICAL INVESTIGATION

Cell death in the neighbourhood: direct microenvironmental effects of apoptosis in normal and neoplastic tissues

(2010) Christopher D Gregory et al.   JOURNAL OF PATHOLOGY

Cyclin-Dependent Kinase 4/6 (Cdk4/6) Inhibitors: Perspectives in Cancer Therapy and Imaging

(2010) F. Graf et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Transcriptional role of cyclin D1 in development revealed by a genetic–proteomic screen

(2010) Frédéric Bienvenu et al.   NATURE

Therapeutic CDK4/6 inhibition in breast cancer: key mechanisms of response and failure

(2010) J L Dean et al.   ONCOGENE

Acquired radioresistance of human tumor cells by DNA-PK/AKT/GSK3β-mediated cyclin D1 overexpression

(2010) T Shimura et al.   ONCOGENE

Revertant mosaicism in skin: natural gene therapy

(2010) Joey E. Lai-Cheong et al.   TRENDS IN MOLECULAR MEDICINE

The CDK4-pRB-E2F1 pathway : A new modulator of insulin secretion

(2010) Lluis Fajas et al.   Islets

Cdk2 Is Required for p53-Independent G2/M Checkpoint Control

(2010) Jon H. Chung et al.   PLoS Genetics

Restoration of cyclin D2 has an inhibitory potential on the proliferation of LNCaP cells

(2009) Takashi Kobayashi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Comparisons of the Conformational Stability of Cyclin-Dependent Kinase (CDK) 4-Interacting Ankyrin Repeat (AR) Proteins

(2009) Yi Guo et al.   BIOCHEMISTRY

Naturally occurring antisense RNA: function and mechanisms of action

(2009) Andreas Werner et al.   CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION

A putative role for cell cycle-related proteins in microtubule-based neuroplasticity

(2009) Stefanie Schmetsdorf et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Cyclin D2 and the CDK substrate p220NPATare required for self-renewal of human embryonic stem cells

(2009) Klaus A. Becker et al.   JOURNAL OF CELLULAR PHYSIOLOGY

p16INK4A inactivation mechanisms in non-small-cell lung cancer patients occupationally exposed to asbestos

(2009) Pascal Andujar et al.   LUNG CANCER

Targeted capture and massively parallel sequencing of 12 human exomes

(2009) Sarah B. Ng et al.   NATURE

p16 Gene Expression in Basal Cell Carcinoma

(2008) Sima Ataollahi Eshkoor et al.   ARCHIVES OF MEDICAL RESEARCH

Drug Resistance Caused by Reversion Mutation

(2008) A. Ashworth   CANCER RESEARCH

p27Kip1 Inhibits Cyclin D-Cyclin-Dependent Kinase 4 by Two Independent Modes

(2008) A. Ray et al.   MOLECULAR AND CELLULAR BIOLOGY

Combined Inactivation of MYC and K-Ras Oncogenes Reverses Tumorigenesis in Lung Adenocarcinomas and Lymphomas

(2008) Phuoc T. Tran et al.   PLoS One