Article
Pharmacology & Pharmacy
Yanting Zhou, Xiandeng Li, Peifang Luo, Huiting Chen, Yan Zhou, Xueting Zheng, Yuan Yin, Haoche Wei, Hongji Liu, Wen Xia, Mingsong Shi, Xiaoan Li
Summary: CDK4/6 is a crucial player in various cancers and a potential target for anticancer drugs. The interaction between abemaciclib and human CDK6 was studied, and C2231-A was identified as a promising candidate compound with significant inhibitory effects on human breast cancer cell lines.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Dermatology
Emanuel Raschi, Michele Fusaroli, Michelangelo La Placa, Andrea Ardizzoni, Claudio Zamagni, Elisabetta Poluzzi, Fabrizio De Ponti
Summary: In the real world setting, CDK4/6 inhibitors have been associated with a variety of cutaneous adverse events, including alopecia, rash, and pruritus. Serious cases may require drug discontinuation, and the onset of different skin toxicities varies. Specific skin reactions may be more common with certain CDK4/6 inhibitors.
AMERICAN JOURNAL OF CLINICAL DERMATOLOGY
(2022)
Review
Oncology
Mitra Zabihi, Ramin Lotfi, Amir-Mohammad Yousefi, Davood Bashash
Summary: CDKs, cyclins, and CKIs play important roles in the cell cycle regulatory machinery, and dysregulation of their expression or function can contribute to tumorigenesis. While designing CDK inhibitors to target tumor cells shows promise, the non-canonical functions of CDKs pose challenges in their application. This review aims to explore the biology of CDKs and their contribution to tumorigenesis, and discuss the pros and cons of CDK inhibition in the treatment of human cancers.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Review
Chemistry, Medicinal
Mohammed Al-Kassim Hassan, Zeynep Ates-Alagoz
Summary: Breast cancer is the leading cause of cancer-related deaths in women worldwide. FDA has approved three CDK4/6 inhibitors for the targeted treatment of advanced or metastatic breast cancer, and several compounds derived from various synthetic scaffolds are showing promising results in clinical trials. This review highlights the potent anti-CDK4/6 activities of these compounds and emphasizes the potential for discovering novel CDK inhibitor compounds in the future, expanding therapeutic options for cancer treatment.
MINI-REVIEWS IN MEDICINAL CHEMISTRY
(2023)
Article
Oncology
Shinya Kitamura, Teruki Yanagi, Takuya Maeda, Hideyuki Ujiie
Summary: Extramammary Paget's disease (EMPD) is a rare adnexal neoplasm commonly found in the genital areas of the elderly population. Studies have shown that CDK4/6 inhibitors may have potential therapeutic effects against EMPD, significantly suppressing tumor growth.
Article
Cell Biology
Sun Hye Kim, Liliana R. L. Rodriguez, Everardo Macias, Marcelo L. Rodriguez-Puebla
Summary: CDK4 protein level plays a role in regulating the proliferation and number of hair follicle stem cells.
CELL BIOLOGY INTERNATIONAL
(2022)
Article
Biology
Tanya L. Brown, Emma C. Horton, Evan W. Craig, Camille E. A. Goo, Erik C. Black, Madeleine N. Hewitt, Nathaniel G. Yee, Everett T. Fan, David W. Raible, Jeffrey P. Rasmussen, Marianne E. Bronner
Summary: This study discovered Merkel cells in zebrafish epidermis and identified Atoh1a as a marker for zebrafish Merkel cells. Merkel cells in zebrafish develop from basal keratinocytes and exhibit neurosecretory and mechanosensory machinery, actin-rich microvilli, and complex with somatosensory axons, similar to mammalian Merkel cells. The study also found region-specific densities and distribution patterns of Merkel cells in different skin compartments.
Article
Biochemistry & Molecular Biology
Feifei Shi, Xizeng Feng
Summary: In this study, it was found that DBDPE exposure did not affect the first polar body extrusion of oocytes in mice. However, exposure to DBDPE impaired the asymmetric division of oocytes, resulting in larger polar bodies. This was due to the inhibition of spindle migration and membrane protrusion in oocytes during anaphase I, as well as the suppression of cyclin-dependent kinase 1 inactivation.
Review
Biochemistry & Molecular Biology
Georgia Gomatou, Ioannis Trontzas, Stephanie Ioannou, Maria Drizou, Nikolaos Syrigos, Elias Kotteas
Summary: CDK 4/6 inhibitors have shown promise in treating breast cancer, but patients often develop resistance. Studies indicate that resistance mechanisms involve aberrations of cell cycle molecules and rewiring of the cell to reduce dependence on CDK 4/6.
MOLECULAR BIOLOGY REPORTS
(2021)
Article
Dermatology
Andrey A. Panteleyev
Summary: The periderm in mice is bilayered, with an outer layer containing microvilli and an inner layer with specific granules. The shedding patterns differ for the two layers, with the outer periderm shedding in utero and the inner periderm retained postnatally.
EXPERIMENTAL DERMATOLOGY
(2022)
Article
Oncology
Emanuel Raschi, Michele Fusaroli, Andrea Ardizzoni, Elisabetta Poluzzi, Fabrizio De Ponti
Summary: This post-marketing research studied the role of cyclin-dependent kinase 4/6 inhibitors in cancer-associated thrombosis, finding a potential class effect for venous thrombosis and distinctive arterial events for ribociclib. The study suggests proactive monitoring by oncologists for thromboembolic events with CDK4/6 inhibitors and supports pharmacovigilance for safe prescribing in oncology.
Article
Biochemistry & Molecular Biology
Hong Zhou, Qixiang Zhao, Chengcheng Yue, Jiadong Yu, Huaping Zheng, Jing Hu, Zhonglan Hu, Haozhou Zhang, Xiu Teng, Xiao Liu, Xiaoqiong Wei, Yuxi Zhou, Fanlian Zeng, Yan Hao, Yawen Hu, Xiaoyan Wang, Chen Zhang, Linna Gu, Wenling Wu, Yifan Zhou, Kaijun Cui, Nongyu Huang, Wei Li, Zhen Wang, Jiong Li
Summary: IL-38 is downregulated in cutaneous squamous cell carcinoma and its knockout suppresses skin tumor formation and malignant progression. Deletion of IL-38 leads to reduced expression of inflammatory cytokines and myeloid cell infiltration in the tumor microenvironment. IL-38 activates the JNK/AP-1 pathway in an IL-1Rrp2-dependent manner to promote cancer-related inflammatory cytokines expression, tumor cell proliferation, and migration.
Article
Biochemistry & Molecular Biology
Marian Kratzke, George Scaria, Stephen Porter, Betsy Kren, Mark A. Klein
Summary: Advanced mesothelioma is an incurable disease, and new treatment strategies are needed. This study demonstrated that the inhibitors auranofin and palbociclib could effectively decrease mesothelioma cell proliferation and inhibit activity related to antioxidant defense and cell cycle progression. Further investigation of this drug combination may reveal a new treatment strategy for mesothelioma.
Editorial Material
Chemistry, Medicinal
Mark Klein
Summary: Cyclin-dependent kinases (CDKs) have important roles in normal cells and can be targeted for cancer therapy. CDK4 inhibitors have been approved for advanced breast cancer treatment. However, the development of selective inhibitors for individual CDKs is challenging due to the highly conserved ATP-binding site.
Article
Microbiology
Juri Kim, Eun-Ah Park, Mee Young Shin, Soon-Jung Park
Summary: This study investigated the functional roles of Giardia lamblia CDKs (GlCDKs) and their cognate cyclins. Using morpholino-mediated knockdown and coimmunoprecipitation, the functions of GlCDK1 and GlCDK2 were distinguished. GlCDK1 with Glcyclin 3977 plays a crucial role in flagellum formation and cell cycle control of G. lamblia, while GlCDK2 with Glcyclin 22394/6584 is involved in cell cycle control.
MICROBIOLOGY SPECTRUM
(2023)
Article
Oncology
Shalini Jain, Xiao Wang, Chia-Chi Chang, Catherine Ibarra-Drendall, Hai Wang, Qingling Zhang, Samuel W. Brady, Ping Li, Hong Zhao, Jessica Dobbs, Matt Kyrish, Tomasz S. Tkaczyk, Adrian Ambrose, Christopher Sistrunk, Banu K. Arun, Rebecca Richards-Kortum, Wei Jia, Victoria L. Seewaldt, Dihua Yu
Article
Biochemistry & Molecular Biology
Jason C. Tung, J. Matthew Barnes, Shraddha R. Desai, Christopher Sistrunk, Matthew W. Conklin, Pepper Schedin, Kevin W. Eliceiri, Patricia J. Keely, Victoria L. Seewaldt, Valerie M. Weaver
FREE RADICAL BIOLOGY AND MEDICINE
(2015)
Article
Oncology
Sun Hye Kim, Christopher Sistrunk, Paula L. Miliani de Marval, Marcelo L. Rodriguez-Puebla
Article
Pathology
Christopher Sistrunk, Sun Hye Kim, Xian Wang, Sung Hyun Lee, Yongbaek Kim, Everardo Macias, Marcelo L. Rodriguez-Puebla
AMERICAN JOURNAL OF PATHOLOGY
(2013)
Article
Cell Biology
Xian Wang, Christopher Sistrunk, Paula L. Miliani de Marval, Yongbaek Kim, Marcelo L. Rodriguez-Puebla
Article
Multidisciplinary Sciences
Nicholas C. D'Amato, Julie H. Ostrander, Michelle L. Bowie, Christopher Sistrunk, Alexander Borowsky, Robert D. Cardiff, Katie Bell, Lawrence J. T. Young, Karl Simin, Robin E. Bachelder, Jeff Delrow, Alyssa Dawson, Lisa D. Yee, Krzysztof Mrozek, Timothy M. Clay, Takuya Osada, Victoria L. Seewaldt
Article
Biochemistry & Molecular Biology
Iliana Tenvooren, Monica Z. Jenks, Hamza Rashid, Katherine L. Cook, Joelle K. Muhlemann, Christopher Sistrunk, Julia Holmes, Kevin Wang, Keith Bonin, Kurt Hodges, Hui-Wen Lo, Ayaz Shaikh, Ignacio G. Camarillo, Sophie A. Lelievre, Victoria Seewaldt, Pierre-Alexandre Vidi
Review
Environmental Sciences
Rama Natarajan, Dana Aljaber, Dawn Au, Christine Thai, Angelica Sanchez, Alan Nunez, Cristal Resto, Tanya Chavez, Marta M. Jankowska, Tarik Benmarhnia, Jiue-An Yang, Veronica Jones, Jerneja Tomsic, Jeannine S. McCune, Christopher Sistrunk, Stacey Doan, Mayra Serrano, Robert D. Cardiff, Eric C. Dietze, Victoria L. Seewaldt
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2020)
Article
Oncology
David A. Skaar, Eric C. Dietze, Jackelyn A. Alva-Ornelas, David Ann, Dustin E. Schones, Terry Hyslop, Christopher Sistrunk, Carola Zalles, Adrian Ambrose, Kendall Kennedy, Ombeni Idassi, Gustavo Miranda Carboni, Michael N. Gould, Randy L. Jirtle, Victoria L. Seewaldt
Summary: Genomic imprinting is a specific form of epigenetic regulation that is influenced by poor prenatal nutrition and environmental toxins. KCNK9, a gene associated with breast cancer, was found to be imprinted in breast tissue and hypomethylation at its differentially methylated region was significantly associated with triple-negative breast cancer, particularly in African-American women. The study suggests that hypomethylation of the KCNK9 DMR may serve as a marker of risk and a potential target for prevention of TNBC.
Review
Cardiac & Cardiovascular Systems
Christopher Sistrunk, Nora Tolbert, Maria Dulfary Sanchez-Pino, Loretta Erhunmwunsee, Nikita Wright, Veronica Jones, Terry Hyslop, Gustavo Miranda-Carboni, Eric C. Dietze, Ernest Martinez, Sophia George, Augusto C. Ochoa, Robert A. Winn, Victoria L. Seewaldt
Summary: Racist and discriminatory housing policies contribute to disparities in cardiovascular health for Black/African American individuals. Redlining, zoning, and highway construction limit access to healthcare, increase exposure to carcinogens and heat, and perpetuate racial inequities. The societal and structural factors are linked to biological processes such as inflammation and plaque formation.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Review
Oncology
Nikita Jinna, Tijana Jovanovic-Talisman, Mark LaBarge, Rama Natarajan, Rick Kittles, Christopher Sistrunk, Padmashree Rida, Victoria L. Seewaldt
Summary: In this article, the authors reviewed molecular distinctions in Quadruple negative breast cancer (QNBC) biology between Black/African-American and White/European-American populations, as well as potential non-genetic risk factors that contribute to the racial disparities. The goal is to provide insight into therapeutic targets and lifestyle changes for improving the outcomes of Black/AA QNBC patients.
Article
Medicine, Research & Experimental
David E. Frankhauser, Tijana Jovanovic-Talisman, Lily Lai, Lisa D. Yee, Lihong V. Wang, Ashish Mahabal, Joseph Geradts, Russell C. Rockne, Jerneja Tomsic, Veronica Jones, Christopher Sistrunk, Gustavo Miranda-Carboni, Eric C. Dietze, Loretta Erhunmwunsee, Terry Hyslop, Victoria L. Seewaldt
Summary: While over 90% of breast cancer cases are cured, there are still highly aggressive types that are difficult to treat or prevent. This research team focuses on identifying multiscale integrated strategies to detect biologically aggressive precancerous breast lesions, utilizing new technologies such as single cell transcriptional profiling and nanoscale evaluation. By understanding spatial and temporal relationships in breast cancer development, they hope to improve early detection and treatment of aggressive forms of the disease.
WIRES MECHANISMS OF DISEASE
(2021)
Article
Oncology
Katherine Tossas-Milligan, Sundus Shalabi, Veronica Jones, Patricia J. Keely, Matthew W. Conklin, Kevin W. Eliceiri, Robert Winn, Christopher Sistrunk, Joseph Geradts, Gustavo A. Miranda-Carboni, Eric C. Dietze, Lisa D. Yee, Victoria L. Seewaldt
CURRENT BREAST CANCER REPORTS
(2019)
Review
Oncology
Eric C. Dietze, Christopher Sistrunk, Gustavo Miranda-Carboni, Ruth O'Regan, Victoria L. Seewaldt
NATURE REVIEWS CANCER
(2015)