Hyper-mitogenic drive coexists with mitotic incompetence in senescent cells

The choice between p53-induced senescence and quiescence is determined in part by the mTOR pathway

(2016) Lioubov G. Korotchkina et al.   Aging-US

Inhibition of Polo-like kinase 1 reduces beta-amyloid-induced neuronal cell death in Alzheimer's disease

(2016) Bing Song et al.   Aging-US

Cell cycle arrest is not yet senescence, which is not just cell cycle arrest: terminology for TOR-driven aging

(2016) Mikhail V. Blagosklonny   Aging-US

Rapamycin slows aging in mice

(2012) John E. Wilkinson et al.   AGING CELL

Prospective Treatment of Age-Related Diseases by Slowing Down Aging

(2012) Mikhail V. Blagosklonny   AMERICAN JOURNAL OF PATHOLOGY

Rapamycin increases lifespan and inhibits spontaneous tumorigenesis in inbred female mice

(2012) Vladimir N. Anisimov et al.   CELL CYCLE

Cyclin-dependent kinase 5 regulates E2F transcription factor through phosphorylation of Rb protein in neurons

(2012) Akira Futatsugi et al.   CELL CYCLE

Rapamycin slows aging in mice

(2012) Adam Spong et al.   CELL CYCLE

Drosophila cyclin D/Cdk4 regulates mitochondrial biogenesis and aging and sensitizes animals to hypoxic stress

(2012) Amalia Icreverzi et al.   CELL CYCLE

Cyclin D1 inhibits hepatic lipogenesis via repression of carbohydrate response element binding protein and hepatocyte nuclear factor 4α

(2012) Eric A. Hanse et al.   CELL CYCLE

Cyclin D1 goes metabolic

(2012) Karen E. Knudsen   CELL CYCLE

Hypoxia suppresses conversion from proliferative arrest to cellular senescence

(2012) O. V. Leontieva et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A longer and healthier life with TOR down-regulation: genetics and drugs: Figure 1

(2011) Ivana Bjedov et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Pharmacologic inhibition of MEK and PI-3K converges on the mTOR/S6 pathway to decelerate cellular senescence

(2011) Zoya N. Demidenko et al.   CELL CYCLE

When senescence masquerades as DNA damage: Is DNA replication stress the culprit?

(2011) Zbigniew Darzynkiewicz   CELL CYCLE

Rapamycin decelerates cellular senescence

(2011) Zoya N. Demidenko et al.   CELL CYCLE

Pseudo-DNA damage response in senescent cells

(2011) Tatyana V. Pospelova et al.   CELL CYCLE

Reviewing once more the c-myc and Ras collaboration

(2011) Chenguang Wang et al.   CELL CYCLE

mTOR signaling in disease

(2011) Eva Dazert et al.   CURRENT OPINION IN CELL BIOLOGY

Hypoxia-Inducible Factor 1 Is Activated by Dysregulated Cyclin E during Mammary Epithelial Morphogenesis

(2011) T. Sengupta et al.   MOLECULAR AND CELLULAR BIOLOGY

Rapamycin Extends Maximal Lifespan in Cancer-Prone Mice

(2010) Vladimir N. Anisimov et al.   AMERICAN JOURNAL OF PATHOLOGY

Cyclin E Deregulation Impairs Mitotic Progression through Premature Activation of Cdc25C

(2010) Rozita Bagheri-Yarmand et al.   CANCER RESEARCH

Low Molecular Weight Cyclin E Overexpression Shortens Mitosis, Leading to Chromosome Missegregation and Centrosome Amplification

(2010) Rozita Bagheri-Yarmand et al.   CANCER RESEARCH

Growth stimulation leads to cellular senescence when the cell cycle is blocked

(2010) Zoya N. Demidenko et al.   CELL CYCLE

A novel hypothesis for Alzheimer disease based on neuronal tetraploidy induced by p75NTR

(2010) Jose Maria Frade et al.   CELL CYCLE

DNA-SCARS: distinct nuclear structures that sustain damage-induced senescence growth arrest and inflammatory cytokine secretion

(2010) F. Rodier et al.   JOURNAL OF CELL SCIENCE

Rapamycin, But Not Resveratrol or Simvastatin, Extends Life Span of Genetically Heterogeneous Mice

(2010) Richard A. Miller et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Paradoxical suppression of cellular senescence by p53

(2010) Z. N. Demidenko et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanism of G1-like arrest by low concentrations of paclitaxel: next cell cycle p53-dependent arrest with sub G1 DNA content mediated by prolonged mitosis

(2008) Z N Demidenko et al.   ONCOGENE