Biological functions of p53 isoforms through evolution: lessons from animal and cellular models

Drosophila melanogaster p53 has developmental stage-specific and sex-specific effects on adult life span indicative of sexual antagonistic pleiotropy

(2016) Morris Waskar et al.   Aging-US

Hyperproliferation, cancer, and inflammation in mice expressing a  133p53-like isoform

(2011) T. L. Slatter et al.   BLOOD

Distinct p53 Transcriptional Programs Dictate Acute DNA-Damage Responses and Tumor Suppression

(2011) Colleen A. Brady et al.   CELL

p63 is a suppressor of tumorigenesis and metastasis interacting with mutant p53

(2011) G Melino   CELL DEATH AND DIFFERENTIATION

ΔNp63α Is an Oncogene that Targets Chromatin Remodeler Lsh to Drive Skin Stem Cell Proliferation and Tumorigenesis

(2011) William M. Keyes et al.   Cell Stem Cell

 40 Isoform of p53 Controls  -Cell Proliferation and Glucose Homeostasis in Mice

(2011) C. Hinault et al.   DIABETES

The p53 family: guardians of maternal reproduction

(2011) Arnold J. Levine et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Effect of mutations on the p53 IRES RNA structure: Implications for de-regulation of the synthesis of p53 isoforms

(2011) Richa Grover et al.   RNA Biology

Altered longevity-assurance activity of p53:p44 in the mouse causes memory loss, neurodegeneration and premature death

(2010) Mariana Pehar et al.   AGING CELL

Differential regulation of p53 function by the N-terminal ΔNp53 and Δ113p53 isoforms in zebrafish embryos

(2010) William R Davidson et al.   BMC DEVELOPMENTAL BIOLOGY

G-quadruplex structures in TP53 intron 3: role in alternative splicing and in production of p53 mRNA isoforms

(2010) Virginie Marcel et al.   CARCINOGENESIS

Functional characterization of p53β and p53γ, two isoforms of the tumor suppressor p53

(2010) Vilma Graupner et al.   CELL CYCLE

First International p53 Isoforms Meeting: ‘p53 isoforms through evolution: from identification to biological function’

(2010) V Marcel et al.   CELL DEATH AND DIFFERENTIATION

p53 directly transactivates Δ133p53α, regulating cell fate outcome in response to DNA damage

(2010) M Aoubala et al.   CELL DEATH AND DIFFERENTIATION

ΔNp63 is an ectodermal gatekeeper of epidermal morphogenesis

(2010) R Shalom-Feuerstein et al.   CELL DEATH AND DIFFERENTIATION

Δ160p53 is a novel N-terminal p53 isoform encoded by Δ133p53 transcript

(2010) Virginie Marcel et al.   FEBS LETTERS

Isoform-specific p73 knockout mice reveal a novel role for  Np73 in the DNA damage response pathway

(2010) M. T. Wilhelm et al.   GENES & DEVELOPMENT

ΔN133p53 expression levels in relation to haplotypes of the TP53 internal promoter region

(2010) Ilaria Bellini et al.   HUMAN MUTATION

Regulation of tumor suppressor p53 at the RNA level

(2010) Anna Vilborg et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

TAp63 suppresses metastasis through coordinate regulation of Dicer and miRNAs

(2010) Xiaohua Su et al.   NATURE

p53 regulates the transcription of its Δ133p53 isoform through specific response elements contained within the TP53 P2 internal promoter

(2010) V Marcel et al.   ONCOGENE

Alternative splicing of p53 and p73: the novel p53 splice variant p53δ is an independent prognostic marker in ovarian cancer

(2010) G Hofstetter et al.   ONCOGENE

p53 family members in cancer diagnosis and treatment

(2010) Alice Machado-Silva et al.   SEMINARS IN CANCER BIOLOGY

Phylogeny and Function of the Invertebrate p53 Superfamily

(2010) R. Rutkowski et al.   Cold Spring Harbor Perspectives in Biology

Zebrafish Models of p53 Functions

(2010) N. Y. Storer et al.   Cold Spring Harbor Perspectives in Biology

Recent advances in using Drosophila to model neurodegenerative diseases

(2009) Bingwei Lu   APOPTOSIS

Dual roles of Drosophila p53 in cell death and cell differentiation

(2009) Y Fan et al.   CELL DEATH AND DIFFERENTIATION

TAp63 Prevents Premature Aging by Promoting Adult Stem Cell Maintenance

(2009) Xiaohua Su et al.   Cell Stem Cell

ER stress protects from retinal degeneration

(2009) César S Mendes et al.   EMBO JOURNAL

p53 isoform  113p53 is a p53 target gene that antagonizes p53 apoptotic activity via BclxL activation in zebrafish

(2009) J. Chen et al.   GENES & DEVELOPMENT

Detailed haplotype analysis at theTP53locus in p.R337H mutation carriers in the population of Southern Brazil: evidence for a founder effect

(2009) Sonia Garritano et al.   HUMAN MUTATION

Apoptosis in Drosophila: compensatory proliferation and undead cells

(2009) Francisco A. Martin et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY

TP53 PIN3 and MDM2 SNP309 polymorphisms as genetic modifiers in the Li-Fraumeni syndrome: impact on age at first diagnosis

(2009) V Marcel et al.   JOURNAL OF MEDICAL GENETICS

p53 isoforms Δ133p53 and p53β are endogenous regulators of replicative cellular senescence

(2009) Kaori Fujita et al.   NATURE CELL BIOLOGY

TAp63 induces senescence and suppresses tumorigenesis in vivo

(2009) Xuecui Guo et al.   NATURE CELL BIOLOGY

The Isoforms of the p53 Protein

(2009) M. P. Khoury et al.   Cold Spring Harbor Perspectives in Biology

Posttranslational Modification of p53: Cooperative Integrators of Function

(2009) D. W. Meek et al.   Cold Spring Harbor Perspectives in Biology

The DEAD box RNA helicases p68 (Ddx5) and p72 (Ddx17): novel transcriptional co-regulators

(2008) Frances V. Fuller-Pace et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

p53 isoforms - A conspiracy to kidnap p53 tumor suppressor activity?

(2008) V. Marcel et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Small Molecular Weight Variants of p53 Are Expressed in Human Melanoma Cells and Are Induced by the DNA-Damaging Agent Cisplatin

(2008) K. A. Avery-Kiejda et al.   CLINICAL CANCER RESEARCH

TAp73 knockout shows genomic instability with infertility and tumor suppressor functions

(2008) R. Tomasini et al.   GENES & DEVELOPMENT

ΔNp63 Is Essential for Epidermal Commitment of Embryonic Stem Cells

(2008) Alain Medawar et al.   PLoS One