Accessing New Chemical Entities through Microfluidic Systems

Seamless Integration of Dose-Response Screening and Flow Chemistry: Efficient Generation of Structure-Activity Relationship Data of β-Secretase (BACE1) Inhibitors

(2014) Michael Werner et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Automated Solid-Phase Synthesis of Chondroitin Sulfate Glycosaminoglycans

(2013) Steffen Eller et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Heating under High-Frequency Inductive Conditions: Application to the Continuous Synthesis of the Neurolepticum Olanzapine (Zyprexa)

(2013) Jan Hartwig et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

In Situ Generation of Diimide from Hydrazine and Oxygen: Continuous-Flow Transfer Hydrogenation of Olefins

(2013) Bartholomäus Pieber et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Rapid and Efficient Trifluoromethylation of Aromatic and Heteroaromatic Compounds Using Potassium Trifluoroacetate Enabled by a Flow System

(2013) Mao Chen et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Automated Polysaccharide Synthesis: Assembly of a 30mer Mannoside

(2013) Oliviana Calin et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Small but Smart: Sensitive Microgel Capsules

(2013) Sebastian Seiffert   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Combining On-Chip Synthesis of a Focused Combinatorial Library with Computational Target Prediction Reveals Imidazopyridine GPCR Ligands

(2013) Michael Reutlinger et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

End-to-End Continuous Manufacturing of Pharmaceuticals: Integrated Synthesis, Purification, and Final Dosage Formation

(2013) Salvatore Mascia et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Continuous-Flow Synthesis of 1-Substituted Benzotriazoles from Chloronitrobenzenes and Amines in a CN Bond Formation/Hydrogenation/Diazotization/Cyclization Sequence

(2013) Mao Chen et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Odorless Isocyanide Chemistry: An Integrated Microfluidic System for a Multistep Reaction Sequence

(2013) Siddharth Sharma et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Asymmetric Carbon-Carbon Bond Formation under Continuous-Flow Conditions with Chiral Heterogeneous Catalysts

(2013) Tetsu Tsubogo et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A Continuous-Flow Process for the Synthesis of Artemisinin

(2013) Daniel Kopetzki et al.   CHEMISTRY-A EUROPEAN JOURNAL

A Machine-Assisted Flow Synthesis of SR48692: A Probe for the Investigation of Neurotensin Receptor-1

(2013) Claudio Battilocchio et al.   CHEMISTRY-A EUROPEAN JOURNAL

Rapid Discovery of a Novel Series of Abl Kinase Inhibitors by Application of an Integrated Microfluidic Synthesis and Screening Platform

(2013) Bimbisar Desai et al.   JOURNAL OF MEDICINAL CHEMISTRY

Chemically Advanced Template Search (CATS) for Scaffold-Hopping and Prospective Target Prediction for ‘Orphan’ Molecules

(2013) Michael Reutlinger et al.   Molecular Informatics

The past, present and potential for microfluidic reactor technology in chemical synthesis

(2013) Katherine S. Elvira et al.   Nature Chemistry

Photocatalytic Synthesis of Allylic Trifluoromethyl Substituted Styrene Derivatives in Batch and Flow

(2013) Lukas M. Kreis et al.   ORGANIC LETTERS

Preparative Microfluidic Electrosynthesis of Drug Metabolites

(2013) Romain Stalder et al.   ACS Medicinal Chemistry Letters

Integrated Synthesis and Testing of Substituted Xanthine Based DPP4 Inhibitors: Application to Drug Discovery

(2013) Werngard Czechtizky et al.   ACS Medicinal Chemistry Letters

Disubstituted 1-Aryl-4-Aminopiperidine Library Synthesis Using Computational Drug Design and High-Throughput Batch and Flow Technologies

(2013) Marian C. Bryan et al.   ACS Combinatorial Science

Enantioselective β-Arylation of Ketones Enabled by Lithiation/Borylation/1,4-Addition Sequence Under Flow Conditions

(2012) Wei Shu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Droplet Microfluidics-A Tool for Single-Cell Analysis

(2012) Haakan N. Joensson et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Continuous Synthesis and Purification by Direct Coupling of a Flow Reactor with Simulated Moving-Bed Chromatography

(2012) Alexander G. O'Brien et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Continuous-Flow Synthesis of the Anti-Malaria Drug Artemisinin

(2012) François Lévesque et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Continuous Flow Synthesis. A Pharma Perspective

(2012) Laia Malet-Sanz et al.   JOURNAL OF MEDICINAL CHEMISTRY

Revisiting lab-on-a-chip technology for drug discovery

(2012) Pavel Neužil et al.   NATURE REVIEWS DRUG DISCOVERY

Diagnosing the decline in pharmaceutical R&D efficiency

(2012) Jack W. Scannell et al.   NATURE REVIEWS DRUG DISCOVERY

The synthesis of Bcr-Abl inhibiting anticancer pharmaceutical agents imatinib, nilotinib and dasatinib

(2012) Benjamin J. Deadman et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

An expeditious synthesis of imatinib and analogues utilising flow chemistry methods

(2012) Mark D. Hopkin et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

A Flow-Based Synthesis of 2-Aminoadamantane-2-carboxylic Acid

(2012) Claudio Battilocchio et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Flow chemistry synthesis of zolpidem, alpidem and other GABAAagonists and their biological evaluation through the use of in-line frontal affinity chromatography

(2012) Lucie Guetzoyan et al.   Chemical Science

Rapid Access to Compound Libraries through Flow Technology: Fully Automated Synthesis of a 3-Aminoindolizine Library via Orthogonal Diversification

(2012) Paul P. Lange et al.   ACS Combinatorial Science

Deciding Whether To Go with the Flow: Evaluating the Merits of Flow Reactors for Synthesis

(2011) Ryan L. Hartman et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Recent advances in micro reaction technology

(2011) Charlotte Wiles et al.   CHEMICAL COMMUNICATIONS

Microfluidics for single cell analysis

(2011) Huabing Yin et al.   CURRENT OPINION IN BIOTECHNOLOGY

Synthesis of Annulated Pyridines by Intramolecular Inverse-Electron-Demand Hetero-Diels-Alder Reaction under Superheated Continuous Flow Conditions

(2011) Rainer E. Martin et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Small Molecule Library Synthesis Using Segmented Flow

(2011) Christina M. Thompson et al.   MOLECULES

Synthesis of a Drug-Like Focused Library of Trisubstituted Pyrrolidines Using Integrated Flow Chemistry and Batch Methods

(2011) Marcus Baumann et al.   ACS Combinatorial Science

An Integrated Synthesis–Purification System to Accelerate the Generation of Compounds in Pharmaceutical Discovery

(2011) Jill E. Hochlowski et al.   Journal of Flow Chemistry

A flow-based synthesis of Imatinib: the API of Gleevec

(2010) Mark D. Hopkin et al.   CHEMICAL COMMUNICATIONS

A Continuous Flow Process Using a Sequence of Microreactors with In-line IR Analysis for the Preparation of N,N-Diethyl-4-(3-fluorophenylpiperidin-4-ylidenemethyl)benzamide as a Potent and Highly Selective δ-Opioid Receptor Agonist

(2010) Zizheng Qian et al.   CHEMISTRY-A EUROPEAN JOURNAL

Advances in microfluidics for drug discovery

(2010) Dario Lombardi et al.   Expert Opinion on Drug Discovery

The flow synthesis of heterocycles for natural product and medicinal chemistry applications

(2010) Marcus Baumann et al.   MOLECULAR DIVERSITY

The application of flow microreactors to the preparation of a family of casein kinase I inhibitors

(2010) Francesco Venturoni et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Continuous flow multi-step organic synthesis

(2010) Damien Webb et al.   Chemical Science

Automated Lead Optimization of MMP-12 Inhibitors Using a Genetic Algorithm

(2010) Stephen D. Pickett et al.   ACS Medicinal Chemistry Letters

An integrated microfluidic device for large-scale in situ click chemistry screening

(2009) Yanju Wang et al.   LAB ON A CHIP

A Multistep Continuous-Flow System for Rapid On-Demand Synthesis of Receptor Ligands

(2009) Trine P. Petersen et al.   ORGANIC LETTERS

Microfluidics for drug discovery and development: From target selection to product lifecycle management

(2007) L KANG   DRUG DISCOVERY TODAY