Asymmetric Carbon-Carbon Bond Formation under Continuous-Flow Conditions with Chiral Heterogeneous Catalysts

Flow Chemistry - A Key Enabling Technology for (Multistep) Organic Synthesis

(2012) Jens Wegner et al.   ADVANCED SYNTHESIS & CATALYSIS

Enantioselective β-Arylation of Ketones Enabled by Lithiation/Borylation/1,4-Addition Sequence Under Flow Conditions

(2012) Wei Shu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Chiral Copper(II)-Catalyzed Enantioselective Boron Conjugate Additions to α,β-Unsaturated Carbonyl Compounds in Water

(2012) Shū Kobayashi et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Toward Efficient Asymmetric Carbon-Carbon Bond Formation: Continuous Flow with Chiral Heterogeneous Catalysts

(2012) Tetsu Tsubogo et al.   CHEMISTRY-A EUROPEAN JOURNAL

Highly Efficient 1,4-Addition of Aldehydes to Nitroolefins: Organocatalysis in Continuous Flow by Solid-Supported Peptidic Catalysts

(2012) Sándor B. Ötvös et al.   ChemSusChem

A Solid-Supported Organocatalyst for Continuous-Flow Enantioselective Aldol Reactions

(2012) Carles Ayats et al.   ChemSusChem

Enamine Catalysis in Flow with an Immobilized Peptidic Catalyst

(2012) Yukihiro Arakawa et al.   ChemSusChem

Fast, solvent-free and hydrogen-bonding-mediated asymmetric Michael addition in a ball mill

(2012) Yi-Feng Wang et al.   GREEN CHEMISTRY

A Redox-Reconfigurable, Ambidextrous Asymmetric Catalyst

(2012) Shahab Mortezaei et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Polystyrene-Supported (2S)-(−)-3-exo-Piperazinoisoborneol: An Efficient Catalyst for the Batch and Continuous Flow Production of Enantiopure Alcohols

(2012) Laura Osorio-Planes et al.   ORGANIC LETTERS

Solid Acids as Heterogeneous Support for Primary Amino Acid-Derived Diamines in Direct Asymmetric Aldol Reactions

(2011) Anneleen L. W. Demuynck et al.   ADVANCED SYNTHESIS & CATALYSIS

Efficient Recovery and Reuse of an Immobilized Peptidic Organocatalyst

(2011) Yukihiro Arakawa et al.   ADVANCED SYNTHESIS & CATALYSIS

An Additional Coordination Group Leads to Extremely Efficient Chiral Iridium Catalysts for Asymmetric Hydrogenation of Ketones

(2011) Jian-Hua Xie et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Chiral Zinc-Catalyzed Asymmetric α-Alkylallylation and α-Chloroallylation of Aldehydes

(2011) Shū Kobayashi et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Deciding Whether To Go with the Flow: Evaluating the Merits of Flow Reactors for Synthesis

(2011) Ryan L. Hartman et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Coupled chemo(enzymatic) reactions in continuous flow

(2011) Ruslan Yuryev et al.   Beilstein Journal of Organic Chemistry

Efficient and selective chemical transformations under flow conditions: The combination of supported catalysts and supercritical fluids

(2011) M Isabel Burguete et al.   Beilstein Journal of Organic Chemistry

Continuous flow hydrogenation using polysilane-supported palladium/alumina hybrid catalysts

(2011) Hidekazu Oyamada et al.   Beilstein Journal of Organic Chemistry

Hydrogen bonding mediated enantioselective organocatalysis in brine: significant rate acceleration and enhanced stereoselectivity in enantioselective Michael addition reactions of 1,3-dicarbonyls to β-nitroolefins

(2011) Han Yong Bae et al.   CHEMICAL COMMUNICATIONS

Ten key issues in modern flow chemistry

(2011) Jens Wegner et al.   CHEMICAL COMMUNICATIONS

Design of molecular catalysts for achievement of high turnover number in homogeneous hydrogenation

(2011) Noriyoshi Arai et al.   CHEMICAL RECORD

Cross-coupling in flow

(2011) Timothy Noël et al.   CHEMICAL SOCIETY REVIEWS

Continuous Flow System with a Polymer-Supported Dirhodium(II) Catalyst: Application to Enantioselective Carbonyl Ylide Cycloaddition Reactions

(2011) Koji Takeda et al.   CHEMISTRY-A EUROPEAN JOURNAL

Heterogeneous Catalytic Hydrogenation Reactions in Continuous-Flow Reactors

(2011) Muhammad Irfan et al.   ChemSusChem

Chiral 1,1′-Bi(tetrahydroisoquinoline)-Type Diamines as Efficient Ligands for Nickel-Catalysed Enantioselective Michael Addition to Nitroalkenes

(2011) Kristina Wilckens et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Efficient enhancement of copper-pyridineoxazoline catalysts through immobilization and process design

(2011) C. Aranda et al.   GREEN CHEMISTRY

The immobilisation of chiral organocatalysts on magnetic nanoparticles: the support particle cannot always be considered inert

(2011) Oliver Gleeson et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Biscinchona alkaloids as highly efficient bifunctional organocatalysts for the asymmetric conjugate addition of malonates to nitroalkenes at ambient temperature

(2011) Fei Li et al.   TETRAHEDRON

Chiral alkaline-earth metal catalysts for asymmetric bond-forming reactions

(2011) Yasuhiro Yamashita et al.   Chemical Science

Multiphase Flow Systems for Selective Aerobic Oxidation of Alcohols Catalyzed by Bimetallic Nanoclusters

(2011) Kosuke Kaizuka et al.   Journal of Flow Chemistry

Alkaline Earth Metal Catalysts for Asymmetric Reactions

(2010) Shu̅  Kobayashi et al.   ACCOUNTS OF CHEMICAL RESEARCH

Direct Asymmetric syn-Aldol Reactions of Linear Aliphatic Ketones with Primary Amino Acid-Derived Diamines

(2010) Anneleen L. W. Demuynck et al.   ADVANCED SYNTHESIS & CATALYSIS

The Flow’s the Thing…︁Or Is It? Assessing the Merits of Homogeneous Reactions in Flask and Flow

(2010) Fernando E. Valera et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Aldehyde allylation with allylboronates providing α-addition products

(2010) Shū Kobayashi et al.   CHEMICAL COMMUNICATIONS

Polymer-incarcerated metal(0) cluster catalysts

(2010) Shū Kobayashi et al.   CHEMICAL RECORD

From Limestone to Catalysis: Application of Calcium Compounds as Homogeneous Catalysts

(2010) Sjoerd Harder   CHEMICAL REVIEWS

Highly Enantioselective Friedel-Crafts-type Alkylation Reactions of Indoles with Chalcone Derivatives using a Chiral Barium Catalyst

(2010) Tetsu Tsubogo et al.   Chemistry-An Asian Journal

Polymer-Supported Chiral Organocatalysts: Synthetic Strategies for the Road Towards Affordable Polymeric Immobilization

(2010) Tor E. Kristensen et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Heterogeneous catalytic synthesis using microreactor technology

(2010) Christopher G. Frost et al.   GREEN CHEMISTRY

Asymmetric Mannich Reaction of Malonates with Imines Catalyzed by a Chiral Calcium Complex

(2010) Thomas Poisson et al.   JOURNAL OF ORGANIC CHEMISTRY

Catalytic Asymmetric Protonation of Chiral Calcium Enolates via 1,4-Addition of Malonates

(2010) Thomas Poisson et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The flow synthesis of heterocycles for natural product and medicinal chemistry applications

(2010) Marcus Baumann et al.   MOLECULAR DIVERSITY

Toward the optimization of continuous-flow aldol and α-amination reactions by means of proline-functionalized silicon packed-bed microreactors

(2010) Alessandro Massi et al.   TETRAHEDRON LETTERS

Synthesis of optically active, unnatural α-substituted glutamic acid derivatives by a chiral calcium-catalyzed 1,4-addition reaction

(2010) Tetsu Tsubogo et al.   TETRAHEDRON-ASYMMETRY

Solvent-free catalytic enantioselective C–C bond forming reactions with very high catalyst turnover numbers

(2010) Philip Pelphrey et al.   Chemical Science

Continuous flow multi-step organic synthesis

(2010) Damien Webb et al.   Chemical Science

Novel Cinchona-Aminobenzimidazole Bifunctional Organocatalysts

(2009) Lei Zhang et al.   ADVANCED SYNTHESIS & CATALYSIS

Chiral Calcium Catalysts with Neutral Coordinative Ligands: Enantioselective 1,4-Addition Reactions of 1,3-Dicarbonyl Compounds to Nitroalkenes

(2009) Tetsu Tsubogo et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Continuous flow enantioselective arylation of aldehydes with ArZnEt using triarylboroxins as the ultimate source of aryl groups

(2009) Julien Rolland et al.   Beilstein Journal of Organic Chemistry

Asymmetric reactions in continuous flow

(2009) Xiao Yin Mak et al.   Beilstein Journal of Organic Chemistry

“Microencapsulated” and Related Catalysts for Organic Chemistry and Organic Synthesis

(2009) Ryo Akiyama et al.   CHEMICAL REVIEWS

Recyclable Stereoselective Catalysts

(2009) Alexandre F. Trindade et al.   CHEMICAL REVIEWS

Organic Polymer Supports for Synthesis and for Reagent and Catalyst Immobilization

(2009) Jinni Lu et al.   CHEMICAL REVIEWS

A Solid-Supported Organocatalyst for Highly Stereoselective, Batch, and Continuous-Flow Mannich Reactions

(2009) Esther Alza et al.   CHEMISTRY-A EUROPEAN JOURNAL

Chiral 2-Aminobenzimidazoles as Recoverable Organocatalysts for the Addition of 1,3-Dicarbonyl Compounds to Nitroalkenes†

(2009) Diana Almaşi et al.   JOURNAL OF ORGANIC CHEMISTRY

Microchemical systems for continuous-flow synthesis

(2009) Ryan L. Hartman et al.   LAB ON A CHIP

An Efficient Synthesis of Chiral Diamines with Rigid Backbones: Application in Enantioselective Michael Addition of Malonates to Nitroalkenes

(2009) Qiming Zhu et al.   ORGANIC LETTERS

Thiol-ene “click” reactions and recent applications in polymer and materials synthesis

(2009) Andrew B. Lowe   Polymer Chemistry

Fast and Enantioselective Production of 1-Aryl-1-propanols through a Single Pass, Continuous Flow Process

(2008) Miquel A. Pericàs et al.   ADVANCED SYNTHESIS & CATALYSIS

Photochemical Surface Patterning by the Thiol-Ene Reaction

(2008) Pascal Jonkheijm et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Tripeptides as Efficient Asymmetric Catalysts for 1,4-Addition Reactions of Aldehydes to Nitroolefins–A Rational Approach

(2008) Markus Wiesner et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

An Immobilization Method of Chiral Quaternary Ammonium Salts onto Polymer Supports

(2008) Yukihiro Arakawa et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Controlling the formation of 1 out of 64 stereoisomers using organocatalysis

(2008) Søren Bertelsen et al.   CHEMICAL COMMUNICATIONS

Supported proline and proline-derivatives as recyclable organocatalysts

(2008) Michelangelo Gruttadauria et al.   CHEMICAL SOCIETY REVIEWS

Flash Chemistry: Fast Chemical Synthesis by Using Microreactors

(2008) Jun-ichi Yoshida et al.   CHEMISTRY-A EUROPEAN JOURNAL

Heterogeneous Catalytic Hydrogenation in Supercritical Fluids: Potential and Limitations

(2008) Tsunetake Seki et al.   INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH

Zn-Catalyzed Asymmetric Allylation for the Synthesis of Optically Active Allylglycine Derivatives. Regio- and Stereoselective Formal α-Addition of Allylboronates to Hydrazono Esters

(2008) Mari Fujita et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Development of Catalytic Asymmetric 1,4-Addition and [3 + 2] Cycloaddition Reactions Using Chiral Calcium Complexes

(2008) Tetsu Tsubogo et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Catalytic Enantioselective Intermolecular Cycloaddition of 2-Diazo-3,6-diketoester-Derived Carbonyl Ylides with Alkynes and Styrenes Using Chiral Dirhodium(II) Carboxylates

(2008) Naoyuki Shimada et al.   ORGANIC LETTERS

Calcium-Catalyzed Diastereo- and Enantioselective 1,4-Addition of Glycine Derivatives to α,β-Unsaturated Esters

(2008) Shū Kobayashi et al.   ORGANIC LETTERS

Diphenylprolinol Silyl Ether Catalysis in an Asymmetric Formal Carbo [3 + 3] Cycloaddition Reaction via a Domino Michael/Knoevenagel Condensation

(2008) Yujiro Hayashi et al.   ORGANIC LETTERS

Practical Implications of Boron-to-Zinc Transmetalation for the Catalytic Asymmetric Arylation of Aldehydes

(2007) Ciril Jimeno et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Noncovalently Supported Heterogeneous Chiral Amine Catalysts for Asymmetric Direct Aldol and Michael Addition Reactions

(2007) Sanzhong Luo et al.   CHEMISTRY-A EUROPEAN JOURNAL