An expeditious synthesis of imatinib and analogues utilising flow chemistry methods

Flow Chemistry - A Key Enabling Technology for (Multistep) Organic Synthesis

(2012) Jens Wegner et al.   ADVANCED SYNTHESIS & CATALYSIS

The synthesis of Bcr-Abl inhibiting anticancer pharmaceutical agents imatinib, nilotinib and dasatinib

(2012) Benjamin J. Deadman et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

The application of a monolithic triphenylphosphine reagent for conducting Appel reactions in flow microreactors

(2011) Kimberley A Roper et al.   Beilstein Journal of Organic Chemistry

Ten key issues in modern flow chemistry

(2011) Jens Wegner et al.   CHEMICAL COMMUNICATIONS

Diastereoselective Chain-Elongation Reactions Using Microreactors for Applications in Complex Molecule Assembly

(2011) Catherine F. Carter et al.   CHEMISTRY-A EUROPEAN JOURNAL

Teflon AF-2400 mediated gas–liquid contact in continuous flow methoxycarbonylations and in-line FTIR measurement of CO concentration

(2011) Peter Koos et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Flow synthesis of organic azides and the multistep synthesis of imines and amines using a new monolithic triphenylphosphine reagent

(2011) Catherine J. Smith et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

A fully automated, multistep flow synthesis of 5-amino-4-cyano-1,2,3-triazoles

(2011) Catherine J. Smith et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

A New Enabling Technology for Convenient Laboratory Scale Continuous Flow Processing at Low Temperatures

(2011) Duncan L. Browne et al.   ORGANIC LETTERS

Continuous Flow Processing of Slurries: Evaluation of an Agitated Cell Reactor

(2011) Duncan L. Browne et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

A breakthrough method for the accurate addition of reagents in multi-step segmented flow processing

(2011) Heiko Lange et al.   Chemical Science

Hydrogenation in flow: Homogeneous and heterogeneous catalysis using Teflon AF-2400 to effect gas–liquid contact at elevated pressure

(2011) Matthew O'Brien et al.   Chemical Science

The Continuous-Flow Synthesis of Carboxylic Acids using CO2 in a Tube-In-Tube Gas Permeable Membrane Reactor

(2010) Anastasios Polyzos et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The flow synthesis of heterocycles for natural product and medicinal chemistry applications

(2010) Marcus Baumann et al.   MOLECULAR DIVERSITY

Microwave and flow syntheses of Pseudomonasquinolone signal (PQS) and analogues

(2010) James T. Hodgkinson et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Safe and Reliable Synthesis of Diazoketones and Quinoxalines in a Continuous Flow Reactor

(2010) Laetitia J. Martin et al.   ORGANIC LETTERS

Continuous flow multi-step organic synthesis

(2010) Damien Webb et al.   Chemical Science

Palladium-catalyzed coupling of functionalized primary and secondary amines with aryl and heteroaryl halides: two ligands suffice in most cases

(2010) Debabrata Maiti et al.   Chemical Science

Multi-Step Synthesis by Using Modular Flow Reactors: The Preparation of YneOnes and Their Use in Heterocycle Synthesis

(2009) Ian R. Baxendale et al.   CHEMISTRY-A EUROPEAN JOURNAL

Biaryl Phosphane Ligands in Palladium-Catalyzed Amination

(2008) David S. Surry et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A Highly Active Catalyst for Pd-Catalyzed Amination Reactions: Cross-Coupling Reactions Using Aryl Mesylates and the Highly Selective Monoarylation of Primary Amines Using Aryl Chlorides

(2008) Brett P. Fors et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A New Class of Easily Activated Palladium Precatalysts for Facile C−N Cross-Coupling Reactions and the Low Temperature Oxidative Addition of Aryl Chlorides

(2008) Mark R. Biscoe et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A Facile Total Synthesis of Imatinib Base and Its Analogues

(2008) Yi-Feng Liu et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT