Use of Humanized Mice to Study the Pathogenesis of Autoimmune and Inflammatory Diseases

A chimeric human–mouse model of Sjögren's syndrome

(2015) Nicholas A. Young et al.   CLINICAL IMMUNOLOGY

IL-10 exacerbates xenogeneic GVHD by inducing massive human T cell expansion

(2015) Sojan Abraham et al.   CLINICAL IMMUNOLOGY

Effective treatment against severe graft-versus-host disease with allele-specific anti-HLA monoclonal antibody in a humanized mouse model

(2015) Yusuke Nakauchi et al.   EXPERIMENTAL HEMATOLOGY

Immunogenetics of type 1 diabetes mellitus

(2015) Michael P. Morran et al.   MOLECULAR ASPECTS OF MEDICINE

The biology of graft-versus-host disease: experimental systems instructing clinical practice

(2014) K. A. Markey et al.   BLOOD

Acute graft-versus-host disease: a bench-to-bedside update

(2014) S. G. Holtan et al.   BLOOD

A Humanized Mouse Model of Autoimmune Insulitis

(2014) Ashley A. Viehmann Milam et al.   DIABETES

Linking susceptibility genes and pathogenesis mechanisms using mouse models of systemic lupus erythematosus

(2014) S. P. Crampton et al.   Disease Models & Mechanisms

From classic to spontaneous and humanized models of multiple sclerosis: Impact on understanding pathogenesis and drug development

(2014) Avraham Ben-Nun et al.   JOURNAL OF AUTOIMMUNITY

Systematic Reviews and Meta-Analysis of Preclinical Studies: Why Perform Them and How to Appraise Them Critically

(2014) Emily S Sena et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Critical assessment of human antibody generation in humanized mouse models

(2014) Julien Villaudy et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Generation of improved humanized mouse models for human infectious diseases

(2014) Michael A. Brehm et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Production of bone marrow, liver, thymus (BLT) humanized mice on the C57BL/6 Rag2−/−γc−/−CD47−/− background

(2014) Kerry J. Lavender et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Humanized Mice as a Model for Aberrant Responses in Human T Cell Immunotherapy

(2014) Nalini K. Vudattu et al.   JOURNAL OF IMMUNOLOGY

Human Hematopoietic Reconstitution and HLA-Restricted Responses in Nonpermissive Alymphoid Mice

(2014) M. Serra-Hassoun et al.   JOURNAL OF IMMUNOLOGY

Development and function of human innate immune cells in a humanized mouse model

(2014) Anthony Rongvaux et al.   NATURE BIOTECHNOLOGY

Of mice and men: how animal models advance our understanding of T-cell function in RA

(2014) Tamás Kobezda et al.   Nature Reviews Rheumatology

Genomic responses in mouse models greatly mimic human inflammatory diseases

(2014) Keizo Takao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

“Do you catch my drift?”

(2014) Timothy Hannon   TRANSFUSION

Humanized mouse models in transplantation research

(2014) Marieke Hogenes et al.   Transplantation Reviews

Recent Advances and Future Challenges in the Genetics of Multiple Sclerosis

(2014) Christina M. Lill   Frontiers in Neurology

The value of experimental models of colitis in predicting efficacy of biological therapies for inflammatory bowel diseases

(2013) Vassilis Valatas et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Human Hemato-Lymphoid System Mice: Current Use and Future Potential for Medicine

(2013) Anthony Rongvaux et al.   Annual Review of Immunology

Mice Engrafted with Human Fetal Thymic Tissue and Hematopoietic Stem Cells Develop Pathology Resembling Chronic Graft-versus-Host Disease

(2013) Jennifer L. Lockridge et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

BLT-humanized C57BL/6 Rag2-/- c-/-CD47-/- mice are resistant to GVHD and develop B- and T-cell immunity to HIV infection

(2013) K. J. Lavender et al.   BLOOD

Humanized NOD-SCID IL2rg –/– mice as a preclinical model for cancer research and its potential use for individualized cancer therapies

(2013) Qianjun Zhou et al.   CANCER LETTERS

Homeostasis in Intestinal Epithelium Is Orchestrated by the Circadian Clock and Microbiota Cues Transduced by TLRs

(2013) Atish Mukherji et al.   CELL

Oxazolone and ethanol induce colitis in non-obese diabetic-severe combined immunodeficiency interleukin-2Rγnullmice engrafted with human peripheral blood mononuclear cells

(2013) T. Nolte et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Human immune system development and survival of non-obese diabetic (NOD)-scid IL2rγnull(NSG) mice engrafted with human thymus and autologous haematopoietic stem cells

(2013) L. Covassin et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Humanized mice for the study of infectious diseases

(2013) Michael A Brehm et al.   CURRENT OPINION IN IMMUNOLOGY

Differences in the repertoire, regulation and function of Toll-like Receptors and inflammasome-forming Nod-like Receptors between human and mouse

(2013) Juliana K Ariffin et al.   CURRENT OPINION IN MICROBIOLOGY

Role of the enteric microbiota in intestinal homeostasis and inflammation

(2013) Iurii Koboziev et al.   FREE RADICAL BIOLOGY AND MEDICINE

Beyond Gene Discovery in Inflammatory Bowel Disease: The Emerging Role of Epigenetics

(2013) Nicholas T. Ventham et al.   GASTROENTEROLOGY

Intestinal dendritic cells: Their role in intestinal inflammation, manipulation by the gut microbiota and differences between mice and men

(2013) Elizabeth R. Mann et al.   IMMUNOLOGY LETTERS

Induction of Functional Human Macrophages from Bone Marrow Promonocytes by M-CSF in Humanized Mice

(2013) Y. Li et al.   JOURNAL OF IMMUNOLOGY

Humoral Immunity in Humanized Mice: A Work in Progress

(2013) E. Seung et al.   JOURNAL OF INFECTIOUS DISEASES

Overcoming Current Limitations in Humanized Mouse Research

(2013) Michael A. Brehm et al.   JOURNAL OF INFECTIOUS DISEASES

Subclinical CNS Inflammation as Response to a Myelin Antigen in Humanized Mice

(2013) Morad Zayoud et al.   Journal of Neuroimmune Pharmacology

Third-party Mesenchymal Stem Cells Improved Human Islet Transplantation in a Humanized Diabetic Mouse Model

(2013) Hao Wu et al.   MOLECULAR THERAPY

Genomic responses in mouse models poorly mimic human inflammatory diseases

(2013) Junhee Seok et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

When Mice Mislead

(2013) J. Couzin-Frankel   SCIENCE

Murine Models of Inflammatory Bowel Disease (IBD)

(2013) Jason DeVoss et al.   TOXICOLOGIC PATHOLOGY

Ex Vivo Expanded Human Regulatory T Cells Can Prolong Survival of a Human Islet Allograft in a Humanized Mouse Model

(2013) Douglas C. Wu et al.   TRANSPLANTATION

Cryptopatches Are Essential for the Development of Human GALT

(2013) Tomonori Nochi et al.   Cell Reports

Advancing Animal Models of Human Type 1 Diabetes by Engraftment of Functional Human Tissues in Immunodeficient Mice

(2013) M. A. Brehm et al.   Cold Spring Harbor Perspectives in Medicine

Histological Assessment of the Sclerotic Graft-versus-Host Response in the Humanized RAG2−/−γc−/− Mouse Model

(2012) Marieke C.H. Hogenes et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

Membrane-bound human SCF/KL promotes in vivo human hematopoietic engraftment and myeloid differentiation

(2012) S. Takagi et al.   BLOOD

Gut Immune Maturation Depends on Colonization with a Host-Specific Microbiota

(2012) Hachung Chung et al.   CELL

Human allograft rejection in humanized mice: a historical perspective

(2012) Michael A Brehm et al.   Cellular & Molecular Immunology

Human mesenchymal stem cells suppress donor CD4+T cell proliferation and reduce pathology in a humanized mouse model of acute graft-versus-host disease

(2012) L. M. Tobin et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Adoptive Transfer With In Vitro Expanded Human Regulatory T Cells Protects Against Porcine Islet Xenograft Rejection via Interleukin-10 in Humanized Mice

(2012) Shounan Yi et al.   DIABETES

Induction of oxazolone-mediated features of atopic dermatitis in NOD-scid IL2R null mice engrafted with human peripheral blood mononuclear cells

(2012) T. Nolte et al.   Disease Models & Mechanisms

Enhanced humoral and HLA-A2-restricted dengue virus-specific T-cell responses in humanized BLT NSG mice

(2012) Smita Jaiswal et al.   IMMUNOLOGY

Induction of human humoral immune responses in a novel HLA-DR-expressing transgenic NOD/Shi-scid/ cnull mouse

(2012) M. Suzuki et al.   INTERNATIONAL IMMUNOLOGY

Allergen-induced IgE-dependent gut inflammation in a human PBMC–engrafted murine model of allergy

(2012) Benno Weigmann et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

The T cell in Sjogren's syndrome: Force majeure, not spectateur

(2012) Namrata Singh et al.   JOURNAL OF AUTOIMMUNITY

Development of Mature and Functional Human Myeloid Subsets in Hematopoietic Stem Cell-Engrafted NOD/SCID/IL2r KO Mice

(2012) S. Tanaka et al.   JOURNAL OF IMMUNOLOGY

GM-CSF and IL-4 Stimulate Antibody Responses in Humanized Mice by Promoting T, B, and Dendritic Cell Maturation

(2012) Q. Chen et al.   JOURNAL OF IMMUNOLOGY

Development of a new humanized mouse model to study acute inflammatory arthritis

(2012) Alexander V Misharin et al.   Journal of Translational Medicine

NOD/scid IL-2Rgnull mice: a preclinical model system to evaluate human dendritic cell-based vaccine strategies in vivo

(2012) Stefani Spranger et al.   Journal of Translational Medicine

Raise standards for preclinical cancer research

(2012) C. Glenn Begley et al.   NATURE

Xenogeneic Graft-versus-Host-Disease in NOD-scid IL-2Rγnull Mice Display a T-Effector Memory Phenotype

(2012) Niwa Ali et al.   PLoS One

Islet-Specific CTL Cloned from a Type 1 Diabetes Patient Cause Beta-Cell Destruction after Engraftment into HLA-A2 Transgenic NOD/SCID/IL2RG Null Mice

(2012) Wendy W. J. Unger et al.   PLoS One

Generation and Large-Scale Expansion of Human Inducible Regulatory T Cells That Suppress Graft-Versus-Host Disease

(2011) K. L. Hippen et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Humanized mice as a preclinical tool for infectious disease and biomedical research

(2011) Leonard D. Shultz et al.   Annals of the New York Academy of Sciences

Engraftment of peripheral blood mononuclear cells from systemic lupus erythematosus and antiphospholipid syndrome patient donors into BALB-RAG-2−/−IL-2Rγ−/− mice: A promising model for studying human disease

(2011) Danieli Andrade et al.   ARTHRITIS AND RHEUMATISM

Efficient differentiation and function of human macrophages in humanized CSF-1 mice

(2011) C. Rathinam et al.   BLOOD

Development of human CD4+FoxP3+ regulatory T cells in human stem cell factor-, granulocyte-macrophage colony-stimulating factor-, and interleukin-3-expressing NOD-SCID IL2R null humanized mice

(2011) E. Billerbeck et al.   BLOOD

Macrophages prevent human red blood cell reconstitution in immunodeficient mice

(2011) Z. Hu et al.   BLOOD

Microbiota and Autoimmune Disease: The Hosted Self

(2011) Diane Mathis et al.   Cell Host & Microbe

Human peripheral blood CD4 T cell-engrafted non-obese diabetic-scid IL2rγnull H2-Ab1 tm1Gru Tg (human leucocyte antigen D-related 4) mice: a mouse model of human allogeneic graft-versus-host disease

(2011) L. Covassin et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Human T cell development in the liver of humanized NOD/SCID/IL-2Rγnull(NSG) mice generated by intrahepatic injection of CD34+ human (h) cord blood (CB) cells

(2011) Bongkum Choi et al.   CLINICAL IMMUNOLOGY

Superoxide Production by Macrophages and T Cells Is Critical for the Induction of Autoreactivity and Type 1 Diabetes

(2011) T. C. Thayer et al.   DIABETES

HLA-A2-Matched Peripheral Blood Mononuclear Cells From Type 1 Diabetic Patients, but Not Nondiabetic Donors, Transfer Insulitis to NOD-scid/ cnull/HLA-A2 Transgenic Mice Concurrent With the Expansion of Islet-Specific CD8+ T cells

(2011) F. Whitfield-Larry et al.   DIABETES

Epidemiology and Natural History of Inflammatory Bowel Diseases

(2011) Jacques Cosnes et al.   GASTROENTEROLOGY

Increasing Incidence and Prevalence of the Inflammatory Bowel Diseases With Time, Based on Systematic Review

(2011) Natalie A. Molodecky et al.   GASTROENTEROLOGY

Human immune system mice: current potential and limitations for translational research on human antibody responses

(2011) Raja Vuyyuru et al.   IMMUNOLOGIC RESEARCH

Humoral immune responses in humanized BLT mice immunized with West Nile virus and HIV-1 envelope proteins are largely mediated via human CD5+ B cells

(2011) Subhabrata Biswas et al.   IMMUNOLOGY

Pharmacological intervention studies using mouse models of the inflammatory bowel diseases

(2011) Iurii Koboziev et al.   INFLAMMATORY BOWEL DISEASES

Mouse and human intestinal immunity: same ballpark, different players; different rules, same score

(2011) D L Gibbons et al.   Mucosal Immunology

Genetics and pathogenesis of inflammatory bowel disease

(2011) Bernard Khor et al.   NATURE

Phase II failures: 2008–2010

(2011) John Arrowsmith   NATURE REVIEWS DRUG DISCOVERY

Phase III and submission failures: 2007–2010

(2011) John Arrowsmith   NATURE REVIEWS DRUG DISCOVERY

The Pathogenesis of Rheumatoid Arthritis

(2011) Iain B. McInnes et al.   NEW ENGLAND JOURNAL OF MEDICINE

Expression of HLA Class II Molecules in Humanized NOD.Rag1KO.IL2RgcKO Mice Is Critical for Development and Function of Human T and B Cells

(2011) Rebecca Danner et al.   PLoS One

Epstein-Barr Virus Induces Erosive Arthritis in Humanized Mice

(2011) Yoshikazu Kuwana et al.   PLoS One

IL-15 transpresentation promotes both human T-cell reconstitution and T-cell-dependent antibody responses in vivo

(2011) N. D. Huntington et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human thrombopoietin knockin mice efficiently support human hematopoiesis in vivo

(2011) A. Rongvaux et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human IL-3/GM-CSF knock-in mice support human alveolar macrophage development and human immune responses in the lung

(2011) T. Willinger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transgenic expression of human signal regulatory protein alpha in Rag2−/−γc−/−mice improves engraftment of human hematopoietic cells in humanized mice

(2011) Till Strowig et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Functional Regulatory T Cells Produced by Inhibiting Cyclic Nucleotide Phosphodiesterase Type 3 Prevent Allograft Rejection

(2011) G. Feng et al.   Science Translational Medicine

Human Regulatory T Cells with Alloantigen Specificity Are More Potent Inhibitors of Alloimmune Skin Graft Damage than Polyclonal Regulatory T Cells

(2011) P. Sagoo et al.   Science Translational Medicine

Superior human leukocyte reconstitution and susceptibility to vaginal HIV transmission in humanized NOD-scid IL-2Rγ−/− (NSG) BLT mice

(2011) Cheryl A. Stoddart et al.   VIROLOGY

Humanized mouse models to study human diseases

(2011) Michael A Brehm et al.   Current Opinion in Endocrinology Diabetes and Obesity

Selective destruction of mouse islet beta cells by human T lymphocytes in a newly-established humanized type 1 diabetic model

(2010) Yong Zhao et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Comparison of human cord blood engraftment between immunocompromised mouse strains

(2010) S. P. McDermott et al.   BLOOD

Parameters for establishing humanized mouse models to study human immunity: Analysis of human hematopoietic stem cell engraftment in three immunodeficient strains of mice bearing the IL2rγnull mutation

(2010) Michael A. Brehm et al.   CLINICAL IMMUNOLOGY

Human Immune System Development and Rejection of Human Islet Allografts in Spontaneously Diabetic NOD-Rag1null IL2r null Ins2Akita Mice

(2010) M. A. Brehm et al.   DIABETES

Th1 and Th17 immunocompetence in humanized NOD/SCID/IL2rγnull mice

(2010) Deepika Rajesh et al.   HUMAN IMMUNOLOGY

Etiology of Type 1 Diabetes

(2010) John A. Todd   IMMUNITY

The IL-7 Signaling Pathway Regulates Lymph Node Development Independent of Peripheral Lymphocytes

(2010) S. Chappaz et al.   JOURNAL OF IMMUNOLOGY

In vivo prevention of transplant arteriosclerosis by ex vivo–expanded human regulatory T cells

(2010) Satish N Nadig et al.   NATURE MEDICINE

Geoepidemiology of autoimmune rheumatic diseases

(2010) Yinon Shapira et al.   Nature Reviews Rheumatology

Generation of functional human T-cell subsets with HLA-restricted immune responses in HLA class I expressing NOD/SCID/IL2r null humanized mice

(2010) L. D. Shultz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Epithelial crosstalk at the microbiota-mucosal interface

(2010) J. M. Wells et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rag2−/− γ-chain−/− mice as hosts for human vessel transplantation and allogeneic human leukocyte reconstitution

(2010) Silke Abele-Ohl et al.   TRANSPLANT IMMUNOLOGY

NOD-scid IL2rγnull Mouse Model of Human Skin Transplantation and Allograft Rejection

(2010) Waldemar J. Racki et al.   TRANSPLANTATION

Ex Vivo–Expanded Human Regulatory T Cells Prevent the Rejection of Skin Allografts in a Humanized Mouse Model

(2010) Fadi Issa et al.   TRANSPLANTATION

Publication Bias in Reports of Animal Stroke Studies Leads to Major Overstatement of Efficacy

(2010) Emily S. Sena et al.   PLOS BIOLOGY

Humanized Mice for the Study of Type 1 Diabetes and Beta Cell Function

(2009) Marie King et al.   Annals of the New York Academy of Sciences

Human peripheral blood leucocyte non-obese diabetic-severe combined immunodeficiency interleukin-2 receptor gamma chain gene mouse model of xenogeneic graft-versus-host-like disease and the role of host major histocompatibility complex

(2009) M. A. King et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

High diversity of the immune repertoire in humanized NOD.SCID.γc−/− mice

(2009) Gilles Marodon et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Comparison of human fetal liver, umbilical cord blood, and adult blood hematopoietic stem cell engraftment in NOD-scid/γc−/−, Balb/c-Rag1−/−γc−/−, and C.B-17-scid/bg immunodeficient mice

(2009) Christin M. Lepus et al.   HUMAN IMMUNOLOGY

The analysis of the functions of human B and T cells in humanized NOD/shi-scid/γcnull (NOG) mice (hu-HSC NOG mice)

(2009) Yohei Watanabe et al.   INTERNATIONAL IMMUNOLOGY

Priming of protective T cell responses against virus-induced tumors in mice with human immune system components

(2009) Till Strowig et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Sepsis-induced human lymphocyte apoptosis and cytokine production in “humanized” mice

(2009) Jacqueline Unsinger et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Induction of Robust Cellular and Humoral Virus-Specific Adaptive Immune Responses in Human Immunodeficiency Virus-Infected Humanized BLT Mice

(2009) D. M. Brainard et al.   JOURNAL OF VIROLOGY

Dengue Virus Infection and Virus-Specific HLA-A2 Restricted Immune Responses in Humanized NOD-scid IL2rγnull Mice

(2009) Smita Jaiswal et al.   PLoS One

Expression of human cytokines dramatically improves reconstitution of specific human-blood lineage cells in humanized mice

(2009) Q. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Alloreactivity but Failure to Reject Human Islet Transplants by Humanized Balb/c/Rag2−/−gc−/−Mice

(2009) S. Jacobson et al.   SCANDINAVIAN JOURNAL OF IMMUNOLOGY

Highly Sensitive Model for Xenogenic GVHD Using Severe Immunodeficient NOG Mice

(2009) Ryoji Ito et al.   TRANSPLANTATION

Antigen-specific human T-cell responses and T cell-dependent production of human antibodies in a humanized mouse model

(2008) N. Tonomura et al.   BLOOD

Disorders of a modern lifestyle: reconciling the epidemiology of inflammatory bowel diseases

(2008) C. N Bernstein et al.   GUT

Biological Roles for the NOX Family NADPH Oxidases

(2008) William M. Nauseef   JOURNAL OF BIOLOGICAL CHEMISTRY

IL-15 trans-presentation promotes human NK cell development and differentiation in vivo

(2008) Nicholas D. Huntington et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Human BLyS Facilitates Engraftment of Human PBL Derived B Cells in Immunodeficient Mice

(2008) Madelyn R. Schmidt et al.   PLoS One

A new Hu-PBL model for the study of human islet alloreactivity based on NOD-scid mice bearing a targeted mutation in the IL-2 receptor gamma chain gene

(2007) Marie King et al.   CLINICAL IMMUNOLOGY