Journal
JOURNAL OF INFECTIOUS DISEASES
Volume 208, Issue -, Pages S155-S159Publisher
OXFORD UNIV PRESS INC
DOI: 10.1093/infdis/jit448
Keywords
immunology; humanized mice; BLT mice; fetal tissue transplantation; humoral immunity; B cells; antibody
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Funding
- Harvard University Center for AIDS Research (HU CFAR, National Institutes of Health/National Institute of Allergy and Infectious Diseases [NIH/NIAID]) [P30-AI060354]
- NIH/NIAID [P01-AI104715]
- HU CFAR [NIH/NIAID P30-AI060354]
- Ragon Institute Initiative
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Humanized mice historically have not been good models of human humoral immunity induced by either infection or immunization. However, newer versions of humanized mice generated in severely immunodeficient mice with a targeted disruption of the IL2R gamma(c) gene have recently been reported to produce antigen-specific class-switched human antibodies, with some demonstrating neutralizing activities. Here we review the growing ability of humanized mice to support the study of human humoral immune responses, discussing the current and future potential of these models as well as their current limitations.
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